{"id":18713,"date":"2021-10-29T18:52:08","date_gmt":"2021-10-29T09:52:08","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/?p=18713"},"modified":"2025-08-11T14:56:04","modified_gmt":"2025-08-11T05:56:04","slug":"japanese-mothers-aged-35-and-older","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/japanese-mothers-aged-35-and-older\/","title":{"rendered":"35\u6b73\u4ee5\u4e0a\u306e\u65e5\u672c\u4eba\u6bcd\u89aa\u306b\u5bfe\u3059\u308b\u598a\u5a20\u7b2c2\u671f\u7f8a\u6c34\u7a7f\u523a\u6642\u306e\u67d3\u8272\u4f53\u7570\u5e38\u306e\u5e74\u9f62\u7279\u7570\u7684\u767a\u751f\u7387:5484\u4f8b\u306e\u5171\u540c\u7814\u7a76"},"content":{"rendered":"\n<h2 class=\"wp-block-heading hidden-heading\"><\/h2>\n\n\n\n<h3 class=\"wp-block-heading hidden-heading\"><\/h3>\n\n\n\n<p>JB .H Juomch Gimesneent e(t1 9a9l.8: )S 4te3t:t8e5r-ia9 0hydrogenophila \u00a9 Jpn Soc Hum Genet and Springer-Verlag 198958<\/p>\n\n\n\n<p>\u539f\u8457<\/p>\n\n\n\n<p>Nobuo Yaegashi \u00b7 Masato Senoo \u00b7 Shigeki Uehara<br>Hisako Suzuki \u00b7 Tohru Maeda \u00b7 Keiya Fujimori<br>Fumiki Hirahara \u00b7 Akira Yajima<\/p>\n\n\n\n<p>\u53d7\u9818:1997\u5e747\u670823\u65e5\/\u53d7\u7406:1997\u5e7412\u67081\u65e5<\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">\u8981\u7d04<\/h4>\n\n\n\n<p>\u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u300135\u6b73\u4ee5\u4e0a\u306e\u65e5\u672c\u4eba\u5973\u6027\u306e\u7f8a\u6c34\u7a7f\u523a\u3067\u767a\u898b\u3055\u308c\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u4e88\u60f3\u767a\u751f\u7387\u3092\u7b97\u51fa\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002\u65e5\u672c\u306e4\u3064\u306e\u30af\u30ea\u30cb\u30c3\u30af\u304b\u3089\u300135\u6b73\u4ee5\u4e0a\u306e\u9ad8\u9f62\u3067\u3042\u308b\u3053\u3068\u306e\u307f\u304c\u30ea\u30b9\u30af\u3068\u306a\u308b5484\u4eba\u306e\u598a\u5a66\u306e\u907a\u4f1d\u5b50<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/amniocentesis\/\">\u7f8a\u6c34\u691c\u67fb<\/a>\u30c7\u30fc\u30bf\u3092\u96c6\u3081\u307e\u3057\u305f\u3002\u305d\u306e\u30c7\u30fc\u30bf\u3092\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u89e3\u6790\u3057\u305f\u30025484\u4eba\u306e\u80ce\u5150\u306e\u3046\u3061\u3001117\u4eba\uff082.1\uff05\uff09\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u5185\u8a33\u306f\u300121\u30c8\u30ea\u30bd\u30df\u30fc\u304c42\u4f8b\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304c13\u4f8b\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304c7\u4f8b\u300147,XXY\u304c10\u4f8b\u300147,XXX\u304c4\u4f8b\u300147,XYY\u304c1\u4f8b\u3001\u69d8\u3005\u306a\u69cb\u9020\u7570\u5e38\u304c27\u4f8b\u3001\u69d8\u3005\u306a\u30bf\u30a4\u30d7\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u304c13\u4f8b\u3067\u3042\u3063\u305f\u3002\u30c8\u30ea\u30bd\u30df\u30fc21\u3001\u81f4\u6b7b\u6027\u5e38\u67d3\u8272\u4f53\u7570\u6570\u6027\uff08\u30c8\u30ea\u30bd\u30df\u30fc18\u3001\u30c8\u30ea\u30bd\u30df\u30fc13\uff09\u3001\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\uff08XXY\u3001XXX\u3001XYY\uff09\u306e\u767a\u751f\u7387\u306f\u3001\u6bcd\u89aa\u306e\u5e74\u9f62\u3068\u3068\u3082\u306b\u5897\u52a0\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u56de\u5e30\u5f0f\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u3068\u305d\u306e\u6a19\u6e96\u8aa4\u5dee\u3092\u7b97\u51fa\u3057\u3001\u5404\u6bcd\u89aa\u306e\u5e74\u9f62\u306b\u304a\u3051\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u4e88\u60f3\u767a\u751f\u7387\u3092\u6c42\u3081\u305f\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u4e88\u60f3\u767a\u751f\u7387\u306f\u3001\u65e5\u672c\u3067\u306f\u521d\u3081\u3066\u306e\u30c7\u30fc\u30bf\u3067\u3042\u308a\u3001\u598a\u5a66\u306e\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306b\u5f79\u7acb\u3064\u3082\u306e\u3068\u601d\u308f\u308c\u308b\u300221\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u767a\u751f\u7387\u306f\u3001\u6b27\u7c73\u8af8\u56fd\u3067\u904e\u53bb\u306b\u767a\u8868\u3055\u308c\u305f\u7387\u3068\u5909\u308f\u3089\u306a\u3044\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u767a\u751f\u7387\u306f\u3001\u4eba\u7a2e\u3084\u5730\u7406\u7684\u306a\u8981\u56e0\u306b\u5f71\u97ff\u3055\u308c\u306a\u3044\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9<\/h4>\n\n\n\n<p>\u6bcd\u89aa\u306e\u9ad8\u9f62\u30fb\u7f8a\u6c34\u7a7f\u523a\u30fb<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u30fb\u67d3\u8272\u4f53\u30fb<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u5019\u7fa4<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/japanese-mothers-aged-35-and-older\/#%E3%81%AF%E3%81%98%E3%82%81%E3%81%AB\" >\u306f\u3058\u3081\u306b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/japanese-mothers-aged-35-and-older\/#%E6%9D%90%E6%96%99%E3%81%8A%E3%82%88%E3%81%B3%E6%96%B9%E6%B3%95\" >\u6750\u6599\u304a\u3088\u3073\u65b9\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/japanese-mothers-aged-35-and-older\/#%E7%B5%90%E6%9E%9C\" >\u7d50\u679c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/japanese-mothers-aged-35-and-older\/#%E8%80%83%E5%AF%9F\" >\u8003\u5bdf<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/japanese-mothers-aged-35-and-older\/#%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\" >\u53c2\u8003\u6587\u732e<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%81%AF%E3%81%98%E3%82%81%E3%81%AB\"><\/span>\u306f\u3058\u3081\u306b<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u5019\u7fa4(21\u30c8\u30ea\u30bd\u30df\u30fc)\u304a\u3088\u3073\u4ed6\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u983b\u5ea6\u306f\u3001\u6bcd\u89aa\u306e\u5e74\u9f62\u304c\u9032\u3080\u306b\u3064\u308c\u3066\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b(Polani\u3089)\u3002 1976\u5e74; Schreinemachers\u3089 1982; Ferguson-Smith and Yates 1984; Hook\u30891984)\u3002\u7523\u79d1\u533b\u3001\u5bb6\u5ead\u533b\u3001\u304a\u3088\u3073\u81e8\u5e8a\u907a\u4f1d\u5b66\u8005\u306f\u3001\u305d\u306e\u5b50\u5b6b\u304c\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7570\u5e38\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u598a\u5a66\u304b\u3089\u8cea\u554f\u3092\u53d7\u3051\u3066\u3044\u308b\u3002 \u5b9f\u969b\u3001\u305f\u3068\u3048\u8cea\u554f\u3055\u308c\u3066\u3044\u306a\u304f\u3066\u3082\u3001\u63a8\u5b9a\u4e0a\u9ad8\u30ea\u30b9\u30af\u306e\u72b6\u6cc1\u4e0b\u3067\u598a\u5a66\u306b\u305d\u306e\u3088\u3046\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u306a\u304b\u3063\u305f\u3053\u3068\u306f\u3001\u6cd5\u7684\u8cac\u4efb\u306e\u6839\u62e0\u3068\u3057\u3066\u5f15\u7528\u3055\u308c\u3066\u3044\u308b\u3002 <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u524d\u306e\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u306f\u3001\u598a\u5a66\u306b\u7570\u5e38\u306e\u30ea\u30b9\u30af\u3092\u6b63\u78ba\u306b\u63a8\u5b9a\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u9ad8\u9f62\u5973\u6027\u306e\u5834\u5408\u3001\u533b\u5e2b\u306f\u60a3\u8005\u306e\u5e74\u9f62\u3067<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u767a\u751f\u7387\u3092\u4e88\u6e2c\u3057\u3001\u691c\u67fb\u524d\u306b\u60a3\u8005\u306e\u30a4\u30f3\u30d5\u30a9\u30fc\u30e0\u30c9\u30fb\u30b3\u30f3\u30bb\u30f3\u30c8\u3092\u5f97\u308b\u3002 <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306b\u3001\u907a\u4f1d\u7684\u7f8a\u6c34\u7a7f\u523a\u306f\u3001\u975e\u5e38\u306b\u6b63\u78ba\u304b\u3064\u5b89\u5168\u3067\u3042\u308a\u3001\u80ce\u5150\u55aa\u5931\u307e\u305f\u306f\u640d\u50b7\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u306a\u3044\u305f\u3081\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306e\u305f\u3081\u306e\u3044\u304f\u3064\u304b\u306e\u691c\u67fb\u6cd5\u306e1\u3064\u3068\u3057\u3066\u598a\u5a20\u4e2d\u671f\u306b\u4e00\u822c\u7684\u306b\u5b9f\u65bd\u3055\u308c\u308b(NICHD National Registry for Amniocentes Study Group, 1976)\u3002<\/p>\n\n\n\n<p>\u65e5\u672c\u3067\u306f\u300135\u6b73\u4ee5\u4e0a\u306e\u5973\u6027\u306e\u598a\u5a20\u6570\u3068\u5272\u5408\u304c20\u5e74\u9593\u3067\u5897\u52a0\u3057\u30011995\u5e74(\u6bcd\u5b50\u4fdd\u5065\u6a5f\u69cb1996\u5e74)\u306b\u306f\u5168\u51fa\u751f\u306e10%\u306b\u9054\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3068<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306e\u9700\u8981\u304c\u8457\u3057\u304f\u5897\u52a0\u3057\u3066\u3044\u308b\u3002 \u3057\u304b\u3057\u306a\u304c\u3089\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u63a8\u5b9a\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u63a1\u7528\u3055\u308c\u305f\u30c7\u30fc\u30bf\u306f\u3001\u4e3b\u306b\u30e8\u30fc\u30ed\u30c3\u30d1\u3001\u5317\u7c73\u304a\u3088\u3073\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u306a\u3069\u306e\u897f\u6b27\u8af8\u56fd\u304b\u3089\u5f97\u3089\u308c\u3066\u3044\u308b\u3002 \u751f\u7269\u5b66\u7684\u304a\u3088\u3073\u74b0\u5883\u7684\u5dee\u7570\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u767a\u751f\u7387\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u65e5\u672c\u4eba\u6bcd\u89aa\u304b\u3089\u5f97\u3089\u308c\u305f\u5165\u624b\u53ef\u80fd\u306a\u30c7\u30fc\u30bf\u3092\u96c6\u3081\u3066\u30011\u5e74\u9593\u306e\u6bcd\u89aa\u306e\u5e74\u9f62\u9593\u9694\u3067\u3059\u3079\u3066\u306e\u6709\u610f\u306a\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7570\u5e38\u306e\u767a\u751f\u7387\u3092\u63a8\u5b9a\u3059\u308b\u3053\u3068\u306f\u4fa1\u5024\u304c\u3042\u308b\u3068\u601d\u308f\u308c\u305f\u3002<\/p>\n\n\n\n<p>\u672c\u5831\u544a\u3067\u306f\u3001\u65e5\u672c\u306e4\u3064\u306e\u907a\u4f1d\u5b50\u30af\u30ea\u30cb\u30c3\u30af\u304b\u3089\u3001\u6bcd\u89aa\u306e\u5e74\u9f62\u304c\u9ad8\u3044\u305f\u3081\u306b\u306e\u307f\u598a\u5a20\u4e2d\u671f\u306b\u5b9f\u65bd\u3055\u308c\u305f\u691c\u67fb\u304b\u3089\u907a\u4f1d\u7684\u7f8a\u6c34\u7a7f\u523a\u30c7\u30fc\u30bf\u306e\u30d7\u30fc\u30eb\u3092\u5f97\u305f\u3002 \u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u3092\u7528\u3044\u3066\u6bcd\u89aa\u306e\u5e74\u9f62\u3068\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7570\u5e38\u306e\u767a\u751f\u7387\u3068\u306e\u95a2\u4fc2\u3092\u5206\u6790\u3057\u3001\u65e5\u672c\u4eba\u306b\u304a\u3051\u308b\u7f8a\u6c34\u7a7f\u523a\u6642\u306e\u6bcd\u89aa\u306e\u5e74\u9f62\u5225\u7570\u5e38\u767a\u751f\u7387\u3092\u63a8\u5b9a\u3057\u305f\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%9D%90%E6%96%99%E3%81%8A%E3%82%88%E3%81%B3%E6%96%B9%E6%B3%95\"><\/span>\u6750\u6599\u304a\u3088\u3073\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u598a\u5a20\u5f8c\u671f(14\uff5e18\u9031)\u306b\u7523\u79d1\u533b\u304c\u65e5\u5e38\u7684\u306b\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7f8a\u6c34\u7a7f\u523a\u3092\u884c\u3063\u305f4\u3064\u306e\u907a\u4f1d\u5b50\u30af\u30ea\u30cb\u30c3\u30af\u3001\u5317\u91cc\u5927\u5b66\u75c5\u9662\u3001\u798f\u5cf6\u770c\u7acb\u5927\u5b66\u75c5\u9662\u3001\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u75c5\u9662\u3001\u6771\u5317\u5927\u5b66\u75c5\u9662\u304b\u3089\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7f8a\u6c34\u7a7f\u523a\u306e\u65e5\u672c\u75c7\u4f8b\u306e\u30c7\u30fc\u30bf\u3092\u53ce\u96c6\u3057\u3001\u7d50\u679c\u3092\u7d71\u5408\u3057\u305f\u3002 \u598a\u5a20\u671f\u9593\u306f\u6700\u7d42\u6708\u7d4c\u671f\u9593\u304b\u3089\u63a8\u5b9a\u3057\u3001\u80ce\u5150\u306e\u8d85\u97f3\u6ce2\u6e2c\u5b9a\u306b\u3088\u308a\u88dc\u6b63\u3057\u305f\u3002 \u5bc4\u7a3f\u8005\u306b\u306f\u3001\u6bcd\u89aa\u306e\u5e74\u9f62\u306e\u307f\u3092\u7406\u7531\u306b\u691c\u67fb\u3057\u305f\u598a\u5a20\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u3001\u4ee5\u524d\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3001\u89aa\u306e\u67d3\u8272\u4f53\u8ee2\u5ea7\u306a\u3069\u3001\u67d3\u8272\u4f53\u306e\u5fb4\u5019\u304c\u8ffd\u52a0\u3055\u308c\u305f\u598a\u5a20\u3092\u9664\u5916\u3059\u308b\u3088\u3046\u4f9d\u983c\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u7f8a\u819c\u7d30\u80de\u306f\u300110%\u307e\u305f\u306f15%\u306e\u725b\u80ce\u5150\u8840\u6e05\u3092\u542b\u3080Ham F10\u307e\u305f\u306fChang\u2019s\u57f9\u5730\u3092\u7528\u3044\u30015%CO2\u4e0b\u300137\u2103\u30672\u9031\u9593\u4ee5\u4e0a\u57f9\u990a\u3057\u305f\u3002\u30b3\u30eb\u30bb\u30df\u30c9\u6dfb\u52a0\u5f8c\u3001\u3055\u3089\u306b5\u6642\u9593\u57f9\u990a\u3057\u3066\u7d30\u80de\u3092\u63a1\u53d6\u3057\u3001\u4f4e\u5f35\u6027KCl\u6eb6\u6db2\uff0875\u03bcmM\uff09\u3067\u51e6\u7406\u3057\u305f\u5f8c\u3001\u30e1\u30bf\u30ce\u30fc\u30eb\uff0f\u9162\u9178\u56fa\u5b9a\u6db2\uff083\uff1a1\uff09\u3067\u56fa\u5b9a\u3057\uff0c\u30b9\u30e9\u30a4\u30c9\u30b0\u30e9\u30b9\u306b\u4ed8\u7740\u3055\u305b\u305f\u3002<\/p>\n\n\n\n<p>\u30ac\u30e9\u30b9\u30b9\u30e9\u30a4\u30c9\u3092\u98a8\u4e7e\u307e\u305f\u306f\u6a5f\u68b0\u7684\u4e7e\u71e5\u3057\u305f\u5f8c\u3001\u6a19\u6e96\u7684\u65b9\u6cd5\u3092\u7528\u3044\u3066G\u30d0\u30f3\u30c7\u30a3\u30f3\u30b0\u3092\u884c\u3063\u305f\u3002\u672c\u660e\u7d30\u66f8\u3067\u7814\u7a76\u3055\u308c\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306b\u306f\u3001\u7570\u6570\u6027\u3001\u8ee2\u5ea7\u304a\u3088\u3073\u9006\u4f4d\u306e\u3088\u3046\u306a\u69cb\u9020\u7684\u7570\u5e38\u3001\u306a\u3089\u3073\u306b\u5e38\u67d3\u8272\u4f53\u4e0a\u3060\u3051\u3067\u306a\u304f\u6027\u67d3\u8272\u4f53\u4e0a\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u73fe\u8c61\u304c\u542b\u307e\u308c\u308b\u3002 \u3057\u304b\u3057\u3001\u67d3\u8272\u4f53\u69cb\u9020\u306e\u6b63\u5e38\u306a\u5909\u7570\u4f53\u3001\u4f8b\u3048\u30709\u756a\u67d3\u8272\u4f53\u306e\u30da\u30ea\u30bb\u30f3\u30c8\u30ea\u30c3\u30af\u9006\u4f4d\u3001\u7a2e\u3005\u306e\u67d3\u8272\u4f53\u4e0a\u306e\u62e1\u5927\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u3001\u62e1\u5927\u3057\u305f\u30b5\u30c6\u30e9\u30a4\u30c8\u306a\u3069\u306f\u9664\u53bb\u3055\u308c\u305f\u3002 <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u73fe\u8c61\u304c\u30a2\u30fc\u30c1\u30d5\u30a1\u30af\u30c8\u3067\u3042\u308b\u304b\u3069\u3046\u304b\u304c\u4e0d\u660e\u306a\u5834\u5408\u306f\u3001\u78ba\u5b9f\u306b\u7b2c2\u56de\u7f8a\u6c34\u7a7f\u523a\u307e\u305f\u306f\u80ce\u5150\u63a1\u8840\u3092\u884c\u3063\u305f\u3002\u7f8a\u6c34\u7a7f\u523a\u6642\u306e\u6bcd\u89aa\u306e\u5e74\u9f62\u3068<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u767a\u751f\u7387\u306e\u5bfe\u6570\u3068\u306e\u95a2\u4fc2\u3092\u5206\u6790\u3059\u308b\u305f\u3081\u306b\u3001\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u5206\u6790\u3092 <em>y<\/em> = exp(<em>a<\/em> + <em>bx<\/em>) \u5f0f\u3092\u7528\u3044\u3066\u884c\u3063\u305f\u3002\u3053\u3053\u3067\u3001<em>x<\/em>\u306f\u7f8a\u6c34\u7a7f\u523a\u6642\u306e\u6bcd\u89aa\u306e\u5e74\u9f62\u3067\u3042\u308a\u3001<em>y<\/em> \u306f <em>x<\/em>\u6b73\u3067\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7570\u5e38\u306e\u767a\u751f\u7387\u3067\u3042\u308b\u3002 \u30d1\u30e9\u30e1\u30fc\u30bf<em>a <\/em>\u304a\u3088\u3073 <em>b <\/em>\u306e\u5024\u306f\u3001\u6700\u5c24\u56de\u5e30\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u305f\u3002 \u6bcd\u4f53\u5e74\u9f62\u4fc2\u6570b\u304c\u6a19\u6e96\u8aa4\u5dee\u3092\u8003\u616e\u3057\u305f\u5834\u5408\u306e\u30bc\u30ed(<em>P<\/em> &lt; 0.05)\u3068\u6709\u610f\u5dee\u304c\u3042\u308b\u5834\u5408\u3001\u76f8\u95a2\u306f\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u3067\u3042\u308b\u3068\u8a55\u4fa1\u3055\u308c\u305f\u3002<em>y<\/em> = exp(a + <em>bx<\/em>) \u3092\u7528\u3044\u3066\u3001\u7f8a\u6c34\u7a7f\u523a\u6642\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u4e88\u60f3\u767a\u751f\u7387\u3092\u6bcd\u89aa\u306e1\u6b73\u9593\u9694\u3067\u7b97\u51fa\u3057\u305f\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%90%E6%9E%9C\"><\/span>\u7d50\u679c<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>\u88681<\/strong>\u306f\u300135\u6b73\u3092\u8d85\u3048\u308b\u6bcd\u4f53\u306e\u5e74\u9f62\u306b\u3088\u308a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3055\u308c\u305f\u598a\u5a20\u4e2d\u306e\u598a\u5a20\u7b2c2\u671f\u306e\u7f8a\u6c34\u7a7f\u523a5484\u4ef6\u306e\u8abf\u67fb\u306b\u304a\u3051\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3092\u793a\u3057\u3066\u3044\u308b\u3002 \u3053\u306e\u3046\u3061117\u4f8b\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3068\u8a3a\u65ad\u3055\u308c\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u7dcf\u767a\u751f\u7387\u306f2.1%(117\/5484)\u3067\u3042\u3063\u305f\u3002 \u975e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u5e38\u67d3\u8272\u4f53\u304a\u3088\u3073\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027\u306f\u3001\u305d\u308c\u305e\u308c62\u4f8b(21\u30c8\u30ea\u30bd\u30df\u30fc42\u4f8b\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>13\u4f8b\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>7\u4f8b)\u304a\u3088\u307315\u4f8b(XXY10\u4f8b\u3001XXX4\u4f8b\u3001\u304a\u3088\u3073XYY1\u4f8b)\u3067\u3042\u3063\u305f\u3002 X\u2010\u30e2\u30ce\u30bd\u30df\u30fc(\u30bf\u30fc\u30ca\u30fc\u75c7\u5019\u7fa4)\u306e\u75c7\u4f8b\u306f\u8a3a\u65ad\u3055\u308c\u306a\u304b\u3063\u305f<\/p>\n\n\n\n<section class=\"note_table\">\n<p><strong>\u88681<\/strong> \u6bcd\u89aa\u306e\u5e74\u9f62\u5225\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u6570\u3068\u767a\u751f\u7387<\/p>\n<div class=\"table-sp-scroll\">\n<figure>\n<table>\n<colgroup>\n    <col style=\"width:calc(100% \/ 11)\">\n    <col style=\"width:calc(100% \/ 11)\">\n    <col style=\"width:calc(100% \/ 11)\">\n    <col style=\"width:calc(100% \/ 11)\">\n    <col style=\"width:calc(100% \/ 11)\">\n    <col style=\"width:calc(100% \/ 11)\">\n    <col style=\"width:calc(100% \/ 11)\">\n    <col style=\"width:calc(100% \/ 11)\">\n    <col style=\"width:calc(100% \/ 11)\">\n    <col style=\"width:calc(100% \/ 11)\">\n    <col style=\"width:calc(100% \/ 11)\">\n<\/colgroup>\n<thead>\n<tr>\n<th rowspan=\"2\">\u7f8a\u6c34\u7a7f\u523a\u6642\u306e\u6bcd\u89aa\u306e\u5e74\u9f62<\/th><th rowspan=\"2\">\u80ce\u5150\u6570<\/th><th colspan=\"7\">\u7570\u6570\u6027(<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u73fe\u8c61\u3092\u9664\u304f)<\/th><th rowspan=\"2\">\u305d\u306e\u4ed6<\/th><th rowspan=\"2\">\u5408\u8a08<\/th>\n<\/tr>\n<tr>\n<th>47, +21<\/th><th>47, +18<\/th><th>47, +13<\/th><th>XXY<\/th><th>XXX<\/th><th>XYY<\/th><th>\u5168\u7570\u6570\u6027<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>35<\/td><td>736<\/td><td>1(1.36)<sup>a<\/sup><\/td><td colspan=\"5\"><\/td><td>1(1.36)<\/td><td>1(1.36)<\/td><td>2(2.72)<\/td>\n<\/tr>\n<tr>\n<td>36<\/td><td>850<\/td><td>4(4.71)<\/td><td>2(2.35)<\/td><td><\/td><td>2(2.35)<\/td><td colspan=\"2\"><\/td><td>8(9,41)<\/td><td>4(4.71)<\/td><td>12(14.12)<\/td>\n<\/tr>\n<tr>\n<td>37<\/td><td>824<\/td><td>8(9.71)<\/td><td colspan=\"5\"><\/td><td>8(9.71)<\/td><td>4(4.85)<\/td><td>12(14.56)<\/td>\n<\/tr>\n<tr>\n<td>38<\/td><td>800<\/td><td>2(2.50)<\/td><td><\/td><td>2(2.50)<\/td><td><\/td><td>2(2.50)<\/td><td><\/td><td>6(7.50)<\/td><td>7(8.75)<\/td><td>13(16.25)<\/td>\n<\/tr>\n<tr>\n<td>39<\/td><td>713<\/td><td>8(11.22)<\/td><td><\/td><td>2(2.81)<\/td><td>1(1.40)<\/td><td><\/td><td>1(1.40)<\/td><td>12(19.17)<\/td><td>8(11.22)<\/td><td>20(28.05)<\/td>\n<\/tr>\n<tr>\n<td>40<\/td><td>626<\/td><td>6(9.58)<\/td><td>5(7.99)<\/td><td>1(1.60)<\/td><td>1(1.60)<\/td><td colspan=\"2\"><\/td><td>13(20.77)<\/td><td>10(15.97)<\/td><td>23(36.74)<\/td>\n<\/tr>\n<tr>\n<td>41<\/td><td>417<\/td><td>3(7.19)<\/td><td>3(7.19)<\/td><td>2(4.80)<\/td><td>2(4.80)<\/td><td colspan=\"2\"><\/td><td>10(23.98)<\/td><td>1(2.40)<\/td><td>11(26.38)<\/td>\n<\/tr>\n<tr>\n<td>42<\/td><td>255<\/td><td>6(23.53)<\/td><td>1(3.92)<\/td><td><\/td><td>3(11.76)<\/td><td>1(3.92)<\/td><td><\/td><td>11(43.14)<\/td><td>2(7.84)<\/td><td>13(50.98)<\/td>\n<\/tr>\n<tr>\n<td>43<\/td><td>146<\/td><td>2(13.70)<\/td><td>1(6.85)<\/td><td><\/td><td>1(6.85)<\/td><td>1(6.85)<\/td><td><\/td><td>5(34.23)<\/td><td>2(13.70)<\/td><td>7(47.95)<\/td>\n<\/tr>\n<tr>\n<td>44<\/td><td>87<\/td><td>2(22.99)<\/td><td colspan=\"5\"><\/td><td>2(22.99)<\/td><td>1(11.49)<\/td><td>3(34.48)<\/td>\n<\/tr>\n<tr>\n<td>45<\/td><td>22<\/td><td><\/td><td>1(45.45)<\/td><td colspan=\"4\"><\/td><td>1(45.45)<\/td><td><\/td><td>1(45.45)<\/td>\n<\/tr>\n<tr>\n<td>46<\/td><td>7<\/td><td colspan=\"9\"><\/td>\n<\/tr>\n<tr>\n<td>47<\/td><td>1<\/td><td colspan=\"9\"><\/td>\n<\/tr>\n<tr>\n<td>\u5408\u8a08<\/td><td>5484<\/td><td>42(7.66)<\/td><td>13(2.37)<\/td><td>7(1.28)<\/td><td>10(2.82)<\/td><td>4(0.73)<\/td><td>1(0.18)<\/td><td>77(14.04)<\/td><td>40(7.29)<\/td><td>117(21.33)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<\/div>\n<\/section>\n<p><sup>a<\/sup>\u6570\u5b57(\u304a\u3088\u30731000\u3042\u305f\u308a\u306e\u767a\u751f\u7387)\u3002<\/p>\n\n\n\n<p>21\u30c8\u30ea\u30bd\u30df\u30fc\u306b\u3064\u3044\u3066\u306f\u3001\u6a19\u6e96\u8aa4\u5dee(SE = 0.063)\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u6bcd\u4f53\u5e74\u9f62\u4fc2\u6570<em>b<\/em>\u306f\u6b63\u3067\u3042\u308a(<em>b<\/em> = 0.245)\u3001\u30bc\u30ed(95%\u4fe1\u983c\u533a\u9593(CI): 0.100-0.389\u3001<em>P<\/em> = 0.0045)\u3068\u306f\u6709\u610f\u306b\u7570\u306a\u308a\u300121\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u767a\u751f\u7387\u306f\u6bcd\u4f53\u5e74\u9f62\u306e\u5897\u52a0\u306b\u4f34\u3063\u3066\u6307\u6570\u95a2\u6570\u7684\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f(<strong>\u56f31<\/strong>\u3001<strong>\u88682<\/strong>)\u3002<\/p>\n\n\n\n<section class=\"note_table\">\n<p><strong>\u88682<\/strong> \u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u8a08\u7b97\u306e\u4fc2\u6570\u3068\u6a19\u6e96\u8aa4\u5dee*<\/p>\n<div class=\"table-sp-scroll\">\n<figure>\n<table>\n<colgroup>\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n<\/colgroup>\n<thead>\n<tr>\n<th><\/th><th colspan=\"2\">\u5b9a\u6570\u9805<\/th><th colspan=\"4\">\u6bcd\u8a9e<\/th>\n<\/tr>\n<tr>\n<th><\/th><th>a<\/th><th>SE<\/th><th>b<\/th><th>SE<\/th><th>95%\u4fe1\u983c\u533a\u9593<\/th><th>P\u5024<\/th>\n<\/tr>\n<tr>\n<td>21\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>-7.605<\/td><td>2.485<\/td><td>0.245<\/td><td>0.063<\/td><td>0.100-0.389<\/td><td>0.0045<\/td>\n<\/tr>\n<tr>\n<td>+18, +13<\/td><td>-9.661<\/td><td>3.464<\/td><td>0.284<\/td><td>0.085<\/td><td>0.075-0.493<\/td><td>0.0159<\/td>\n<\/tr>\n<tr>\n<td>\u6027\u67d3\u8272\u4f53<\/td><td>-10.087<\/td><td>4.196<\/td><td>0.290<\/td><td>0.105<\/td><td>0.020-0.560<\/td><td>0.0400<\/td>\n<\/tr>\n<tr>\n<td>\u3059\u3079\u3066\u306e\u7570\u6570\u6027**<\/td><td>-7.719<\/td><td>2.085<\/td><td>0.261<\/td><td>0.052<\/td><td>0.144-0.379<\/td><td>0.0007<\/td>\n<\/tr>\n\n<\/thead><\/table>\n<\/figure>\n<\/div>\n<\/section>\n<p>95%CI: 95%\u4fe1\u983c\u533a\u9593<br>\n* \u30e2\u30c7\u30eby = exp(a + bx) \u3053\u3053\u3067\u3001x = \u7f8a\u6c34\u7a7f\u523a\u6642\u306e\u5e74\u9f62\u3067\u306e\u6bcd\u89aa\u306e\u5e74\u9f62\u3001y = <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u767a\u751f\u7387\u3002<br>\n** <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u3068\u69cb\u9020\u7570\u5e38\u3092\u9664\u304f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u306b\u3064\u3044\u3066\u306f\u3001\u305d\u308c\u305e\u308c\u306e\u30c8\u30ea\u30bd\u30df\u30fc\u306b\u3064\u3044\u3066\u9ad8\u9f62\u306e\u6bcd\u89aa\u306b\u304a\u3051\u308b\u767a\u751f\u7387\u306e\u5897\u52a0\u304c\u89b3\u5bdf\u3055\u308c\u300121\u30c8\u30ea\u30bd\u30df\u30fc\u3068\u540c\u69d8\u3067\u3042\u3063\u305f\u304c\u3001\u305d\u306e\u95a2\u4fc2\u306f\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u3067\u306f\u306a\u304b\u3063\u305f\u3002 \u3053\u308c\u30892\u3064\u306e\u7570\u6570\u6027\u3092\u81f4\u6b7b\u7684\u306a\u5e38\u67d3\u8272\u4f53\u7570\u6570\u6027\u3068\u3057\u3066\u4e00\u7dd2\u306b\u8a08\u7b97\u3057\u305f\u5834\u5408\u3001\u767a\u751f\u7387\u306f\u6bcd\u89aa\u306e\u5e74\u9f62\u306e\u9032\u884c\u3068\u3068\u3082\u306b\u5897\u52a0\u3057\u305f(<em>b<\/em> = 0.284\u3001SE = 0.085\u300195% CI: 0.075-0.493\u3001<em>P<\/em> = 0.0159)(<strong>\u56f32<\/strong>\u3001<strong>\u88682<\/strong>)\u3002<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p><strong>\u56f31<\/strong> 21\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u5272\u5408\uff08\u80ce\u51501000\u4eba\u3042\u305f\u308a\uff09\uff08\u7e26\u8ef8\uff09\u3068\u6bcd\u89aa\u306e\u5e74\u9f62\uff08\u6a2a\u8ef8\uff09<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"934\" src=\"\/nipt\/wp-content\/uploads\/2021\/10\/ma_tri21-1024x934.png\" alt=\"\" class=\"wp-image-18714\"\/><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p><strong>\u56f32<\/strong> \u81f4\u6b7b\u6027\u5e38\u67d3\u8272\u4f53\u7570\u6570\u4f53\uff08\u30c8\u30ea\u30bd\u30df\u30fc18\u304a\u3088\u3073\u30c8\u30ea\u30bd\u30df\u30fc13\uff09\u306e\u5272\u5408\uff08\u80ce\u51501000\u4eba\u3042\u305f\u308a\uff09\uff08\u7e26\u8ef8\uff09\u3068\u6bcd\u89aa\u306e\u5e74\u9f62\uff08\u6a2a\u8ef8\uff09<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"936\" src=\"\/nipt\/wp-content\/uploads\/2021\/10\/ma_1813-1024x936.png\" alt=\"\" class=\"wp-image-18716\"\/><\/figure>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<p>\u305d\u308c\u305e\u308c\u306e\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027\u306b\u3064\u3044\u3066\u300121\u30c8\u30ea\u30bd\u30df\u30fc\u3068\u540c\u69d8\u306b\u3001\u9ad8\u9f62\u306e\u6bcd\u89aa\u306b\u304a\u3051\u308b\u767a\u751f\u7387\u306e\u5897\u52a0\u50be\u5411\u304c\u8a8d\u3081\u3089\u308c\u305f\u304c\u3001\u76f8\u95a2\u306f\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u3067\u306f\u306a\u304b\u3063\u305f\u3002 3\u7a2e\u985e\u306e\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027\u3092\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027\u3068\u3057\u3066\u4e00\u7dd2\u306b\u8a08\u7b97\u3057\u305f\u5834\u5408\u3001\u767a\u751f\u7387\u306f\u6bcd\u89aa\u306e\u5e74\u9f62\u306e\u9032\u884c\u306b\u4f34\u3063\u3066\u6709\u610f\u306b\u5897\u52a0\u3057\u305f (<em>b<\/em> = 0.290,SE = 0.105, 95% CI: 0.020\uff5e0.560, <em>P<\/em> = 0.040) (<strong>\u56f33<\/strong>\u3001<strong>\u88682<\/strong>)\u3002 \u3059\u3079\u3066\u306e\u7570\u6570\u6027\u306b\u3064\u3044\u3066\u3001\u6bcd\u89aa\u306e\u5e74\u9f62\u4fc2\u6570<em>b<\/em>\u3082\u6b63\u3067\u3042\u308a (<em>b<\/em> = 0.261)\u3001\u6a19\u6e96\u8aa4\u5dee(SE = 0.052)\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u30bc\u30ed (95% CI: 0.144-0.379\u3001<em>P<\/em> = 0.0007) \u3068\u6709\u610f\u306b\u7570\u306a\u3063\u3066\u3044\u305f(<strong>\u56f34<\/strong>\u3001<strong>\u88682<\/strong>)\u3002 \u5217\u6319\u3057\u305f6\u7a2e\u985e\u4ee5\u5916\u306e\u975e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u30c8\u30ea\u30bd\u30df\u30fc\u306f\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p><strong>\u56f33<\/strong> \u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\uff08XXY\u3001XXX\u3001XYY\uff09\u306e\u5272\u5408\uff08\u80ce\u51501000\u4eba\u3042\u305f\u308a\uff09\uff08\u7e26\u8ef8\uff09\u3068\u6bcd\u89aa\u306e\u5e74\u9f62\uff08\u6a2a\u8ef8\uff09<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"928\" src=\"\/nipt\/wp-content\/uploads\/2021\/10\/ma_sex_mono-1024x928.png\" alt=\"\" class=\"wp-image-18718\"\/><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p><strong>\u56f34<\/strong> <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u3084\u69cb\u9020\u7570\u5e38\u3092\u9664\u304f\u3059\u3079\u3066\u306e\u7570\u6570\u6027\u4f53\u306e\u5272\u5408\uff08\u7e26\u8ef8\uff09\u3068\u6bcd\u4f53\u5e74\u9f62\uff08\u6a2a\u8ef8\uff09<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"929\" src=\"\/nipt\/wp-content\/uploads\/2021\/10\/ma_all_aneuploidies-1024x929.png\" alt=\"\" class=\"wp-image-18720\"\/><\/figure>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<section class=\"note_table\">\n<p><strong>\u88683<\/strong> \u56de\u5e30\u5e73\u6ed1\u5316\u3055\u308c\u305f\u7570\u5e38\u767a\u73fe\u7387\/\u7f8a\u6c34\u7a7f\u523a\u6642\u306e1000(\u6bcd\u89aa\u306e\u5e74\u9f62\u5225)<\/p>\n<div class=\"table-sp-scroll\">\n<figure>\n<table>\n<colgroup>\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n    <col style=\"width:calc(100% \/ 7)\">\n<\/colgroup>\n<thead>\n<tr>\n<th rowspan=\"2\">\u7f8a\u6c34\u7a7f\u523a\u6642\u306e\u6bcd\u89aa\u306e\u5e74\u9f62<\/th><th colspan=\"4\">\u56de\u5e30\u5e73\u6ed1\u5316\u671f\u5f85\u767a\u751f\u7387(1000\u4eba\u3042\u305f\u308a)<\/th>\n<\/tr>\n<tr>\n<th>21\u30c8\u30ea\u30bd\u30df\u30fc<\/th><th>+18, +13<\/th><th>\u6027\u67d3\u8272\u4f53<\/th><th>\u5168\u7570\u6570\u6027\n<\/th><\/tr>\n<tr>\n<td>35<\/td><td>2.62<\/td><td>1.32<\/td><td>1.07<\/td><td>4.12<\/td>\n<\/tr>\n<tr>\n<td>36<\/td><td>3.37<\/td><td>1.76<\/td><td>1.42<\/td><td>5.35<\/td>\n<\/tr>\n<tr>\n<td>37<\/td><td>4.31<\/td><td>2.33<\/td><td>1.90<\/td><td>6.94<\/td>\n<\/tr>\n<tr>\n<td>38<\/td><td>5.50<\/td><td>3.10<\/td><td>2.54<\/td><td>9.02<\/td>\n<\/tr>\n<tr>\n<td>39<\/td><td>7.03<\/td><td>4.12<\/td><td>3.40<\/td><td>11.70<\/td>\n<\/tr>\n<tr>\n<td>40<\/td><td>8.98<\/td><td>5.47<\/td><td>4.54<\/td><td>15.20<\/td>\n<\/tr>\n<tr>\n<td>41<\/td><td>11.47<\/td><td>7.26<\/td><td>6.07<\/td><td>19.73<\/td>\n<\/tr>\n<tr>\n<td>42<\/td><td>14.66<\/td><td>9.65<\/td><td>8.11<\/td><td>25.61<\/td>\n<\/tr>\n<tr>\n<td>43<\/td><td>18.73<\/td><td>12.82<\/td><td>10.84<\/td><td>33.25<\/td>\n<\/tr>\n<tr>\n<td>44<\/td><td>23.93<\/td><td>17.03<\/td><td>14.48<\/td><td>43.16<\/td>\n<\/tr>\n<tr>\n<td>45<\/td><td>30.57<\/td><td>22.62<\/td><td>19.36<\/td><td>56.04<\/td>\n<\/tr>\n\n<\/thead><\/table>\n<\/figure>\n<\/div>\n<\/section>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u56de\u5e30\u5206\u6790\u306b\u57fa\u3065\u3044\u3066\u3001\u65e5\u672c\u4eba\u306b\u304a\u3051\u308b\u598a\u5a20\u4e2d\u671f\u306e\u7f8a\u6c34\u7a7f\u523a\u306b\u304a\u3051\u308b21\u30c8\u30ea\u30bd\u30df\u30fc\u3001\u81f4\u6b7b\u7684\u5e38\u67d3\u8272\u4f53\u7570\u6570\u6027(<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>)\u3001\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027(47,XXY; 47,XXX; 47,XXYY)\u3001\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u304a\u3088\u3073\u69cb\u9020\u7684\u7570\u5e38\u3092\u9664\u304f\u3059\u3079\u3066\u306e\u7570\u6570\u6027\u306e\u4e88\u60f3\u767a\u751f\u7387\u3092\u8a08\u7b97\u3057\u305f(<strong>\u88683<\/strong>)\u3002 \u3053\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u4fc2\u6570\u3068\u4ed6\u306e\u56fd\u306e\u4ee5\u524d\u306e\u7814\u7a76(Polani\u3089)\u304b\u3089\u5f97\u3089\u308c\u305f\u4fc2\u6570\u3068\u306e\u9593\u306b\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\u3002 1976\u5e74; Schreinemachers\u3089 1982; Ferguson-Smith and Yates 1984; Hook\u3089 \u5171\u5206\u6563\u5206\u6790(1984);\u4f8b\u3048\u3070\u3001\u5317\u7c73\u306e\u7814\u7a76(Hook\u3089)\u304b\u3089\u5f97\u3089\u308c\u305f21\u30c8\u30ea\u30bd\u30df\u30fc <em>y<\/em> = exp(-14.7 + 0.262<em>x<\/em>)\u306e\u65b9\u7a0b\u5f0f\u3002 1984).<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u305d\u306e\u4ed6\u306e\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u8a3a\u65ad\u306f\u3059\u3079\u3066<strong>\u88684<\/strong>\u306b\u793a\u3057\u305f\u3002\u69cb\u9020\u7570\u5e38\u306e\u7dcf\u6570\u306f27\u500b\uff08\u4e0d\u5747\u8861\u306a\u30ed\u30d0\u30fc\u30c8\u30bd\u30f3\u8ee2\u5ea71\u500b\uff0c\u5747\u8861\u306a\u76f8\u4e92\u8ee2\u5ea710\u500b\uff0c\u5747\u8861\u306a\u30ed\u30d0\u30fc\u30c8\u30bd\u30f3\u8ee2\u5ea74\u500b\uff0c\u9006\u4f4d12\u500b\uff09\u3067\u3042\u3063\u305f\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u72b6\u5e38\u67d3\u8272\u4f53\u7570\u6570\u4f53\u306f11\u4f8b\u3001\u6027\u67d3\u8272\u4f53\u7570\u6570\u4f53\u306f2\u4f8b\u3067\u3042\u3063\u305f\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u5e38\u67d3\u8272\u4f53\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u75c7\u4f8b\u3067\u306f\uff0c21\uff0c18\uff0c13\u756a\u4ee5\u5916\u306e\u67d3\u8272\u4f53\u306e\u7570\u6570\u6027\u304c\u8a3a\u65ad\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<section class=\"note_table\">\n<p><strong>\u88684<\/strong> \u6bcd\u89aa\u306e\u5e74\u9f62\u5225\u306e\u305d\u306e\u4ed6\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a><\/p>\n<div class=\"table-sp-scroll\">\n<figure>\n<table>\n<colgroup>\n    <col style=\"width:calc(100% \/ 8)\">\n    <col style=\"width:calc(100% \/ 8)\">\n    <col style=\"width:calc(100% \/ 8)\">\n    <col style=\"width:calc(100% \/ 8)\">\n    <col style=\"width:calc(100% \/ 8)\">\n    <col style=\"width:calc(100% \/ 8)\">\n    <col style=\"width:calc(100% \/ 8)\">\n    <col style=\"width:calc(100% \/ 8)\">\n<\/colgroup>\n<thead>\n<tr>\n<th rowspan=\"3\">\u7f8a\u6c34\u7a7f\u523a\u6642\u306e\u6bcd\u89aa\u306e\u5e74\u9f62<\/th><th colspan=\"3\">\u8ee2\u5ea7<\/th><th rowspan=\"3\">\u53cd\u8ee2<\/th><th colspan=\"2\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u4e3b\u7fa9<\/th><th rowspan=\"3\">\u5408\u8a08<\/th>\n<\/tr>\n<tr>\n<th>\u30a2\u30f3\u30d0\u30e9\u30f3\u30b9<\/th><th colspan=\"2\">\u30d0\u30e9\u30f3\u30b9<\/th><th rowspan=\"2\">\u5e38\u67d3\u8272\u4f53<\/th><th rowspan=\"2\">45\u3001X\/46\u3001XY<\/th>\n<\/tr>\n<tr>\n<th>\u30ed\u30d0\u30fc\u30c8\u30bd\u30f3\u578b<\/th><th>\u76f8\u4e92<\/th><th>\u30ed\u30d0\u30fc\u30c8\u30bd\u30f3\u578b<\/th>\n<\/tr>\n<tr>\n<td>35<\/td><td><\/td><td>1(1.36)<sup>a<\/sup><\/td><td colspan=\"4\"><\/td><td>1(1.36)<\/td>\n<\/tr>\n<tr>\n<td>36<\/td><td><\/td><td>1(1.18)<\/td><td>1(1.18)<\/td><td>1(1.18)<\/td><td>1(1.18)<\/td><td><\/td><td>4(4.71)<\/td>\n<\/tr>\n<tr>\n<td>37<\/td><td><\/td><td>3(3.64)<\/td><td><\/td><td>1(1.21)<\/td><td colspan=\"2\"><\/td><td>4(4.85)<\/td>\n<\/tr>\n<tr>\n<td>38<\/td><td>1(1.25)<\/td><td>2(2.50)<\/td><td><\/td><td>2(2.50)<\/td><td>1(1.25)<\/td><td>1(1.25)<\/td><td>7(8.75)<\/td>\n<\/tr>\n<tr>\n<td>39<\/td><td><\/td><td>1(1.40)<\/td><td><\/td><td>5(7.01)<\/td><td>2(2.81)<\/td><td><\/td><td>8(11.22)<\/td>\n<\/tr>\n<tr>\n<td>40<\/td><td><\/td><td>2(3.19)<\/td><td>2(3.19)<\/td><td>1(1.60)<\/td><td>4(6.39)<\/td><td>1(1.60)<\/td><td>10(15.97)<\/td>\n<\/tr>\n<tr>\n<td>41<\/td><td colspan=\"4\"><\/td><td>1(2.40)<\/td><td><\/td><td>1(2.40)<\/td>\n<\/tr>\n<tr>\n<td>42<\/td><td colspan=\"2\"><\/td><td>1(3.92)<\/td><td><\/td><td>1(3.92)<\/td><td><\/td><td>2(7.84)<\/td>\n<\/tr>\n<tr>\n<td>43<\/td><td colspan=\"3\"><\/td><td>1(6.85)<\/td><td>1(6.85)<\/td><td><\/td><td>2(13.70)<\/td>\n<\/tr>\n<tr>\n<td>44<\/td><td colspan=\"4\"><\/td><td>1(11.49)<\/td><td><\/td><td>1(11.49)<\/td>\n<\/tr>\n<tr>\n<td>\u5408\u8a08<\/td><td>1(0.18)<\/td><td>10(1.82)<\/td><td>4(0.73)<\/td><td>12(2.19)<\/td><td>11(2.01)<\/td><td>2(0.36)<\/td><td>40(7.29)<\/td>\n<\/tr>\n\n<\/thead><\/table>\n<\/figure>\n<\/div>\n<\/section>\n<p><sup>a<\/sup>\u6570\u5b57(\u304a\u3088\u30731000\u3042\u305f\u308a\u306e\u767a\u751f\u7387)\u3002<\/p>\n\n\n\n<p>\u8ee2\u5ea7\u3001\u9006\u4f4d\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u3092\u542b\u3080\u305d\u306e\u4ed6\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306b\u3064\u3044\u3066\u306f\u3001\u6bcd\u89aa\u306e\u5e74\u9f62\u3068\u767a\u751f\u7387\u306b\u6709\u610f\u306a\u95a2\u4fc2\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%80%83%E5%AF%9F\"><\/span>\u8003\u5bdf<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u65e5\u672c\u306b\u304a\u3051\u308b\u6bcd\u4f53\u5e74\u9f62\u5225\u306e\u7f8a\u6c34\u7a7f\u523a\u6642\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u767a\u751f\u7387\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306f\u3001\u6b27\u7c73\u4ee5\u5916\u306e\u56fd\u30fb\u5730\u57df\u3067\u767a\u8868\u3055\u308c\u305f\u521d\u3081\u3066\u306e\u30c7\u30fc\u30bf\u3067\u3059\u3002\u56de\u5e30\u5206\u6790\u306e\u7d50\u679c\u3001\u3053\u308c\u307e\u3067\u306e\u5831\u544a\uff08Polani\u30891976\u5e74\u3001Schreinemachers\u30891982\u5e74\u3001Ferguson-Smith and Yates 1984\u5e74\u3001Hook\u30891984\u5e74\u3001Hassold\u30891996\u5e74\uff09\u3068\u540c\u69d8\u306b\u3001\u30c8\u30ea\u30bd\u30df\u30fc21\u3001\u81f4\u6b7b\u6027\u5e38<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3001\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u767a\u751f\u7387\u304c\u6bcd\u4f53\u5e74\u9f62\u306e\u4e0a\u6607\u3068\u3068\u3082\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u660e\u78ba\u306b\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5404<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u4e88\u60f3\u767a\u751f\u7387\u306e\u5f0f\u3082\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001\u65e5\u672c\u4eba\u5973\u6027\u306e\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306b\u5f79\u7acb\u3064\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>\u5f0f [<em>y<\/em> = exp(a + <em>bx<\/em>)] (<strong>\u88682<\/strong>)\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u3092\u8a08\u7b97\u3057\u300121\u30c8\u30ea\u30bd\u30df\u30fc\u3001\u81f4\u6b7b\u6027\u5e38\u67d3\u8272\u4f53\u30c8\u30ea\u30bd\u30df\u30fc(<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>)\u3001\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027\u3001\u304a\u3088\u307335\u6b73\u4ee5\u4e0a\u306e\u5404\u6bcd\u4f53\u5e74\u9f62\u306b\u304a\u3051\u308b\u3059\u3079\u3066\u306e\u7570\u6570\u6027\u306e\u65b9\u7a0b\u5f0f\u304b\u3089\u5c0e\u51fa\u3055\u308c\u305f\u5e73\u6ed1\u5316\u3055\u308c\u305f\u671f\u5f85\u7387\u3092\u8a08\u7b97\u3057\u305f(<strong>\u88683<\/strong>)\u3002 \u672c\u7814\u7a76\u304b\u3089\u5f97\u3089\u308c\u305f21\u30c8\u30ea\u30bd\u30df\u30fc [<em>y<\/em> = exp(-7.6 + 0.245<em>x<\/em>)] \u3068\u3001\u30e8\u30fc\u30ed\u30c3\u30d1\u304a\u3088\u3073\u5317\u7c73\u306e\u7814\u7a76\u304b\u3089\u5f97\u3089\u308c\u305f [<em>y<\/em> = exp(-14.7 + 0.262<em>x<\/em>)] \u306e\u5f0f\u3092\u6bd4\u8f03\u3059\u308b(Hook\u3089)\u3002 1984\u5e74\u3001\u30d1\u30e9\u30e1\u30fc\u30bf\u306b\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u300121\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u6709\u75c5\u7387\u306f\u4eba\u7a2e\u307e\u305f\u306f\u5730\u7406\u7684\u8981\u56e0\u306e\u3044\u305a\u308c\u306b\u3082\u5f71\u97ff\u3055\u308c\u306a\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u3002 \u6700\u8fd1\u306e\u7814\u7a76\u306f\u3001\u6e1b\u6570\u5206\u88c2\u2010I\u3060\u3051\u3067\u306a\u304f\u6e1b\u6570\u5206\u88c2\u2010II\u306b\u8d77\u56e0\u3059\u308b\u7570\u6570\u6027\u304c\u6bcd\u89aa\u306e\u5e74\u9f62\u3068\u76f8\u95a2\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f(Plachot\u3089)\u3002 1988\u5e74; Macas\u3089 1990\u5e74\u3001Dailey\u3089 1996; Hassold\u3089 1996). \u3053\u308c\u3089\u306e\u4e8b\u5b9f\u306b\u57fa\u3065\u3044\u3066\u3001\u4e0d\u5206\u96e2\u306f\u52a0\u9f62\u306b\u3088\u3063\u3066\u306e\u307f\u8a98\u767a\u3055\u308c\u308b\u56e0\u5b50\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u30d2\u30c8\u306e\u7e41\u6b96\u306b\u304a\u3044\u3066\u666e\u904d\u7684\u306a\u73fe\u8c61\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u7f8a\u6c34\u7a7f\u523a\u306b\u3088\u3063\u3066\u51fa\u751f\u524d\u306b\u8a3a\u65ad\u3055\u308c\u305f\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7570\u5e38\u306f\u3001\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u306b\u6b63\u5e38\u306a\u80ce\u5150\u3088\u308a\u3082\u81ea\u7136<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u304a\u3088\u3073\/\u307e\u305f\u306f\u6b7b\u7523\u306e\u5272\u5408\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3059\u305f\u3081(Hook 1983; Hook\u3089)\u3002 1988, 1989; Halliday\u3089 1995\u5e74; Macintosh\u3089 1995\u5e74\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306e\u767a\u751f\u7387\u306f\u51fa\u751f\u6642\u306e\u767a\u751f\u7387\u3068\u306f\u8457\u3057\u304f\u7570\u306a\u308b\u3002 \u51fa\u751f\u6642\u306b\u8a3a\u65ad\u3055\u308c\u305f\u975e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u7570\u6570\u6027\u306b\u95a2\u3059\u308b\u3053\u308c\u307e\u3067\u306e\u5831\u544a\u3068\u6bd4\u8f03\u3057\u3066(Hook\u3089)\u3002 1984\u5e74; Mutton\u3089 1991\u5e74\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u7570\u5e38\u6838\u578b\u304a\u3088\u3073\u305d\u306e\u9806\u5e8f\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u4f8b\u5916\u3092\u9664\u3044\u3066\u307b\u307c\u540c\u3058\u3067\u3042\u3063\u305f\u304c\u3001\u5404\u975e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u7570\u6570\u6027\u306e\u767a\u751f\u7387\u306f\u8457\u3057\u304f\u9ad8\u304f\u3001\u4f8b\u3048\u3070\u3001\u65e5\u672c\u306b\u304a\u3051\u308b21\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u767a\u751f\u7387\u306f1.42\/1000\u51fa\u751f\u3067\u3042\u3063\u305f(\u524d\u7530\u3089)\u3002 1991). \u3053\u308c\u3089\u306e\u9ad8\u3044\u767a\u751f\u7387\u306f\u3001\u598a\u5a20\u4e2d\u671f\u307e\u305f\u306f\u5f8c\u671f\u306b\u8d77\u3053\u308b\u9078\u629e\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u3001\u7570\u6570\u6027\u3092\u6709\u3059\u308b\u80ce\u5150\u306f\u6b7b\u7523\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u3002 \u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u969b\u306b\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u30c7\u30fc\u30bf\u304b\u3089\u5f97\u3089\u308c\u305f\u63a8\u5b9a\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u8a71\u3057\u5408\u3044\u3001\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u81ea\u7136\u6b7b\u4ea1\u3078\u306e\u5bc4\u4e0e\u306e\u63a8\u5b9a\u5024\u3092\u63d0\u4f9b\u3059\u3079\u304d\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u598a\u5a20\u4e2d\u671f\u306e\u7f8a\u6c34\u7a7f\u523a\u3067\u8a3a\u65ad\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u975e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u7570\u6570\u6027\u4f53\u3067\u306f\u3001\u308f\u305a\u304b6\u7a2e\u985e\u306e\u30c8\u30ea\u30bd\u30df\u30fc\u3057\u304b\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3002 X\u30e2\u30ce\u30bd\u30df\u30fc\u304a\u3088\u307316\u30c8\u30ea\u30bd\u30df\u30fc\u306f\u7d68\u6bdb\u30b5\u30f3\u30d7\u30ea\u30f3\u30b0(CVS)\u306b\u304a\u3044\u3066\u7570\u6570\u6027\u3068\u3057\u3066\u691c\u51fa\u3055\u308c\u305f\u304c(Hook\u3089)\u3001 1988\u5e74\u3001\u307e\u305f\u306f\u7f8a\u6c34\u7a7f\u523a\u306e\u521d\u671f(Lockwood and Neu 1993)\u3067\u306f\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u3053\u306e\u3088\u3046\u306a\u7570\u6570\u6027\u306f\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3002 \u7d30\u80de\u907a\u4f1d\u5b66\u7684CVS\u304a\u3088\u3073\u65e9\u671f\u7f8a\u6c34\u7a7f\u523a\u306f\u901a\u5e38\u598a\u5a20\u7b2c1\u30c8\u30e9\u30a4\u30e1\u30b9\u30bf\u30fc\u306b\u5b9f\u65bd\u3055\u308c\u308b\u305f\u3081(\u598a\u5a20\u7b2c9~\u7b2c11\u9031\u306eCVS;\u598a\u5a20\u7b2c11~\u7b2c14\u9031\u306e\u65e9\u671f\u7f8a\u6c34\u7a7f\u523a)\u3001\u7570\u6570\u6027\u3092\u6709\u3059\u308b\u307b\u3068\u3093\u3069\u306e\u80ce\u5150\u306f\u3001\u598a\u5a20\u7b2c2\u30c8\u30e9\u30a4\u30e1\u30b9\u30bf\u30fc\u306e\u7f8a\u6c34\u7a7f\u523a\u524d\u306b\u81ea\u7136<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3057\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 \u8ffd\u52a0\u306e\u75c7\u4f8b\u3092\u691c\u8a0e\u3059\u308b\u3068\u3001\u3053\u306e\u3088\u3046\u306a\u7570\u6570\u6027\u306f\u4f8b\u5916\u7684\u306a\u75c7\u4f8b\u3068\u3057\u3066\u598a\u5a20\u4e2d\u671f\u306e\u7f8a\u6c34\u7a7f\u523a\u3067\u691c\u51fa\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<p>35\u6b73\u4ee5\u4e0a\u306e\u598a\u7523\u5a66\u306e\u5272\u5408\u306f\u5f90\u3005\u306b\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u73fe\u5728\u3001\u65e5\u672c\u306e\u598a\u7523\u5a66\u306e10%\u4ee5\u4e0a\u3092\u5360\u3081\u3066\u3044\u308b(\u6bcd\u5b50\u4fdd\u5065\u6a5f\u69cb1996)\u3002 \u3053\u308c\u3089\u306e\u5973\u6027\u306f\u3001\u9ad8\u9f62\u306b\u3088\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u9ad8\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u30de\u30b9\u30e1\u30c7\u30a3\u30a2\u3084\u533b\u7642\u60c5\u5831\u6e90\u304b\u3089\u53d7\u3051\u53d6\u308a\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u53d7\u3051\u308b\u305f\u3081\u3001\u307e\u305f\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u3092\u4f9d\u983c\u3059\u308b\u305f\u3081\u306b\u7523\u79d1\u30af\u30ea\u30cb\u30c3\u30af\u3092\u53d7\u8a3a\u3059\u308b\u3002 \u9ad8\u9f62\u306e\u598a\u5a66\u306b\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u60c5\u5831\u304c\u306a\u3044\u5834\u5408\u306f\u3001\u7523\u79d1\u533b\u306b\u8aac\u660e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 \u9ad8\u9f62\u306e\u305f\u3081\u30ea\u30b9\u30af\u306e\u3042\u308b\u5973\u6027\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u9593\u3001\u7523\u79d1\u533b\u307e\u305f\u306f\u4ed6\u306e\u533b\u7642\u5c02\u9580\u5bb6\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u63a8\u5b9a\u53ef\u80fd\u6027\u3092\u63d0\u793a\u3057\u3001\u3053\u306e\u53ef\u80fd\u6027\u306b\u57fa\u3065\u3044\u3066<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u3092\u53d7\u3051\u305f\u3044\u304b\u3069\u3046\u304b\u3092\u60a3\u8005\u306b\u9078\u629e\u3055\u305b\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002 \u3053\u306e\u53ef\u80fd\u6027\u306f\u3001\u672c\u8a66\u9a13\u3067\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u4e88\u6e2c\u7387\u306a\u3069\u3001\u8a66\u9a13\u6642\u306e\u30c7\u30fc\u30bf\u304b\u3089\u5c0e\u304d\u51fa\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u65e5\u672c\u4eba\u5973\u6027\u306e\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u305f\u3081\u306e\u6709\u76ca\u306a\u30c7\u30fc\u30bf\u3092\u63d0\u4f9b\u3059\u308b\u3002 \u3057\u304b\u3057\u306a\u304c\u3089\u3001\u598a\u5a20\u4e2d\u671f\u306e\u7f8a\u6c34\u7a7f\u523a\u306b\u304a\u3051\u308b\u5404<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u5272\u5408\u3092\u3088\u308a\u6b63\u78ba\u306b\u4e88\u6e2c\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3055\u3089\u306b\u591a\u304f\u306e\u75c7\u4f8b\u3092\u691c\u8a0e\u3059\u3079\u304d\u3067\u3042\u308b\u3002<\/p>\n<\/div><\/div>\n\n\n\n    <a href=\"\/nipt\/7q21-3-31-1deletion\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u91cd\u5ea6\u306e\u7dd1\u5185\u969c\u3092\u542b\u3080\u591a\u767a\u6027\u5148\u5929\u7570\u5e38\u306e\u5973\u5150\u306b\u304a\u3051\u308bCGH\u2010SNP\u30a2\u30ec\u30a4\u306b\u3088\u308bde novo 7q21.3q31.1\u6b20\u5931\u306e\u6982\u8981\u8aac\u660e\u3010\u8ad6\u6587\u3011 <\/div>\n          <div class=\"blog-card-excerpt\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30afNIPT\u3067\u306f\u30017q21.3q31.1\u6b20\u5931\u3092\u7279\u5b9a\u3059\u308b\u5c02\u9580\u7684NIPT\u691c\u67fb\u3092\u63d0\u4f9b\u3002\u3053\u306e\u8907\u96d1\u306a\u907a\u4f1d\u5b50\u7570\u5e38\u306e\u65e9\u671f\u767a\u898b\u306b\u8ca2\u732e\u3057\u307e\u3059\u3002...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\"><\/span>\u53c2\u8003\u6587\u732e<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dailey T, Dale B, Cohen J, Munne S (1996) \u6e1b\u6570\u5206\u88c2-II\u30d2\u30c8\u5375\u6bcd\u7d30\u80de\u306b\u304a\u3051\u308b\u4e0d\u5206\u96e2\u3068\u6bcd\u89aa\u306e\u5e74\u9f62\u3068\u306e\u95a2\u9023 Am J Hum Genet 59: 176-184<\/li>\n\n\n\n<li>Ferguson-Smith MA, Yates JRW (1984) <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u6bcd\u89aa\u306e\u5e74\u9f62\u7279\u7570\u7684\u5272\u5408\u304a\u3088\u3073\u305d\u308c\u3089\u306b\u5f71\u97ff\u3059\u308b\u56e0\u5b50: 52,965\u306e\u7f8a\u6c34\u7a7f\u523a\u306b\u95a2\u3059\u308b\u30e8\u30fc\u30ed\u30c3\u30d1\u5171\u540c\u7814\u7a76\u306e\u5831\u544a\u3002 \u598a\u5a20\u671f4: 5-44<\/li>\n\n\n\n<li>Halliday JL, Watson LF, Lumley J, Danks DM, Sheffield LJ (1995) \u72ec\u81ea\u306b\u5b9a\u7fa9\u3055\u308c\u305f\u6bcd\u89aa\u306e\u9ad8\u9f62\u5973\u6027\u306b\u304a\u3051\u308b\u7d68\u6bdb\u30b5\u30f3\u30d7\u30ea\u30f3\u30b0\u3001\u7f8a\u6c34\u7a7f\u523a\u3001\u51fa\u7523\u6642\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u5019\u7fa4\u30ea\u30b9\u30af\u306e\u65b0\u305f\u306a\u63a8\u5b9a\u5024\u3002 \u598a\u5a20\u671f15: 455-465<\/li>\n\n\n\n<li>Hassold T, Abruzzo M, Adkins K, Griffin D, Merrill M, Millie E, Sakar D, Shen J, Zaragoza M (1996) \u30d2\u30c8\u7570\u6570\u6027\u306e\u767a\u751f\u7387\u3001\u8d77\u6e90\u304a\u3088\u3073\u75c5\u56e0 \u74b0\u5883\u30e2\u30fc\u30eb\u7a81\u7136\u5909\u7570\u8a98\u767a\u7269\u8cea28: 167-175]<\/li>\n\n\n\n<li>Fook EB (1983) \u7f8a\u6c34\u7a7f\u523a\u5f8c\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304a\u3088\u3073\u81ea\u7136\u80ce\u5150\u6b7b\u4ea1: \u3055\u3089\u306a\u308b\u30c7\u30fc\u30bf\u304a\u3088\u3073\u6bcd\u4f53\u5e74\u9f62\u3068\u306e\u95a2\u9023\u6027 Am J Hum Genet 35: 110-116<\/li>\n\n\n\n<li>Hook EB, Cross PK, Regal RR (1984) \u6bcd\u4f53\u5e74\u9f62\u306e\u6700\u4e0a\u7aef\u306b\u304a\u3051\u308b47,121\u300147,118\u3001\u304a\u3088\u307347,113\u306e\u983b\u5ea6: 56,094\u5339\u306e\u80ce\u5150\u306b\u95a2\u3059\u308b\u7d50\u679c\u3001\u51fa\u751f\u524d\u304a\u3088\u3073\u51fa\u751f\u30c7\u30fc\u30bf\u3068\u306e\u6bd4\u8f03\u304c\u884c\u308f\u308c\u305f\u3002 Hum Genet 68: 211-220<\/li>\n\n\n\n<li>\u30d5\u30c3\u30afEB\u3001\u30af\u30ed\u30b9PK\u3001Jackson L\u3001Pergament E\u3001Brambati B (1988) \u7d68\u6bdb\u751f\u691c\u6a19\u672c\u306b\u304a\u3044\u3066\u598a\u5a20\u521d\u671f\u306b\u8a3a\u65ad\u3055\u308c\u305f\u6bcd\u89aa\u306e\u5e74\u9f62\u7279\u7570\u7684\u5272\u540847,121\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7570\u5e38:\u7f8a\u6c34\u7a7f\u523a\u6642\u306e\u89b3\u5bdf\u304b\u3089\u4e88\u6e2c\u3055\u308c\u308b\u5272\u5408\u3068\u306e\u6bd4\u8f03\u3002 Am J Hum Genet 42: 797-807<\/li>\n\n\n\n<li>Hook EB, Topol BB, Cross PK (1989) \u598a\u5a20\u4e2d\u671f\u306e\u7f8a\u6c34\u7a7f\u523a\u3067\u691c\u51fa\u3055\u308c\u305f\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u306b\u7570\u5e38\u306a\u80ce\u5150\u306e\u81ea\u7136\u53f2: 47,121\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u7570\u5e38\u306a\u6838\u578b\u306b\u95a2\u9023\u3059\u308b\u6669\u671f\u80ce\u5150\u6b7b\u4ea1\u306e\u904e\u5270\u304a\u3088\u3073\u76f8\u5bfe\u30ea\u30b9\u30af\u306e\u65b0\u305f\u306a\u30c7\u30fc\u30bf\u304a\u3088\u3073\u63a8\u5b9a\u5024\u3002 Am J Hum Genet 45: 855-861<\/li>\n\n\n\n<li>Lockwood DH, Neu RL (1993) \u598a\u5a2014\u9031\u672a\u6e80\u306e\u598a\u5a20\u304b\u3089\u63a1\u53d6\u3057\u305f\u7f8a\u6c341375\u691c\u4f53\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u5206\u6790\u3002 \u598a\u5a20\u8a3a\u65ad13: 801-805<\/li>\n\n\n\n<li>Macas E, Floersheim Y, Hotz E, Imthurn B, Keller PJ, Walt H (1990) \u30d2\u30c8\u5375\u6bcd\u7d30\u80de\u306b\u304a\u3051\u308b\u7570\u5e38\u306a\u67d3\u8272\u4f53\u914d\u5217\u3002 \u30cf\u30e0\u30ea\u30d7\u30ed\u30c3\u30c95: 703-707<\/li>\n\n\n\n<li>Macintosh MCM, Wald NJ, Chard T, Hansen J, Mikkelsen M, Therkelsen AJ, Petersen GB, Lundsteen C (1995) 35\u6b73\u4ee5\u4e0a\u306e\u5973\u6027\u306b\u304a\u3051\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u5019\u7fa4\u80ce\u5150\u306e\u9078\u629e\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3002 Br J Obstet Gynaecol 102: 798-801<\/li>\n\n\n\n<li>\u524d\u7530\u30fb\u5927\u91ce\u30fb\u677e\u91ce\u30fbA\u30fb\u5409\u539f\u30fbYabe N (1991) \u9023\u7d9a\u751f\u307e\u308c\u305f14,835\u4eba\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u8abf\u67fb\u3002 Jpn J\u30d2\u30c8\u907a\u4f1d\u5b5036: 117-129<\/li>\n\n\n\n<li>\u6bcd\u5b50\u4fdd\u5065\u6a5f\u69cb(1996)\u6bcd\u89aa\u306e\u5e74\u9f62\u5225\u306e\u751f\u5b58\u51fa\u7523\u6570\u3002 \u300c1996\u5e74\u65e5\u672c\u6bcd\u5b50\u4fdd\u5065\u7d71\u8a08\u300d(\u7de8) \u6771\u4eac47-53\u9801<br>Mutton DE, Alberman E, Ide R, Bobrow M (1991) Ingland and Wales\u306b\u304a\u3051\u308bDown\u2019s\u75c7\u5019\u7fa4\u306e\u5168\u56fd\u767b\u9332\u306e1\u5e74\u76ee(1989)\u306e\u7d50\u679c\u3002 Br\u30e1\u30c3\u30c9J 303: 1295-1297<\/li>\n\n\n\n<li>NICHD National Registry for Amniocentissis Study Group (1976) <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306e\u305f\u3081\u306e\u598a\u5a20\u4e2d\u671f\u306e\u7f8a\u6c34\u7a7f\u523a: \u5b89\u5168\u6027\u3068\u6b63\u78ba\u6027 \u65e5\u672c\u81ea\u52d5\u8eca\u5de5\u696d\u4f1a236: 1471-1476<\/li>\n\n\n\n<li>Plachot M, de Grouchy J, Junca AM, Mandelbaum J, Salat-Baroux J, Cohen J (1988) \u30d2\u30c8\u5375\u6bcd\u7d30\u80de\u304a\u3088\u3073\u80da\u306e\u67d3\u8272\u4f53\u5206\u6790: \u53d7\u7cbe\u9045\u5ef6\u306f\u67d3\u8272\u4f53\u4e0d\u5747\u8861\u3092\u5897\u52a0\u3055\u305b\u308b\u304b? \u30d2\u30c8\u751f\u6b96\u56683: 125-127<\/li>\n\n\n\n<li>Polani PE\u3001Alberman E\u3001Berry AC\u3001Blunt S\u3001Singer JD(1976)<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304a\u3088\u3073\u6bcd\u89aa\u306e\u5e74\u9f62\u3002 \u30e9\u30f3\u30bb\u30c3\u30c8II: 516-517<\/li>\n\n\n\n<li>Schreinemachers DM, Cross PK, Hook EB (1982) \u7d0420,000\u4ef6\u306e\u51fa\u751f\u524d\u7814\u7a76\u306b\u304a\u3051\u308b\u30c8\u30ea\u30bd\u30df\u30fc21\u300118\u300113\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u5272\u5408\u3092\u3001\u63a8\u5b9a\u51fa\u751f\u7387\u3068\u6bd4\u8f03\u3057\u305f\u3002 Hum Genet 61: 318-324<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"JB .H Juomch Gimesne&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/japanese-mothers-aged-35-and-older\/\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":1,"featured_media":523,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[71],"tags":[57,74,43,49,73],"class_list":["post-18713","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatise","tag-down-syndrome","tag-duplication-syndrome","tag-gene","tag-genetic-disease","tag-deletion-syndrome"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/18713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=18713"}],"version-history":[{"count":7,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/18713\/revisions"}],"predecessor-version":[{"id":109711,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/18713\/revisions\/109711"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/523"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=18713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=18713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=18713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}