{"id":122398,"date":"2026-01-13T14:08:04","date_gmt":"2026-01-13T05:08:04","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?p=122398"},"modified":"2026-03-31T17:02:26","modified_gmt":"2026-03-31T08:02:26","slug":"smaled2b-dync1h1-guide","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/smaled2b-dync1h1-guide\/","title":{"rendered":"\u5e38\u67d3\u8272\u4f53\u9855\u6027\u30fb\u4e0b\u80a2\u512a\u4f4d\u578b\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c72B\u578b\uff08SMALED2B\uff09"},"content":{"rendered":"\n<p>\u304a\u5b50\u69d8\u3084\u3054\u81ea\u8eab\u304c\u300c\u4e0b\u80a2\u512a\u4f4d\u578b\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c72B\u578b\uff08SMALED2B\uff09\u300d\u3001\u3042\u308b\u3044\u306f\u300cDYNC1H1\uff08\u30c0\u30a4\u30f3\u30fb\u30b7\u30fc\u30fb\u30ef\u30f3\u30fb\u30a8\u30a4\u30c1\u30fb\u30ef\u30f3\uff09\u95a2\u9023\u306e\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c7\u300d\u3068\u3044\u3046\u8a3a\u65ad\u3092\u53d7\u3051\u305f\u3068\u304d\u3001\u3042\u307e\u308a\u306b\u3082\u9577\u304f\u8907\u96d1\u306a\u75c5\u540d\u306b\u3001\u8a00\u3044\u3088\u3046\u306e\u306a\u3044\u4e0d\u5b89\u3068\u6238\u60d1\u3044\u3092\u611f\u3058\u3089\u308c\u305f\u3053\u3068\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>\u300c\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c7\uff08SMA\uff09\u3063\u3066\u3001\u96e3\u75c5\u306e\uff1f\u547d\u306b\u95a2\u308f\u308b\u306e\uff1f\u300d<\/p>\n\n\n\n<p>\u300c\u4e0b\u80a2\u512a\u4f4d\u3063\u3066\u3069\u3046\u3044\u3046\u3053\u3068\uff1f\u300d<\/p>\n\n\n\n<p>\u300c\u907a\u4f1d\u3059\u308b\u306e\uff1f\u300d<\/p>\n\n\n\n<p>\u307e\u305a\u6700\u521d\u306b\u304a\u4f1d\u3048\u3057\u305f\u3044\u6700\u3082\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u3053\u306e\u300cSMALED2B\u300d\u3068\u3044\u3046\u75c5\u6c17\u306f\u3001\u30c6\u30ec\u30d3\u3084\u30cb\u30e5\u30fc\u30b9\u3067\u3088\u304f\u8033\u306b\u3059\u308b\u3001\u547c\u5438\u5668\u304c\u5fc5\u8981\u306b\u306a\u3063\u305f\u308a\u547d\u306b\u95a2\u308f\u3063\u305f\u308a\u3059\u308b\u4e00\u822c\u7684\u306a\u300c\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c7\uff085q-SMA\uff09\u300d\u3068\u306f\u3001\u539f\u56e0\u3082\u7d4c\u904e\u3082\u7570\u306a\u308b\u5225\u306e\u30bf\u30a4\u30d7\u306e\u75c5\u6c17\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u75c5\u6c17\u306f\u975e\u5e38\u306b\u5e0c\u5c11\u3067\u3042\u308a\u3001\u30a4\u30f3\u30bf\u30fc\u30cd\u30c3\u30c8\u3067\u691c\u7d22\u3057\u3066\u3082\u3001\u5c02\u9580\u7684\u306a\u82f1\u8a9e\u306e\u8ad6\u6587\u3084\u3001\u975e\u5e38\u306b\u96e3\u3057\u3044\u533b\u5b66\u7528\u8a9e\u3070\u304b\u308a\u304c\u51fa\u3066\u304d\u3066\u3001\u5177\u4f53\u7684\u306a\u751f\u6d3b\u306e\u30a4\u30e1\u30fc\u30b8\u304c\u6e67\u304d\u306b\u304f\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u3053\u306e\u75c5\u6c17\u306f\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u304c\u7279\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u4f53\u306e\u4e2d\u3067\u4f55\u304c\u8d77\u304d\u3066\u3044\u308b\u306e\u304b\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u539f\u56e0\u304c\u5206\u304b\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u9069\u5207\u306a\u5bfe\u7b56\u3084\u7ba1\u7406\u65b9\u6cd5\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n<!--nipt_mono-->\r\n<div 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\u753b\u50cf\u691c\u67fb\uff08MRI\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/smaled2b-dync1h1-guide\/#5_%E9%81%BA%E4%BC%9D%E5%AD%A6%E7%9A%84%E6%A4%9C%E6%9F%BB%EF%BC%88%E7%A2%BA%E5%AE%9A%E8%A8%BA%E6%96%AD%EF%BC%89\" >5. \u907a\u4f1d\u5b66\u7684\u691c\u67fb\uff08\u78ba\u5b9a\u8a3a\u65ad\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/smaled2b-dync1h1-guide\/#%E6%B2%BB%E7%99%82%E3%81%A8%E7%AE%A1%E7%90%86%EF%BC%9A%E3%81%93%E3%82%8C%E3%81%8B%E3%82%89%E3%81%AE%E3%83%AD%E3%83%BC%E3%83%89%E3%83%9E%E3%83%83%E3%83%97\" >\u6cbb\u7642\u3068\u7ba1\u7406\uff1a\u3053\u308c\u304b\u3089\u306e\u30ed\u30fc\u30c9\u30de\u30c3\u30d7<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/smaled2b-dync1h1-guide\/#1_%E3%83%AA%E3%83%8F%E3%83%93%E3%83%AA%E3%83%86%E3%83%BC%E3%82%B7%E3%83%A7%E3%83%B3%EF%BC%88%E6%9C%80%E9%87%8D%E8%A6%81%EF%BC%89\" >1. \u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\uff08\u6700\u91cd\u8981\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/smaled2b-dync1h1-guide\/#2_%E8%A3%85%E5%85%B7%E7%99%82%E6%B3%95\" >2. \u88c5\u5177\u7642\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/smaled2b-dync1h1-guide\/#3_%E6%95%B4%E5%BD%A2%E5%A4%96%E7%A7%91%E7%9A%84%E6%B2%BB%E7%99%82\" >3. \u6574\u5f62\u5916\u79d1\u7684\u6cbb\u7642<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/smaled2b-dync1h1-guide\/#4_%E5%AE%9A%E6%9C%9F%E7%9A%84%E3%81%AA%E7%B5%8C%E9%81%8E%E8%A6%B3%E5%AF%9F\" >4. \u5b9a\u671f\u7684\u306a\u7d4c\u904e\u89b3\u5bdf<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/smaled2b-dync1h1-guide\/#%E6%97%A5%E3%80%85%E3%81%AE%E7%94%9F%E6%B4%BB%E3%81%A7%E3%81%AE%E5%B7%A5%E5%A4%AB\" >\u65e5\u3005\u306e\u751f\u6d3b\u3067\u306e\u5de5\u592b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/smaled2b-dync1h1-guide\/#%E3%82%88%E3%81%8F%E3%81%82%E3%82%8B%E8%B3%AA%E5%95%8F%EF%BC%88FAQ%EF%BC%89\" >\u3088\u304f\u3042\u308b\u8cea\u554f\uff08FAQ\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/smaled2b-dync1h1-guide\/#%E3%81%BE%E3%81%A8%E3%82%81\" >\u307e\u3068\u3081<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%A6%82%E8%A6%81%EF%BC%9A%E3%81%A9%E3%81%AE%E3%82%88%E3%81%86%E3%81%AA%E7%97%85%E6%B0%97%E3%81%8B\"><\/span><strong>\u6982\u8981\uff1a\u3069\u306e\u3088\u3046\u306a\u75c5\u6c17\u304b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Spinal muscular atrophy, lower extremity-predominant, 2B\uff08\u4ee5\u4e0b\u3001SMALED2B\uff09\u306f\u3001\u751f\u307e\u308c\u3064\u304d\u3001\u3042\u308b\u3044\u306f\u5e7c\u5c11\u671f\u304b\u3089\u3001\u4e3b\u306b\u592a\u3082\u3082\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u300c\u8db3\u306e\u7b4b\u8089\u300d\u306e\u529b\u304c\u5f31\u304f\u306a\u308b\u795e\u7d4c\u306e\u75c5\u6c17\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%97%85%E5%90%8D%E3%81%AE%E5%88%86%E8%A7%A3%E3%81%A8%E6%84%8F%E5%91%B3\"><\/span><strong>\u75c5\u540d\u306e\u5206\u89e3\u3068\u610f\u5473<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u3053\u306e\u9577\u304f\u8907\u96d1\u306a\u75c5\u540d\u306b\u306f\u3001\u75c5\u6c17\u306e\u7279\u5fb4\u304c\u3059\u3079\u3066\u8a70\u3081\u8fbc\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u3064\u305a\u3064\u7d10\u89e3\u3044\u3066\u3044\u304d\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c7\uff08Spinal Muscular Atrophy: SMA\uff09<\/p>\n\n\n\n<p>\u7b4b\u8089\u305d\u306e\u3082\u306e\u306e\u75c5\u6c17\u3067\u306f\u306a\u304f\u3001\u7b4b\u8089\u306b\u300c\u52d5\u3051\u300d\u3068\u547d\u4ee4\u3092\u51fa\u3059\u795e\u7d4c\uff08\u810a\u9ac4\u306e\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\uff09\u306e\u50cd\u304d\u304c\u5f31\u3044\u305f\u3081\u306b\u3001\u7d50\u679c\u3068\u3057\u3066\u7b4b\u8089\u304c\u75e9\u305b\u3066\uff08\u840e\u7e2e\u3057\u3066\uff09\u529b\u304c\u5f31\u304f\u306a\u308b\u75c5\u6c17\u306e\u7dcf\u79f0\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u80a2\u512a\u4f4d\u578b\uff08Lower Extremity-Predominant\uff09<\/p>\n\n\n\n<p>\u5168\u8eab\u306e\u7b4b\u8089\u304c\u5747\u7b49\u306b\u5f31\u304f\u306a\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u7279\u306b\u300c\u8db3\uff08\u4e0b\u80a2\uff09\u300d\u3001\u305d\u308c\u3082\u592a\u3082\u3082\u306e\u7b4b\u8089\u306b\u75c7\u72b6\u304c\u5f37\u304f\u51fa\u308b\u306e\u304c\u7279\u5fb4\u3067\u3059\u3002\u624b\u306e\u529b\u3084\u98f2\u307f\u8fbc\u3080\u529b\u306a\u3069\u306f\u6bd4\u8f03\u7684\u4fdd\u305f\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<p>2B\u578b<\/p>\n\n\n\n<p>\u4e0b\u80a2\u512a\u4f4d\u578b\u306eSMA\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u30bf\u30a4\u30d7\u304c\u3042\u308a\u3001\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u756a\u53f7\u304c\u632f\u3089\u308c\u3066\u3044\u307e\u3059\u30022B\u578b\u306f\u300cDYNC1H1\u300d\u3068\u3044\u3046\u907a\u4f1d\u5b50\u304c\u539f\u56e0\u306e\u30bf\u30a4\u30d7\u3092\u6307\u3057\u307e\u3059\uff08\u3061\u306a\u307f\u306b2A\u578b\u306fBICD2\u3068\u3044\u3046\u5225\u306e\u907a\u4f1d\u5b50\u304c\u539f\u56e0\u3067\u3059\uff09\u3002<\/p>\n\n\n\n<p>\u5e38\u67d3\u8272\u4f53\u9855\u6027\uff08\u512a\u6027\uff09\u907a\u4f1d<\/p>\n\n\n\n<p>\u89aa\u304b\u3089\u5b50\u3078\u3068\u4f1d\u308f\u308b\u907a\u4f1d\u306e\u5f62\u5f0f\u306e\u4e00\u3064\u3067\u3059\u3002\u5f8c\u307b\u3069\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u304c\u3001\u89aa\u5fa1\u3055\u3093\u306e\u3069\u3061\u3089\u304b\u304c\u540c\u3058\u4f53\u8cea\u3092\u6301\u3063\u3066\u3044\u308b\u304b\u3001\u3042\u308b\u3044\u306f\u7a81\u7136\u5909\u7570\u3067\u767a\u751f\u3057\u305f\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%80%E8%88%AC%E7%9A%84%E3%81%AASMA%EF%BC%885q-SMA%EF%BC%89%E3%81%A8%E3%81%AE%E9%81%95%E3%81%84\"><\/span><strong>\u4e00\u822c\u7684\u306aSMA\uff085q-SMA\uff09\u3068\u306e\u9055\u3044<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u3053\u3053\u304c\u4e00\u756a\u306e\u8aa4\u89e3\u30dd\u30a4\u30f3\u30c8\u3067\u3042\u308a\u3001\u5b89\u5fc3\u6750\u6599\u3067\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308bSMA\uff08SMN1\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u306b\u3088\u308b\u3082\u306e\uff09\u306f\u3001\u91cd\u75c7\u306e\u5834\u5408\u3001\u8d64\u3061\u3083\u3093\u306e\u9803\u304b\u3089\u547c\u5438\u304c\u3067\u304d\u306a\u304f\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u306eSMALED2B\u306f\u3001\u4e00\u822c\u7684\u306b\u9032\u884c\u304c\u975e\u5e38\u306b\u3086\u3063\u304f\u308a\u304b\u3001\u3042\u308b\u3044\u306f\u307b\u3068\u3093\u3069\u9032\u884c\u3057\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u304c\u3001\u3086\u3063\u304f\u308a\u306a\u304c\u3089\u3082\u904b\u52d5\u6a5f\u80fd\u306e\u767a\u9054\u3092\u898b\u305b\u3001\u901a\u5e38\u306e\u5bff\u547d\u3092\u5168\u3046\u3057\u3001\u793e\u4f1a\u751f\u6d3b\u3092\u9001\u3063\u3066\u3044\u307e\u3059\u3002\u540c\u3058\u300cSMA\u300d\u3068\u3044\u3046\u540d\u524d\u304c\u3064\u3044\u3066\u3044\u307e\u3059\u304c\u3001\u7d4c\u904e\u306f\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%BD%93%E3%81%AE%E4%B8%AD%E3%81%A7%E4%BD%95%E3%81%8C%E8%B5%B7%E3%81%8D%E3%81%A6%E3%81%84%E3%82%8B%E3%81%AE%E3%81%8B%EF%BC%9F\"><\/span><strong>\u4f53\u306e\u4e2d\u3067\u4f55\u304c\u8d77\u304d\u3066\u3044\u308b\u306e\u304b\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u3053\u306e\u75c5\u6c17\u306e\u539f\u56e0\u306f\u3001\u300cDYNC1H1\u300d\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306b\u5909\u5316\u304c\u3042\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u79c1\u305f\u3061\u306e\u795e\u7d4c\u7d30\u80de\u306f\u3001\u3068\u3066\u3082\u9577\u3044\u7a81\u8d77\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u8170\u306e\u3042\u305f\u308a\u304b\u3089\u8db3\u306e\u5148\u307e\u3067\u4f38\u3073\u308b\u795e\u7d4c\u306f\u3001\u4f53\u306e\u4e2d\u3067\u6700\u3082\u9577\u3044\u7d30\u80de\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u9577\u3044\u795e\u7d4c\u306e\u4e2d\u3092\u3001\u6804\u990a\u3084\u4e0d\u8981\u306b\u306a\u3063\u305f\u7269\u8cea\u3092\u904b\u3076\u300c\u30c8\u30e9\u30c3\u30af\u300d\u306e\u3088\u3046\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u8d70\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30c8\u30e9\u30c3\u30af\u306e\u540d\u524d\u304c\u300c\u30c0\u30a4\u30cb\u30f3\uff08Dynein\uff09\u300d\u3067\u3059\u3002DYNC1H1\u907a\u4f1d\u5b50\u306f\u3001\u3053\u306e\u30c8\u30e9\u30c3\u30af\u306e\u30a8\u30f3\u30b8\u30f3\u90e8\u5206\u3092\u4f5c\u308b\u8a2d\u8a08\u56f3\u3067\u3059\u3002<\/p>\n\n\n\n<p>SMALED2B\u3067\u306f\u3001\u8a2d\u8a08\u56f3\u306e\u30df\u30b9\u306b\u3088\u308a\u3001\u30c8\u30e9\u30c3\u30af\u306e\u30a8\u30f3\u30b8\u30f3\u306e\u6027\u80fd\u304c\u5c11\u3057\u843d\u3061\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u305f\u3081\u3001\u9577\u3044\u795e\u7d4c\u306e\u4e2d\u3067\u306e\u7269\u8cea\u8f38\u9001\u304c\u6ede\u308a\u3001\u795e\u7d4c\u306e\u5143\u6c17\u304c\u306a\u304f\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u7b4b\u8089\u3078\u306e\u6307\u4ee4\u304c\u5f31\u304f\u306a\u308a\u3001\u8db3\u306e\u7b4b\u8089\u304c\u75e9\u305b\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%BB%E3%81%AA%E7%97%87%E7%8A%B6\"><\/span><strong>\u4e3b\u306a\u75c7\u72b6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>SMALED2B\u306e\u75c7\u72b6\u306f\u3001\u60a3\u8005\u3055\u3093\u4e00\u4eba\u3072\u3068\u308a\u306b\u3088\u3063\u3066\u7a0b\u5ea6\u3084\u73fe\u308c\u65b9\u304c\u7570\u306a\u308a\u307e\u3059\u3002\u4e00\u822c\u7684\u306b\u898b\u3089\u308c\u308b\u75c7\u72b6\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_%E7%AD%8B%E5%8A%9B%E4%BD%8E%E4%B8%8B%E3%81%A8%E7%AD%8B%E8%90%8E%E7%B8%AE%EF%BC%88%E7%89%B9%E3%81%AB%E5%A4%AA%E3%82%82%E3%82%82%EF%BC%89\"><\/span><strong>1. \u7b4b\u529b\u4f4e\u4e0b\u3068\u7b4b\u840e\u7e2e\uff08\u7279\u306b\u592a\u3082\u3082\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6700\u3082\u4e2d\u6838\u3068\u306a\u308b\u75c7\u72b6\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u8fd1\u4f4d\u7b4b\uff08\u304d\u3093\u3044\u304d\u3093\uff09\u306e\u5f31\u3055<\/p>\n\n\n\n<p>\u300c\u8fd1\u4f4d\u7b4b\u300d\u3068\u306f\u3001\u4f53\u306e\u4e2d\u5fc3\u306b\u8fd1\u3044\u7b4b\u8089\u306e\u3053\u3068\u3067\u3059\u3002\u8db3\u3067\u8a00\u3048\u3070\u300c\u592a\u3082\u3082\uff08\u5927\u817f\u56db\u982d\u7b4b\u306a\u3069\uff09\u300d\u306b\u3042\u305f\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u592a\u3082\u3082\u306e\u529b\u304c\u5f31\u3044\u305f\u3081\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u52d5\u4f5c\u304c\u82e6\u624b\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5e8a\u304b\u3089\u7acb\u3061\u4e0a\u304c\u308b\u306e\u304c\u5927\u5909\uff08\u624b\u3092\u4f7f\u3063\u3066\u4f53\u3092\u652f\u3048\u308b\uff09<\/p>\n\n\n\n<p>\u968e\u6bb5\u3092\u4e0a\u308b\u306e\u304c\u82e6\u624b<\/p>\n\n\n\n<p>\u8d70\u308b\u306e\u304c\u9045\u3044\u3001\u8ee2\u3073\u3084\u3059\u3044<\/p>\n\n\n\n<p>\u3057\u3083\u304c\u3093\u3060\u59ff\u52e2\u304b\u3089\u7acb\u3061\u4e0a\u304c\u308c\u306a\u3044<\/p>\n\n\n\n<p>\u7b4b\u8089\u306e\u840e\u7e2e<\/p>\n\n\n\n<p>\u592a\u3082\u3082\u306e\u524d\u306e\u7b4b\u8089\u304c\u75e9\u305b\u3066\u7d30\u304f\u306a\u308b\u305f\u3081\u3001\u819d\u304b\u3089\u4e0b\u304c\u76f8\u5bfe\u7684\u306b\u592a\u304f\u898b\u3048\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_%E8%B6%B3%E3%81%AE%E5%A4%89%E5%BD%A2%E3%81%A8%E6%8B%98%E7%B8%AE%EF%BC%88%E3%81%93%E3%81%86%E3%81%97%E3%82%85%E3%81%8F%EF%BC%89\"><\/span><strong>2. \u8db3\u306e\u5909\u5f62\u3068\u62d8\u7e2e\uff08\u3053\u3046\u3057\u3085\u304f\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u751f\u307e\u308c\u3064\u304d\u3001\u3042\u308b\u3044\u306f\u6210\u9577\u306b\u4f34\u3063\u3066\u3001\u8db3\u306e\u95a2\u7bc0\u304c\u786c\u304f\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5148\u5929\u6027\u5185\u53cd\u8db3\uff08\u306a\u3044\u306f\u3093\u305d\u304f\uff09<\/p>\n\n\n\n<p>\u751f\u307e\u308c\u305f\u6642\u306b\u3001\u8db3\u306e\u88cf\u304c\u5185\u5074\u3092\u5411\u3044\u3066\u3044\u308b\u72b6\u614b\u3067\u3059\u3002SMALED2B\u306e\u8d64\u3061\u3083\u3093\u306b\u3088\u304f\u898b\u3089\u308c\u308b\u7279\u5fb4\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u95a2\u7bc0\u62d8\u7e2e<\/p>\n\n\n\n<p>\u95a2\u7bc0\u304c\u56fa\u307e\u3063\u3066\u4f38\u3073\u306b\u304f\u304f\u306a\u308b\u3053\u3068\u3067\u3059\u3002\u80a1\u95a2\u7bc0\u3084\u819d\u95a2\u7bc0\u3001\u8db3\u9996\u306b\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u304b\u304b\u3068\u304c\u6d6e\u3044\u3066\u3057\u307e\u3046\uff08\u5c16\u8db3\uff09\u3053\u3068\u3082\u3042\u308a\u3001\u3053\u308c\u3089\u304c\u6b69\u884c\u306e\u4e0d\u5b89\u5b9a\u3055\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_%E9%81%8B%E5%8B%95%E7%99%BA%E9%81%94%E3%81%AE%E9%81%85%E3%82%8C\"><\/span><strong>3. \u904b\u52d5\u767a\u9054\u306e\u9045\u308c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u9996\u306e\u3059\u308f\u308a\u3084\u304a\u5ea7\u308a\u306f\u9806\u8abf\u3067\u3082\u3001\u300c\u3064\u304b\u307e\u308a\u7acb\u3061\u300d\u3084\u300c\u72ec\u308a\u6b69\u304d\u300d\u306e\u958b\u59cb\u304c\u5e73\u5747\u3088\u308a\u3082\u9045\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306f\u9045\u308c\u306a\u304c\u3089\u3082\u72ec\u308a\u6b69\u304d\u3092\u7372\u5f97\u3067\u304d\u307e\u3059\u3002\u4e2d\u306b\u306f\u3001\u5927\u4eba\u306b\u306a\u308b\u307e\u3067\u75c5\u6c17\u306b\u6c17\u3065\u304b\u305a\u3001\u300c\u904b\u52d5\u304c\u82e6\u624b\u306a\u5b50\u3060\u3068\u601d\u3063\u3066\u3044\u305f\u300d\u3068\u3044\u3046\u30b1\u30fc\u30b9\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_%E6%AD%A9%E8%A1%8C%E3%81%AE%E7%89%B9%E5%BE%B4\"><\/span><strong>4. \u6b69\u884c\u306e\u7279\u5fb4<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u7b4b\u529b\u4f4e\u4e0b\u3084\u8db3\u306e\u5909\u5f62\u306b\u3088\u308a\u3001\u7279\u5fb4\u7684\u306a\u6b69\u304d\u65b9\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u52d5\u63fa\u6027\u6b69\u884c\uff08\u30a2\u30d2\u30eb\u6b69\u304d\uff09\uff1a\u304a\u5c3b\u3092\u5de6\u53f3\u306b\u632f\u3063\u3066\u6b69\u304f\u3002<\/p>\n\n\n\n<p>\u3064\u307e\u5148\u6b69\u304d\uff1a\u304b\u304b\u3068\u304c\u3064\u304b\u306a\u3044\u305f\u3081\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E7%97%87%E7%8A%B6\"><\/span><strong>5. \u305d\u306e\u4ed6\u306e\u75c7\u72b6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u4e0a\u534a\u8eab\u3078\u306e\u5f71\u97ff<\/p>\n\n\n\n<p>\u4e00\u822c\u7684\u306b\u306f\u8db3\u306e\u75c7\u72b6\u304c\u30e1\u30a4\u30f3\u3067\u3059\u304c\u3001\u7a00\u306b\u624b\u306e\u6307\u5148\u306e\u529b\u304c\u5f31\u304f\u306a\u308b\u3053\u3068\u3084\u3001\u80cc\u9aa8\u304c\u66f2\u304c\u308b\uff08\u5074\u5f2f\u75c7\uff09\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u77e5\u7684\u306a\u767a\u9054<\/p>\n\n\n\n<p>SMALED2B\uff08\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c7\u3068\u3057\u3066\u306e\u5074\u9762\uff09\u3067\u306f\u3001\u77e5\u7684\u306a\u767a\u9054\u306f\u6b63\u5e38\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001DYNC1H1\u907a\u4f1d\u5b50\u306f\u8133\u306e\u767a\u9054\u306b\u3082\u95a2\u308f\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306e\u5834\u6240\u306b\u3088\u3063\u3066\u306f\u3001\u8133\u306e\u69cb\u9020\u7684\u306a\u5909\u5316\u3084\u3001\u5b66\u7fd2\u306e\u9045\u308c\u3001\u3066\u3093\u304b\u3093\u306a\u3069\u3092\u5408\u4f75\u3059\u308b\u30b1\u30fc\u30b9\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u3053\u308c\u306fDYNC1H1\u95a2\u9023\u795e\u7d4c\u75be\u60a3\u3068\u3057\u3066\u5305\u62ec\u7684\u306b\u6349\u3048\u3089\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff09\u3002<\/p>\n\n\n<!--nipt_mono-->\r\n<div class=\"nipt-mono\">\r\n    <div class=\"nipt-mono-btn\">\r\n        <a href=\"\/nipt\/nipt-mono\/\">\r\n            <img decoding=\"async\" loading=\"lazy\" src=\"\/nipt\/wp-content\/uploads\/2026\/03\/NIPT-MONO.webp\" alt=\"NIPT-MONO\u3067\u8abf\u3079\u3089\u308c\u307e\u3059\">\r\n         <\/a>\r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.nipt-mono {\r\n    text-align: center; \/* \u89aa\u8981\u7d20\u3067\u6a2a\u4e2d\u592e *\/\r\n}\r\n.nipt-mono a img {\r\n    display: inline-block; \/* \u753b\u50cf\u3092\u30a4\u30f3\u30e9\u30a4\u30f3\u30d6\u30ed\u30c3\u30af\u5316\u3057\u3066 text-align \u306b\u53cd\u6620 *\/\r\n    width: 333px;\r\n}\r\n<\/style>\r\n<!--\/nipt_mono-->\r\n\r\n\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%8E%9F%E5%9B%A0%E3%81%A8%E9%81%BA%E4%BC%9D%E3%81%AE%E4%BB%95%E7%B5%84%E3%81%BF\"><\/span><strong>\u539f\u56e0\u3068\u907a\u4f1d\u306e\u4ed5\u7d44\u307f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u3054\u5bb6\u65cf\u304c\u300c\u306a\u305c\uff1f\u300d\u3068\u60a9\u307f\u3001\u6642\u306b\u3054\u81ea\u8eab\u3092\u8cac\u3081\u3066\u3057\u307e\u3046\u306e\u304c\u300c\u539f\u56e0\u300d\u306b\u3064\u3044\u3066\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u58f0\u3092\u5927\u306b\u3057\u3066\u304a\u4f1d\u3048\u3057\u305f\u3044\u306e\u306f\u3001\u3054\u4e21\u89aa\u306e\u80b2\u3066\u65b9\u3084\u598a\u5a20\u4e2d\u306e\u904e\u3054\u3057\u65b9\u304c\u539f\u56e0\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"DYNC1H1%E9%81%BA%E4%BC%9D%E5%AD%90%E3%81%AE%E6%A9%9F%E8%83%BD%E5%A4%89%E5%8C%96\"><\/span><strong>DYNC1H1\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u5909\u5316<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u524d\u8ff0\u306e\u901a\u308a\u300114\u756a\u67d3\u8272\u4f53\u306b\u3042\u308bDYNC1H1\u907a\u4f1d\u5b50\u306e\u5909\u5316\u304c\u539f\u56e0\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u8cea\u30c0\u30a4\u30cb\u30f3\u91cd\u93961\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u795e\u7d4c\u7d30\u80de\u5185\u3067\u306e\u300c\u9006\u884c\u6027\u8f38\u9001\uff08\u795e\u7d4c\u306e\u672b\u7aef\u304b\u3089\u7d30\u80de\u4f53\u3078\u7269\u3092\u904b\u3076\u3053\u3068\uff09\u300d\u3084\u3001\u8133\u304c\u3067\u304d\u308b\u6642\u306e\u795e\u7d4c\u7d30\u80de\u306e\u79fb\u52d5\u306b\u4e0d\u53ef\u6b20\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B8%B8%E6%9F%93%E8%89%B2%E4%BD%93%E9%A1%95%E6%80%A7%E9%81%BA%E4%BC%9D%EF%BC%88%E5%84%AA%E6%80%A7%E9%81%BA%E4%BC%9D%EF%BC%89%E3%81%A8%E3%81%AF\"><\/span><strong>\u5e38\u67d3\u8272\u4f53\u9855\u6027\u907a\u4f1d\uff08\u512a\u6027\u907a\u4f1d\uff09\u3068\u306f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>SMALED2B\u306f\u300c\u9855\u6027\u907a\u4f1d\uff08\u4ee5\u524d\u306f\u512a\u6027\u907a\u4f1d\u3068\u547c\u3070\u308c\u307e\u3057\u305f\uff09\u300d\u3068\u3044\u3046\u5f62\u5f0f\u3092\u3068\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4eba\u9593\u306f\u907a\u4f1d\u5b50\u30922\u3064\u30bb\u30c3\u30c8\uff08\u7236\u304b\u30891\u3064\u3001\u6bcd\u304b\u30891\u3064\uff09\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u9855\u6027\u907a\u4f1d\u3068\u306f\u30012\u3064\u306e\u3046\u3061\u7247\u65b9\u306eDYNC1H1\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308c\u3070\u3001\u75c7\u72b6\u304c\u51fa\u308b\u30bf\u30a4\u30d7\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u5834\u5408\u3001\u4ee5\u4e0b\u306e2\u3064\u306e\u30d1\u30bf\u30fc\u30f3\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u89aa\u304b\u3089\u306e\u907a\u4f1d<br>\u3054\u4e21\u89aa\u306e\u3069\u3061\u3089\u304b\u304c\u540c\u3058\u75c5\u6c17\uff08\u3042\u308b\u3044\u306f\u8efd\u3044\u75c7\u72b6\uff09\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u305d\u306e\u907a\u4f1d\u5b50\u304c50%\u306e\u78ba\u7387\u3067\u304a\u5b50\u69d8\u306b\u53d7\u3051\u7d99\u304c\u308c\u305f\u30b1\u30fc\u30b9\u3002<br>\u3053\u306e\u5834\u5408\u3001\u5bb6\u7cfb\u56f3\u3092\u898b\u308b\u3068\u3001\u7956\u7236\u6bcd\u3084\u304a\u3058\u30fb\u304a\u3070\u306b\u3082\u300c\u8db3\u304c\u5f31\u304f\u3066\u6b69\u304d\u65b9\u304c\u7279\u5fb4\u7684\u306a\u4eba\u300d\u304c\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u7a81\u7136\u5909\u7570\uff08de novo\u5909\u7570\uff09<br>\u3054\u4e21\u89aa\u306e\u907a\u4f1d\u5b50\u306b\u306f\u5168\u304f\u7570\u5e38\u304c\u306a\u304f\u3001\u53d7\u7cbe\u5375\u304c\u3067\u304d\u308b\u904e\u7a0b\u3067\u5076\u7136DYNC1H1\u907a\u4f1d\u5b50\u306b\u5909\u5316\u304c\u8d77\u304d\u305f\u30b1\u30fc\u30b9\u3002<br>\u5b9f\u306f\u3001SMALED2B\u3067\u306f\u3053\u306e\u300c\u7a81\u7136\u5909\u7570\u300d\u306e\u30b1\u30fc\u30b9\u3082\u975e\u5e38\u306b\u591a\u3044\u3067\u3059\u3002\u3053\u306e\u5834\u5408\u3001\u3054\u4e21\u89aa\u306f\u5065\u5eb7\u3067\u3042\u308a\u3001\u8ab0\u306e\u305b\u3044\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u81ea\u7136\u306e\u78ba\u7387\u7684\u306a\u73fe\u8c61\u3067\u3059\u3002<\/li>\n<\/ol>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2026\/01\/24273313_s.webp\" alt=\"\u533b\u8005\" class=\"wp-image-121555\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%A8%BA%E6%96%AD%E3%81%A8%E6%A4%9C%E6%9F%BB\"><\/span><strong>\u8a3a\u65ad\u3068\u691c\u67fb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u8a3a\u65ad\u306f\u3001\u5c0f\u5150\u795e\u7d4c\u79d1\u533b\u3084\u795e\u7d4c\u5185\u79d1\u533b\u306b\u3088\u3063\u3066\u3001\u614e\u91cd\u306b\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_%E8%BA%AB%E4%BD%93%E8%A8%BA%E5%AF%9F\"><\/span><strong>1. \u8eab\u4f53\u8a3a\u5bdf<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u7b4b\u8089\u306e\u75e9\u305b\u65b9\u3084\u529b\u306e\u5165\u308a\u5177\u5408\u3092\u898b\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u592a\u3082\u3082\u306e\u7b4b\u8089\uff08\u5927\u817f\u56db\u982d\u7b4b\uff09\u304c\u7279\u306b\u75e9\u305b\u3066\u3044\u308b\u304b\uff1f<\/p>\n\n\n\n<p>\u8171\u53cd\u5c04\uff08\u819d\u3092\u53e9\u304f\u691c\u67fb\uff09\u304c\u5f31\u304f\u306a\u3063\u3066\u3044\u308b\u304b\u3001\u3042\u308b\u3044\u306f\u9006\u306b\u5f37\u304f\u306a\u3063\u3066\u3044\u308b\u304b\uff1f\uff08SMALED2B\u3067\u306f\u3001\u810a\u9ac4\u306e\u75c5\u6c17\u3067\u3059\u304c\u3001\u53cd\u5c04\u304c\u5f37\u304f\u306a\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_%E8%A1%80%E6%B6%B2%E6%A4%9C%E6%9F%BB%EF%BC%88CK%E5%80%A4%EF%BC%89\"><\/span><strong>2. \u8840\u6db2\u691c\u67fb\uff08CK\u5024\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u7b4b\u8089\u304c\u58ca\u308c\u308b\u75c5\u6c17\uff08\u7b4b\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\u306a\u3069\uff09\u3067\u306f\u306a\u3044\u304b\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002SMALED2B\u3067\u306f\u3001CK\u5024\u306f\u6b63\u5e38\u304b\u3001\u308f\u305a\u304b\u306b\u9ad8\u3044\u7a0b\u5ea6\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_%E7%AD%8B%E9%9B%BB%E5%9B%B3%E6%A4%9C%E6%9F%BB\"><\/span><strong>3. \u7b4b\u96fb\u56f3\u691c\u67fb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u7b4b\u8089\u306b\u7d30\u3044\u91dd\u3092\u523a\u3057\u3066\u3001\u96fb\u6c17\u306e\u6ce2\u5f62\u3092\u898b\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7b4b\u8089\u81ea\u4f53\u306e\u75c5\u6c17\u306a\u306e\u304b\u3001\u795e\u7d4c\u306e\u75c5\u6c17\u306a\u306e\u304b\u3092\u533a\u5225\u3059\u308b\u91cd\u8981\u306a\u691c\u67fb\u3067\u3059\u3002SMALED2B\u3067\u306f\u300c\u795e\u7d4c\u539f\u6027\u5909\u5316\uff08\u795e\u7d4c\u304c\u539f\u56e0\u3067\u3042\u308b\u30b5\u30a4\u30f3\uff09\u300d\u304c\u898b\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_%E7%94%BB%E5%83%8F%E6%A4%9C%E6%9F%BB%EF%BC%88MRI%EF%BC%89\"><\/span><strong>4. \u753b\u50cf\u691c\u67fb\uff08MRI\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u4e0b\u80a2\u306e\u7b4b\u8089MRI\uff1a\u592a\u3082\u3082\u306e\u7b4b\u8089\u304c\u8102\u80aa\u306b\u7f6e\u304d\u63db\u308f\u3063\u3066\u3044\u308b\u30d1\u30bf\u30fc\u30f3\u3092\u898b\u308b\u3053\u3068\u3067\u3001\u8a3a\u65ad\u306e\u624b\u304c\u304b\u308a\u306b\u306a\u308a\u307e\u3059\u3002SMALED2B\u3067\u306f\u5927\u817f\u56db\u982d\u7b4b\u306b\u7279\u5fb4\u7684\u306a\u5909\u5316\u304c\u51fa\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8133\u306eMRI\uff1a\u8133\u306e\u5f62\u6210\u306b\u7570\u5e38\u304c\u306a\u3044\u304b\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_%E9%81%BA%E4%BC%9D%E5%AD%A6%E7%9A%84%E6%A4%9C%E6%9F%BB%EF%BC%88%E7%A2%BA%E5%AE%9A%E8%A8%BA%E6%96%AD%EF%BC%89\"><\/span><strong>5. \u907a\u4f1d\u5b66\u7684\u691c\u67fb\uff08\u78ba\u5b9a\u8a3a\u65ad\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6700\u7d42\u7684\u306a\u8a3a\u65ad\u306f\u3001\u8840\u6db2\u691c\u67fb\u3067DNA\u3092\u8abf\u3079\u3001DYNC1H1\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u304b\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u3067\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6700\u8fd1\u3067\u306f\u3001\u6307\u5b9a\u96e3\u75c5\u306e\u7533\u8acb\u306a\u3069\u306e\u305f\u3081\u306b\u3082\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u884c\u308f\u308c\u308b\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%B2%BB%E7%99%82%E3%81%A8%E7%AE%A1%E7%90%86%EF%BC%9A%E3%81%93%E3%82%8C%E3%81%8B%E3%82%89%E3%81%AE%E3%83%AD%E3%83%BC%E3%83%89%E3%83%9E%E3%83%83%E3%83%97\"><\/span><strong>\u6cbb\u7642\u3068\u7ba1\u7406\uff1a\u3053\u308c\u304b\u3089\u306e\u30ed\u30fc\u30c9\u30de\u30c3\u30d7<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u6b8b\u5ff5\u306a\u304c\u3089\u3001DYNC1H1\u907a\u4f1d\u5b50\u306e\u5909\u5316\u305d\u306e\u3082\u306e\u3092\u6cbb\u3059\u85ac\uff08\u6839\u672c\u6cbb\u7642\u85ac\uff09\u306f\u3001\u73fe\u6642\u70b9\u3067\u306f\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u4e00\u822c\u7684\u306aSMA\uff085q-SMA\uff09\u3067\u4f7f\u308f\u308c\u308b\u907a\u4f1d\u5b50\u6cbb\u7642\u85ac\uff08\u30be\u30eb\u30b2\u30f3\u30b9\u30de\u306a\u3069\uff09\u306f\u3001\u539f\u56e0\u907a\u4f1d\u5b50\u304c\u9055\u3046\u305f\u3081\u3001\u3053\u306e\u75c5\u6c17\u306b\u306f\u52b9\u679c\u304c\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u300c\u6cbb\u7642\u6cd5\u304c\u306a\u3044\u300d\uff1d\u300c\u4f55\u3082\u3067\u304d\u306a\u3044\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u75c7\u72b6\u3092\u548c\u3089\u3052\u3001\u6a5f\u80fd\u3092\u7dad\u6301\u3057\u3001\u751f\u6d3b\u306e\u8cea\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u300c\u5bfe\u75c7\u7642\u6cd5\u300d\u3068\u300c\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u300d\u304c\u975e\u5e38\u306b\u6709\u52b9\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_%E3%83%AA%E3%83%8F%E3%83%93%E3%83%AA%E3%83%86%E3%83%BC%E3%82%B7%E3%83%A7%E3%83%B3%EF%BC%88%E6%9C%80%E9%87%8D%E8%A6%81%EF%BC%89\"><\/span><strong>1. \u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\uff08\u6700\u91cd\u8981\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>SMALED2B\u306e\u7ba1\u7406\u306b\u304a\u3044\u3066\u3001\u30ea\u30cf\u30d3\u30ea\u306f\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30c3\u30c1\uff08\u95a2\u7bc0\u53ef\u52d5\u57df\u8a13\u7df4\uff09<\/p>\n\n\n\n<p>\u95a2\u7bc0\u304c\u56fa\u307e\u308b\uff08\u62d8\u7e2e\uff09\u306e\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u6bce\u65e5\u30b9\u30c8\u30ec\u30c3\u30c1\u3092\u884c\u3044\u307e\u3059\u3002\u7279\u306b\u30a2\u30ad\u30ec\u30b9\u8171\u3001\u819d\u306e\u88cf\u3001\u80a1\u95a2\u7bc0\u3092\u4f38\u3070\u3059\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002\u304a\u98a8\u5442\u4e0a\u304c\u308a\u306a\u3069\u3001\u4f53\u304c\u6e29\u307e\u3063\u3066\u3044\u308b\u6642\u306b\u884c\u3046\u3068\u52b9\u679c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u7b4b\u529b\u7dad\u6301\u8a13\u7df4<\/p>\n\n\n\n<p>\u7121\u7406\u306e\u306a\u3044\u7bc4\u56f2\u3067\u3001\u904a\u3073\u306e\u4e2d\u306b\u904b\u52d5\u3092\u53d6\u308a\u5165\u308c\u3001\u7b4b\u529b\u3092\u7dad\u6301\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8d77\u7acb\u30fb\u6b69\u884c\u8a13\u7df4<\/p>\n\n\n\n<p>\u5e73\u884c\u68d2\u3084\u6b69\u884c\u5668\u3092\u4f7f\u3063\u3066\u3001\u6b69\u304f\u611f\u899a\u3092\u990a\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_%E8%A3%85%E5%85%B7%E7%99%82%E6%B3%95\"><\/span><strong>2. \u88c5\u5177\u7642\u6cd5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u8db3\u306e\u5909\u5f62\u3084\u7b4b\u529b\u4f4e\u4e0b\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u305f\u3081\u306b\u3001\u88c5\u5177\uff08\u30aa\u30fc\u30bd\u30b7\u30b9\uff09\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u77ed\u4e0b\u80a2\u88c5\u5177\uff08AFO\uff09<\/p>\n\n\n\n<p>\u8db3\u9996\u3092\u56fa\u5b9a\u3057\u3001\u3064\u307e\u5148\u304c\u4e0b\u304c\u3089\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u88fd\u306e\u88c5\u5177\u3067\u3059\u3002\u3053\u308c\u3092\u3064\u3051\u308b\u3053\u3068\u3067\u3001\u8ee2\u3073\u306b\u304f\u304f\u306a\u308a\u3001\u6b69\u884c\u304c\u5b89\u5b9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30a4\u30f3\u30bd\u30fc\u30eb\uff08\u4e2d\u6577\u304d\uff09<\/p>\n\n\n\n<p>\u8db3\u306e\u30a2\u30fc\u30c1\u3092\u652f\u3048\u3001\u30d0\u30e9\u30f3\u30b9\u3092\u53d6\u308a\u3084\u3059\u304f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_%E6%95%B4%E5%BD%A2%E5%A4%96%E7%A7%91%E7%9A%84%E6%B2%BB%E7%99%82\"><\/span><strong>3. \u6574\u5f62\u5916\u79d1\u7684\u6cbb\u7642<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5185\u53cd\u8db3\u3084\u95a2\u7bc0\u306e\u62d8\u7e2e\u304c\u5f37\u304f\u3001\u30ea\u30cf\u30d3\u30ea\u3084\u88c5\u5177\u3067\u306f\u5bfe\u5fdc\u3067\u304d\u306a\u3044\u5834\u5408\u3001\u8171\u3092\u5ef6\u9577\u3057\u305f\u308a\u9aa8\u306e\u5f62\u3092\u6574\u3048\u305f\u308a\u3059\u308b\u624b\u8853\u304c\u884c\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u80a1\u95a2\u7bc0\u8131\u81fc\u3084\u5074\u5f2f\u75c7\u304c\u3042\u308b\u5834\u5408\u3082\u3001\u6574\u5f62\u5916\u79d1\u3067\u306e\u5b9a\u671f\u7684\u306a\u30c1\u30a7\u30c3\u30af\u3068\u6cbb\u7642\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_%E5%AE%9A%E6%9C%9F%E7%9A%84%E3%81%AA%E7%B5%8C%E9%81%8E%E8%A6%B3%E5%AF%9F\"><\/span><strong>4. \u5b9a\u671f\u7684\u306a\u7d4c\u904e\u89b3\u5bdf<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u75c5\u6c17\u306e\u9032\u884c\u306f\u975e\u5e38\u306b\u3086\u3063\u304f\u308a\u3067\u3059\u304c\u3001\u5e74\u306b1\u56de\u7a0b\u5ea6\u306f\u5c02\u9580\u533b\u3092\u53d7\u8a3a\u3057\u3001\u80cc\u9aa8\u306e\u66f2\u304c\u308a\u304c\u306a\u3044\u304b\u3001\u95a2\u7bc0\u304c\u56fa\u304f\u306a\u3063\u3066\u3044\u306a\u3044\u304b\u306a\u3069\u3092\u30c1\u30a7\u30c3\u30af\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%97%A5%E3%80%85%E3%81%AE%E7%94%9F%E6%B4%BB%E3%81%A7%E3%81%AE%E5%B7%A5%E5%A4%AB\"><\/span><strong>\u65e5\u3005\u306e\u751f\u6d3b\u3067\u306e\u5de5\u592b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>SMALED2B\u3068\u4ed8\u304d\u5408\u3044\u306a\u304c\u3089\u751f\u6d3b\u3059\u308b\u305f\u3081\u306b\u3001\u77e5\u3063\u3066\u304a\u3044\u3066\u3044\u305f\u3060\u304d\u305f\u3044\u30dd\u30a4\u30f3\u30c8\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u8ee2\u5012\u4e88\u9632<\/p>\n\n\n\n<p>\u8db3\u306e\u529b\u304c\u5f31\u3044\u305f\u3081\u3001\u8ee2\u3073\u3084\u3059\u3044\u3067\u3059\u3002\u5bb6\u306e\u4e2d\u306e\u6bb5\u5dee\u3092\u306a\u304f\u3059\u3001\u624b\u3059\u308a\u3092\u3064\u3051\u308b\u3001\u6ed1\u308a\u3084\u3059\u3044\u9774\u4e0b\u3092\u907f\u3051\u308b\u306a\u3069\u306e\u74b0\u5883\u8abf\u6574\u304c\u6709\u52b9\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4f53\u91cd\u7ba1\u7406<\/p>\n\n\n\n<p>\u8db3\u3078\u306e\u8ca0\u62c5\u3092\u6e1b\u3089\u3059\u305f\u3081\u3001\u9069\u5207\u306a\u4f53\u91cd\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002\u592a\u308a\u3059\u304e\u308b\u3068\u3001\u6b69\u884c\u304c\u96e3\u3057\u304f\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5bd2\u3055\u5bfe\u7b56<\/p>\n\n\n\n<p>\u8db3\u306e\u8840\u884c\u304c\u60aa\u304f\u306a\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u3001\u51ac\u5834\u306f\u30ec\u30c3\u30b0\u30a6\u30a9\u30fc\u30de\u30fc\u306a\u3069\u3067\u4fdd\u6e29\u3092\u5fc3\u304c\u3051\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>\u300c\u3067\u304d\u308b\u3053\u3068\u300d\u306b\u76ee\u3092\u5411\u3051\u308b<\/p>\n\n\n\n<p>\u8d70\u308b\u306e\u306f\u82e6\u624b\u3067\u3082\u3001\u6c34\u6cf3\u306a\u3089\u5f97\u610f\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u8db3\u306f\u5f31\u304f\u3066\u3082\u3001\u624b\u5148\u306f\u5668\u7528\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u304a\u5b50\u69d8\u306e\u300c\u5f97\u610f\u300d\u3092\u898b\u3064\u3051\u3066\u4f38\u3070\u3057\u3066\u3042\u3052\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%82%88%E3%81%8F%E3%81%82%E3%82%8B%E8%B3%AA%E5%95%8F%EF%BC%88FAQ%EF%BC%89\"><\/span><strong>\u3088\u304f\u3042\u308b\u8cea\u554f\uff08FAQ\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Q. \u5c06\u6765\u3001\u8eca\u6905\u5b50\u306b\u306a\u308a\u307e\u3059\u304b\uff1f<\/p>\n\n\n\n<p>A. \u500b\u4eba\u5dee\u304c\u5927\u304d\u3044\u305f\u3081\u4e00\u6982\u306b\u306f\u8a00\u3048\u307e\u305b\u3093\u304c\u3001SMALED2B\u306f\u9032\u884c\u304c\u975e\u5e38\u306b\u3086\u3063\u304f\u308a\u3001\u3042\u308b\u3044\u306f\u9032\u884c\u3057\u306a\u3044\u3053\u3068\u3082\u591a\u3044\u75be\u60a3\u3067\u3059\u3002\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306f\u3001\u88c5\u5177\u306a\u3069\u3092\u4f7f\u7528\u3057\u306a\u304c\u3089\u81ea\u529b\u6b69\u884c\u3092\u7dad\u6301\u3057\u3066\u3044\u307e\u3059\u3002\u9577\u3044\u8ddd\u96e2\u306e\u79fb\u52d5\u3084\u3001\u52a0\u9f62\u306b\u4f34\u3063\u3066\u8eca\u6905\u5b50\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u5b8c\u5168\u306b\u5bdd\u305f\u304d\u308a\u306b\u306a\u308b\u3088\u3046\u306a\u9032\u884c\u6027\u306e\u75c5\u6c17\u3068\u306f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>Q. <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/why-premium-plan\/\">\u77e5\u7684\u969c\u5bb3<\/a>\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/p>\n\n\n\n<p>A. \u4e00\u822c\u7684\u306b\u300c\u4e0b\u80a2\u512a\u4f4d\u578bSMA\u300d\u3068\u3057\u3066\u306eSMALED2B\u3067\u306f\u3001\u77e5\u80fd\u306f\u6b63\u5e38\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u305f\u3060\u3057\u3001DYNC1H1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306e\u30bf\u30a4\u30d7\u306b\u3088\u3063\u3066\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/learning-disabilities-genetics-support\/\">\u5b66\u7fd2\u969c\u5bb3<\/a>\u3084\u77e5\u7684\u767a\u9054\u75c7\u3092\u4f34\u3046\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u4e3b\u6cbb\u533b\u306b\u304a\u5b50\u69d8\u306e\u30bf\u30a4\u30d7\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u805e\u304f\u3053\u3068\u3092\u304a\u52e7\u3081\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Q. \u6b21\u306e\u5b50\u306b\u907a\u4f1d\u3057\u307e\u3059\u304b\uff1f<\/p>\n\n\n\n<p>A. \u60a3\u8005\u3055\u3093\u304c\u89aa\u5fa1\u3055\u3093\u304b\u3089\u907a\u4f1d\u3057\u305f\u5834\u5408\u306f\u3001\u3054\u5144\u5f1f\u308250%\u306e\u78ba\u7387\u3067\u540c\u3058\u907a\u4f1d\u5b50\u3092\u6301\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7a81\u7136\u5909\u7570\u306e\u5834\u5408\u306f\u3001\u3054\u5144\u5f1f\u3078\u306e\u5f71\u97ff\u306f\u4f4e\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u60a3\u8005\u3055\u3093\u3054\u81ea\u8eab\u304c\u5c06\u6765\u304a\u5b50\u69d8\u3092\u6301\u3064\u5834\u5408\u306f\u300150%\u306e\u78ba\u7387\u3067\u907a\u4f1d\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u8a73\u3057\u304f\u306f\u81e8\u5e8a\u907a\u4f1d\u5c02\u9580\u533b\u306b\u3088\u308b\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u53d7\u3051\u308b\u3053\u3068\u3092\u304a\u52e7\u3081\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%81%BE%E3%81%A8%E3%82%81\"><\/span><strong>\u307e\u3068\u3081<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u3053\u3053\u307e\u3067\u306e\u91cd\u8981\u30dd\u30a4\u30f3\u30c8\u3092\u632f\u308a\u8fd4\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ol 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