{"id":122811,"date":"2026-01-15T10:11:57","date_gmt":"2026-01-15T01:11:57","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?p=122811"},"modified":"2026-03-27T16:42:37","modified_gmt":"2026-03-27T07:42:37","slug":"cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/","title":{"rendered":"Cardiofaciocutaneous Syndrome 4"},"content":{"rendered":"\n<p>Cardiofaciocutaneous\uff08CFC\uff09\u75c7\u5019\u7fa4\u306f\u3001\u5fc3\u8840\u7ba1\u7cfb\u3001\u9854\u8c8c\u3001\u5916\u80da\u8449\uff08\u76ae\u819a\u30fb\u6bdb\u9aea\uff09\u306e\u7570\u5e38\u3092\u4e09\u4e3b\u5fb4\u3068\u3059\u308bRAS\u30d1\u30c1\u30fc\uff08RAS\/MAPK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u7570\u5e38\u306b\u3088\u308b\u75be\u60a3\u7fa4\uff09\u306e\u4e00\u7a2e\u3067\u3059\u3002\u305d\u306e\u4e2d\u3067\u300cCardiofaciocutaneous Syndrome 4\uff08CFC4\uff09\u300d\u306f\u3001<strong>MAP2K2\u907a\u4f1d\u5b50<\/strong>\u306e\u75c5\u7684\u5909\u7570\u3092\u539f\u56e0\u3068\u3059\u308b\u6975\u3081\u3066\u7a00\u306a\u30b5\u30d6\u30bf\u30a4\u30d7\u3067\u3059\u3002<\/p>\n\n\n\n<p>CFC\u75c7\u5019\u7fa4\u306e\u7d0475%\u306fBRAF\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08CFC1\uff09\u306b\u3088\u308b\u3082\u306e\u3067\u3059\u304c\u3001CFC4\u3092\u542b\u3080MAP2K2\u5909\u7570\u306b\u3088\u308b\u75c7\u4f8b\u306f\u5168\u4f53\u306e\u6570%\u306b\u904e\u304e\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001\u81e8\u5e8a\u73fe\u5834\u306b\u304a\u3044\u3066\u3082\u305d\u306e\u7279\u6027\u306f\u5341\u5206\u306b\u5468\u77e5\u3055\u308c\u3066\u3044\u308b\u3068\u306f\u8a00\u3048\u305a\u3001\u7cbe\u7dfb\u306a\u907a\u4f1d\u5b50\u8a3a\u65ad\u3068\u30b5\u30d6\u30bf\u30a4\u30d7\u306b\u5fdc\u3058\u305f\u500b\u5225\u5316\u533b\u7642\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001CFC4\u306e\u5206\u5b50\u751f\u7269\u5b66\u7684\u80cc\u666f\u3001\u81e8\u5e8a\u7684\u306a\u7279\u5fb4\u3001\u305d\u3057\u3066\u6700\u65b0\u306e\u6cbb\u7642\u7814\u7a76\u306e\u52d5\u5411\u3092\u30d7\u30ed\u30d5\u30a7\u30c3\u30b7\u30e7\u30ca\u30eb\u306a\u8996\u70b9\u304b\u3089\u8a73\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n<!--nipt_mono-->\r\n<div class=\"nipt-mono\">\r\n    <div class=\"nipt-mono-btn\">\r\n        <a href=\"\/nipt\/nipt-mono\/\">\r\n            <img decoding=\"async\" loading=\"lazy\" src=\"\/nipt\/wp-content\/uploads\/2026\/03\/NIPT-MONO.webp\" alt=\"NIPT-MONO\u3067\u8abf\u3079\u3089\u308c\u307e\u3059\">\r\n         <\/a>\r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.nipt-mono {\r\n    text-align: center; \/* \u89aa\u8981\u7d20\u3067\u6a2a\u4e2d\u592e *\/\r\n}\r\n.nipt-mono a img {\r\n    display: inline-block; \/* \u753b\u50cf\u3092\u30a4\u30f3\u30e9\u30a4\u30f3\u30d6\u30ed\u30c3\u30af\u5316\u3057\u3066 text-align \u306b\u53cd\u6620 *\/\r\n    width: 333px;\r\n}\r\n<\/style>\r\n<!--\/nipt_mono-->\r\n\r\n\n\n\n\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#1_%E5%88%86%E5%AD%90%E6%A8%99%E7%9A%84%EF%BC%9AMAP2K2%E9%81%BA%E4%BC%9D%E5%AD%90%E3%81%AE%E5%A4%89%E7%95%B0%E3%81%A8MEK2%E3%82%BF%E3%83%B3%E3%83%91%E3%82%AF%E8%B3%AA\" >1. \u5206\u5b50\u6a19\u7684\uff1aMAP2K2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3068MEK2\u30bf\u30f3\u30d1\u30af\u8cea<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#MEK2%E3%81%AE%E6%A9%9F%E8%83%BD%E3%81%A8%E6%B4%BB%E6%80%A7%E5%8C%96%E3%83%A1%E3%82%AB%E3%83%8B%E3%82%BA%E3%83%A0\" >MEK2\u306e\u6a5f\u80fd\u3068\u6d3b\u6027\u5316\u30e1\u30ab\u30cb\u30ba\u30e0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#CFC3%EF%BC%88MAP2K1%EF%BC%89%E3%81%A8%E3%81%AE%E5%88%86%E5%AD%90%E7%94%9F%E7%89%A9%E5%AD%A6%E7%9A%84%E3%81%AA%E5%B7%AE%E7%95%B0\" >CFC3\uff08MAP2K1\uff09\u3068\u306e\u5206\u5b50\u751f\u7269\u5b66\u7684\u306a\u5dee\u7570<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#2_CFC4%E3%81%AE%E8%87%A8%E5%BA%8A%E5%83%8F%EF%BC%9A%E5%A4%9A%E7%B3%BB%E7%B5%B1%E3%81%AB%E3%82%8F%E3%81%9F%E3%82%8B%E8%A1%A8%E7%8F%BE%E5%9E%8B%E3%81%AE%E8%A7%A3%E6%9E%90\" >2. CFC4\u306e\u81e8\u5e8a\u50cf\uff1a\u591a\u7cfb\u7d71\u306b\u308f\u305f\u308b\u8868\u73fe\u578b\u306e\u89e3\u6790<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#%E5%BF%83%E8%A1%80%E7%AE%A1%E3%83%97%E3%83%AD%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB\" >\u5fc3\u8840\u7ba1\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#%E7%A5%9E%E7%B5%8C%E7%99%BA%E9%81%94%E3%81%8A%E3%82%88%E3%81%B3%E7%AD%8B%E7%B7%8A%E5%BC%B5%E3%81%AE%E7%95%B0%E5%B8%B8\" >\u795e\u7d4c\u767a\u9054\u304a\u3088\u3073\u7b4b\u7dca\u5f35\u306e\u7570\u5e38<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#%E7%9A%AE%E8%86%9A%E3%81%A8%E4%BB%98%E5%B1%9E%E5%99%A8%E3%81%AE%E7%89%B9%E5%BE%B4\" >\u76ae\u819a\u3068\u4ed8\u5c5e\u5668\u306e\u7279\u5fb4<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#3_%E8%A8%BA%E6%96%AD%E6%88%A6%E7%95%A5%E3%81%A8%E6%9C%80%E6%96%B0%E3%81%AE%E7%AE%A1%E7%90%86%E6%8C%87%E9%87%9D\" >3. \u8a3a\u65ad\u6226\u7565\u3068\u6700\u65b0\u306e\u7ba1\u7406\u6307\u91dd<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#%E9%81%BA%E4%BC%9D%E5%AD%90%E8%A8%BA%E6%96%AD%E3%81%AE%E3%83%97%E3%83%AD%E3%82%BB%E3%82%B9\" >\u907a\u4f1d\u5b50\u8a3a\u65ad\u306e\u30d7\u30ed\u30bb\u30b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#%E5%A4%9A%E8%81%B7%E7%A8%AE%E9%80%A3%E6%90%BA%E3%81%AB%E3%82%88%E3%82%8B%E5%A4%9A%E8%A7%92%E7%9A%84%E7%AE%A1%E7%90%86\" >\u591a\u8077\u7a2e\u9023\u643a\u306b\u3088\u308b\u591a\u89d2\u7684\u7ba1\u7406<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#4_%E6%B2%BB%E7%99%82%E3%81%AE%E6%9C%80%E5%89%8D%E7%B7%9A%EF%BC%9AMEK%E9%98%BB%E5%AE%B3%E8%96%AC%E3%81%AE%E5%8F%AF%E8%83%BD%E6%80%A7\" >4. \u6cbb\u7642\u306e\u6700\u524d\u7dda\uff1aMEK\u963b\u5bb3\u85ac\u306e\u53ef\u80fd\u6027<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#MEK%E9%98%BB%E5%AE%B3%E8%96%AC%E3%81%AB%E3%82%88%E3%82%8B%E4%BB%8B%E5%85%A5\" >MEK\u963b\u5bb3\u85ac\u306b\u3088\u308b\u4ecb\u5165<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#%E3%83%97%E3%83%AC%E3%82%B7%E3%82%B8%E3%83%A7%E3%83%B3%E3%83%BB%E3%83%A1%E3%83%87%E3%82%A3%E3%82%B7%E3%83%B3%E3%81%AE%E6%B7%B1%E5%8C%96\" >\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\u306e\u6df1\u5316<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/#%E7%B5%90%E8%AB%96%EF%BC%9ACFC4%E3%81%A8%E5%85%B1%E3%81%AB%E7%94%9F%E3%81%8D%E3%82%8B%E6%9C%AA%E6%9D%A5%E3%81%B8\" >\u7d50\u8ad6\uff1aCFC4\u3068\u5171\u306b\u751f\u304d\u308b\u672a\u6765\u3078<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_%E5%88%86%E5%AD%90%E6%A8%99%E7%9A%84%EF%BC%9AMAP2K2%E9%81%BA%E4%BC%9D%E5%AD%90%E3%81%AE%E5%A4%89%E7%95%B0%E3%81%A8MEK2%E3%82%BF%E3%83%B3%E3%83%91%E3%82%AF%E8%B3%AA\"><\/span><strong>1. \u5206\u5b50\u6a19\u7684\uff1aMAP2K2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3068MEK2\u30bf\u30f3\u30d1\u30af\u8cea<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>CFC4\u306e\u672c\u614b\u306f\u300119\u756a\u67d3\u8272\u4f53\uff0819p13.3\uff09\u306b\u4f4d\u7f6e\u3059\u308b<strong>MAP2K2\u907a\u4f1d\u5b50<\/strong>\u306e\u751f\u6b96\u7d30\u80de\u7cfb\u5217\u5909\u7570\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"MEK2%E3%81%AE%E6%A9%9F%E8%83%BD%E3%81%A8%E6%B4%BB%E6%80%A7%E5%8C%96%E3%83%A1%E3%82%AB%E3%83%8B%E3%82%BA%E3%83%A0\"><\/span><strong>MEK2\u306e\u6a5f\u80fd\u3068\u6d3b\u6027\u5316\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>MAP2K2\u907a\u4f1d\u5b50\u306f\u3001\u4e8c\u91cd\u7279\u7570\u6027\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u3067\u3042\u308b<strong>MEK2\u30bf\u30f3\u30d1\u30af\u8cea<\/strong>\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002MEK2\u306f\u3001\u7d30\u80de\u5897\u6b96\u3092\u5236\u5fa1\u3059\u308b\u91cd\u8981\u306a\u30ab\u30b9\u30b1\u30fc\u30c9\u3067\u3042\u308b\u300cRAF-MEK-ERK\u300d\u7d4c\u8def\u306b\u304a\u3044\u3066\u3001MEK1\uff08CFC3\u306e\u539f\u56e0\u56e0\u5b50\uff09\u3068\u76f8\u88dc\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>CFC4\u3067\u8a8d\u3081\u3089\u308c\u308b\u5909\u7570\u306e\u591a\u304f\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ad\u30ca\u30fc\u30bc\u30c9\u30e1\u30a4\u30f3\u3084\u8ca0\u306e\u8abf\u7bc0\u30c9\u30e1\u30a4\u30f3\u306b\u751f\u3058\u308b\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001MEK2\u304c\u6301\u7d9a\u7684\u306b\u6d3b\u6027\u5316\u3055\u308c\u308b\u300c\u6a5f\u80fd\u7372\u5f97\u578b\uff08gain-of-function\uff09\u300d\u306e\u8868\u73fe\u578b\u3092\u3068\u308a\u3001\u4e0b\u6d41\u306eERK\u3092\u904e\u5270\u306b\u30ea\u30f3\u9178\u5316\u3057\u307e\u3059\u3002\u3053\u306e\u7d50\u679c\u3001\u7d44\u7e54\u306e\u6b63\u5e38\u306a\u5206\u5316\u30fb\u767a\u80b2\u30d7\u30ed\u30bb\u30b9\u304c\u963b\u5bb3\u3055\u308c\u3001\u591a\u7cfb\u7d71\u306b\u308f\u305f\u308b\u5148\u5929\u6027\u7570\u5e38\u304c\u9855\u5728\u5316\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CFC3%EF%BC%88MAP2K1%EF%BC%89%E3%81%A8%E3%81%AE%E5%88%86%E5%AD%90%E7%94%9F%E7%89%A9%E5%AD%A6%E7%9A%84%E3%81%AA%E5%B7%AE%E7%95%B0\"><\/span><strong>CFC3\uff08MAP2K1\uff09\u3068\u306e\u5206\u5b50\u751f\u7269\u5b66\u7684\u306a\u5dee\u7570<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>CFC3\u306e\u539f\u56e0\u3067\u3042\u308bMEK1\u3068\u3001CFC4\u306e\u539f\u56e0\u3067\u3042\u308bMEK2\u306f\u3001\u30a2\u30df\u30ce\u9178\u914d\u5217\u306e\u76f8\u540c\u6027\u304c\u6975\u3081\u3066\u9ad8\u3044\u30d1\u30e9\u30ed\u30b0\uff08\u76f8\u540c\u907a\u4f1d\u5b50\uff09\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u7d44\u7e54\u3054\u3068\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u3084\u4e0b\u6d41\u3078\u306e\u30b7\u30b0\u30ca\u30eb\u5f37\u5ea6\u306e\u5fae\u7d30\u306a\u9055\u3044\u304c\u3001\u30b5\u30d6\u30bf\u30a4\u30d7\u9593\u3067\u306e\u75c7\u72b6\u306e\u91cd\u75c7\u5ea6\u3084\u5408\u4f75\u75c7\u306e\u983b\u5ea6\u306e\u5dee\u3068\u3057\u3066\u73fe\u308c\u308b\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_CFC4%E3%81%AE%E8%87%A8%E5%BA%8A%E5%83%8F%EF%BC%9A%E5%A4%9A%E7%B3%BB%E7%B5%B1%E3%81%AB%E3%82%8F%E3%81%9F%E3%82%8B%E8%A1%A8%E7%8F%BE%E5%9E%8B%E3%81%AE%E8%A7%A3%E6%9E%90\"><\/span><strong>2. CFC4\u306e\u81e8\u5e8a\u50cf\uff1a\u591a\u7cfb\u7d71\u306b\u308f\u305f\u308b\u8868\u73fe\u578b\u306e\u89e3\u6790<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>CFC4\u306f\u3001\u4ed6\u306eCFC\u75c7\u5019\u7fa4\u306e\u30b5\u30d6\u30bf\u30a4\u30d7\u3068\u591a\u304f\u306e\u81e8\u5e8a\u7684\u7279\u5fb4\u3092\u5171\u6709\u3057\u307e\u3059\u304c\u3001\u305d\u306e\u767a\u73fe\u306e\u5f37\u5f31\u306b\u306f\u500b\u5225\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%BF%83%E8%A1%80%E7%AE%A1%E3%83%97%E3%83%AD%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB\"><\/span><strong>\u5fc3\u8840\u7ba1\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5fc3\u81d3\u306e\u7570\u5e38\u306f\u3001CFC4\u306e\u751f\u547d\u4e88\u5f8c\u306b\u304a\u3044\u3066\u6700\u3082\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u80ba\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\uff08PVS\uff09:<\/strong> \u6700\u3082\u983b\u7e41\u306b\u898b\u3089\u308c\u308b\u69cb\u9020\u7684\u7570\u5e38\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u80a5\u5927\u578b\u5fc3\u7b4b\u75c7\uff08HCM\uff09:<\/strong> \u5fc3\u5ba4\u4e2d\u9694\u3084\u5de6\u5ba4\u58c1\u306e\u80a5\u539a\u3092\u7279\u5fb4\u3068\u3057\u3001\u9032\u884c\u6027\u306e\u7d4c\u904e\u3092\u305f\u3069\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5fc3\u5ba4\u4e2d\u9694\u6b20\u640d\uff08VSD\uff09:<\/strong> \u8840\u6db2\u306e\u5de6\u53f3\u77ed\u7d61\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u5fc3\u4e0d\u5168\u75c7\u72b6\u306e\u539f\u56e0\u3068\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%B5%8C%E7%99%BA%E9%81%94%E3%81%8A%E3%82%88%E3%81%B3%E7%AD%8B%E7%B7%8A%E5%BC%B5%E3%81%AE%E7%95%B0%E5%B8%B8\"><\/span><strong>\u795e\u7d4c\u767a\u9054\u304a\u3088\u3073\u7b4b\u7dca\u5f35\u306e\u7570\u5e38<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>CFC4\u60a3\u8005\u306e\u307b\u307c\u5168\u4f8b\u306b\u304a\u3044\u3066\u3001\u795e\u7d4c\u5b66\u7684\u306a\u8ab2\u984c\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5168\u822c\u7684\u767a\u9054\u9045\u6ede:<\/strong> \u904b\u52d5\u3001\u8a00\u8a9e\u3001\u793e\u4f1a\u6027\u306e\u3059\u3079\u3066\u306e\u9762\u3067\u767a\u9054\u304c\u7de9\u5f90\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u91cd\u5ea6\u306e\u7b4b\u7dca\u5f35\u4f4e\u4e0b\uff08Hypotonia\uff09:<\/strong> \u4e73\u5150\u671f\u306e\u300c\u30d5\u30ed\u30c3\u30d4\u30fc\u30a4\u30f3\u30d5\u30a1\u30f3\u30c8\u300d\u72b6\u614b\u306f\u3001\u6442\u98df\u56f0\u96e3\u3084\u547c\u5438\u5668\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8133\u5f62\u614b\u306e\u7570\u5e38:<\/strong> \u5074\u8133\u5ba4\u62e1\u5927\u3084\u8133\u6881\u6b20\u640d\u3001\u5c0f\u8133\u4f4e\u5f62\u6210\u306a\u3069\u304c\u753b\u50cf\u8a3a\u65ad\uff08MRI\uff09\u3067\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%9A%AE%E8%86%9A%E3%81%A8%E4%BB%98%E5%B1%9E%E5%99%A8%E3%81%AE%E7%89%B9%E5%BE%B4\"><\/span><strong>\u76ae\u819a\u3068\u4ed8\u5c5e\u5668\u306e\u7279\u5fb4<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u76ae\u819a\u75c7\u72b6\u306fCFC\u75c7\u5019\u7fa4\u3092\u5b9a\u7fa9\u3065\u3051\u308b\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u89d2\u5316\u7570\u5e38\u75c7:<\/strong> \u6bdb\u5b54\u6027\u82d4\u766c\u3084\u5e83\u7bc4\u306a\u9b5a\u9c57\u766c\u69d8\u5909\u5316\u304c\u307f\u3089\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6bdb\u9aea\u306e\u7570\u5e38:<\/strong> \u975e\u5e38\u306b\u7e2e\u308c\u305f\u3001\u3042\u308b\u3044\u306f\u307e\u3070\u3089\u306a\u982d\u9aea\u3002\u7709\u6bdb\u306e\u6b20\u640d\u3084\u8584\u6bdb\u3082\u5178\u578b\u7684\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6e7f\u75b9\u30fb\u96e3\u6cbb\u6027\u76ae\u819a\u708e:<\/strong> \u76ae\u819a\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u8457\u3057\u304f\u4f4e\u304f\u3001\u6162\u6027\u7684\u306a\u708e\u75c7\u3092\u4f34\u3046\u3053\u3068\u304c\u591a\u3044\u306e\u304c\u7279\u5fb4\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2026\/01\/32981426_s-10.webp\" alt=\"\u533b\u8005\" class=\"wp-image-121595\"\/><\/figure><\/div>\n\n<!--nipt_mono-->\r\n<div class=\"nipt-mono\">\r\n    <div class=\"nipt-mono-btn\">\r\n        <a href=\"\/nipt\/nipt-mono\/\">\r\n            <img decoding=\"async\" loading=\"lazy\" src=\"\/nipt\/wp-content\/uploads\/2026\/03\/NIPT-MONO.webp\" alt=\"NIPT-MONO\u3067\u8abf\u3079\u3089\u308c\u307e\u3059\">\r\n         <\/a>\r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.nipt-mono {\r\n    text-align: center; \/* \u89aa\u8981\u7d20\u3067\u6a2a\u4e2d\u592e *\/\r\n}\r\n.nipt-mono a img {\r\n    display: inline-block; \/* \u753b\u50cf\u3092\u30a4\u30f3\u30e9\u30a4\u30f3\u30d6\u30ed\u30c3\u30af\u5316\u3057\u3066 text-align \u306b\u53cd\u6620 *\/\r\n    width: 333px;\r\n}\r\n<\/style>\r\n<!--\/nipt_mono-->\r\n\r\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_%E8%A8%BA%E6%96%AD%E6%88%A6%E7%95%A5%E3%81%A8%E6%9C%80%E6%96%B0%E3%81%AE%E7%AE%A1%E7%90%86%E6%8C%87%E9%87%9D\"><\/span><strong>3. \u8a3a\u65ad\u6226\u7565\u3068\u6700\u65b0\u306e\u7ba1\u7406\u6307\u91dd<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>CFC4\u306e\u8a3a\u65ad\u306b\u306f\u3001\u9ad8\u5ea6\u306a\u907a\u4f1d\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3001\u8907\u6570\u306e\u5c02\u9580\u533b\u306b\u3088\u308b\u7dcf\u5408\u7684\u306a\u8a55\u4fa1\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%81%BA%E4%BC%9D%E5%AD%90%E8%A8%BA%E6%96%AD%E3%81%AE%E3%83%97%E3%83%AD%E3%82%BB%E3%82%B9\"><\/span><strong>\u907a\u4f1d\u5b50\u8a3a\u65ad\u306e\u30d7\u30ed\u30bb\u30b9<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u81e8\u5e8a\u7684\u306bCFC\u75c7\u5019\u7fa4\u304c\u7591\u308f\u308c\u308b\u5834\u5408\u3001\u73fe\u5728\u3067\u306f\u5358\u4e00\u907a\u4f1d\u5b50\u306e\u89e3\u6790\u3088\u308a\u3082\u3001<strong>RAS\u30d1\u30c1\u30fc\u30fb\u30de\u30eb\u30c1\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u89e3\u6790<\/strong>\u304c\u4e00\u822c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>NGS\u30d1\u30cd\u30eb\u691c\u67fb:<\/strong> BRAF, MAP2K1, MAP2K2, HRAS, KRAS, PTPN11\u7b49\u306e\u4e00\u62ec\u89e3\u6790\u3002<\/li>\n\n\n\n<li><strong>\u30d0\u30ea\u30a2\u30f3\u30c8\u8a55\u4fa1:<\/strong> \u691c\u51fa\u3055\u308c\u305fMAP2K2\u306e\u5909\u7570\u304c\u3001\u904e\u53bb\u306e\u75c7\u4f8b\u5831\u544a\u3084\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff08ClinVar\u7b49\uff09\u306b\u7167\u3089\u3057\u3066\u300c\u75c5\u7684\uff08Pathogenic\uff09\u300d\u3067\u3042\u308b\u304b\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%A4%9A%E8%81%B7%E7%A8%AE%E9%80%A3%E6%90%BA%E3%81%AB%E3%82%88%E3%82%8B%E5%A4%9A%E8%A7%92%E7%9A%84%E7%AE%A1%E7%90%86\"><\/span><strong>\u591a\u8077\u7a2e\u9023\u643a\u306b\u3088\u308b\u591a\u89d2\u7684\u7ba1\u7406<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>CFC4\u306f\u300c\u5168\u8eab\u75be\u60a3\u300d\u3067\u3042\u308b\u305f\u3081\u3001\u7e26\u5272\u308a\u3067\u306f\u306a\u3044\u533b\u7642\u4f53\u5236\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5c0f\u5150\u5faa\u74b0\u5668\u79d1:<\/strong> HCM\u306e\u9032\u884c\u30ea\u30b9\u30af\u3092\u8003\u616e\u3057\u3001\u5e74\u5358\u4f4d\u3067\u306f\u306a\u304f\u3001\u3088\u308a\u983b\u56de\u306a\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c\u63a8\u5968\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u79d1:<\/strong> \u65e9\u671f\u304b\u3089\u306e\u7642\u80b2\u652f\u63f4\u304c\u3001\u5c06\u6765\u306eADL\uff08\u65e5\u5e38\u751f\u6d3b\u52d5\u4f5c\uff09\u306b\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0:<\/strong> \u307b\u3068\u3093\u3069\u304c\u7a81\u7136\u5909\u7570\uff08de novo\uff09\u3067\u3059\u304c\u3001\u5bb6\u65cf\u3078\u306e\u7cbe\u795e\u7684\u30b1\u30a2\u3068\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u8aac\u660e\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_%E6%B2%BB%E7%99%82%E3%81%AE%E6%9C%80%E5%89%8D%E7%B7%9A%EF%BC%9AMEK%E9%98%BB%E5%AE%B3%E8%96%AC%E3%81%AE%E5%8F%AF%E8%83%BD%E6%80%A7\"><\/span><strong>4. \u6cbb\u7642\u306e\u6700\u524d\u7dda\uff1aMEK\u963b\u5bb3\u85ac\u306e\u53ef\u80fd\u6027<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u73fe\u5728\u3001CFC4\u306b\u5bfe\u3059\u308b\u6839\u672c\u7684\u306a\u85ac\u7269\u7642\u6cd5\u306f\u5b58\u5728\u3057\u307e\u305b\u3093\u304c\u3001\u5206\u5b50\u751f\u7269\u5b66\u7684\u306a\u30bf\u30fc\u30b2\u30c3\u30c8\u306f\u660e\u78ba\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"MEK%E9%98%BB%E5%AE%B3%E8%96%AC%E3%81%AB%E3%82%88%E3%82%8B%E4%BB%8B%E5%85%A5\"><\/span><strong>MEK\u963b\u5bb3\u85ac\u306b\u3088\u308b\u4ecb\u5165<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>MAP2K2\u306e\u904e\u5270\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b\u305f\u3081\u3001\u304c\u3093\u5316\u5b66\u7642\u6cd5\u3067\u4f7f\u7528\u3055\u308c\u308bMEK1\/2\u963b\u5bb3\u85ac\uff08\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u3001\u30b3\u30d3\u30e1\u30c1\u30cb\u30d6\u306a\u3069\uff09\u306e\u8ee2\u7528\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u671f\u5f85\u3055\u308c\u308b\u52b9\u679c:<\/strong> \u5fc3\u7b4b\u80a5\u539a\u306e\u9000\u7e2e\u3001\u76ae\u819a\u306e\u89d2\u5316\u7570\u5e38\u306e\u6539\u5584\u3001\u3055\u3089\u306b\u306f\u8a8d\u77e5\u6a5f\u80fd\u3078\u306e\u597d\u5f71\u97ff\u3002<\/li>\n\n\n\n<li><strong>\u8ab2\u984c:<\/strong> \u9577\u671f\u6295\u4e0e\u306b\u304a\u3051\u308b\u6bd2\u6027\u3001\u7279\u306b\u7db2\u819c\u3001\u7b4b\u7d44\u7e54\u3001\u6210\u9577\u677f\u3078\u306e\u5f71\u97ff\u304c\u61f8\u5ff5\u3055\u308c\u3066\u304a\u308a\u3001\u5c0f\u5150\u3078\u306e\u9069\u5fdc\u62e1\u5927\u306b\u306f\u53b3\u683c\u306a\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u304c\u5f85\u305f\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%83%97%E3%83%AC%E3%82%B7%E3%82%B8%E3%83%A7%E3%83%B3%E3%83%BB%E3%83%A1%E3%83%87%E3%82%A3%E3%82%B7%E3%83%B3%E3%81%AE%E6%B7%B1%E5%8C%96\"><\/span><strong>\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\u306e\u6df1\u5316<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u5909\u7570\u306e\u300c\u7b87\u6240\u300d\u306b\u3088\u3063\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d3b\u6027\u5316\u5ea6\u5408\u3044\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u5c06\u6765\u7684\u306b\u5909\u7570\u90e8\u4f4d\u306b\u57fa\u3065\u3044\u305f\u6295\u85ac\u91cf\u306e\u6700\u9069\u5316\uff08\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\uff09\u304cCFC4\u6cbb\u7642\u306e\u4e2d\u5fc3\u306b\u306a\u308b\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%90%E8%AB%96%EF%BC%9ACFC4%E3%81%A8%E5%85%B1%E3%81%AB%E7%94%9F%E3%81%8D%E3%82%8B%E6%9C%AA%E6%9D%A5%E3%81%B8\"><\/span><strong>\u7d50\u8ad6\uff1aCFC4\u3068\u5171\u306b\u751f\u304d\u308b\u672a\u6765\u3078<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Cardiofaciocutaneous Syndrome 4\uff08CFC4\uff09\u306f\u3001\u305d\u306e\u5e0c\u5c11\u3055\u3086\u3048\u306b\u3001\u8a3a\u65ad\u306b\u81f3\u308b\u307e\u3067\u306e\u9053\u306e\u308a\u304c\u9577\u304f\u3001\u5bb6\u65cf\u304c\u5b64\u7acb\u3057\u3084\u3059\u3044\u75be\u60a3\u3067\u3059\u3002\u3057\u304b\u3057\u3001MAP2K2\u907a\u4f1d\u5b50\u306e\u540c\u5b9a\u3092\u8d77\u70b9\u3068\u3057\u3066\u3001\u75c5\u614b\u306e\u89e3\u660e\u306f\u78ba\u5b9f\u306b\u524d\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u65e9\u671f\u8a3a\u65ad\u3001\u9069\u5207\u306a\u5fc3\u8840\u7ba1\u7ba1\u7406\u3001\u305d\u3057\u3066\u9032\u5316\u3092\u7d9a\u3051\u308b\u5206\u5b50\u6a19\u7684\u85ac\u306e\u7814\u7a76\u306f\u3001\u60a3\u8005\u3068\u305d\u306e\u5bb6\u65cf\u306b\u65b0\u305f\u306a\u5e0c\u671b\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u307e\u3059\u3002\u6700\u65b0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u9069\u5207\u306a\u4ecb\u5165\u3092\u7d99\u7d9a\u3059\u308b\u3053\u3068\u304c\u3001CFC4\u3092\u6301\u3064\u65b9\u3005\u306e\u5065\u5eb7\u3068\u5e78\u798f\u3092\u6700\u5927\u5316\u3059\u308b\u552f\u4e00\u306e\u9053\u3067\u3059\u3002<\/p>\n\n\n<!--nipt_mono-->\r\n<div class=\"nipt-mono\">\r\n    <div class=\"nipt-mono-btn\">\r\n        <a href=\"\/nipt\/nipt-mono\/\">\r\n            <img decoding=\"async\" loading=\"lazy\" src=\"\/nipt\/wp-content\/uploads\/2026\/03\/NIPT-MONO.webp\" alt=\"NIPT-MONO\u3067\u8abf\u3079\u3089\u308c\u307e\u3059\">\r\n         <\/a>\r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.nipt-mono {\r\n    text-align: center; \/* \u89aa\u8981\u7d20\u3067\u6a2a\u4e2d\u592e *\/\r\n}\r\n.nipt-mono a img {\r\n    display: inline-block; \/* \u753b\u50cf\u3092\u30a4\u30f3\u30e9\u30a4\u30f3\u30d6\u30ed\u30c3\u30af\u5316\u3057\u3066 text-align \u306b\u53cd\u6620 *\/\r\n    width: 333px;\r\n}\r\n<\/style>\r\n<!--\/nipt_mono-->\r\n\r\n\n","protected":false},"excerpt":{"rendered":"Cardiofaciocutaneous&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cardiofaciocutaneous-syndrome-4-map2k2-genetic-insights\/\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":122,"featured_media":119919,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1392],"tags":[],"class_list":["post-122811","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1392"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/122811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/122"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=122811"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/122811\/revisions"}],"predecessor-version":[{"id":126213,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/122811\/revisions\/126213"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/119919"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=122811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=122811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=122811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}