{"id":116652,"date":"2025-09-26T10:00:50","date_gmt":"2025-09-26T01:00:50","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/"},"modified":"2025-09-26T10:17:03","modified_gmt":"2025-09-26T01:17:03","slug":"nipt-positive-next-steps-2","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en","title":{"rendered":"The NIPT Result Was Positive\u2026 How to Face the Risk of Intellectual Disability?"},"content":{"rendered":"\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#1_Introduction_Confronting_the_reality_of_NIPT_positivity\" >1. Introduction: Confronting the reality of NIPT positivity<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#2_A_positive_NIPT_is_not_a_definitive_diagnosis\" >2. A positive NIPT is not a definitive diagnosis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#3_Main_chromosomal_abnormalities_that_tend_to_show_positive_on_NIPT\" >3. Main chromosomal abnormalities that tend to show positive on NIPT<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#4_First_steps_in_confronting_the_risk_of_intellectual_disability\" >4. First steps in confronting the risk of intellectual disability<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#5_Psychological_impact_on_the_family_after_a_positive_result\" >5. Psychological impact on the family after a positive result<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#6_Preparations_with_an_eye_toward_postnatal_life\" >6. Preparations with an eye toward postnatal life<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#7_Degrees_of_intellectual_disability_and_possible_life_outcomes\" >7. Degrees of intellectual disability and possible life outcomes<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#8_Importance_of_genetic_counseling\" >8. Importance of genetic counseling<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#9_Social_and_ethical_perspectives\" >9. Social and ethical perspectives<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#10_Future_prospects\" >10. Future prospects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#11_Steps_the_family_should_take_next\" >11. Steps the family should take next<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#12_Support_systems_and_social_resources_available_in_Japan\" >12. Support systems and social resources available in Japan<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#13_Importance_of_building_medical_collaboration_before_birth\" >13. Importance of building medical collaboration before birth<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#14_Learning_from_overseas_cases\" >14. Learning from overseas cases<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#15_Conclusion_Calm_response_and_proactive_preparation_can_change_the_future\" >15. Conclusion: Calm response and proactive preparation can change the future<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\/#References_Evidence\" >References (Evidence)<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_Introduction_Confronting_the_reality_of_NIPT_positivity\"><\/span>1. Introduction: Confronting the reality of NIPT positivity<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> (non\u2011invasive prenatal testing) analyzes fetal DNA in the maternal bloodstream to screen for the possibility of chromosomal abnormalities.<br>If the result is positive, many pregnant women and their families face strong anxiety.<br>\u201cDoes this result mean it\u2019s certain?\u201d<br>\u201cIs there a risk of intellectual disability for the baby?\u201d<br>\u201cWhat should we do next?\u201d<br>To confront such doubts and anxiety, correct medical knowledge and a calm response are essential.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_A_positive_NIPT_is_not_a_definitive_diagnosis\"><\/span>2. A positive NIPT is not a definitive diagnosis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The first thing to understand is that <strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> positive \u2260 fetal abnormality<\/strong>.<br><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is a screening test<br>\u2192 It estimates the likelihood of chromosomal anomaly but does not provide a definitive diagnosis.<\/p>\n\n\n\n<p>There is a possibility of false positives<br>\u2192 Due to maternal chromosomal mosaicism or influence from placental DNA, results may come out positive.<\/p>\n\n\n\n<p>If you receive a positive result, confirmatory testing such as amniocentesis or chorionic villus sampling is required (recommended by the Japan Society of Obstetrics and Gynecology).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_Main_chromosomal_abnormalities_that_tend_to_show_positive_on_NIPT\"><\/span>3. Main chromosomal abnormalities that tend to show positive on NIPT<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The main chromosomal abnormalities that <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is prone to flag as positive include the following:<br><strong>Trisomy 21 (Down syndrome)<\/strong><br>Intellectual disability is often mild to moderate, and life expectancy has been increasing.<\/p>\n\n\n\n<p><strong>Trisomy 18 (Edwards syndrome)<\/strong><br>Often accompanied by severe developmental disorders or congenital heart defects; many become critically ill soon after birth.<\/p>\n\n\n\n<p><strong>Trisomy 13 (Patau syndrome)<\/strong><br>Often accompanied by severe intellectual disability and multiple malformations; prognosis tends to be poor.<\/p>\n\n\n\n<p>Recently, some facilities screen for microdeletion\/duplication syndromes, which may accompany mild\u2011to\u2011moderate intellectual disability or autism spectrum traits.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_First_steps_in_confronting_the_risk_of_intellectual_disability\"><\/span>4. First steps in confronting the risk of intellectual disability<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>When <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is positive, what matters is to follow these steps:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Consult with a physician or genetic counselor about the result<\/li>\n\n\n\n<li>Confirm the test\u2019s accuracy, possibility of false positives, and next testing steps<\/li>\n\n\n\n<li>Decide whether to pursue a confirmatory diagnosis<\/li>\n\n\n\n<li>Amniocentesis is usually done after 15 weeks of pregnancy; miscarriage risk is about 0.1\u20130.3%<\/li>\n\n\n\n<li>Organize information and discuss with family<\/li>\n\n\n\n<li>Consider life, medical care, and support frameworks after birth<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_Psychological_impact_on_the_family_after_a_positive_result\"><\/span>5. Psychological impact on the family after a positive result<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A positive <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> result can impose psychological burdens not only on the pregnant woman but on the entire family.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Shock, anxiety, guilt<\/li>\n\n\n\n<li>Ambiguity about continuing the pregnancy or family planning<\/li>\n\n\n\n<li>Fear of social prejudice<br>These emotions are natural, and it is recommended to seek support from psychologists, genetic counselors, or family support groups.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_Preparations_with_an_eye_toward_postnatal_life\"><\/span>6. Preparations with an eye toward postnatal life<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>If there is a risk of intellectual disability or congenital anomaly, it is reassuring to understand the support system before birth.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Medical side: coordination with pediatrics and the neonatal intensive care unit (NICU)<\/li>\n\n\n\n<li>Therapeutic side: initiating early intervention (physical therapy, occupational therapy, speech therapy)<\/li>\n\n\n\n<li>Welfare side: utilization of medical expense subsidies, special day care for children with disabilities, and special support education<br>Pre-birth preparation is the best way to reduce chaos after delivery.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7_Degrees_of_intellectual_disability_and_possible_life_outcomes\"><\/span>7. Degrees of intellectual disability and possible life outcomes<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The degree of intellectual disability associated with chromosomal abnormalities varies widely.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mild: daily life is nearly independent, with some support needed in learning<\/li>\n\n\n\n<li>Moderate: support is needed in daily life, making use of special support education and welfare services<\/li>\n\n\n\n<li>Severe: requires medical care and lifelong support<br>In recent years, thanks to integration of medical and welfare systems, there are increasing cases of people with disabilities participating in society and working.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"8_Importance_of_genetic_counseling\"><\/span>8. Importance of genetic counseling<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>In genetic counseling, you can receive the following support:<\/p>\n\n\n\n<p>Introduction to postnatal medical and welfare systems<br>Genetic counseling is an indispensable process for reducing anxiety on a positive result and raising the family\u2019s sense of understanding and acceptance.<\/p>\n\n\n\n<p>Accurate interpretation of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> results<\/p>\n\n\n\n<p>Determining the need for confirmatory diagnosis and organizing options<\/p>\n\n\n\n<p>Psychological support for the family<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2025\/09\/24567787_s.webp\" alt=\"\u533b\u8005\" class=\"wp-image-116588\"\/><\/figure><\/div>\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"9_Social_and_ethical_perspectives\"><\/span>9. Social and ethical perspectives<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>There are social and ethical issues in the spread of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The heavy decision of \u201cto continue or not\u201d brings psychological pressure<\/li>\n\n\n\n<li>Regional and economic disparities in access to testing<\/li>\n\n\n\n<li>Lack of societal understanding and support for disabilities<br>As testing technology advances, society as a whole must also strengthen understanding and support systems.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"10_Future_prospects\"><\/span>10. Future prospects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Expansion of screening to whole chromosomes and microdeletion syndromes<\/li>\n\n\n\n<li>Use of next\u2011generation sequencers to improve accuracy<\/li>\n\n\n\n<li>Seamless integration between prenatal diagnosis and postnatal therapy<br><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is evolving from a mere diagnostic tool to a starting point for preparing support from family and society.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"11_Steps_the_family_should_take_next\"><\/span>11. Steps the family should take next<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>If <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> yields a positive result, it\u2019s recommended that the family calmly proceed as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Organize information<br>\u2002 \u2192 Sort out the meaning of test results, possibility of false positives, and next testing options<br>\u2002 \u2192 Take notes during physician explanation, and ask about anything unclear<\/li>\n\n\n\n<li>Consider pursuing confirmatory diagnosis<br>\u2002 \u2192 Conduct amniocentesis or chorionic villus sampling to obtain a definitive diagnosis<br>\u2002 \u2192 This enables the family to make decisions on the basis of medical facts<\/li>\n\n\n\n<li>Plan life with an eye toward postnatal life<br>\u2002 \u2192 <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/early-nipt-august-only\/\">Early<\/a> understanding of medical, therapeutic, and welfare support systems can reduce confusion after birth<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"12_Support_systems_and_social_resources_available_in_Japan\"><\/span>12. Support systems and social resources available in Japan<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>If the risk of chromosomal abnormality is known before birth, understanding social resources can bring great peace of mind.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Medical expense subsidy systems<br>\u2002 \u2192 Subsidies such as for pediatric chronic specific diseases or medical costs for disabled children may be available<\/li>\n\n\n\n<li>Therapeutic support<br>\u2002 \u2192 Introducing early intervention (physical, occupational, speech therapy) can encourage development<\/li>\n\n\n\n<li>Day\u2011care facilities for children with disabilities and special support education<br>\u2002 \u2192 From preschool through elementary school, educational support by specialist staff is available<\/li>\n\n\n\n<li>Use of family associations and patient groups<br>\u2002 \u2192 Sharing information with families who have similar experiences can provide psychological support<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"13_Importance_of_building_medical_collaboration_before_birth\"><\/span>13. Importance of building medical collaboration before birth<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>If risk is known before birth, smooth collaboration with medical institutions is possible.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Choose a birthing facility with NICU<\/li>\n\n\n\n<li>Consultation before birth with pediatrics, neonatology, and genetics departments<\/li>\n\n\n\n<li>Develop a postnatal continuous follow\u2011up plan<br>With this preparation, appropriate response can be made rapidly after birth.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"14_Learning_from_overseas_cases\"><\/span>14. Learning from overseas cases<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>In Western countries, support for pregnant women with <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> positivity is fairly well established:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Prenatal family education programs<br>\u2002 \u2192 Families can learn comprehensively about medical, therapeutic, and life support before birth<\/li>\n\n\n\n<li>Societal acceptance and support of disability<br>\u2002 \u2192 Reducing prejudice in raising children with disabilities and achieving community support<\/li>\n\n\n\n<li>Integration with genomic medicine<br>\u2002 \u2192 Mechanisms connecting to individualized postnatal treatments<br>In Japan, there is hope for establishing a system that provides both testing and support in a one\u2011stop fashion.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"15_Conclusion_Calm_response_and_proactive_preparation_can_change_the_future\"><\/span>15. Conclusion: Calm response and proactive preparation can change the future<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A positive <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is not a definitive diagnosis \u2014 what matters is how you act next<\/li>\n\n\n\n<li>By organizing information with family and considering postnatal life planning, one achieves peace of mind<\/li>\n\n\n\n<li>If medical, therapeutic, and social resources are utilized, a fulfilling life is possible even with intellectual disability<\/li>\n\n\n\n<li>Gaining information before birth is at once a potential source of anxiety and an important step in protecting the family\u2019s future<br>By calmly accepting the facts and steadily building support and preparation, life for the child and family can become more secure and positive.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"References_Evidence\"><\/span><strong>References (Evidence)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Japan Society of Obstetrics and Gynecology: \u201cOpinion on Prenatal Genetic Testing Using Maternal Blood\u201d<br>Norton ME et al., <em>New England Journal of Medicine<\/em>, 2015; 372: 1589\u20111597<br>Gregg AR et al., <em>Genetics in Medicine<\/em>, 2021; 23: 1238\u20111245<br>Gil MM et al., <em>Ultrasound in Obstetrics &amp; Gynecology<\/em>, 2017; 50: 302\u2011314<br>Wilson KL et al., <em>Prenatal Diagnosis<\/em>, 2021; 41: 661\u2011672<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"1. Introduction: Con&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-positive-next-steps-2\/?lang=en\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":122,"featured_media":116644,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[97],"tags":[],"class_list":["post-116652","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/122"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=116652"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116652\/revisions"}],"predecessor-version":[{"id":116661,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/116652\/revisions\/116661"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/116644"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=116652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=116652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=116652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}