{"id":121775,"date":"2026-01-07T17:22:53","date_gmt":"2026-01-07T08:22:53","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?p=121775"},"modified":"2026-01-07T17:54:29","modified_gmt":"2026-01-07T08:54:29","slug":"alagille-syndrome-type-1","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/","title":{"rendered":"\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa41\u578b\uff08ALGS1\uff09"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2026\/01\/22339071_s-1.webp\" alt=\"\u8d64\u3061\u3083\u3093\" class=\"wp-image-121607\"\/><\/figure><\/div>\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span 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6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E3%81%AF%E3%81%98%E3%82%81%E3%81%AB\" >\u306f\u3058\u3081\u306b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#1_%E6%A6%82%E8%A6%81%EF%BC%9A%E3%81%A9%E3%81%AE%E3%82%88%E3%81%86%E3%81%AA%E7%97%85%E6%B0%97%E3%81%8B\" >1. \u6982\u8981\uff1a\u3069\u306e\u3088\u3046\u306a\u75c5\u6c17\u304b<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" 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href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E2%91%A3_%E9%AA%A8%EF%BC%9A%E8%9D%B6%E5%BD%A2%E6%A4%8E%EF%BC%88%E3%81%A1%E3%82%87%E3%81%86%E3%81%91%E3%81%84%E3%81%A4%E3%81%84%EF%BC%89\" >\u2463 \u9aa8\uff1a\u8776\u5f62\u690e\uff08\u3061\u3087\u3046\u3051\u3044\u3064\u3044\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E2%91%A4_%E7%9B%AE%EF%BC%9A%E5%BE%8C%E9%83%A8%E8%83%8E%E7%94%9F%E7%92%B0%EF%BC%88%E3%81%93%E3%81%86%E3%81%B6%E3%81%9F%E3%81%84%E3%81%9B%E3%81%84%E3%81%8B%E3%82%93%EF%BC%89\" >\u2464 \u76ee\uff1a\u5f8c\u90e8\u80ce\u751f\u74b0\uff08\u3053\u3046\u3076\u305f\u3044\u305b\u3044\u304b\u3093\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" 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href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E9%81%BA%E4%BC%9D%E5%BD%A2%E5%BC%8F%EF%BC%9A%E5%B8%B8%E6%9F%93%E8%89%B2%E4%BD%93%E9%A1%95%E6%80%A7%E9%81%BA%E4%BC%9D%EF%BC%88%E5%84%AA%E6%80%A7%E9%81%BA%E4%BC%9D%EF%BC%89\" >\u907a\u4f1d\u5f62\u5f0f\uff1a\u5e38\u67d3\u8272\u4f53\u9855\u6027\u907a\u4f1d\uff08\u512a\u6027\u907a\u4f1d\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#4_%E8%A8%BA%E6%96%AD%E3%81%A8%E6%A4%9C%E6%9F%BB\" >4. \u8a3a\u65ad\u3068\u691c\u67fb<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E8%87%A8%E5%BA%8A%E8%A8%BA%E6%96%AD\" >\u81e8\u5e8a\u8a3a\u65ad<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E9%81%BA%E4%BC%9D%E5%AD%A6%E7%9A%84%E6%A4%9C%E6%9F%BB\" >\u907a\u4f1d\u5b66\u7684\u691c\u67fb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E6%A4%9C%E6%9F%BB\" >\u305d\u306e\u4ed6\u306e\u691c\u67fb<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#5_%E6%B2%BB%E7%99%82%E3%81%A8%E7%AE%A1%E7%90%86\" >5. \u6cbb\u7642\u3068\u7ba1\u7406<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E2%91%A0_%E8%82%9D%E8%87%93%E3%81%AE%E3%82%B1%E3%82%A2%EF%BC%9A%E6%B5%81%E3%82%8C%E3%82%92%E8%89%AF%E3%81%8F%E3%81%97%E3%80%81%E6%A0%84%E9%A4%8A%E3%82%92%E8%A3%9C%E3%81%86\" >\u2460 \u809d\u81d3\u306e\u30b1\u30a2\uff1a\u6d41\u308c\u3092\u826f\u304f\u3057\u3001\u6804\u990a\u3092\u88dc\u3046<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E2%91%A1_%E5%BF%83%E8%87%93%E3%83%BB%E8%A1%80%E7%AE%A1%E3%81%AE%E6%B2%BB%E7%99%82\" >\u2461 \u5fc3\u81d3\u30fb\u8840\u7ba1\u306e\u6cbb\u7642<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E2%91%A2_%E8%85%8E%E8%87%93%E3%83%BB%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E7%AE%A1%E7%90%86\" >\u2462 \u814e\u81d3\u30fb\u305d\u306e\u4ed6\u306e\u7ba1\u7406<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E2%91%A3_%E8%82%9D%E7%A7%BB%E6%A4%8D%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6\" >\u2463 \u809d\u79fb\u690d\u306b\u3064\u3044\u3066<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#6_%E3%81%BE%E3%81%A8%E3%82%81\" >6. \u307e\u3068\u3081<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#7_%E8%A8%BA%E6%96%AD%E3%82%92%E5%8F%97%E3%81%91%E3%81%9F%E3%81%94%E5%AE%B6%E6%97%8F%E3%81%B8%E3%81%AE%E3%83%A1%E3%83%83%E3%82%BB%E3%83%BC%E3%82%B8\" >7. \u8a3a\u65ad\u3092\u53d7\u3051\u305f\u3054\u5bb6\u65cf\u3078\u306e\u30e1\u30c3\u30bb\u30fc\u30b8<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/alagille-syndrome-type-1\/#%E9%95%B7%E6%9C%9F%E7%9A%84%E3%81%AA%E8%A6%96%E7%82%B9%E3%82%92%E6%8C%81%E3%81%A3%E3%81%A6\" >\u9577\u671f\u7684\u306a\u8996\u70b9\u3092\u6301\u3063\u3066<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%81%AF%E3%81%98%E3%82%81%E3%81%AB\"><\/span><strong>\u306f\u3058\u3081\u306b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u304a\u5b50\u69d8\u304c\u300c\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\uff081\u578b\uff09\u300d\u3068\u3044\u3046\u8a3a\u65ad\u3092\u53d7\u3051\u3001\u805e\u304d\u306a\u308c\u306a\u3044\u75c5\u540d\u306b\u6238\u60d1\u3044\u3001\u591a\u304f\u306e\u4e0d\u5b89\u3092\u611f\u3058\u3066\u3044\u3089\u3063\u3057\u3083\u308b\u3053\u3068\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u300c\u809d\u81d3\u306e\u75c5\u6c17\u306a\u306e\uff1f\u300d\u300c\u5fc3\u81d3\u3082\u60aa\u3044\u306e\uff1f\u300d\u300c\u3053\u308c\u304b\u3089\u3069\u3046\u306a\u3063\u3066\u3057\u307e\u3046\u306e\uff1f\u300d<\/p>\n\n\n\n<p>\u30a4\u30f3\u30bf\u30fc\u30cd\u30c3\u30c8\u3067\u691c\u7d22\u3059\u308b\u3068\u3001\u96e3\u3057\u3044\u533b\u5b66\u7528\u8a9e\u3084\u91cd\u3044\u75c7\u72b6\u306e\u60c5\u5831\u3070\u304b\u308a\u304c\u76ee\u306b\u5165\u308a\u3001\u80f8\u304c\u7de0\u3081\u4ed8\u3051\u3089\u308c\u308b\u3088\u3046\u306a\u601d\u3044\u3092\u3055\u308c\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u307e\u305a\u6700\u521d\u306b\u304a\u4f1d\u3048\u3057\u305f\u3044\u306e\u306f\u3001<strong>\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u306f\u3001\u75c7\u72b6\u306e\u51fa\u65b9\u3084\u91cd\u75c7\u5ea6\u304c\u3001\u60a3\u8005\u3055\u3093\u4e00\u4eba\u3072\u3068\u308a\u306b\u3088\u3063\u3066\u9a5a\u304f\u307b\u3069\u7570\u306a\u308b\u75c5\u6c17\u3067\u3042\u308b<\/strong>\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u91cd\u3044\u75c7\u72b6\u304c\u51fa\u308b\u304a\u5b50\u69d8\u3082\u3044\u308c\u3070\u3001\u5927\u4eba\u306b\u306a\u308b\u307e\u3067\u6c17\u3065\u304b\u308c\u306a\u3044\u307b\u3069\u8efd\u3044\u75c7\u72b6\u306e\u65b9\u3082\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u8a18\u4e8b\u306f\u3001\u8a3a\u65ad\u66f8\u306b\u3042\u308b\u300c\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa41\u578b\u300d\u3068\u3044\u3046\u8a00\u8449\u304c\u4f55\u3092\u610f\u5473\u3059\u308b\u306e\u304b\u3001\u304a\u5b50\u69d8\u306e\u4f53\u306b\u3069\u306e\u3088\u3046\u306a\u3053\u3068\u304c\u8d77\u304d\u3066\u3044\u308b\u306e\u304b\u3001\u305d\u3057\u3066\u3053\u308c\u304b\u3089\u3069\u306e\u3088\u3046\u306b\u6210\u9577\u3092\u652f\u3048\u3066\u3044\u3051\u3070\u3088\u3044\u306e\u304b\u3092\u3001\u3067\u304d\u308b\u3060\u3051\u5206\u304b\u308a\u3084\u3059\u304f\u89e3\u8aac\u3059\u308b\u305f\u3081\u306b\u4f5c\u6210\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u533b\u5b66\u7684\u306a\u4e8b\u5b9f\u3060\u3051\u3067\u306a\u304f\u3001\u751f\u6d3b\u4e0a\u306e\u30d2\u30f3\u30c8\u3084\u3054\u5bb6\u65cf\u3078\u306e\u30e1\u30c3\u30bb\u30fc\u30b8\u3082\u76db\u308a\u8fbc\u3093\u3067\u3044\u307e\u3059\u3002\u4e00\u5ea6\u306b\u3059\u3079\u3066\u3092\u7406\u89e3\u3057\u3088\u3046\u3068\u305b\u305a\u3001\u5fc5\u8981\u306a\u90e8\u5206\u304b\u3089\u5c11\u3057\u305a\u3064\u8aad\u307f\u9032\u3081\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_%E6%A6%82%E8%A6%81%EF%BC%9A%E3%81%A9%E3%81%AE%E3%82%88%E3%81%86%E3%81%AA%E7%97%85%E6%B0%97%E3%81%8B\"><\/span><strong>1. \u6982\u8981\uff1a\u3069\u306e\u3088\u3046\u306a\u75c5\u6c17\u304b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%85%A8%E8%BA%AB%E3%81%AE%E3%80%8C%E7%AE%A1%EF%BC%88%E3%81%8F%E3%81%A0%EF%BC%89%E3%80%8D%E3%82%84%E6%A7%8B%E9%80%A0%E3%81%AB%E9%96%A2%E3%82%8F%E3%82%8B%E9%81%BA%E4%BC%9D%E5%AD%90%E3%81%AE%E7%97%85%E6%B0%97\"><\/span><strong>\u5168\u8eab\u306e\u300c\u7ba1\uff08\u304f\u3060\uff09\u300d\u3084\u69cb\u9020\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u75c5\u6c17<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\uff08Alagille Syndrome: ALGS\uff09\u306f\u3001<strong>\u809d\u81d3\u3001\u5fc3\u81d3\u3001\u9854\u8c8c\u3001\u76ee\u3001\u9aa8<\/strong>\u306a\u3069\u3001\u5168\u8eab\u306e\u8907\u6570\u306e\u81d3\u5668\u306b\u7279\u5fb4\u7684\u306a\u75c7\u72b6\u304c\u73fe\u308c\u308b\u907a\u4f1d\u6027\u306e\u75c5\u6c17\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u79c1\u305f\u3061\u306e\u4f53\u306f\u3001\u7d0437\u5146\u500b\u306e\u7d30\u80de\u3067\u3067\u304d\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u75c5\u6c17\u306f\u3001\u7d30\u80de\u540c\u58eb\u304c\u9023\u7d61\u3092\u53d6\u308a\u5408\u3046\u305f\u3081\u306e\u300cNotch\uff08\u30ce\u30c3\u30c1\uff09\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u300d\u3068\u3044\u3046\u4ed5\u7d44\u307f\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306b\u5909\u5316\u304c\u8d77\u304d\u308b\u3053\u3068\u3067\u767a\u751f\u3057\u307e\u3059\u3002\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u306f\u3001\u8d64\u3061\u3083\u3093\u304c\u304a\u8179\u306e\u4e2d\u3067\u80b2\u3064\u6642\u306b\u3001\u4f53\u306e\u69d8\u3005\u306a\u81d3\u5668\uff08\u7279\u306b\u300c\u7ba1\u300d\u306e\u3088\u3046\u306a\u69cb\u9020\uff09\u3092\u6b63\u3057\u304f\u5f62\u4f5c\u308b\u305f\u3081\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%80%8C1%E5%9E%8B%E3%80%8D%E3%81%A8%E3%81%AF%E4%BD%95%E3%81%8B%EF%BC%9F\"><\/span><strong>\u300c1\u578b\u300d\u3068\u306f\u4f55\u304b\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u306b\u306f\u3001\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u300c1\u578b\u300d\u3068\u300c2\u578b\u300d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>1\u578b\uff08ALGS1\uff09:<\/strong> JAG1\uff08\u30b8\u30e3\u30b0\u30ef\u30f3\uff09<strong>\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u8d77\u3053\u308a\u307e\u3059\u3002\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u5168\u4f53\u306e<\/strong>\u7d0498%\u3068\u3001\u5727\u5012\u7684\u591a\u6570\u304c\u3053\u306e1\u578b\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>2\u578b\uff08ALGS2\uff09:<\/strong> NOTCH2\uff08\u30ce\u30c3\u30c1\u30c4\u30fc\uff09\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u8d77\u3053\u308a\u307e\u3059\u3002\u975e\u5e38\u306b\u7a00\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3064\u307e\u308a\u3001\u4e00\u822c\u7684\u306b\u300c\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u300d\u3068\u8a00\u308f\u308c\u308b\u5834\u5408\u3001\u307b\u3068\u3093\u3069\u304c\u3053\u306e\u300c1\u578b\u300d\u3092\u6307\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3066\u5dee\u3057\u652f\u3048\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%A0%BB%E5%BA%A6%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6\"><\/span><strong>\u983b\u5ea6\u306b\u3064\u3044\u3066<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u7d0430,000\u4eba\u301c70,000\u4eba\u306b1\u4eba\u306e\u5272\u5408\u3067\u751f\u307e\u308c\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6c7a\u3057\u3066\u300c\u4e16\u754c\u306b\u6570\u4eba\u3057\u304b\u3044\u306a\u3044\u300d\u3068\u3044\u3046\u3088\u3046\u306a\u6975\u3081\u3066\u7a00\u306a\u75c5\u6c17\u3067\u306f\u306a\u304f\u3001\u4e16\u754c\u4e2d\u306b\u540c\u3058\u75c5\u6c17\u3068\u5171\u306b\u751f\u304d\u308b\u4ef2\u9593\u304c\u3044\u307e\u3059\u3002\u65e5\u672c\u3067\u306f\u6307\u5b9a\u96e3\u75c5\u304a\u3088\u3073\u5c0f\u5150\u6162\u6027\u7279\u5b9a\u75be\u75c5\u306b\u8a8d\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u533b\u7642\u8cbb\u52a9\u6210\u306a\u3069\u306e\u516c\u7684\u306a\u30b5\u30dd\u30fc\u30c8\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_%E4%B8%BB%E3%81%AA%E7%97%87%E7%8A%B6%EF%BC%885%E5%A4%A7%E5%BE%B4%E5%80%99%EF%BC%89\"><\/span><strong>2. \u4e3b\u306a\u75c7\u72b6\uff085\u5927\u5fb4\u5019\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u306b\u306f\u3001\u8a3a\u65ad\u306e\u57fa\u6e96\u3068\u306a\u308b\u300c5\u3064\u306e\u4e3b\u8981\u306a\u7279\u5fb4\uff085\u5927\u5fb4\u5019\uff09\u300d\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u304c\u3059\u3079\u3066\u63c3\u3046\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u3044\u304f\u3064\u304b\uff08\u901a\u5e38\u306f3\u3064\u4ee5\u4e0a\uff09\u304c\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u3067\u8a3a\u65ad\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%91%A0_%E8%82%9D%E8%87%93%EF%BC%9A%E6%85%A2%E6%80%A7%E7%9A%84%E3%81%AA%E8%83%86%E6%B1%81%E3%81%86%E3%81%A3%E6%BB%9E%EF%BC%88%E3%81%9F%E3%82%93%E3%81%98%E3%82%85%E3%81%86%E3%81%86%E3%81%A3%E3%81%9F%E3%81%84%EF%BC%89\"><\/span><strong>\u2460 \u809d\u81d3\uff1a\u6162\u6027\u7684\u306a\u80c6\u6c41\u3046\u3063\u6ede\uff08\u305f\u3093\u3058\u3085\u3046\u3046\u3063\u305f\u3044\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6700\u3082\u6cbb\u7642\u3084\u7ba1\u7406\u304c\u5fc5\u8981\u3068\u306a\u308b\u306e\u304c\u809d\u81d3\u306e\u75c7\u72b6\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4f55\u304c\u8d77\u304d\u3066\u3044\u308b\u304b:<\/strong> \u809d\u81d3\u3067\u4f5c\u3089\u308c\u305f\u6d88\u5316\u6db2\u300c\u80c6\u6c41\uff08\u305f\u3093\u3058\u3085\u3046\uff09\u300d\u306f\u3001\u300c\u80c6\u7ba1\uff08\u305f\u3093\u304b\u3093\uff09\u300d\u3068\u3044\u3046\u7ba1\u3092\u901a\u3063\u3066\u8178\u3078\u6d41\u308c\u307e\u3059\u3002\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u306e\u304a\u5b50\u69d8\u306f\u3001\u809d\u81d3\u306e\u4e2d\u306b\u3042\u308b\u5fae\u7d30\u306a\u80c6\u7ba1\u306e\u6570\u304c\u751f\u307e\u308c\u3064\u304d\u5c11\u306a\u3044\uff08\u809d\u5185\u80c6\u7ba1\u6e1b\u5c11\uff09\u3068\u3044\u3046\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u75c7\u72b6:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u9ec4\u75b8\uff08\u304a\u3046\u3060\u3093\uff09:<\/strong> \u80c6\u6c41\u304c\u3046\u307e\u304f\u6d41\u308c\u305a\u4f53\u306b\u6e9c\u307e\u308b\u305f\u3081\u3001\u76ae\u819a\u3084\u767d\u76ee\u304c\u9ec4\u8272\u304f\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u304b\u3086\u307f\uff08\u305d\u3046\u75d2\u611f\uff09:<\/strong> \u80c6\u6c41\u306b\u542b\u307e\u308c\u308b\u6210\u5206\u304c\u76ae\u819a\u306e\u795e\u7d4c\u3092\u523a\u6fc0\u3057\u3001\u975e\u5e38\u306b\u5f37\u3044\u304b\u3086\u307f\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u304a\u5b50\u69d8\u306b\u3068\u3063\u3066\u5927\u304d\u306a\u30b9\u30c8\u30ec\u30b9\u3068\u306a\u308a\u3001\u7761\u7720\u3092\u59a8\u3052\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u767d\u8272\u4fbf:<\/strong> \u80c6\u6c41\uff08\u4fbf\u3092\u8336\u8272\u304f\u3059\u308b\u6210\u5206\uff09\u304c\u8178\u306b\u6d41\u308c\u306a\u3044\u305f\u3081\u3001\u4fbf\u304c\u767d\u3063\u307d\u304f\u3001\u30af\u30ea\u30fc\u30e0\u8272\u3084\u8584\u3044\u30ec\u30e2\u30f3\u8272\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6804\u990a\u5438\u53ce\u969c\u5bb3:<\/strong> \u80c6\u6c41\u306f\u8102\u80aa\u306e\u5438\u53ce\u3092\u52a9\u3051\u308b\u50cd\u304d\u304c\u3042\u308a\u307e\u3059\u3002\u80c6\u6c41\u304c\u4e0d\u8db3\u3059\u308b\u3068\u8102\u80aa\u3084\u3001\u8102\u80aa\u306b\u6eb6\u3051\u308b\u30d3\u30bf\u30df\u30f3\uff08\u30d3\u30bf\u30df\u30f3A, D, E, K\uff09\u304c\u5438\u53ce\u3067\u304d\u305a\u3001\u6210\u9577\u306e\u9045\u308c\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%91%A1_%E5%BF%83%E8%87%93%E3%83%BB%E8%A1%80%E7%AE%A1%EF%BC%9A%E8%82%BA%E5%8B%95%E8%84%88%E3%81%AE%E7%8B%AD%E7%AA%84%E3%81%AA%E3%81%A9\"><\/span><strong>\u2461 \u5fc3\u81d3\u30fb\u8840\u7ba1\uff1a\u80ba\u52d5\u8108\u306e\u72ed\u7a84\u306a\u3069<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u7d0490%\u4ee5\u4e0a\u306e\u60a3\u8005\u3055\u3093\u306b\u5fc3\u81d3\u3084\u8840\u7ba1\u306e\u7279\u5fb4\u304c\u898b\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u672b\u68a2\u6027\u80ba\u52d5\u8108\u72ed\u7a84\uff08\u307e\u3063\u3057\u3087\u3046\u305b\u3044\u306f\u3044\u3069\u3046\u307f\u3083\u304f\u304d\u3087\u3046\u3055\u304f\uff09:<\/strong> \u5fc3\u81d3\u304b\u3089\u80ba\u3078\u8840\u6db2\u3092\u9001\u308b\u8840\u7ba1\uff08\u80ba\u52d5\u8108\uff09\u306e\u3001\u679d\u5206\u304b\u308c\u3057\u305f\u5148\u306e\u90e8\u5206\u304c\u72ed\u304f\u306a\u3063\u3066\u3044\u308b\u72b6\u614b\u3067\u3059\u3002\u591a\u304f\u306e\u5834\u5408\u306f\u8efd\u5ea6\u3067\u3001\u5fc3\u96d1\u97f3\uff08\u5fc3\u81d3\u306e\u97f3\u306e\u7570\u5e38\uff09\u3068\u3057\u3066\u6307\u6458\u3055\u308c\u307e\u3059\u304c\u3001\u6cbb\u7642\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044\u3053\u3068\u3082\u591a\u3044\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30d5\u30a1\u30ed\u30fc\u56db\u5fb4\u75c7\uff08\u3057\u3061\u3087\u3046\u3057\u3087\u3046\uff09\u306a\u3069:<\/strong> \u3088\u308a\u8907\u96d1\u306a\u5fc3\u81d3\u306e\u75c5\u6c17\u3092\u5408\u4f75\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u3001\u305d\u306e\u5834\u5408\u306f\u624b\u8853\u304c\u5fc5\u8981\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%91%A2_%E7%89%B9%E5%BE%B4%E7%9A%84%E3%81%AA%E9%A1%94%E8%B2%8C%EF%BC%88%E3%81%8C%E3%82%93%E3%81%BC%E3%81%86%EF%BC%89\"><\/span><strong>\u2462 \u7279\u5fb4\u7684\u306a\u9854\u8c8c\uff08\u304c\u3093\u307c\u3046\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u304a\u9854\u7acb\u3061\u306b\u3044\u304f\u3064\u304b\u306e\u5171\u901a\u70b9\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u6210\u9577\u3068\u3068\u3082\u306b\u5c11\u3057\u305a\u3064\u306f\u3063\u304d\u308a\u3057\u3066\u304f\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u984d\uff08\u304a\u3067\u3053\uff09\u304c\u5e83\u304f\u3001\u7a81\u51fa\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li>\u76ee\u304c\u6df1\u304f\u304f\u307c\u3093\u3067\u3044\u308b\uff08\u773c\u7403\u9665\u51f9\uff09\u3002<\/li>\n\n\n\n<li>\u4e21\u76ee\u306e\u9593\u9694\u304c\u96e2\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li>\u3042\u3054\u304c\u5c0f\u3055\u304f\u3001\u5c16\u3063\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li>\u9f3b\u7b4b\u304c\u901a\u3063\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u3054\u5bb6\u65cf\u3078:<\/strong> \u3053\u308c\u3089\u306f\u533b\u5b66\u7684\u306a\u7279\u5fb4\u306e\u8a18\u8ff0\u3067\u3042\u308a\u3001\u304a\u5b50\u69d8\u306e\u500b\u6027\u306e\u4e00\u90e8\u3067\u3059\u3002\u300c\u30a2\u30e9\u30b8\u30fc\u30eb\u7279\u6709\u306e\u9854\u300d\u3068\u3044\u3046\u3088\u308a\u3082\u3001\u3054\u4e21\u89aa\u306b\u4f3c\u3066\u3044\u308b\u90e8\u5206\u3082\u305f\u304f\u3055\u3093\u3042\u308b\u306f\u305a\u3067\u3059\u3002\u591a\u304f\u306e\u304a\u5b50\u69d8\u306f\u3001\u3068\u3066\u3082\u611b\u3089\u3057\u304f\u9b45\u529b\u7684\u306a\u8868\u60c5\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%91%A3_%E9%AA%A8%EF%BC%9A%E8%9D%B6%E5%BD%A2%E6%A4%8E%EF%BC%88%E3%81%A1%E3%82%87%E3%81%86%E3%81%91%E3%81%84%E3%81%A4%E3%81%84%EF%BC%89\"><\/span><strong>\u2463 \u9aa8\uff1a\u8776\u5f62\u690e\uff08\u3061\u3087\u3046\u3051\u3044\u3064\u3044\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u30ec\u30f3\u30c8\u30b2\u30f3\u5199\u771f\u3092\u64ae\u308b\u3068\u3001\u80cc\u9aa8\u306e\u4e00\u90e8\u304c\u8776\u3005\u304c\u7fbd\u3092\u5e83\u3052\u305f\u3088\u3046\u306a\u5f62\u306b\u898b\u3048\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5f71\u97ff:<\/strong> \u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001\u80cc\u9aa8\u306e\u6a5f\u80fd\u306b\u306f\u5168\u304f\u554f\u984c\u304c\u306a\u304f\u3001\u75db\u307f\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u5076\u7136\u30ec\u30f3\u30c8\u30b2\u30f3\u3067\u898b\u3064\u304b\u308b\u3053\u3068\u304c\u591a\u3044\u7279\u5fb4\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%91%A4_%E7%9B%AE%EF%BC%9A%E5%BE%8C%E9%83%A8%E8%83%8E%E7%94%9F%E7%92%B0%EF%BC%88%E3%81%93%E3%81%86%E3%81%B6%E3%81%9F%E3%81%84%E3%81%9B%E3%81%84%E3%81%8B%E3%82%93%EF%BC%89\"><\/span><strong>\u2464 \u76ee\uff1a\u5f8c\u90e8\u80ce\u751f\u74b0\uff08\u3053\u3046\u3076\u305f\u3044\u305b\u3044\u304b\u3093\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u773c\u79d1\u306e\u8a3a\u5bdf\u7528\u9855\u5fae\u93e1\u3067\u8a73\u3057\u304f\u898b\u308b\u3068\u3001\u89d2\u819c\uff08\u9ed2\u76ee\uff09\u306e\u88cf\u5074\u306b\u767d\u3044\u7dda\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u898b\u3048\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5f71\u97ff:<\/strong> \u3053\u308c\u81ea\u4f53\u304c\u8996\u529b\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%91%A5_%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E7%97%87%E7%8A%B6\"><\/span><strong>\u2465 \u305d\u306e\u4ed6\u306e\u75c7\u72b6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u814e\u81d3:<\/strong> \u814e\u81d3\u304c\u5c0f\u3055\u3044\u3001\u56a2\u80de\uff08\u306e\u3046\u307b\u3046\uff09\u304c\u3042\u308b\u3001\u306a\u3069\u306e\u69cb\u9020\u7684\u306a\u7570\u5e38\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8840\u7ba1:<\/strong> \u8133\u3084\u5168\u8eab\u306e\u8840\u7ba1\u306b\u7570\u5e38\uff08\u3082\u3084\u3082\u3084\u75c5\u306a\u3069\uff09\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u7a00\u306b\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6210\u9577\u969c\u5bb3:<\/strong> \u809d\u81d3\u304b\u3089\u306e\u6804\u990a\u5438\u53ce\u4e0d\u826f\u306b\u3088\u308a\u3001\u8eab\u9577\u3084\u4f53\u91cd\u306e\u4f38\u3073\u304c\u3086\u3063\u304f\u308a\u306b\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_%E5%8E%9F%E5%9B%A0%E3%81%A8%E9%81%BA%E4%BC%9D%E3%81%AE%E3%81%97%E3%81%8F%E3%81%BF\"><\/span><strong>3. \u539f\u56e0\u3068\u907a\u4f1d\u306e\u3057\u304f\u307f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%8E%9F%E5%9B%A0%E9%81%BA%E4%BC%9D%E5%AD%90%EF%BC%9AJAG1\"><\/span><strong>\u539f\u56e0\u907a\u4f1d\u5b50\uff1aJAG1<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u524d\u8ff0\u306e\u901a\u308a\u30011\u578b\u306f20\u756a\u67d3\u8272\u4f53\u306b\u3042\u308b<strong>JAG1\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u304c\u539f\u56e0\u3067\u3059\u3002 \u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u540c\u58eb\u304c\u300c\u96a3\u306e\u7d30\u80de\u306b\u6307\u4ee4\u3092\u51fa\u3059\u300d\u305f\u3081\u306e\u30a2\u30f3\u30c6\u30ca\u306e\u3088\u3046\u306a\u5f79\u5272\uff08Notch\u30b7\u30b0\u30ca\u30eb\uff09\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30a2\u30f3\u30c6\u30ca\u304c\u3046\u307e\u304f\u50cd\u304b\u306a\u3044\u3053\u3068\u3067\u3001\u80c6\u7ba1\u3084\u8840\u7ba1\u306e\u5f62\u6210\u304c\u4e0d\u5b8c\u5168\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%81%BA%E4%BC%9D%E5%BD%A2%E5%BC%8F%EF%BC%9A%E5%B8%B8%E6%9F%93%E8%89%B2%E4%BD%93%E9%A1%95%E6%80%A7%E9%81%BA%E4%BC%9D%EF%BC%88%E5%84%AA%E6%80%A7%E9%81%BA%E4%BC%9D%EF%BC%89\"><\/span><strong>\u907a\u4f1d\u5f62\u5f0f\uff1a\u5e38\u67d3\u8272\u4f53\u9855\u6027\u907a\u4f1d\uff08\u512a\u6027\u907a\u4f1d\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u3053\u306e\u75c5\u6c17\u306f\u300c\u5e38\u67d3\u8272\u4f53\u9855\u6027\u907a\u4f1d\uff08\u3058\u3087\u3046\u305b\u3093\u3057\u3087\u304f\u305f\u3044\u3051\u3093\u305b\u3044\u3044\u3067\u3093\uff09\u300d\u3068\u3044\u3046\u5f62\u5f0f\u3092\u3068\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>50\u301c70%\u306f\u300c\u7a81\u7136\u5909\u7570\u300d:<\/strong> \u3053\u3053\u304c\u6700\u3082\u91cd\u8981\u306a\u70b9\u3067\u3059\u304c\u3001\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u306e\u60a3\u8005\u3055\u3093\u306e\u534a\u6570\u4ee5\u4e0a\u306f\u3001<strong>\u3054\u4e21\u89aa\u306e\u907a\u4f1d\u5b50\u306b\u306f\u5168\u304f\u7570\u5e38\u304c\u306a\u304f\u3001\u304a\u5b50\u69d8\u306e\u4ee3\u3067\u521d\u3081\u3066\u5076\u7136\u306b\u5909\u5316\u304c\u8d77\u304d\u305f\uff08de novo\u5909\u7570\uff09\u30b1\u30fc\u30b9<\/strong>\u3067\u3059\u3002 <strong>\u6c7a\u3057\u3066\u3001\u598a\u5a20\u4e2d\u306e\u304a\u6bcd\u69d8\u306e\u98df\u4e8b\u3001\u884c\u52d5\u3001\u30b9\u30c8\u30ec\u30b9\u3001\u85ac\u306a\u3069\u304c\u539f\u56e0\u3067\u8d77\u3053\u3063\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/li>\n\n\n\n<li><strong>30\u301c50%\u306f\u300c\u907a\u4f1d\u300d:<\/strong> \u3054\u4e21\u89aa\u306e\u3069\u3061\u3089\u304b\u304c\u3001\u5b9f\u306f\u8efd\u5ea6\u306e\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\uff08\u307e\u305f\u306f\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308b\u304c\u75c7\u72b6\u304c\u306a\u3044\uff09\u3067\u3042\u308a\u3001\u305d\u308c\u304c\u304a\u5b50\u69d8\u306b\u53d7\u3051\u7d99\u304c\u308c\u305f\u30b1\u30fc\u30b9\u3067\u3059\u3002\u3053\u306e\u5834\u5408\u3001\u6b21\u306e\u304a\u5b50\u69d8\u306b\u907a\u4f1d\u3059\u308b\u78ba\u7387\u306f50%\u3068\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u203b\u6b21\u306e\u304a\u5b50\u69d8\u3092\u5e0c\u671b\u3055\u308c\u308b\u5834\u5408\u306a\u3069\u3001\u8a73\u3057\u304f\u306f\u81e8\u5e8a\u907a\u4f1d\u5c02\u9580\u533b\u3084\u8a8d\u5b9a\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\u306b\u3088\u308b\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u53d7\u3051\u308b\u3053\u3068\u3092\u304a\u52e7\u3081\u3057\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2026\/01\/24693730_s.webp\" alt=\"\u8d64\u3061\u3083\u3093\" class=\"wp-image-121534\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_%E8%A8%BA%E6%96%AD%E3%81%A8%E6%A4%9C%E6%9F%BB\"><\/span><strong>4. \u8a3a\u65ad\u3068\u691c\u67fb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u8a3a\u65ad\u306f\u3001\u75c7\u72b6\u306e\u7d44\u307f\u5408\u308f\u305b\u3068\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%87%A8%E5%BA%8A%E8%A8%BA%E6%96%AD\"><\/span><strong>\u81e8\u5e8a\u8a3a\u65ad<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u4f1d\u7d71\u7684\u306b\u306f\u3001\u4ee5\u4e0b\u306e5\u3064\u306e\u4e3b\u306a\u75c7\u72b6\u306e\u3046\u3061\u30013\u3064\u4ee5\u4e0a\u304c\u8a8d\u3081\u3089\u308c\u3001\u304b\u3064\u809d\u751f\u691c\uff08\u809d\u81d3\u306e\u7d44\u7e54\u3092\u91dd\u3067\u5c11\u3057\u63a1\u3063\u3066\u8abf\u3079\u308b\u691c\u67fb\uff09\u3067\u80c6\u7ba1\u306e\u6e1b\u5c11\u304c\u78ba\u8a8d\u3055\u308c\u305f\u5834\u5408\u306b\u8a3a\u65ad\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u6162\u6027\u7684\u306a\u80c6\u6c41\u3046\u3063\u6ede<\/li>\n\n\n\n<li>\u5fc3\u8840\u7ba1\u7cfb\u306e\u7570\u5e38<\/li>\n\n\n\n<li>\u7279\u5fb4\u7684\u306a\u9854\u8c8c<\/li>\n\n\n\n<li>\u8776\u5f62\u690e<\/li>\n\n\n\n<li>\u5f8c\u90e8\u80ce\u751f\u74b0<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%81%BA%E4%BC%9D%E5%AD%A6%E7%9A%84%E6%A4%9C%E6%9F%BB\"><\/span><strong>\u907a\u4f1d\u5b66\u7684\u691c\u67fb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u73fe\u5728\u3067\u306f\u3001\u8840\u6db2\u691c\u67fb\u3067JAG1\u907a\u4f1d\u5b50\uff08\u307e\u305f\u306fNOTCH2\u907a\u4f1d\u5b50\uff09\u306b\u5909\u7570\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u3001\u78ba\u5b9a\u8a3a\u65ad\u306e\u4e3b\u6d41\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u75c7\u72b6\u304c\u5178\u578b\u7684\u3067\u306a\u3044\u5834\u5408\u3084\u3001\u8efd\u3044\u5834\u5408\u3067\u3082\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u8a3a\u65ad\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E6%A4%9C%E6%9F%BB\"><\/span><strong>\u305d\u306e\u4ed6\u306e\u691c\u67fb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8840\u6db2\u691c\u67fb:<\/strong> \u809d\u6a5f\u80fd\uff08GOT, GPT, \u03b3-GTP\u306a\u3069\uff09\u3001\u30d3\u30bf\u30df\u30f3\u6fc3\u5ea6\u3001\u814e\u6a5f\u80fd\u306a\u3069\u3092\u5b9a\u671f\u7684\u306b\u30c1\u30a7\u30c3\u30af\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u753b\u50cf\u691c\u67fb:<\/strong> \u8d85\u97f3\u6ce2\uff08\u30a8\u30b3\u30fc\uff09\u3001CT\u3001MRI\u306a\u3069\u3067\u3001\u809d\u81d3\u306e\u5f62\u3084\u5fc3\u81d3\u306e\u8840\u7ba1\u306e\u72b6\u614b\u3092\u8abf\u3079\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_%E6%B2%BB%E7%99%82%E3%81%A8%E7%AE%A1%E7%90%86\"><\/span><strong>5. \u6cbb\u7642\u3068\u7ba1\u7406<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u306e\u907a\u4f1d\u5b50\u305d\u306e\u3082\u306e\u3092\u6cbb\u3059\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u306f\u3001\u73fe\u6642\u70b9\u3067\u306f\u307e\u3060\u3042\u308a\u307e\u305b\u3093\u3002 \u3057\u304b\u3057\u3001\u305d\u308c\u305e\u308c\u306e\u75c7\u72b6\u3092\u548c\u3089\u3052\u3001\u5408\u4f75\u75c7\u3092\u9632\u3050\u305f\u3081\u306e\u6cbb\u7642\u6cd5\uff08\u5bfe\u75c7\u7642\u6cd5\uff09\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u3059\u3002**\u300c\u3046\u307e\u304f\u4ed8\u304d\u5408\u3063\u3066\u3044\u304f\u300d**\u3053\u3068\u304c\u6cbb\u7642\u306e\u76ee\u6a19\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%91%A0_%E8%82%9D%E8%87%93%E3%81%AE%E3%82%B1%E3%82%A2%EF%BC%9A%E6%B5%81%E3%82%8C%E3%82%92%E8%89%AF%E3%81%8F%E3%81%97%E3%80%81%E6%A0%84%E9%A4%8A%E3%82%92%E8%A3%9C%E3%81%86\"><\/span><strong>\u2460 \u809d\u81d3\u306e\u30b1\u30a2\uff1a\u6d41\u308c\u3092\u826f\u304f\u3057\u3001\u6804\u990a\u3092\u88dc\u3046<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6700\u3082\u91cd\u8981\u306a\u306e\u304c\u3001\u809d\u81d3\u306e\u7ba1\u7406\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u80c6\u6c41\u306e\u6d41\u308c\u3092\u4fc3\u3059\u85ac:<\/strong> \u30a6\u30eb\u30bd\u30c7\u30aa\u30ad\u30b7\u30b3\u30fc\u30eb\u9178\uff08\u30a6\u30eb\u30bd\uff09\u306a\u3069\u304c\u51e6\u65b9\u3055\u308c\u307e\u3059\u3002\u80c6\u6c41\u306e\u6d41\u308c\u3092\u826f\u304f\u3057\u3001\u809d\u81d3\u3092\u5b88\u308b\u50cd\u304d\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u304b\u3086\u307f\uff08\u305d\u3046\u75d2\uff09\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb:<\/strong> \u304b\u3086\u307f\u306f\u751f\u6d3b\u306e\u8cea\uff08QOL\uff09\u3092\u5927\u304d\u304f\u4e0b\u3052\u307e\u3059\u3002\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u85ac\u3084\u3001\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\uff08\u672c\u6765\u306f\u7d50\u6838\u306e\u85ac\u3067\u3059\u304c\u3001\u304b\u3086\u307f\u306b\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\uff09\u3001\u30ca\u30eb\u30d5\u30e9\u30d5\u30a3\u30f3\u5869\u9178\u5869\u306a\u3069\u306e\u98f2\u307f\u85ac\u304c\u4f7f\u308f\u308c\u307e\u3059\u3002\u808c\u306e\u4fdd\u6e7f\u3082\u5927\u5207\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6804\u990a\u7ba1\u7406\uff08\u975e\u5e38\u306b\u91cd\u8981\uff09:<\/strong> \u8102\u80aa\u306e\u5438\u53ce\u304c\u60aa\u3044\u305f\u3081\u3001\u666e\u901a\u306e\u98df\u4e8b\u3060\u3051\u3067\u306f\u30ab\u30ed\u30ea\u30fc\u3084\u30d3\u30bf\u30df\u30f3\u304c\u4e0d\u8db3\u3057\u304c\u3061\u3067\u3059\u3002\n<ul class=\"wp-block-list\">\n<li><strong>MCT\u30aa\u30a4\u30eb\uff08\u4e2d\u9396\u8102\u80aa\u9178\uff09:<\/strong> \u80c6\u6c41\u304c\u306a\u304f\u3066\u3082\u5438\u53ce\u3055\u308c\u3084\u3059\u3044\u6cb9\uff08MCT\u30aa\u30a4\u30eb\uff09\u3092\u542b\u3080\u7279\u6b8a\u30df\u30eb\u30af\uff08\u30a8\u30ec\u30f3\u30bf\u30fc\u30ebP\u3084MCT\u30df\u30eb\u30af\uff09\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u306e\u88dc\u5145:<\/strong> \u30d3\u30bf\u30df\u30f3A\uff08\u76ee\u3084\u76ae\u819a\uff09\u3001D\uff08\u9aa8\uff09\u3001E\uff08\u795e\u7d4c\uff09\u3001K\uff08\u8840\u6db2\u51dd\u56fa\uff09\u3092\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3084\u5185\u670d\u85ac\u3067\u5927\u91cf\u306b\u88dc\u5145\u3057\u307e\u3059\u3002\u5438\u53ce\u7387\u304c\u60aa\u3044\u305f\u3081\u3001\u901a\u5e38\u3088\u308a\u304b\u306a\u308a\u591a\u3044\u91cf\u3092\u98f2\u3080\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%91%A1_%E5%BF%83%E8%87%93%E3%83%BB%E8%A1%80%E7%AE%A1%E3%81%AE%E6%B2%BB%E7%99%82\"><\/span><strong>\u2461 \u5fc3\u81d3\u30fb\u8840\u7ba1\u306e\u6cbb\u7642<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7d4c\u904e\u89b3\u5bdf:<\/strong> \u8efd\u5ea6\u306e\u80ba\u52d5\u8108\u72ed\u7a84\u3067\u3042\u308c\u3070\u3001\u7279\u306b\u6cbb\u7642\u3092\u305b\u305a\u3001\u5b9a\u671f\u7684\u306a\u691c\u67fb\u3067\u69d8\u5b50\u3092\u898b\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30ab\u30c6\u30fc\u30c6\u30eb\u6cbb\u7642\u30fb\u624b\u8853:<\/strong> \u5fc3\u81d3\u306e\u8ca0\u62c5\u304c\u5927\u304d\u3044\u5834\u5408\u3084\u3001\u8907\u96d1\u306a\u5fc3\u5947\u5f62\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u8840\u7ba1\u3092\u5e83\u3052\u308b\u30ab\u30c6\u30fc\u30c6\u30eb\u6cbb\u7642\u3084\u5916\u79d1\u624b\u8853\u304c\u884c\u308f\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%91%A2_%E8%85%8E%E8%87%93%E3%83%BB%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E7%AE%A1%E7%90%86\"><\/span><strong>\u2462 \u814e\u81d3\u30fb\u305d\u306e\u4ed6\u306e\u7ba1\u7406<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5b9a\u671f\u7684\u306a\u5c3f\u691c\u67fb\u3084\u8840\u6db2\u691c\u67fb\u3067\u814e\u6a5f\u80fd\u3092\u30c1\u30a7\u30c3\u30af\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u8840\u5727\u306e\u7ba1\u7406\u306a\u3069\u3092\u884c\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%91%A3_%E8%82%9D%E7%A7%BB%E6%A4%8D%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6\"><\/span><strong>\u2463 \u809d\u79fb\u690d\u306b\u3064\u3044\u3066<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5185\u79d1\u7684\u306a\u6cbb\u7642\uff08\u85ac\u3084\u6804\u990a\u7ba1\u7406\uff09\u3092\u884c\u3063\u3066\u3082\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u72b6\u614b\u306b\u306a\u3063\u305f\u5834\u5408\u306f\u3001\u809d\u79fb\u690d\u304c\u691c\u8a0e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u809d\u786c\u5909\u306b\u9032\u307f\u3001\u809d\u81d3\u304c\u6a5f\u80fd\u3057\u306a\u304f\u306a\u3063\u305f\u5834\u5408\u3002<\/li>\n\n\n\n<li>\u300c\u304b\u3086\u307f\u300d\u304c\u3042\u307e\u308a\u306b\u3082\u3072\u3069\u304f\u3001\u65e5\u5e38\u751f\u6d3b\u3084\u7761\u7720\u306b\u6df1\u523b\u306a\u652f\u969c\u304c\u51fa\u3066\u3044\u308b\u5834\u5408\u3002<\/li>\n\n\n\n<li>\u9aa8\u6298\u3092\u7e70\u308a\u8fd4\u3059\u306a\u3069\u3001\u6804\u990a\u72b6\u614b\u306e\u6539\u5584\u304c\u898b\u8fbc\u3081\u306a\u3044\u5834\u5408\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u809d\u79fb\u690d\u3092\u884c\u3046\u3068\u3001\u9ec4\u75b8\u3084\u304b\u3086\u307f\u306f\u5287\u7684\u306b\u6539\u5584\u3057\u3001\u98df\u4e8b\u5236\u9650\u3082\u5927\u5e45\u306b\u7de9\u548c\u3055\u308c\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u79fb\u690d\u306f\u5927\u304d\u306a\u624b\u8853\u3067\u3042\u308a\u3001\u4e00\u751f\u514d\u75ab\u6291\u5236\u5264\u3092\u98f2\u3080\u5fc5\u8981\u304c\u3042\u308b\u305f\u3081\u3001\u4e3b\u6cbb\u533b\u3084\u79fb\u690d\u30bb\u30f3\u30bf\u30fc\u3068\u614e\u91cd\u306b\u76f8\u8ac7\u3057\u3066\u6c7a\u5b9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_%E3%81%BE%E3%81%A8%E3%82%81\"><\/span><strong>6. \u307e\u3068\u3081<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u3053\u3053\u307e\u3067\u306e\u91cd\u8981\u30dd\u30a4\u30f3\u30c8\u3092\u632f\u308a\u8fd4\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u75c5\u614b:<\/strong> \u5168\u8eab\u306e\u69d8\u3005\u306a\u81d3\u5668\uff08\u809d\u81d3\u3001\u5fc3\u81d3\u3001\u9854\u3001\u9aa8\u3001\u76ee\u306a\u3069\uff09\u306b\u5f71\u97ff\u304c\u51fa\u308b\u907a\u4f1d\u6027\u306e\u75c5\u6c17\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u500b\u4eba\u5dee:<\/strong> \u75c7\u72b6\u306e\u91cd\u3055\u306f\u4eba\u306b\u3088\u3063\u3066\u5168\u304f\u9055\u3044\u307e\u3059\u3002\u300c\u6700\u60aa\u306e\u30b1\u30fc\u30b9\u300d\u3070\u304b\u308a\u3092\u60f3\u50cf\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/li>\n\n\n\n<li><strong>\u809d\u81d3:<\/strong> \u80c6\u6c41\u304c\u6d41\u308c\u306b\u304f\u3044\u305f\u3081\u3001\u300c\u9ec4\u75b8\u300d\u300c\u304b\u3086\u307f\u300d\u300c\u30d3\u30bf\u30df\u30f3\u4e0d\u8db3\u300d\u304c\u8d77\u304d\u307e\u3059\u3002\u3053\u308c\u3089\u306b\u5bfe\u3059\u308b\u85ac\u3068\u6804\u990a\u7ba1\u7406\u304c\u6cbb\u7642\u306e\u4e2d\u5fc3\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5fc3\u81d3:<\/strong> \u8840\u7ba1\u304c\u7d30\u3044\u306a\u3069\u306e\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u3044\u8efd\u75c7\u4f8b\u3082\u591a\u3044\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u539f\u56e0:<\/strong> \u591a\u304f\u306e\u5834\u5408\u306f\u7a81\u7136\u5909\u7570\u3067\u3042\u308a\u3001\u89aa\u306e\u305b\u3044\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7_%E8%A8%BA%E6%96%AD%E3%82%92%E5%8F%97%E3%81%91%E3%81%9F%E3%81%94%E5%AE%B6%E6%97%8F%E3%81%B8%E3%81%AE%E3%83%A1%E3%83%83%E3%82%BB%E3%83%BC%E3%82%B8\"><\/span><strong>7. \u8a3a\u65ad\u3092\u53d7\u3051\u305f\u3054\u5bb6\u65cf\u3078\u306e\u30e1\u30c3\u30bb\u30fc\u30b8<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u300c\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u300d\u3068\u3044\u3046\u8a3a\u65ad\u3092\u53d7\u3051\u3001\u4eca\u3001\u51fa\u53e3\u306e\u306a\u3044\u30c8\u30f3\u30cd\u30eb\u306e\u4e2d\u306b\u3044\u308b\u3088\u3046\u306a\u304a\u6c17\u6301\u3061\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 \u7279\u306b\u304a\u5b50\u69d8\u304c\u5c0f\u3055\u304f\u3001\u9ec4\u75b8\u304c\u5f37\u304b\u3063\u305f\u308a\u3001\u4f53\u91cd\u304c\u5897\u3048\u306a\u304b\u3063\u305f\u308a\u3059\u308b\u6642\u671f\u306f\u3001\u3054\u4e21\u89aa\u306b\u3068\u3063\u3066\u672c\u5f53\u306b\u8f9b\u3044\u65e5\u3005\u3060\u3068\u601d\u3044\u307e\u3059\u3002 \u300c\u304b\u3086\u304c\u3063\u3066\u6ce3\u304f\u5b50\u3092\u3069\u3046\u3057\u3066\u3042\u3052\u308b\u3053\u3068\u3082\u3067\u304d\u306a\u3044\u300d\u300c\u30df\u30eb\u30af\u3092\u98f2\u3093\u3067\u304f\u308c\u306a\u3044\u300d\u3068\u3001\u81ea\u5206\u3092\u8cac\u3081\u3066\u3057\u307e\u3046\u591c\u3082\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3067\u3082\u3001\u3069\u3046\u304b\u4e00\u4eba\u3067\u62b1\u3048\u8fbc\u307e\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%95%B7%E6%9C%9F%E7%9A%84%E3%81%AA%E8%A6%96%E7%82%B9%E3%82%92%E6%8C%81%E3%81%A3%E3%81%A6\"><\/span><strong>\u9577\u671f\u7684\u306a\u8996\u70b9\u3092\u6301\u3063\u3066<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u3053\u306e\u75c5\u6c17\u306f\u3001\u4e73\u5e7c\u5150\u671f\uff08\u7279\u306b0\u6b73\u301c3\u6b73\u9803\uff09\u304c\u3001\u75c7\u72b6\u304c\u6700\u3082\u5f37\u304f\u3001\u7ba1\u7406\u304c\u5927\u5909\u306a\u6642\u671f\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002 \u6210\u9577\u3068\u3068\u3082\u306b\u80c6\u7ba1\u304c\u5897\u3048\u305f\u308a\u3001\u809d\u81d3\u306e\u50cd\u304d\u304c\u5b89\u5b9a\u3057\u305f\u308a\u3057\u3066\u3001\u75c7\u72b6\u304c\u843d\u3061\u7740\u3044\u3066\u304f\u308b\u60a3\u8005\u3055\u3093\u3082\u305f\u304f\u3055\u3093\u3044\u307e\u3059\uff08\u3053\u308c\u3092\u300c\u809d\u6a5f\u80fd\u306e\u81ea\u7136\u8efd\u5feb\u300d\u3068\u547c\u3076\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff09\u3002 \u3082\u3061\u308d\u3093\u500b\u4eba\u5dee\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u300c\u4eca\u306e\u8f9b\u3044\u72b6\u614b\u304c\u4e00\u751f\u7d9a\u304f\u308f\u3051\u3067\u306f\u306a\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u300d\u3068\u3044\u3046\u5e0c\u671b\u3092\u6301\u3063\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p>\u75c5\u6c17\u306f\u3001\u304a\u5b50\u69d8\u306e\u4e00\u90e8\u5206\u306b\u904e\u304e\u307e\u305b\u3093\u3002 \u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u304c\u3042\u3063\u3066\u3082\u3001\u5b66\u6821\u306b\u901a\u3044\u3001\u53cb\u9054\u3068\u904a\u3073\u3001\u30b9\u30dd\u30fc\u30c4\u3092\u697d\u3057\u307f\u3001\u5927\u4eba\u306b\u306a\u3063\u3066\u4ed5\u4e8b\u3084\u5bb6\u5ead\u3092\u6301\u3063\u3066\u3044\u308b\u65b9\u306f\u4e16\u754c\u4e2d\u306b\u305f\u304f\u3055\u3093\u3044\u307e\u3059\u3002 \u5b9a\u671f\u7684\u306a\u901a\u9662\u3084\u5185\u670d\u306f\u5fc5\u8981\u3067\u3059\u304c\u3001\u305d\u308c\u4ee5\u5916\u306e\u6642\u9593\u306f\u3001\u4ed6\u306e\u304a\u5b50\u69d8\u3068\u540c\u3058\u3088\u3046\u306b\u7b11\u3044\u3001\u6ce3\u304d\u3001\u6210\u9577\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u65e5\u672c\u306b\u306f\u300c\u65e5\u672c\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\u306e\u4f1a\u300d\u3068\u3044\u3046\u60a3\u8005\u5bb6\u65cf\u4f1a\u304c\u3042\u308a\u307e\u3059\u3002 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\u4e3b\u6cbb\u533b\u3084\u770b\u8b77\u5e2b\u3001\u85ac\u5264\u5e2b\u3001\u6804\u990a\u58eb\u3001\u305d\u3057\u3066\u60a3\u8005\u4f1a\u306e\u4ef2\u9593\u305f\u3061\u3002\u305f\u304f\u3055\u3093\u306e\u4eba\u304c\u3042\u306a\u305f\u306e\u5473\u65b9\u3067\u3059\u3002 \u4eca\u65e5\u3001\u3059\u3079\u3066\u306e\u3053\u3068\u3092\u7406\u89e3\u3057\u3001\u6c7a\u5b9a\u3059\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u304a\u5b50\u69d8\u306e\u7b11\u9854\u3092\u5b88\u308b\u305f\u3081\u306b\u3001\u4e00\u65e5\u4e00\u65e5\u3092\u3001\u533b\u7642\u30c1\u30fc\u30e0\u3068\u4e00\u7dd2\u306b\u3086\u3063\u304f\u308a\u3068\u6b69\u3093\u3067\u3044\u304d\u307e\u3057\u3087\u3046\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"\u306f\u3058\u3081\u306b \u304a\u5b50\u69d8\u304c\u300c\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\uff081&#8230;\n <a 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