{"id":49230,"date":"2022-12-09T16:33:32","date_gmt":"2022-12-09T07:33:32","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/"},"modified":"2024-10-11T14:56:35","modified_gmt":"2024-10-11T05:56:35","slug":"principles-of-nipt","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans","title":{"rendered":"NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u539f\u7406\u662f\u4ec0\u4e48"},"content":{"rendered":"\n<div class=\"toc\">\n\t<ul>\n\t\t<li><a href=\"#c1\">\u7b80\u4ecb<\/a><\/li>\n\t\t<li><a href=\"#c2\">NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u539f\u7406<\/a>\n\t\t\t<ul>\n\t\t\t\t<li><a href=\"#c2-1\">NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u6240\u9700\u7684DNA<\/a><\/li>\n\t\t\t\t<li><a href=\"#c2-2\">\u6d4b\u5e8f\u4eea<\/a><\/li>\n\t\t\t\t<li><a href=\"#c2-3\">\u5206\u6790\u65b9\u6cd5<\/a><\/li>\n\t\t\t<\/ul>\n\t\t<\/li>\n\t\t<li><a href=\"#c3\">NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u68c0\u67e5\u673a\u5236<\/a>\n\t\t\t<ul>\n\t\t\t\t<li><a href=\"#c3-1\">\u4ece\u6bcd\u4eb2\u8eab\u4e0a\u62bd\u8840<\/a>\t\t\t\t\t\n\t\t\t\t\t<ul>\n\t\t\t\t\t\t<li><a href=\"#c3-1-1\">\u4e3a\u4ec0\u4e48\u9700\u8981\u62bd\u8840<\/a><\/li>\n\t\t\t\t\t<\/ul>\n\t\t\t\t<\/li>\n\t\t\t\t<li><a href=\"#c3-2\">\u6bcd\u4f53\u8840\u6db2\u7684\u79bb\u5fc3\u5206\u79bb<\/a><\/li>\n\t\t\t\t<li><a href=\"#c3-3\">\u5206\u6790\u7684\u7ed3\u679c<\/a>\n\t\t\t\t\t<ul>\n\t\t\t\t\t\t<li><a href=\"#c3-3-1\">\u6d4b\u5e8f<\/a><\/li>\n\t\t\t\t\t\t<li><a href=\"#c3-3-2\">\u9274\u522b<\/a><\/li>\n\t\t\t\t\t\t<li><a href=\"#c3-3-3\">\u5224\u5b9a<\/a><\/li>\n\t\t\t\t\t<\/ul>\n\t\t\t\t<\/li>\n\t\t\t<\/ul>\n\t\t<\/li>\n\t\t<li><a href=\"#c4\">NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u6ce8\u610f\u4e8b\u9879<\/a>\n\t\t\t<ul>\n\t\t\t\t<li><a href=\"#c4-1\">\u80ce\u76d8\u5d4c\u5408\u4f53 (CPM)<\/a><\/li>\n\t\t\t\t<li><a href=\"#c4-2\">\u6d88\u5931\u7684\u53cc\u80de\u80ce<\/a><\/li>\n\t\t\t\t<li><a href=\"#c4-3\">\u5224\u5b9a\u7ed3\u679c\u4e3a \u300c\u5047\u9633\u6027\u300d \u300c\u5047\u9634\u6027\u300d \u300c\u518d\u6b21\u68c0\u67e5 (\u5f85\u5224\u5b9a) \u300d \u65f6<\/a><\/li>\n\t\t\t<\/ul>\n\t\t<\/li>\n\t\t<li><a href=\"#c5\">\u603b\u7ed3<\/a><\/li>\n\t<\/ul>\n<\/div>\n\n\n<p style=\"width:100%;max-width:300px;margin:0 auto;\"><a href=\"\/nipt\/\" class=\"content-bnr about\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/themes\/hiro_nipt\/img\/banner\/nipt04pc.png\" alt=\"\u80ce\u5150\u306e\u6027\u5225\u306f10\u9031\u76ee\u3067\u308f\u304b\u308b\"><\/a> <\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E7%AE%80%E4%BB%8B\" >\u7b80\u4ecb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#NIPT_%E6%96%B0%E5%9E%8B%E4%BA%A7%E5%89%8D%E8%AF%8A%E6%96%AD_%E7%9A%84%E5%8E%9F%E7%90%86\" >NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u539f\u7406<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#NIPT_%E6%96%B0%E5%9E%8B%E4%BA%A7%E5%89%8D%E8%AF%8A%E6%96%AD_%E6%89%80%E9%9C%80%E7%9A%84DNA\" >NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u6240\u9700\u7684DNA<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E6%B5%8B%E5%BA%8F%E4%BB%AA\" >\u6d4b\u5e8f\u4eea<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E5%88%86%E6%9E%90%E6%96%B9%E6%B3%95\" >\u5206\u6790\u65b9\u6cd5<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#NIPT_%E6%96%B0%E5%9E%8B%E4%BA%A7%E5%89%8D%E8%AF%8A%E6%96%AD_%E7%9A%84%E6%A3%80%E6%9F%A5%E6%9C%BA%E5%88%B6\" >NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u68c0\u67e5\u673a\u5236<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E4%BB%8E%E6%AF%8D%E4%BA%B2%E8%BA%AB%E4%B8%8A%E6%8A%BD%E8%A1%80\" >\u4ece\u6bcd\u4eb2\u8eab\u4e0a\u62bd\u8840<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E4%B8%BA%E4%BB%80%E4%B9%88%E9%9C%80%E8%A6%81%E6%8A%BD%E8%A1%80\" >\u4e3a\u4ec0\u4e48\u9700\u8981\u62bd\u8840<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E6%AF%8D%E4%BD%93%E8%A1%80%E6%B6%B2%E7%9A%84%E7%A6%BB%E5%BF%83%E5%88%86%E7%A6%BB\" >\u6bcd\u4f53\u8840\u6db2\u7684\u79bb\u5fc3\u5206\u79bb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E5%88%86%E6%9E%90%E7%9A%84%E7%BB%93%E6%9E%9C\" >\u5206\u6790\u7684\u7ed3\u679c<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E6%B5%8B%E5%BA%8F\" >\u6d4b\u5e8f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E9%89%B4%E5%88%AB\" >\u9274\u522b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E5%88%A4%E5%AE%9A\" >\u5224\u5b9a<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#NIPT_%E6%96%B0%E5%9E%8B%E4%BA%A7%E5%89%8D%E8%AF%8A%E6%96%AD_%E7%9A%84%E6%B3%A8%E6%84%8F%E4%BA%8B%E9%A1%B9\" >NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u6ce8\u610f\u4e8b\u9879<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E8%83%8E%E7%9B%98%E5%B5%8C%E5%90%88%E4%BD%93_CPM\" >\u80ce\u76d8\u5d4c\u5408\u4f53 (CPM)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E6%B6%88%E5%A4%B1%E7%9A%84%E5%8F%8C%E8%83%9E%E8%83%8E\" >\u6d88\u5931\u7684\u53cc\u80de\u80ce<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E5%88%A4%E5%AE%9A%E7%BB%93%E6%9E%9C%E4%B8%BA_%E3%80%8C%E5%81%87%E9%98%B3%E6%80%A7%E3%80%8D_%E3%80%8C%E5%81%87%E9%98%B4%E6%80%A7%E3%80%8D_%E3%80%8C%E5%86%8D%E6%AC%A1%E6%A3%80%E6%9F%A5_%E5%BE%85%E5%88%A4%E5%AE%9A_%E3%80%8D_%E6%97%B6\" >\u5224\u5b9a\u7ed3\u679c\u4e3a \u300c\u5047\u9633\u6027\u300d \u300c\u5047\u9634\u6027\u300d \u300c\u518d\u6b21\u68c0\u67e5 (\u5f85\u5224\u5b9a) \u300d \u65f6<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\/#%E6%80%BB%E7%BB%93\" >\u603b\u7ed3<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\" id=\"c1\"><span class=\"ez-toc-section\" id=\"%E7%AE%80%E4%BB%8B\"><\/span><strong>\u7b80\u4ecb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/?lang=zh-hans\">NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad)<\/a>\u662f\u6307\u300c\u4ece\u6bcd\u4eb2\u7684\u8840\u6db2\u4e2d\u68c0\u67e5\u80ce\u513f\u67d3\u8272\u4f53\u5f02\u5e38,\u5982<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=zh-hans\">21\u53f7\u67d3\u8272\u4f53\u4e09\u4f53\u7efc\u5408\u75c7 (\u5510\u6c0f\u7efc\u5408\u75c7)<\/a>\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/?lang=zh-hans\">18\u53f7\u67d3\u8272\u4f53\u4e09\u4f53 (\u7231\u5fb7\u534e\u5179\u7efc\u5408\u75c7)<\/a>\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/?lang=zh-hans\">13\u53f7\u67d3\u8272\u4f53\u4e09\u4f53 (\u5e15\u6258\u7efc\u5408\u75c7)<\/a>\u300d \u7684\u68c0\u67e5\u3002\u4e0e\u4f20\u7edf\u7684\u8840\u6db2\u4ea7\u524d\u8bca\u65ad\u76f8\u6bd4\uff0c\u4ece\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u6765\u770b\uff0c\u6d4b\u8bd5\u672c\u8eab\u7684\u51c6\u786e\u6027\u975e\u5e38\u9ad8\u3002\u5b55\u5987\u7684\u8840\u6db2\u4e2d\u5b58\u5728\u6765\u81ea\u5a74\u513f\u7684DNA\u7247\u6bb5\u3002NIPT\u53ef\u4ee5\u901a\u8fc7\u5206\u6790\u6765\u81ea\u5a74\u513f\u7684DNA\u7247\u6bb5\u6765\u68c0\u67e5\u5a74\u513f\u5728\u51fa\u751f\u524d\u662f\u5426\u5b58\u5728\u8fd9\u4e9b\u67d3\u8272\u4f53\u5f02\u5e38\u7684\u53ef\u80fd\u6027\u3002<\/p>\n\n\n\n<p>NIPT\u7684\u4f18\u70b9\u662f\uff0c\u4e0d\u50cf\u7f8a\u6c34\u6216\u7ed2\u6bdb\u68c0\u67e5\u9700\u8981\u5728\u5b50\u5bab\u5185\u624e\u9488,\u56e0\u4e3aNIPT\u662f\u901a\u8fc7\u4ece\u6bcd\u4eb2\u7684\u624b\u81c2\u62bd\u53d6\u8840\u6db2\u8fdb\u884c\u7684\u4ea7\u524d\u8bca\u65ad,\u4e0d\u4ec5\u5bf9\u6bcd\u4eb2\u7684\u4fb5\u88ad\u6027 (\u5bf9\u8eab\u4f53\u7684\u4f24\u5bb3) \u4f4e,\u800c\u4e14\u8fd9\u4e9b\u68c0\u67e5\u4e5f\u6ca1\u6709\u6d41\u4ea7\u7684\u98ce\u9669 (0.3%~1%) \u3002\u6b64\u5916\uff0c\u7531\u4e8eNIPT\u68c0\u67e5\u7684\u51c6\u786e\u6027\u5f88\u9ad8\uff0c\u56e0\u6b64NIPT\u53ef\u4ee5\u4f5c\u4e3a\u53ef\u9760\u7684\u6307\u6807,\u4ee5\u5e2e\u52a9\u533b\u751f\u6839\u636e\u68c0\u67e5\u7ed3\u679c\u786e\u5b9a\u6f5c\u5728\u7684\u75be\u75c5\u98ce\u9669\u3002<\/p>\n\n\n\n<p>\u4f46\u662f\uff0c\u4f5c\u4e3aNIPT\u7684\u6ce8\u610f\u4e8b\u9879\uff0c\u5e94\u4e86\u89e3NIPT\u662f\u4e00\u79cd\u7b5b\u67e5\u6d4b\u8bd5,\u800c\u4e0d\u662f\u53ef\u63d0\u4f9b\u660e\u786e\u7b54\u6848\u7684\u786e\u5b9a\u6027\u68c0\u67e5\u3002\u5f52\u6839\u7ed3\u5e95\u662f\u4f5c\u4e3a\u6982\u7387\u8c03\u67e5\u80ce\u513f\u60a3\u67d3\u8272\u4f53\u75be\u75c5\u7684\u98ce\u9669\u662f\u9ad8\u8fd8\u662f\u4f4e\u3002\u56e0\u6b64\uff0c\u5728\u8fdb\u884cNIPT\u68c0\u67e5\u4e4b\u524d\uff0c\u5efa\u8bae\u5728\u4e0e\u533b\u751f\u5145\u5206\u8ba8\u8bbaNIPT\u53ef\u80fd\u53d1\u73b0\u7684\u67d3\u8272\u4f53\u75be\u75c5\u3001NIPT\u539f\u7406\u3001\u68c0\u67e5\u673a\u5236\u3001\u4f18\u70b9\u548c\u6ce8\u610f\u4e8b\u9879\u540e\u518d\u8fdb\u884c\u68c0\u67e5\u3002<\/p>\n\n\n\n<p>\u5728\u672c\u6587\u4e2d\uff0c\u6839\u636eNIPT\u7684\u539f\u7406,\u5c06\u4ecb\u7ecd\u5728\u8fdb\u884cNIPT\u68c0\u67e5\u65f6\u5982\u4f55\u68c0\u67e5\u4ece\u6bcd\u4eb2\u5904\u91c7\u96c6\u7684\u8840\u6db2\u5e76\u83b7\u5f97\u5206\u6790\u7ed3\u679c\u4ee5\u53caNIPT\u7684\u6ce8\u610f\u4e8b\u9879\u3002<\/p>\n\n\n\n    <a href=\"\/nipt\/nipt\/nipt\/?lang=zh-hans\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u77e5\u7684\u969c\u304c\u3044\u304c\u308f\u304b\u308bNIPT\u3068\u306f\uff08NIPT\u306e\u57fa\u672c\uff09 <\/div>\n          <div class=\"blog-card-excerpt\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u884c\u3063\u3066\u3044\u308bNIPT\u306e\u307e\u3068\u3081\u3067\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u306eNIPT\u3067\u306f\u77e5\u7684\u969c\u5bb3\u30fb\u767a\u9054\u969c\u5bb3\u3092\u4f34\u3046\u591a\u6570\u306e\u75be\u60a3\u3092\u51fa\u751f\u524d\u306b\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"c2\"><span class=\"ez-toc-section\" id=\"NIPT_%E6%96%B0%E5%9E%8B%E4%BA%A7%E5%89%8D%E8%AF%8A%E6%96%AD_%E7%9A%84%E5%8E%9F%E7%90%86\"><\/span><strong><strong>NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u539f\u7406<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u6839\u636e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/?lang=zh-hans\">NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad)<\/a>\u7684\u539f\u7406,\u4ece\u5b55\u5987\u7684\u8840\u6db2\u4e2d\u63d0\u53d6\u80ce\u513f\u7684DNA\u7247\u6bb5,\u5e76\u901a\u8fc7\u673a\u5668 (\u6d4b\u5e8f\u4eea) \u8be6\u7ec6\u5206\u6790DNA\u7247\u6bb5\u6765\u68c0\u67e5\u80ce\u513f\u662f\u5426\u60a3\u6709\u67d3\u8272\u4f53\u75be\u75c5,\u598221\u53f7\u67d3\u8272\u4f53\u4e09\u4f53\u7efc\u5408\u75c7\u300118\u53f7\u67d3\u8272\u4f53\u4e09\u4f53\u7efc\u5408\u75c7\u548c13\u53f7\u67d3\u8272\u4f53\u4e09\u4f53\u7efc\u5408\u75c7\u3002NIPT\u68c0\u67e5\u7684\u5bf9\u8c61\u662f\u5b55\u5987\u8840\u6db2\u4e2d\u7684\u80ce\u513f\u7684DNA,\u56e0\u4e3a\u9700\u8981\u5206\u6790\u6765\u81ea\u80ce\u513f\u800c\u4e0d\u662f\u6bcd\u4f53\u7684DNA,\u4ee5\u786e\u5b9a\u80ce\u513f\u800c\u4e0d\u662f\u5b55\u5987\u662f\u5426\u6709\u67d3\u8272\u4f53\u5f02\u5e38,\u5e76\u68c0\u67e5\u80ce\u513f\u662f\u5426\u60a3\u6709\u8fd9\u4e9b\u67d3\u8272\u4f53\u75be\u75c5\u3002\u5728\u672c\u9879\u76ee\u4e2d\uff0c\u5c06\u4ecb\u7ecdNIPT\u68c0\u67e5\u6240\u9700\u7684DNA,\u6d4b\u5e8f\u5668\u548c\u5206\u6790\u65b9\u6cd5\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c2-1\"><span class=\"ez-toc-section\" id=\"NIPT_%E6%96%B0%E5%9E%8B%E4%BA%A7%E5%89%8D%E8%AF%8A%E6%96%AD_%E6%89%80%E9%9C%80%E7%9A%84DNA\"><\/span><strong><strong>NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u6240\u9700\u7684DNA<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u4f20\u7edf\u7684\u4ea7\u524d\u8bca\u65ad\u662f\u901a\u8fc7\u6536\u96c6\u542b\u6709\u80ce\u513fDNA\u7684\u7f8a\u6c34\u6216\u7ed2\u6bdb\u5e76\u68c0\u67e5\u80ce\u513fDNA\u5e8f\u5217\u6765\u786e\u5b9a\u67d3\u8272\u4f53\u75be\u75c5\u3002<\/p>\n\n\n\n<p>\u53e6\u4e00\u65b9\u9762\uff0c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/?lang=zh-hans\">NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad)<\/a>\u5219\u5229\u7528\u5b58\u5728\u4e8e\u6bcd\u4f53\u8840\u6db2\u4e2d\u7684\u80ce\u513fDNA\u3002DNA\u6700\u521d\u4ee5\u67d3\u8272\u4f53\u7684\u5f62\u5f0f\u5b58\u5728,\u5b58\u50a8\u5728\u4f53\u5185\u76841\u4e2a\u7ec6\u80de (cell) \u7684\u7ec6\u80de\u6838\u4e2d,\u4f46\u5df2\u77e5DNA\u7247\u6bb5\u4e5f\u4f1a\u6d41\u5165\u8840\u6db2\u4e2d,\u8fd9\u4e5f\u88ab\u79f0\u4e3acell free DNA (cfDNA) \u3002NIPT\u68c0\u67e5\u4f7f\u7528\u8fd9\u79cdcfDNA,\u4f46cfDNA\u4e0d\u4ec5\u7528\u4e8eNIPT,\u8fd8\u7528\u4e8e\u764c\u75c7\u548c\u5176\u4ed6\u75be\u75c5\u7684\u68c0\u67e5\uff0c\u4ececfDNA\u91c7\u96c6\u5230\u786e\u5b9a\u7684\u6d41\u7a0b\u662f\u53ef\u9760\u548c\u5b89\u5168\u7684\u3002\u8fd9\u88ab\u8ba4\u4e3a\u662f\u5177\u6709\u9ad8\u5ea6\u5b89\u5168\u6027\u7684\u68c0\u67e5\u6280\u672f\u4e4b\u4e00\u3002<\/p>\n\n\n\n<p>\u7528\u4e8eNIPT\u68c0\u67e5\u7684cfDNA\u6e90\u4e8e\u80ce\u76d8\u4e2d\u7684\u80ce\u513f\u7684\u8840\u6db2\u4e26\u901a\u8fc7\u6bcd\u4f53\u8840\u6db2\u6d41\u51fa,\u68c0\u67e5\u673a\u6784\u63d0\u53d6cfDNA\u5e76\u5206\u6790DNA\u5e8f\u5217,\u7136\u540e\u6839\u636e\u7ed3\u679c,\u533b\u751f\u5728\u80ce\u513f\u51fa\u751f\u524d\u786e\u5b9a\u80ce\u513f\u662f\u5426\u60a3\u6709\u67d3\u8272\u4f53\u75be\u75c5\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"\/nipt\/wp-content\/uploads\/2022\/12\/principles-of-nipt02.jpg\" alt=\"NIPT(\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad)\u306e\u539f\u7406\" class=\"wp-image-48142\"\/><\/figure><\/div>\n\n\n<h3 class=\"wp-block-heading\" id=\"c2-2\"><span class=\"ez-toc-section\" id=\"%E6%B5%8B%E5%BA%8F%E4%BB%AA\"><\/span><strong><strong>\u6d4b\u5e8f\u4eea<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6d4b\u5e8f\u4eea\u662f\u4e00\u79cd\u8bfb\u53d6DNA\u6392\u5217 (\u5e8f\u5217) \u7684\u673a\u5668,\u76ee\u524d\u6709\u4e00\u79cd\u88ab\u79f0\u4e3a\u65b0\u751f\u4ee3\u6d4b\u5e8f\u4eeaNGS (New Generation Sequencing) \u7684\u6700\u65b0\u4ea7\u54c1\u3002\u6d4b\u5e8f\u4eea\u57281970\u5e74\u4ee3\u4f7f\u7528\u4e86\u4e00\u79cd\u88ab\u79f0\u4e3aSanger\u65b9\u6cd5\u7684\u6280\u672f,\u5373\u4f7f\u6210\u4e3a\u4e86NGS,\u57fa\u672c\u673a\u5236\u4e5f\u4e0d\u4f1a\u6539\u53d8,\u5176\u76ee\u7684\u662f\u8bfb\u53d6\u6240\u63d0\u53d6\u7684DNA\u7684\u78b1\u57fa\u5e8f\u5217\u3002<\/p>\n\n\n\n<p>\u751f\u7269\u7684DNA\u7531A (\u817a\u560c\u5464) \u3001T (\u80f8\u817a\u5627\u5576) \u3001G (\u9e1f\u560c\u5464) \u3001C (\u80de\u5627\u5576) 4\u79cd\u78b1\u57fa\u6392\u5217\u800c\u6210\uff0c\u800c\u4e14\u78b1\u57fa\u57fa\u672c\u4e0a\u662f\u6210\u5bf9\u7684, A\u548cT\u3001G\u548cC\u6210\u5bf9 (\u4e92\u8865\u6027) ,\u4ee52\u6839DNA\u7ed3\u5408\u7684\u5f62\u5f0f (\u53cc\u94feDNA) \u5b58\u5728\u3002\u901a\u8fc7\u6298\u53e0\u8fd9\u4e9b\u7269\u8d28,\u5f62\u6210\u79f0\u4e3a\u67d3\u8272\u4f53\u7684\u7ed3\u6784,\u5e76\u5c06\u5176\u5b58\u50a8\u5728\u79f0\u4e3a\u7ec6\u80de\u6838\u7684\u6bcf\u4e2a\u7ec6\u80de\u4e2d\u3002DNA\u4e2d\u5b58\u5728\u5177\u6709\u7279\u5b9a\u5171\u540c\u78b1\u57fa\u5e8f\u5217\u7684\u4f4d\u70b9\uff0c\u901a\u8fc7\u8bfb\u53d6\u8be5\u5e8f\u5217\u662f\u5426\u6b63\u5e38 (\u57fa\u56e0\u6d4b\u5e8f) \u6765\u53d1\u73b0\u57fa\u56e0\u5f02\u5e38\u3002<\/p>\n\n\n\n<p>\u4f5c\u4e3a\u6d4b\u5e8f\u4eea\u7684\u5177\u4f53\u65b9\u6cd5\uff0c\u9996\u5148\u4ece\u6837\u672c\u4e2d\u63d0\u53d6\u548c\u7eaf\u5316\u76ee\u6807DNA,\u4f7f\u5176\u6210\u4e3a\u5355\u4e2aDNA\u72b6\u6001\u3002\u7136\u540e\uff0c\u5177\u6709\u7279\u5b9a\u78b1\u57fa\u5e8f\u5217\u88ab\u79f0\u4e3a\u5f15\u7269\u7684\u8bd5\u5242\u4ee5\u914d\u5bf9\u7684\u65b9\u5f0f\u8fde\u63a5\u5230\u76ee\u6807DNA\u4e2d\u5b58\u5728\u7684\u78b1\u57fa\u5e8f\u5217\u7684\u672b\u7aef\u3002\u4e4b\u540e\uff0c\u5c06\u88ab\u79f0\u4e3addNTP\u7684A\u3001T\u3001G\u3001C\u5206\u522b\u6dfb\u52a0\u4e86\u7531\u4e0d\u540c\u989c\u8272\u7684\u8367\u5149\u7684\u78b1\u57fa\u6df7\u5408\u800c\u6210\u7684\u8bd5\u5242,\u4e0e\u88ab\u79f0\u4e3aDNA\u805a\u5408\u9176\u914d\u5bf9\u7684\u5404\u78b1\u57fa\u8fde\u63a5\u5e76\u5ef6\u4f38\u7684\u8bd5\u5242\u76f8\u4e92\u914d\u5408,\u5c061\u4e2a\u78b1\u57fa\u9010\u4e00\u6dfb\u52a0\u5230\u5355\u4e2aDNA\u4e0a,\u4ece\u800c\u8bfb\u53d6\u539f\u6765\u63d0\u53d6\u7684DNA\u7684\u57fa\u56e0\u5e8f\u5217\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u4f7f\u7528\u4f20\u7edf\u6d4b\u5e8f\u5668\u8fdb\u884c\u6d4b\u5e8f\u4e3b\u8981\u67092\u4e2a\u95ee\u9898\u3002\u4e00\u4e2a\u662f\u6bcf\u6b21\u6d4b\u5e8f\u53ea\u80fd\u8bfb\u53d6\u4e00\u4e2aDNA,\u5e76\u4e14\u4e3a\u4e86\u627e\u5230\u591a\u4e2a\u57fa\u56e0\u5f02\u5e38,\u6709\u5fc5\u8981\u63d0\u53d6\u548c\u6d4b\u5e8f\u591a\u4e2aDNA,\u8fd9\u9700\u8981\u82b1\u8d39\u5927\u91cf\u65f6\u95f4\u548c\u7cbe\u529b\u3002\u5176\u6b21,\u4f20\u7edf\u7684\u6d4b\u5e8f\u9700\u8981\u5927\u91cf\u7684DNA,\u4e5f\u5c31\u662f\u8bf4\u5728DNA\u63d0\u53d6\u7684\u9636\u6bb5\u9700\u8981\u5927\u91cf\u7684\u6837\u672c,\u56e0\u6b64\u4e3a\u4e86\u8bfb\u53d6\u50cfcfDNA\u8fd9\u6837\u672c\u6765\u5b58\u5728\u91cf\u5c31\u5f88\u5c11\u7684DNA,\u5c31\u9700\u8981\u63d0\u53d6\u76f8\u5f53\u6570\u91cf\u7684\u8840\u6db2\u548c\u7ec4\u7ec7,\u8fd9\u4f7f\u5f97\u4fb5\u5165\u6027\u5f88\u9ad8\u5e76\u4e14\u56f0\u96be\u3002<\/p>\n\n\n\n<p>\u56e0\u6b64\uff0c NGS\u5c31\u662f\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u800c\u65b0\u5f00\u53d1\u51fa\u6765\u7684\u3002\u5bf9\u4e8e\u4e0a\u9762\u63d0\u5230\u7684\u7b2c1\u4e2a\u95ee\u9898, NGS\u5728\u6d4b\u8bd5\u8fc7\u7a0b\u4e2d\u521b\u5efa\u4e86\u4e00\u4e2a\u540d\u4e3aDNA\u6570\u636e\u5e93\u7684DNA\u76ee\u5f55,\u5e76\u53ef\u4ee5\u5728\u4e00\u6b21\u6d4b\u5e8f\u4e2d\u4ee5\u6570\u767e\u4e07\u5230\u6570\u5341\u4ebf\u4e2a\u5355\u4f4d\u7684\u6c34\u5e73\u4e00\u6b21\u6027\u8bfb\u53d6DNA\u78b1\u57fa\u5e8f\u5217\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u73b0\u5728\u6267\u884c\u4e00\u6b21\u53ef\u4ee5\u4e0e\u6267\u884c\u6570\u767e\u4e07\u6b21\u4f20\u7edf\u6d4b\u5e8f\u76f8\u540c\u7684\u6c34\u5e73\u3002\u9488\u5bf9\u7b2c\u4e8c\u4e2a\u95ee\u9898,\u5df2\u7ecf\u5f00\u53d1\u51fa\u66f4\u6709\u6548\u548c\u66f4\u591a\u5730\u63d0\u53d6DNA\u7684\u8bd5\u5242\u548c\u65b9\u6cd5,\u4f46\u5728NGS\u7684\u60c5\u51b5\u4e0b,\u5373\u4f7fDNA\u7684\u91cf\u5f88\u5c11,\u4e5f\u53ef\u4ee5\u8bfb\u53d6\u78b1\u57fa\u5e8f\u5217\u3002\u5373\u4f7fDNA\u7684\u539f\u59cb\u5b58\u5728\u91cf\u8f83\u5c11,\u4f8b\u5982cfDNA,\u4e5f\u53ef\u4ee5\u53d1\u73b0\u57fa\u56e0\u5f02\u5e38\u3002<\/p>\n\n\n\n    <a href=\"\/nipt\/about-clinic\/nipt-machine\/?lang=zh-hans\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u63d0\u643a\u691c\u67fb\u6a5f\u95a2\u306b\u3064\u3044\u3066 <\/div>\n          <div class=\"blog-card-excerpt\">\u975e\u8a8d\u8a3c\u65bd\u8a2d\u3067\u3082\u56fd\u5185\u691c\u67fb\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u691c\u67fb\u7d50\u679c\u304c\u65e9\u304f\u51fa\u3066\u56fd\u5185\u3067\u3059\u3079\u3066\u5b8c\u7d50\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30afNIPT\u306f\u5b89\u5fc3\u3092\u5c4a\u3051\u307e\u3059\u3002...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c2-3\"><span class=\"ez-toc-section\" id=\"%E5%88%86%E6%9E%90%E6%96%B9%E6%B3%95\"><\/span><strong><strong>\u5206\u6790\u65b9\u6cd5<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u4f5c\u4e3a\u80da\u80ce\u6765\u6e90\u7684cfDNA\u7684\u5206\u6790\u65b9\u6cd5,\u4ee5\u524d\u4e5f\u6709\u7528\u4e8e\u5176\u4ed6\u57fa\u56e0\u5206\u6790\u7684SNP\u5206\u6790 (single nucleotide polymorphism:\u4e5f\u79f0\u4e3a\u5355\u6838\u82f7\u9178\u591a\u6001\u6027,\u7528\u4e8e\u68c0\u67e51\u4e2a\u78b1\u57fa\u662f\u5426\u4e0d\u540c (\u4f8b\u5982:\u6b63\u5e38\u60c5\u51b5\u4e0b\u4e3aA\u7684\u5730\u65b9\u4e3aT) ) ,\u5fae\u9635\u5217\u5206\u6790 (\u591a\u4e2aDNA\u5e8f\u5217\u6392\u5217\u5728\u82af\u7247 (\u57fa\u677f) \u4e0a,\u901a\u8fc7\u7ed3\u5408\u4ece\u60f3\u8981\u68c0\u67e5\u7684\u6837\u672c\u4e2d\u83b7\u5f97\u7684DNA\u6765\u68c0\u6d4bDNA\u91cf\u7684\u65b9\u6cd5) \u7b49,\u4f46\u88ab\u79f0\u4e3aMPS\u6cd5 (massively parallel sequencing) \u7684\u5206\u6790\u65b9\u6cd5\u88ab\u8ba4\u4e3a\u662f\u6807\u51c6\u7684\u3002<\/p>\n\n\n\n<p>MPS\u6cd5\u662f\u5229\u7528\u6765\u81ea\u80ce\u513f\u7684cfDNA\u8fdb\u884cNGS\u7684\u5206\u6790,\u5e76\u7ed3\u5408\u6765\u81ea\u5404\u67d3\u8272\u4f53\u7684\u6210\u5206\u91cf\u7684\u5206\u6790\u6765\u8fdb\u884c\u7684\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u5728\u5f97\u5230\u7684\u80ce\u513f\u6765\u6e90\u7684cfDNA\u4e2d\uff0c\u53ef\u4ee5\u5b9a\u91cf\u5730\u8c03\u67e5\u662f\u6765\u81ea\u54ea\u4e2a\u67d3\u8272\u4f53\u3002\u4f8b\u5982\uff0c\u5982\u679c\u80ce\u513f\u5f88\u53ef\u80fd\u662f21\u53f7\u67d3\u8272\u4f53\u4e09\u4f53\u7efc\u5408\u75c7\uff0c\u521921\u53f7\u67d3\u8272\u4f53\u6bd4\u6b63\u5e38\u76842\u6761\u67d3\u8272\u4f53\u591a\u4e861\u6761,\u4e5f\u5c31\u662f\u8bf4,\u6765\u81ea21\u53f7\u67d3\u8272\u4f53\u7684DNA\u6570\u91cf\u4e5f\u589e\u52a0\u4e861.5\u500d (3\u00f72=1.5) \u3002<\/p>\n\n\n\n<p>\u4f46\u662f\uff0c\u4e0d\u4ec5\u662fNIPT\u7684\u68c0\u67e5,\u7528\u4e8e\u786e\u8ba4\u5176\u4ed6\u57fa\u56e0\u75be\u75c5\u7684\u57fa\u56e0\u68c0\u67e5\u4e5f\u662f\u4e00\u6837,\u65e0\u8bba\u91c7\u7528\u54ea\u79cd\u5206\u6790\u65b9\u6cd5,\u90fd\u8fd8\u672a\u80fd\u5f97\u5230100%\u7684\u786e\u5207\u8bc1\u660e,\u8bf4\u5230\u5e95\u8fd8\u662f\u5e94\u8be5\u8ba4\u4e3a\u53ea\u662f\u7b5b\u67e5\u68c0\u67e5\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"c3\"><span class=\"ez-toc-section\" id=\"NIPT_%E6%96%B0%E5%9E%8B%E4%BA%A7%E5%89%8D%E8%AF%8A%E6%96%AD_%E7%9A%84%E6%A3%80%E6%9F%A5%E6%9C%BA%E5%88%B6\"><\/span><strong><strong>NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u68c0\u67e5\u673a\u5236<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u4f5c\u4e3a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/?lang=zh-hans\">NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad)<\/a>\u7684\u673a\u5236,\u5927\u81f4\u6d41\u7a0b\u5982\u4e0b\u3002<\/p>\n\n\n\n<p>\u4ece\u5b55\u5987\u8eab\u4e0a\u62bd\u8840\u2192\u63d0\u53d6\u80ce\u513f\u6765\u6e90\u7684cfDNA\u2192\u5236\u5907\u57fa\u56e0\u5e93\u2192\u5206\u6790cfDNA\u5e8f\u5217\u2192\u5224\u65ad\u67d3\u8272\u4f53\u5f02\u5e38\u7684\u53ef\u80fd\u6027<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c3-1\"><span class=\"ez-toc-section\" id=\"%E4%BB%8E%E6%AF%8D%E4%BA%B2%E8%BA%AB%E4%B8%8A%E6%8A%BD%E8%A1%80\"><\/span><strong><strong>\u4ece\u6bcd\u4eb2\u8eab\u4e0a\u62bd\u8840<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5177\u4f53\u800c\u8a00\uff0c\u5728\u6000\u5b55\u7b2c10\u54680\u5929\u540e,\u4ece\u5b55\u5987\u7684\u624b\u81c2\u91c7\u96c610~20mL (\u7ea62\u5c0f\u5319\u81f31\u5927\u5319) \u8840\u6db2,\u4ee5\u63d0\u53d6\u6f02\u6d6e\u4e8e\u8840\u6db2\u4e2d\u7684\u80ce\u513fcfDNA\u3002\u5f53\u7136\uff0c\u6b64\u65f6\u4e5f\u5305\u542b\u6765\u81ea\u6bcd\u4f53\u7684cfDNA,\u56e0\u6b64\u6709\u5fc5\u8981\u7559\u610f\u8fd9\u4e00\u70b9,\u5e76\u5728\u540e\u9762\u8fdb\u884c\u8bf4\u660e\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"c3-1-1\"><span class=\"ez-toc-section\" id=\"%E4%B8%BA%E4%BB%80%E4%B9%88%E9%9C%80%E8%A6%81%E6%8A%BD%E8%A1%80\"><\/span><strong><strong>\u4e3a\u4ec0\u4e48\u9700\u8981\u62bd\u8840<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u56e0\u4e3a\u4ece\u6bcd\u4eb2\u5904\u62bd\u53d6\u8840\u6db2\u6bd4\u5176\u4ed6\u65b9\u6cd5,\u5982\u6536\u96c6\u7f8a\u6c34\u548c\u7ed2\u6bdb,\u5177\u6709\u66f4\u4f4e\u7684\u4fb5\u5165\u6027\u3002<\/p>\n\n\n\n<p>\u5982\u679c\u76f4\u63a5\u63d0\u53d6\u80ce\u513fDNA\u7684\u7ec4\u7ec7\u6216\u7ec6\u80de,\u53ef\u83b7\u5f97\u6700\u51c6\u786e\u7684\u68c0\u6d4b\u7ed3\u679c,\u4f46\u76f4\u63a5\u63d0\u53d6\u5bf9\u80ce\u513f\u7684\u98ce\u9669\u975e\u5e38\u5927,\u53ef\u80fd\u4f1a\u5bfc\u81f4\u5b55\u5987\u548c\u80ce\u513f\u7684\u6d41\u4ea7\u98ce\u9669\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u6536\u96c6\u6bcd\u4f53\u8840\u6db2\u4e2d\u7684\u80ce\u513fcfDNA,\u53ef\u4ee5\u5728\u4e0d\u5f71\u54cd\u80ce\u513f\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u4ea7\u524d\u8bca\u65ad\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c3-2\"><span class=\"ez-toc-section\" id=\"%E6%AF%8D%E4%BD%93%E8%A1%80%E6%B6%B2%E7%9A%84%E7%A6%BB%E5%BF%83%E5%88%86%E7%A6%BB\"><\/span><strong><strong>\u6bcd\u4f53\u8840\u6db2\u7684\u79bb\u5fc3\u5206\u79bb<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u4e3a\u4e86\u4ece\u6bcd\u4eb2\u8840\u6db2\u4e2d\u63d0\u53d6\u6765\u81ea\u80ce\u513f\u7684cfDNA,\u5c06\u6bcd\u4f53\u7528\u4e00\u79cd\u53eb\u505a\u79bb\u5fc3\u5206\u79bb\u673a\u7684\u8bbe\u5907\u5206\u79bb\u6210\u5404\u4e2a\u6210\u5206\u3002<\/p>\n\n\n\n<p>\u6211\u4eec\u4eba\u7c7b\u7684\u8840\u6db2\u57fa\u672c\u4e0a\u5206\u4e3a\u4e24\u90e8\u5206\uff0c\u6db2\u4f53\u6210\u5206 (\u8840\u6d46:\u7ea655%) \u548c\u5176\u4ed6\u6210\u5206\uff0c\u5982\u7ec6\u80de\u6216\u86cb\u767d\u8d28\uff0c\u8fd9\u4e9b\u6210\u5206\u5728\u6574\u4e2a\u8eab\u4f53\u4e2d\u76f8\u4e92\u6df7\u5408\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u5c06\u4ece\u8840\u7ba1\u4e2d\u6536\u96c6\u7684\u8840\u6db2\u79bb\u5fc3\u5206\u79bb,\u5c06\u5176\u5206\u79bb\u4e3a\u8840\u6d46, Bafe\u6d82\u5c42 (\u663e\u793a\u4e3a\u542b\u6709\u8840\u7ec6\u80de\u7684\u8584\u5c42) \u548c\u7ea2\u8840\u7403\u7684\u5404\u4e2a\u5c42\u3002\u4e3e\u4f8b\u6765\u8bf4,\u5982\u679c\u4f60\u628a\u6c34\u548c\u6cb9\u653e\u5728\u540c\u4e00\u4e2a\u5bb9\u5668\u91cc,\u6c34\u548c\u6cb9\u5c31\u4e0d\u4f1a\u6df7\u5408,\u6240\u4ee5\u6bd4\u6c34\u66f4\u91cd\u7684\u6cb9\u4f1a\u4e0b\u6c89\u3002\u8fd9\u79cd\u6280\u672f\u901a\u5e38\u7528\u4e8e\u533b\u9662\u548c\u5065\u5eb7\u68c0\u67e5\u4e2d\u7684\u8840\u6db2\u68c0\u67e5\u3002<\/p>\n\n\n\n<p>\u7531\u4e8e\u8840\u6d46\u4e2d\u542b\u6709\u6765\u81ea\u80ce\u513f\u7684cfDNA,\u800c\u6765\u81ea\u6bcd\u4f53\u7684\u8840\u6db2\u6210\u5206\u4e2d\u7684\u767d\u8840\u7403\u6d53\u539a\u6db2\u548c\u7ea2\u8840\u7403,\u4e3a\u4e86\u51c6\u786e\u5730\u8fdb\u884cNIPT\u68c0\u67e5,\u5728\u51c6\u5907\u68c0\u67e5\u7684\u9636\u6bb5,\u9700\u8981\u4ed4\u7ec6\u5730\u53ea\u63d0\u53d6\u8840\u6d46\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c3-3\"><span class=\"ez-toc-section\" id=\"%E5%88%86%E6%9E%90%E7%9A%84%E7%BB%93%E6%9E%9C\"><\/span><strong><strong>\u5206\u6790\u7684\u7ed3\u679c<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u7ed3\u679c\u7684\u5206\u6790\u9996\u5148\u6536\u96c6\u6bcd\u4f53\u8840\u6d46\u4e2d\u7684\u6240\u6709DNA\u7247\u6bb5,\u5e76\u5236\u5907\u5177\u6709\u7279\u6b8a\u6807\u8bb0\u7684\u57fa\u56e0\u5e93\u3002\u7528NGS\u5bf9\u8be5\u57fa\u56e0\u5e93\u8fdb\u884c\u6d4b\u5e8f (MPS\u65b9\u6cd5) \uff0c\u5e76\u5728\u5206\u6790\u6b65\u9aa4\u4e2d\u9274\u5b9a\u6bcf\u4e2aDNA\u7247\u6bb5\u6765\u6e90\u4e8e\u591a\u5c11\u53f7\u67d3\u8272\u4f53\u3002<\/p>\n\n\n\n<p>\u5c06\u4eceDNA\u7247\u6bb5\u4e2d\u5f97\u5230\u7684\u9057\u4f20\u4fe1\u606f\u5728\u53c2\u8003\u5e8f\u5217\u4e0a\u8fdb\u884c\u6392\u5e8f,\u5c06\u76f8\u5e94\u90e8\u4f4d\u7684\u9057\u4f20\u4fe1\u606f\u591a\u5be1\u4e0e\u4e34\u754c\u503c (\u5224\u65ad21\u53f7\u300118\u53f7\u300113\u53f7\u67d3\u8272\u4f53\u7684\u6b63\u5e38\u548c\u5f02\u5e38\u7684\u57fa\u51c6\u503c) \u8fdb\u884c\u6bd4\u8f83,\u786e\u5b9a\u9633\u6027\u3001\u9634\u6027\u6216\u5224\u5b9a\u4fdd\u7559\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/?lang=zh-hans\">Hiro\u8bca\u6240NIPT<\/a>\u7684\u68c0\u67e5\u6839\u636e\u65b9\u6848\u800c\u6709\u6240\u4e0d\u540c,\u4f46\u7ed3\u679c\u5c06\u4f1a\u57282\u301c6\u5929\u5185\u516c\u5e03\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u662f\u8fd9\u4e9b\u6b65\u9aa4\u7684\u9010\u6b65\u4ecb\u7ecd\u3002<\/p>\n\n\n\n    <a href=\"\/nipt\/nipt\/nipt\/?lang=zh-hans\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u77e5\u7684\u969c\u304c\u3044\u304c\u308f\u304b\u308bNIPT\u3068\u306f\uff08NIPT\u306e\u57fa\u672c\uff09 <\/div>\n          <div class=\"blog-card-excerpt\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u884c\u3063\u3066\u3044\u308bNIPT\u306e\u307e\u3068\u3081\u3067\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u306eNIPT\u3067\u306f\u77e5\u7684\u969c\u5bb3\u30fb\u767a\u9054\u969c\u5bb3\u3092\u4f34\u3046\u591a\u6570\u306e\u75be\u60a3\u3092\u51fa\u751f\u524d\u306b\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"c3-3-1\"><span class=\"ez-toc-section\" id=\"%E6%B5%8B%E5%BA%8F\"><\/span><strong><strong>\u6d4b\u5e8f<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u5982\u4e0a\u6240\u8ff0\uff0c NIPT\u68c0\u67e5\u4f7f\u7528NGS\u5bf9\u6765\u81ea\u80ce\u513f\u7684cfDNA\u8fdb\u884c\u6d4b\u5e8f\u3002\u7531\u4e8e\u6bcd\u4f53\u8840\u6db2\u4e2d\u4e5f\u542b\u6709\u6765\u81ea\u6bcd\u4f53\u7684cfDNA (\u6709\u4e00\u79cd\u8bf4\u6cd5\u8ba4\u4e3a,\u5728\u6000\u5b55\u7b2c10\u5468\u5de6\u53f3\u7684\u6bcd\u4f53\u8840\u6db2\u4e2d,\u7ea610%\u5de6\u53f3\u662f\u6765\u81ea\u80ce\u513f\u7684cfDNA) ,\u56e0\u6b64\u53ef\u4ee5\u5c06\u6765\u81ea\u6bcd\u4f53\u7684cfDNA\u548c\u6765\u81ea\u80ce\u513f\u7684cfDNA\u4e00\u8d77\u8fdb\u884c\u5168\u9762\u6d4b\u5e8f\u3002<\/p>\n\n\n\n<p>\u5177\u4f53\u6765\u8bf4\uff0c\u9996\u5148\u5728\u8bca\u6240\u89c2\u770bNIPT\u7684\u89e3\u8bf4\u89c6\u9891\u3001\u586b\u5199\u95ee\u8bca\u8868\u548c\u540c\u610f\u4e66\u3001\u7531\u533b\u751f\u8fdb\u884c\u8bca\u5bdf\u548c\u62bd\u8840\u3002\u7136\u540e\u5728\u8bca\u6240\u6216\u8ba4\u8bc1\u673a\u6784\u901a\u8fc7\u5206\u79bb\u6cd5\u83b7\u5f97\u6bcd\u4eb2\u7684\u8840\u6d46,\u7136\u540e\u4ece\u6bcd\u4eb2\u7684\u8840\u6d46\u4e2d\u63d0\u53d6cfDNA\u5e76\u901a\u8fc7NGS\u8fdb\u884c\u5168\u9762\u6d4b\u5e8f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"c3-3-2\"><span class=\"ez-toc-section\" id=\"%E9%89%B4%E5%88%AB\"><\/span><strong><strong>\u9274\u522b<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u5728\u8fdb\u884c\u5168\u9762\u6d4b\u5e8f (MPS\u65b9\u6cd5) \u540e\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u8fdb\u884c\u9274\u5b9a\u7684\u6b65\u9aa4\u3002\u5982\u5206\u6790\u65b9\u6cd5\u9879\u76ee\u4e2d\u6240\u8ff0\uff0c\u901a\u8fc7\u5b9a\u91cf\u6d4b\u91cf\u6765\u81ea\u80ce\u513f\u7684cfDNA\u6765\u81ea\u54ea\u6761\u67d3\u8272\u4f53,\u53ef\u4ee5\u68c0\u6d4b21\u300118\u300113\u53f7\u67d3\u8272\u4f53\u4e09\u4f53\u6216\u6027\u67d3\u8272\u4f53 (\u751f\u7269\u5b66\u4e0a,\u7537\u6027\u6709X\u67d3\u8272\u4f53\u548cY\u67d3\u8272\u4f53,\u5973\u6027\u5219\u6709\u4e24\u6761X\u67d3\u8272\u4f53) \u7684\u5f02\u5e38\u3002\u6b64\u5916,\u8fd8\u53ef\u4ee5\u8fdb\u884c\u6027\u522b\u5224\u65ad\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"c3-3-3\"><span class=\"ez-toc-section\" id=\"%E5%88%A4%E5%AE%9A\"><\/span><strong>\u5224\u5b9a<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u5173\u4e8eNIPT\u7684\u5224\u65ad\uff0c\u5982\u8bc6\u522b\u4e2d\u7684\u9879\u76ee\u90e8\u5206\u6240\u793a,\u901a\u8fc7\u5b9a\u91cf\u6d4b\u91cf\u8fdb\u884c\u5224\u65ad\u3002\u7531\u4e8eDNA\u4e0d\u662f\u8089\u773c\u53ef\u89c1\u7684,\u56e0\u6b64\u9700\u8981\u91cf\u5316\u6570\u636e\u548c\u660e\u786e\u7684\u6807\u51c6\u3002<\/p>\n\n\n\n<p>\u5177\u4f53\u800c\u8a00\uff0c\u901a\u8fc7\u5c06\u6765\u81eaNGS\u7684\u6570\u636e\u4e0e\u4e34\u754c\u503c\u8fdb\u884c\u6bd4\u8f83\u6765\u5224\u65ad\u3002\u4e34\u754c\u503c\u7b80\u800c\u8a00\u4e4b\u5c31\u662f\u57fa\u51c6\u503c\u3002\u901a\u8fc7\u786e\u5b9a\u7279\u5b9a\u6570\u503c\u4f5c\u4e3a\u53c2\u8003\u503c\uff0c\u53ef\u4ee5\u786e\u5b9a\u7ed3\u679c\u4e2d\u51fa\u73b0\u7684\u6570\u503c\u8ddd\u79bb\u8be5\u6570\u503c\u6709\u591a\u8fdc\u3002<\/p>\n\n\n\n<p>\u4f8b\u5982\uff0c\u5f53\u5065\u5eb7\u68c0\u67e5\u62a5\u544a\u7ed3\u679c\u65f6,\u300c\u6807\u51c6\u503c\u300d \u8bb0\u5f55\u4e3a\u8303\u56f4,\u5982\u679c\u8d85\u51fa\u8303\u56f4,\u5219\u5224\u65ad\u4e3a \u300c\u5f85\u68c0\u67e5\u300d \u3002\u540c\u6837\uff0c NIPT\u68c0\u67e5\u4e5f\u8bbe\u5b9a\u57fa\u51c6\u503c (\u4e34\u754c\u503c) ,\u4e0e\u6b64\u5bf9\u7167\u8fdb\u884c\u5224\u5b9a\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"\/nipt\/wp-content\/uploads\/2022\/12\/principles-of-nipt01.jpg\" alt=\"NIPT(\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad)\u306e\u691c\u67fb\u306e\u4ed5\u7d44\u307f\" class=\"wp-image-48145\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\" id=\"c4\"><span class=\"ez-toc-section\" id=\"NIPT_%E6%96%B0%E5%9E%8B%E4%BA%A7%E5%89%8D%E8%AF%8A%E6%96%AD_%E7%9A%84%E6%B3%A8%E6%84%8F%E4%BA%8B%E9%A1%B9\"><\/span><strong><strong>NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u6ce8\u610f\u4e8b\u9879<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/?lang=zh-hans\">NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad)<\/a>\u662f\u4e00\u79cd\u975e\u786e\u5b9a\u6027\u7684\u68c0\u67e5,\u7528\u4e8e\u5728\u4ea7\u524d\u786e\u5b9a\u80ce\u513f\u662f\u5426\u67d3\u8272\u4f53\u5f02\u5e38,\u5e76\u5224\u65ad\u5f02\u5e38\u7684\u6982\u7387\u662f\u9ad8\u8fd8\u662f\u4f4e (\u5305\u62ec\u6bcd\u4f53\u8840\u6e05\u6807\u5fd7\u7269) \u3002\u56e0\u6b64\uff0c\u6839\u636eNIPT\u7684\u7ed3\u679c\uff0c\u5982\u679c\u5224\u5b9a\u81ea\u5df1\u7684\u80ce\u513f\u6709\u67d3\u8272\u4f53\u5f02\u5e38\u7684\u53ef\u80fd\u6027\u9ad8\u7684\u8bdd\uff0c\u8fdb\u884c\u786e\u5b9a\u6027\u8bca\u65ad\u662f\u5f88\u91cd\u8981\u7684\u3002\u660e\u786e\u8bca\u65ad\u9700\u8981\u8fdb\u884c\u786e\u5b9a\u578b\u68c0\u67e5 (\u5982\u7f8a\u6c34\u68c0\u67e5\u548c\u7ed2\u6bdb\u68c0\u67e5) \u3002\u4ee5\u4e0b\u662f\u5176\u4ed6NIPT\u7684\u6ce8\u610f\u4e8b\u9879\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c4-1\"><span class=\"ez-toc-section\" id=\"%E8%83%8E%E7%9B%98%E5%B5%8C%E5%90%88%E4%BD%93_CPM\"><\/span><strong><strong>\u80ce\u76d8\u5d4c\u5408\u4f53 (CPM)<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c NIPT\u6240\u4f7f\u7528\u7684\u6bcd\u4f53\u8840\u6d46\u4e2d\u542b\u6709\u7684\u80ce\u513fcfDNA\u5927\u90e8\u5206\u6e90\u81ea\u80ce\u76d8,\u56e0\u6b64\u5e76\u4e0d\u662f\u53ea\u68c0\u6d4b\u80ce\u513f\u7684cfDNA\u3002\u56e0\u6b64\uff0c\u5f53\u80ce\u513f\u548c\u80ce\u76d8\u7684\u67d3\u8272\u4f53\u6838\u578b\u4e0d\u540c (\u79f0\u4e3a\u80ce\u76d8\u5d4c\u5408\u4f53 (CPM) ) \u65f6,\u68c0\u67e5\u7ed3\u679c\u65e0\u6cd5\u6b63\u786e\u53cd\u6620\u80ce\u513f\u7684\u67d3\u8272\u4f53\u4fe1\u606f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c4-2\"><span class=\"ez-toc-section\" id=\"%E6%B6%88%E5%A4%B1%E7%9A%84%E5%8F%8C%E8%83%9E%E8%83%8E\"><\/span><strong><strong>\u6d88\u5931\u7684\u53cc\u80de\u80ce<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u521d\u59cb\u9636\u6bb5\u4ee5\u53cc\u80de\u80ce (twins) \u5f62\u5f0f\u53d7\u5b55,\u5728\u6000\u5b55\u65e9\u671f,\u5176\u4e2d\u4e00\u4e2a\u80ce\u513f\u6b7b\u4ea1,\u5e76\u5728\u5b50\u5bab\u5185\u88ab\u5438\u6536,\u8fd9\u4e00\u73b0\u8c61\u88ab\u79f0\u4e3a\u6d88\u5931\u7684\u53cc\u80de\u80ce\u3002\u662f\u5728\u5b50\u5bab\u5185\u901a\u8fc7\u8d85\u58f0\u6ce2\u68c0\u67e5\u7b49\u4e5f\u770b\u4e0d\u5230\u7684\u72b6\u6001 (\u6d88\u5931) \u3002\u5373\u4f7f\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u4e5f\u5b58\u5728\u68c0\u6d4b\u51fa\u6b7b\u4ea1\u80ce\u513f\u7684DNA\u7b49\u5f71\u54cdNIPT\u7ed3\u679c\u7684\u53ef\u80fd\u6027\u3002<\/p>\n\n\n\n    <a href=\"\/nipt\/vanishing-twins\/?lang=zh-hans\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u30d0\u30cb\u30b7\u30f3\u30b0\u30c4\u30a4\u30f3\u3063\u3066\u306a\u306b\uff1f\u53cc\u5b50\u306e\u598a\u5a20\u3067\u77e5\u3063\u3066\u304a\u304d\u305f\u3044\u3053\u3068\u3010\u533b\u5e2b\u76e3\u4fee\u3011 <\/div>\n          <div class=\"blog-card-excerpt\">\u53cc\u5b50\u306e\u7247\u65b9\u304c\u6d88\u3048\u305f\u3088\u3046\u306b\u898b\u3048\u308b\u300c\u30d0\u30cb\u30b7\u30f3\u30b0\u30c4\u30a4\u30f3\u300d\u3002\u53cc\u5b50\u306e\u598a\u5a20\u3067\u306f\u73cd\u3057\u304f\u306a\u3044\u73fe\u8c61\u3067\u3059\u304c\u3001\u7a81\u7136\u544a\u3052\u3089\u308c\u308b\u3068\u30b7\u30e7\u30c3\u30af\u3092\u53d7\u3051\u308b\u3053\u3068\u3067\u3057\u3087\u3046\u3002\u30d0\u30cb\u30b7...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c4-3\"><span class=\"ez-toc-section\" id=\"%E5%88%A4%E5%AE%9A%E7%BB%93%E6%9E%9C%E4%B8%BA_%E3%80%8C%E5%81%87%E9%98%B3%E6%80%A7%E3%80%8D_%E3%80%8C%E5%81%87%E9%98%B4%E6%80%A7%E3%80%8D_%E3%80%8C%E5%86%8D%E6%AC%A1%E6%A3%80%E6%9F%A5_%E5%BE%85%E5%88%A4%E5%AE%9A_%E3%80%8D_%E6%97%B6\"><\/span><strong><strong>\u5224\u5b9a\u7ed3\u679c\u4e3a \u300c\u5047\u9633\u6027\u300d \u300c\u5047\u9634\u6027\u300d \u300c\u518d\u6b21\u68c0\u67e5 (\u5f85\u5224\u5b9a) \u300d \u65f6<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u57fa\u672c\u4e0a\uff0c\u68c0\u6d4b\u7ed3\u679c\u62a5\u544a\u4e3a\u300c\u9633\u6027\u300d \u6216\u662f \u300c\u9634\u6027\u300d ,\u4f46\u4e5f\u4e0d\u80fd\u5b8c\u5168\u6392\u9664\u662f \u300c\u5047\u9633\u6027\u300d \u3001 \u300c\u5047\u9634\u6027\u300d \u6216\u662f \u300c\u91cd\u65b0\u68c0\u67e5 (\u5f85\u5224\u5b9a) \u300d \u7684\u53ef\u80fd\u6027\u3002<\/p>\n\n\n\n<p>\u300c\u5047\u9633\u6027\u300d \u662f\u6307\u80ce\u513f\u5b9e\u9645\u4e0a\u662f\u5065\u5eb7\u7684\u5374\u88ab\u5224\u5b9a\u4e3a\u9633\u6027, \u300c\u5047\u9634\u6027\u300d \u662f\u6307\u80ce\u513f\u5b9e\u9645\u4e0a\u6709\u67d3\u8272\u4f53\u5f02\u5e38\u5374\u88ab\u5224\u5b9a\u4e3a\u9634\u6027\u3002<\/p>\n\n\n\n<p>\u8fd9\u4e9b\u62a5\u544a\u7ed3\u679c\u7684\u539f\u56e0\u6709\u5f88\u591a,\u4f46\u5927\u81f4\u5206\u4e3a\u6bcd\u4eb2\u6216\u80ce\u513f\u7684\u751f\u7269\u5b66\u539f\u56e0,\u4ee5\u53ca\u4e0a\u8ff0\u80ce\u76d8\u5d4c\u5408\u4f53 (CPM) \u3002\u5982\u679c\u6bcd\u4f53\u6216\u80ce\u513f\u5b58\u5728\u751f\u7269\u56e0\u7d20,\u53ef\u80fd\u5305\u62ec\u6d88\u5931\u7684\u53cc\u80de\u80ce\u7684\u5f71\u54cd\u3001\u6bcd\u4f53\u9690\u6027\u67d3\u8272\u4f53\u5f02\u5e38 (\u65e0\u75c7\u72b6) \u548c\u6bcd\u4f53\u4e34\u5e8a\u75c7\u72b6\u7684\u5f71\u54cd (\u5982\u5b58\u5728\u80bf\u7624\u3001\u836f\u7269\u3001\u81ea\u4f53\u514d\u75ab\u75be\u75c5\u3001\u5668\u5b98\u6216\u9aa8\u9ad3\u79fb\u690d) \u3002\u9664\u6b64\u4e4b\u5916\uff0c\u8fd8\u53ef\u4ee5\u5217\u4e3e\u7531\u4e8e\u68c0\u67e5\u7684\u754c\u9650\u5bfc\u81f4\u7684\u8bef\u5dee\u7b49\u3002<\/p>\n\n\n\n<p>\u76ee\u524d\uff0c\u4ece\u56fd\u5185\u7814\u7a76\u7ed3\u679c\u6765\u770b\uff0c\u8fd9\u4e9b\u7ed3\u679c\u7684\u6bd4\u4f8b\u4f30\u8ba1\u7ea6\u4e3a0.1%~0.3%\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"c5\"><span class=\"ez-toc-section\" id=\"%E6%80%BB%E7%BB%93\"><\/span><strong><strong>\u603b\u7ed3<\/strong><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/?lang=zh-hans\">NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad)<\/a>&nbsp;\u662f\u4e00\u79cd\u4ea7\u524d\u8bca\u65ad,\u53ef\u5728\u6000\u5b55\u65e9\u671f\u8fdb\u884c,\u662f\u7b80\u5355\u3001\u5fae\u521b\u548c\u51c6\u786e\u6027\u9ad8\u7684\u68c0\u67e5\u3002\u53e6\u5916\uff0c\u7531\u4e8e\u91c7\u7528\u4e86\u6700\u5148\u8fdb\u7684\u6280\u672f\uff0c\u4eca\u540e\u8fd8\u6709\u671b\u66f4\u8fdb\u4e00\u6b65\u63d0\u9ad8\u7cbe\u5ea6\uff0c\u80fd\u591f\u4ee5\u66f4\u5c11\u7684\u68c0\u6837\u91cf\u8fdb\u884c\u68c0\u67e5\u7b49\u8fdb\u4e00\u6b65\u7684\u6539\u5584\u3002<\/p>\n\n\n\n<p>\u5bf9\u4e8e\u7236\u6bcd\u6765\u8bf4\uff0c\u5bf9\u4e8e\u5373\u5c06\u51fa\u751f\u7684\u5b69\u5b50\u662f\u5426\u6709\u67d3\u8272\u4f53\u5f02\u5e38,\u4e3a\u4e86\u6d88\u9664\u5176\u4e0d\u5b89,\u53ef\u4ee5\u8ba4\u4e3a\u662f\u6709\u4ef7\u503c\u7684\u68c0\u67e5\u3002\u4f46\u662f\uff0c NIPT\u4ec5\u5b9a\u4f4d\u4e8e\u975e\u786e\u5b9a\u6027\u68c0\u67e5 (\u7b5b\u9009\u68c0\u67e5) \uff0c\u9700\u8981\u8003\u8651\u6839\u636e\u7ed3\u679c\u8fdb\u884c\u4fb5\u5165\u6027\u5f3a\u7684\u786e\u5b9a\u6027\u68c0\u67e5\uff0c\u5e76\u4e14\u9700\u8981\u6ce8\u610f\u4e00\u4e9b\u4e8b\u9879\u3002\u56e0\u6b64\uff0c\u662f\u5426\u63a5\u53d7\u68c0\u67e5\u8981\u5728\u4e0e\u533b\u751f\u548c\u5fc3\u7406\u54a8\u8be2\u5e08\u7b49\u533b\u7597\u4eba\u5458\u5145\u5206\u5546\u91cf\u540e\u51b3\u5b9a,\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002<\/p>\n\n\n\n<div class=\"wp-block-group references\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p>\u3010\u53c2\u8003\u6587\u732e\u3011<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u539a\u751f\u52b3\u52a8\u7701 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/www.mhlw.go.jp\/content\/11908000\/000559098.pdf\" data-type=\"URL\" data-id=\"https:\/\/www.mhlw.go.jp\/content\/11908000\/000559098.pdf\" target=\"_blank\">NIPT: noninvasive prenatal testing \u65e0\u521b\u4ea7\u524d\u9057\u4f20\u5b66\u68c0\u67e5<\/a><\/li>\n\n\n\n<li>ACOG &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/www.acog.org\/advocacy\/policy-priorities\/non-invasive-prenatal-testing\" data-type=\"URL\" data-id=\"https:\/\/www.acog.org\/advocacy\/policy-priorities\/non-invasive-prenatal-testing\" target=\"_blank\">Non-Invasive Prenatal Testing<\/a><\/li>\n\n\n\n<li>ACOG &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/www.acog.org\/advocacy\/policy-priorities\/non-invasive-prenatal-testing\/current-acog-guidance\" data-type=\"URL\" data-id=\"https:\/\/www.acog.org\/advocacy\/policy-priorities\/non-invasive-prenatal-testing\/current-acog-guidance\" target=\"_blank\">Current ACOG Guidance<\/a><\/li>\n\n\n\n<li>ACOG &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/www.acog.org\/womens-health\/faqs\/prenatal-genetic-screening-tests\" data-type=\"URL\" data-id=\"https:\/\/www.acog.org\/womens-health\/faqs\/prenatal-genetic-screening-tests\" target=\"_blank\">Prenatal Genetic Screening Tests<\/a><\/li>\n\n\n\n<li>\u65e5\u672c\u533b\u5b66\u4f1a &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/jams.med.or.jp\/news\/061_2_2.pdf\" data-type=\"URL\" data-id=\"https:\/\/jams.med.or.jp\/news\/061_2_2.pdf\" target=\"_blank\">NIPT\u7b49\u6709\u5173\u4ea7\u524d\u68c0\u67e5\u7684\u4fe1\u606f\u63d0\u4f9b\u53ca\u8bbe\u65bd (\u533b\u7597\u673a\u6784\u30fb\u68c0\u67e5\u5206\u6790\u673a\u6784) \u8ba4\u8bc1\u7684\u65b9\u9488<\/a><\/li>\n\n\n\n<li>\u65e5\u672c\u533b\u5b66\u4f1a &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/jams.med.or.jp\/news\/061_nipt_setumei_sassi.pdf\" data-type=\"URL\" data-id=\"https:\/\/jams.med.or.jp\/news\/061_nipt_setumei_sassi.pdf\" target=\"_blank\">\u975e\u4fb5\u5165\u6027\u4ea7\u524d\u9057\u4f20\u5b66\u68c0\u67e5&nbsp; \u624b\u518c<\/a><\/li>\n\n\n\n<li>\u65e5\u672c\u533b\u5b66\u4f1a &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/jams.med.or.jp\/news\/061_nipt_setumei_a4.pdf\" data-type=\"URL\" data-id=\"https:\/\/jams.med.or.jp\/news\/061_nipt_setumei_a4.pdf\" target=\"_blank\">\u975e\u4fb5\u5165\u6027\u4ea7\u524d\u9057\u4f20\u5b66\u68c0\u67e5<\/a><\/li>\n\n\n\n<li>J-STAGE &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/www.jstage.jst.go.jp\/article\/jjsca\/38\/4\/38_538\/_pdf\/-char\/ja\" data-type=\"URL\" data-id=\"https:\/\/www.jstage.jst.go.jp\/article\/jjsca\/38\/4\/38_538\/_pdf\/-char\/ja\" target=\"_blank\">\u80ce\u513f\u751f\u7406\u5b66&nbsp; \u65e5\u4e34\u9ebb\u4f1a\u520a Vol.38 No.4, 538 \u301c 541, 2018<\/a><\/li>\n\n\n\n<li>\u5175\u5e93\u533b\u79d1\u5927\u5b66\u533b\u9662\u5987\u4ea7\u79d1 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/www.prenatal-diagnosis.org\/%E6%A4%9C%E6%9F%BB%E6%96%B9%E6%B3%95%E3%81%AE%E9%81%B8%E6%8A%9E\/%E7%B5%A8%E6%AF%9B%E6%A4%9C%E6%9F%BB\/\" data-type=\"URL\" data-id=\"https:\/\/www.prenatal-diagnosis.org\/%E6%A4%9C%E6%9F%BB%E6%96%B9%E6%B3%95%E3%81%AE%E9%81%B8%E6%8A%9E\/%E7%B5%A8%E6%AF%9B%E6%A4%9C%E6%9F%BB\/\" target=\"_blank\">\u4ea7\u524d\u8bca\u65ad\u6307\u5357<\/a><\/li>\n\n\n\n<li>ACOG &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/www.genetech.co.jp\/academic_information\/article20200315\/\" data-type=\"URL\" data-id=\"https:\/\/www.genetech.co.jp\/academic_information\/article20200315\/\" target=\"_blank\">\u4eceNIPT\u7684\u57fa\u7840\u5230\u672a\u6765\u7684\u5c55\u671b<\/a><\/li>\n\n\n\n<li>Illumina &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/jp.illumina.com\/science\/technology\/next-generation-sequencing\/ngs-vs-sanger-sequencing.html\" data-type=\"URL\" data-id=\"https:\/\/jp.illumina.com\/science\/technology\/next-generation-sequencing\/ngs-vs-sanger-sequencing.html\" target=\"_blank\">NGS\u548c\u73ca\u683c\u5e8f\u5217\u7684\u533a\u522b<\/a><\/li>\n\n\n\n<li>Illumina &#8211;<a rel=\"noreferrer noopener\" href=\"https:\/\/jp.illumina.com\/content\/dam\/illumina-marketing\/documents\/products\/other\/infographic-targeted-ngs-vs-sanger-qpcr.pdf\" data-type=\"URL\" data-id=\"https:\/\/jp.illumina.com\/content\/dam\/illumina-marketing\/documents\/products\/other\/infographic-targeted-ngs-vs-sanger-qpcr.pdf\" target=\"_blank\">Targeted next-generation sequencing versus qPCR and Sanger sequencing<\/a><\/li>\n\n\n\n<li>Thermo Fisher Scientific &#8211; <a href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/start-microarray\/\" data-type=\"URL\" data-id=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/start-microarray\/\">\u4ec0\u4e48\u662f\u5fae\u9635\u5217?|\u4f7f\u7528\u5fae\u9635\u5217\u8fdb\u884c\u8868\u8fbe\u5206\u6790\u7684\u539f\u7406\u548c\u5206\u6790\u65b9\u6cd5<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"\u7b80\u4ecb NIPT (\u65b0\u578b\u4ea7\u524d\u8bca\u65ad) \u7684\u539f\u7406&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/principles-of-nipt\/?lang=zh-hans\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":13,"featured_media":48140,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-49230","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/49230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=49230"}],"version-history":[{"count":18,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/49230\/revisions"}],"predecessor-version":[{"id":83124,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/49230\/revisions\/83124"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/48140"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=49230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=49230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=49230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}