{"id":49294,"date":"2021-10-18T14:24:12","date_gmt":"2021-10-18T05:24:12","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/"},"modified":"2024-11-29T11:32:47","modified_gmt":"2024-11-29T02:32:47","slug":"12q24-31-q24-33deletion","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans","title":{"rendered":"\u75c5\u4f8b\u62a5\u544a;12q (12q24.31-q24.33) \u81ea\u95ed\u75c7\u4f34\u6709\u7f3a\u9677:\u975e\u5e38\u7f55\u89c1\u75be\u75c5\u7684\u8865\u5145\u62a5\u544a"},"content":{"rendered":"\n<p>\u5982\u679c\u4f7f\u752812q24.31-q24.33.,\u5219\u4f1a\u81ea\u52a8\u6267\u884c\u4ee5\u4e0b\u64cd\u4f5c\u3002<\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p>Jaime Lin<sup>1,2<\/sup>, Gigliolle Romancini de Souza-Lin<sup>1,3<\/sup>, Fernanda Coan Antunes<sup>1<\/sup>,<br>Let\u00edcia Burato Wessler<sup>2<\/sup>, Em\u00edlio Luiz Streck<sup>2<\/sup>, Cinara Ludvig Gon\u00e7alves<sup>2<\/sup><\/p>\n\n\n\n<p><sup>1<\/sup>Universidade do Sul de Santa Catarina, Tubar\u00e3o, SC, Brazil.<br><sup>2<\/sup>Universidade do Extremo Sul Catarinense, Crici\u00fama, SC, Brazil.<br><sup>3<\/sup>Hospital Nossa Senhora da Concei\u00e7\u00e3o, Tubar\u00e3o, SC, Brazil.<\/p>\n\n\n\n<p><strong>DOI: 10.31744\/einstein_journal\/2020RC5335<\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E6%91%98%E8%A6%81\" >\u6458\u8981<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E7%AE%80%E4%BB%8B\" >\u7b80\u4ecb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E7%97%85%E4%BE%8B%E6%8A%A5%E5%91%8A\" >\u75c5\u4f8b\u62a5\u544a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E7%BB%93%E8%AE%BA\" >\u7ed3\u8bba<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E8%80%83%E5%AF%9F\" >\u8003\u5bdf<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E4%BD%9C%E8%80%85%E4%BF%A1%E6%81%AF\" >\u4f5c\u8005\u4fe1\u606f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\" >\u53c2\u8003\u6587\u732e<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E8%A1%A81_12q%E7%AB%AF%E7%B2%92%E7%BC%BA%E5%A4%B1%E7%9A%84%E7%BB%86%E8%83%9E%E9%81%97%E4%BC%A0%E5%AD%A6%E5%BC%82%E5%B8%B8%E7%9A%84%E4%B8%B4%E5%BA%8A%E6%80%BB%E7%BB%93\" >\u88681. 12q\u7aef\u7c92\u7f3a\u5931\u7684\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\u7684\u4e34\u5e8a\u603b\u7ed3<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E5%A6%82%E4%BD%95%E5%BC%95%E7%94%A8%E8%BF%99%E7%AF%87%E6%96%87%E7%AB%A0\" >\u5982\u4f55\u5f15\u7528\u8fd9\u7bc7\u6587\u7ae0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E4%B8%BB%E8%A6%81%E4%BD%9C%E8%80%85\" >\u4e3b\u8981\u4f5c\u8005:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E6%8E%A5%E6%94%B6%E6%97%A5%E6%9C%9F\" >\u63a5\u6536\u65e5\u671f:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E5%8F%97%E7%90%86\" >\u53d7\u7406:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\/#%E7%89%88%E6%9D%832020\" >\u7248\u67432020<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%91%98%E8%A6%81\"><\/span><strong>\u6458\u8981<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u67d3\u8272\u4f53\u5f02\u5e38<\/a>\u5728\u4e16\u754c\u4e0a\u5f15\u8d77\u4e86\u591a\u79cd\u5148\u5929\u6027\u7578\u5f62\u7684\u539f\u56e0,\u5176\u4e2d\u4e00\u4e9b\u4e0e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7ec8\u672b\u7aef\u7c92\/\u6b21\u7ec8\u672b\u7aef\u7c92\u7684\u7f3a\u5931<\/a>\u6709\u5173\u3002\u5728\u6587\u732e\u4e2d\u5f88\u5c11\u62a5\u9053\u6d89\u53ca<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">12\u53f7\u67d3\u8272\u4f53\u7aef\u7c92\u7684\u5f02\u5e38<\/a>\u5e76\u4e14\u6d89\u53ca12q24.31\u533a\u57df\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7f3a\u5931<\/a>,\u636e\u6211\u4eec\u6240\u77e5,12q24.31-q24.33\u533a\u57df\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7f3a\u5931<\/a>\u4ec5\u4e3a4\u4f8b\u3002\u672c\u7814\u7a76\u5c06\u8fdb\u4e00\u6b65\u62a5\u905312q24.31-q24.33\u6761\u5e26\u95f4\u8d28\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7f3a\u5931<\/a>\u4f34\u6709\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u75c5\u4f8b\u3002\u4e00\u540d2\u5c81\u7537\u5b69\u60a3\u6709\u5168\u9762\u53d1\u80b2\u8fdf\u7f13\uff0c\u4e26\u4f34\u6709\u591a\u79cd\u51fa\u751f\u7f3a\u9677\u3002\u4eba\u7c7b\u57fa\u56e0\u7ec4CGH\u5fae\u9635\u521760K\u8bca\u65ad\u4e3a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">12q\u7f3a\u5931\u7efc\u5408\u75c7<\/a>\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u56de\u987e\u4e86\u6211\u4eec\u7684\u60a3\u8005\u4e0e\u5148\u524d\u62a5\u9053\u7684\u75c5\u4f8b\u7684\u6700\u65b0\u6587\u732e\u3002\u8fd9\u4e9b\u6df1\u5165\u7684\u5206\u6790\u6709\u52a9\u4e8e\u5efa\u7acb<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">12q\u7f3a\u5931<\/a>\u7684\u57fa\u56e0\u578b\u548c\u8868\u578b\u7684\u76f8\u5173\u5173\u7cfb\uff0c\u6709\u52a9\u4e8e\u8be5<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7f3a\u5931<\/a>\u7684\u8bca\u65ad\u548c\u6539\u5584\u9884\u540e\u3002<\/p>\n\n\n\n<p><strong><strong>\u5173\u952e\u8bcd:<\/strong><\/strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u67d3\u8272\u4f53\u5f02\u5e38<\/a>\u3001\u795e\u7ecf\u7cfb\u7edf\u7578\u5f62\u3001\u53d1\u80b2\u969c\u788d\u3001\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u300112q24.31<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7f3a\u5931\u7efc\u5408\u75c7<\/a><\/p>\n<\/div><\/div>\n\n\n\n    <a href=\"\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u90e8\u5206\u6b20\u5931\u91cd\u8907\u306e\u691c\u67fb <\/div>\n          <div class=\"blog-card-excerpt\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u59d4\u8a17\u3059\u308b\u6771\u4eac\u885b\u751f\u691c\u67fb\u6240\u3067\u3001\u90e8\u5206\u6b20\u5931\u30fb\u91cd\u8907\u75be\u60a3\u3082\u691c\u67fb\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3053\u3068\u306b\u4f34\u3044\u3001\u598a\u5a20\u304c\u5224\u660e\u3057\u305f\u65e9\u671f\u6bb5\u968e\u304b\u3089\u5168\u67d3\u8272\u4f53\u306e\u90e8...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%AE%80%E4%BB%8B\"><\/span><strong>\u7b80\u4ecb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u7531\u4e8e\u83b7\u5f97\u6216\u8005<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7f3a\u5931<\/a>\u5927\u578b\u57fa\u56e0\u7ec4\u533a\u57df\u5bfc\u81f4\u7684\u57fa\u56e0\u8d28\u91cf\u53d8\u5316\u662f\u8bb8\u591a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u9057\u4f20\u75be\u75c5<\/a>\u7684\u539f\u56e0\u3002\u901a\u5e38\u6d89\u53ca\u8868\u578b\uff0c\u4f8b\u5982\u667a\u529b\u969c\u788d\uff0c\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff0c\u667a\u529b\u969c\u788d\uff0c\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d (ASD)<sup><a href=\"#reference01\">(1)<\/a><\/sup>\u3002<br>\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u662f\u6307\u4e00\u7cfb\u5217\u795e\u7ecf\u53d1\u80b2\u969c\u788d,\u5176\u7279\u5f81\u5728\u4e8e\u7f3a\u4e4f\u793e\u4ea4\u884c\u4e3a\u548c\u975e\u8a00\u8bed\u76f8\u4e92\u4f5c\u7528,\u5982\u4e0b\u6240\u793a (\u51fa\u751f\u540e3\u5e74\u5185) \u3002\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\uff0c\u8fd9\u4e0d\u662f\u4e00\u79cd\u5355\u4e00\u7684\u75be\u75c5\uff0c\u800c\u662f\u4e00\u79cd\u591a\u56e0\u7d20\u75be\u75c5\uff0c\u5176\u7531\u9057\u4f20\u548c\u975e\u9057\u4f20\u5371\u9669\u56e0\u7d20\u4ee5\u53ca\u8fd9\u4e9b\u56e0\u7d20\u7684\u76f8\u4e92\u4f5c\u7528\u5f15\u8d77\u3002ASD\u662f\u4e00\u79cd\u975e\u5e38\u590d\u6742\u548c\u5f02\u8d28\u6027\u7684\u75be\u75c5\uff0c\u4f46\u5374\u662f\u4e00\u79cd<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u9057\u4f20\u6027\u75be\u75c5<\/a><sup><a href=\"#reference01\">(1)<\/a><\/sup>\u3002<br>\u5728\u68c0\u6d4bASD\u6613\u611f\u57fa\u56e0\u7684\u6280\u672f\u4e2d\uff0c\u6bd4\u8f83\u57fa\u56e0\u7ec4\u6df7\u5408 (CGH) \u6280\u672f\u88ab\u5e7f\u6cdb\u7528\u4e8eASD\u7684\u7814\u7a76\u548c\u4e34\u5e8a\u5b9e\u8df5,\u4ee5\u68c0\u6d4b\u57fa\u56e0\u7ec4\u4e0a\u7684\u590d\u5236\u7a81\u53d8 (CNV) \u3002\u590d\u5236\u53f7\u7801\u53d8\u4f53\u662f\u9057\u4f20\u591a\u6837\u6027\u7684\u91cd\u8981\u6765\u6e90\uff0c\u5e76\u5bfc\u81f4\u4e00\u4e9b\u795e\u7ecf\u884c\u4e3a\u8868\u578b\u7684\u75be\u75c5\u6613\u611f\u6027<sup><a href=\"#reference02\">(2)<\/a><\/sup>\u3002<br>\u4e00\u4e9b\u5bfc\u81f4\u5148\u5929\u6027\u7578\u5f62\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u57fa\u56e0\u5f02\u5e38<\/a>\u4e0e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7aef\u7c92\u6216\u4e9a\u7aef\u7c92\u7f3a\u5931<\/a>\u6709\u5173\u3002\u5176\u4e2d<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">12q\u67d3\u8272\u4f53\u7aef\u7c92\u4f53\/\u4e9a\u7aef\u7c92\u4f53\u7f3a\u5931<\/a>\u8f83\u4e3a\u7f55\u89c1,\u8fc4\u4eca\u4e3a\u6b62\u4ec5\u6709\u5c11\u6570\u60a3\u8005\u51fa\u73b0\u8eab\u6750\u77ee\u5c0f\u7684\u75c5\u4f8b\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u67d3\u8272\u4f5312q\u7684\u7aef\u7c92\/\u4e9a\u7aef\u7c92\u7f3a\u5931<\/a>\u975e\u5e38\u7f55\u89c1,\u76ee\u524d\u4ec5\u6709\u51e0\u4f8b\u60a3\u8005\u5448\u5c0f\u6761\u5e2612q24.31-q24.33\u95f4\u8d28\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7f3a\u5931<\/a>,\u65e0\u5176\u4ed6\u6838\u578b\u5f02\u5e38\u3002<sup><a href=\"#reference03\">(3-6)<\/a><\/sup><br>\u672c\u7814\u7a76\u901a\u8fc7\u62a5\u544a\u5177\u670912q24.31-q24.33\u6761\u5e26\u95f4\u8d28<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7f3a\u5931<\/a>\u5e76\u5c06\u5176\u4e0e\u5148\u524d\u62a5\u9053\u7684\u5305\u62ec12q24.31\u533a\u57df\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7f3a\u5931<\/a>\u7684\u4e00\u4e9b\u5176\u4ed6\u75c5\u4f8b\u8fdb\u884c\u6bd4\u8f83\u6765\u56de\u987e\u6700\u65b0\u6587\u732e\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%97%85%E4%BE%8B%E6%8A%A5%E5%91%8A\"><\/span><strong>\u75c5\u4f8b\u62a5\u544a<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u4e00\u540d2\u5c81\u7537\u5b69\u56e0\u4e0e\u591a\u53d1\u6027\u5148\u5929\u5f02\u5e38\u76f8\u5173\u7684\u5168\u9762\u53d1\u80b2\u5ef6\u8fdf\u800c\u63a5\u53d7\u4e86\u513f\u7ae5\u795e\u7ecf\u7cfb\u7edf\u68c0\u67e5\u3002<br>\u60a3\u8005\u51fa\u751f\u4e8e\u5065\u5eb7\u4eb2\u5c5e\u7684\u7b2c\u4e00\u6b21\u6000\u5b55 (\u5176\u7236\u6bcd\u662f\u7b2c\u4e00\u4e2a\u8868\u4eb2) \u3002\u6000\u5b55\u65f6\uff0c\u6bcd\u4eb224\u5c81\uff0c\u7236\u4eb236\u5c81\u3002\u65e2\u5f80\u65e0\u6d41\u4ea7\u53f2\uff0c\u65e0\u5904\u65b9\u836f\u6216\u975e\u5904\u65b9\u836f\u4f7f\u7528\u62a5\u544a,\u6000\u5b55\u671f\u95f4\u672a\u63a5\u89e6\u8fc7\u81f4\u7578\u7269\u8d28\u3002<br>\u6000\u5b555\u4e2a\u6708\u65f6\u901a\u8fc7\u8d85\u58f0\u6ce2\u68c0\u67e5\u5408\u5e76\u5fc3\u5ba4\u6269\u5927\u3002\u5728\u6000\u5b557\u4e2a\u6708\u65f6\u65e9\u4ea7\u5e76\u5256\u8179\u4ea7\u3002\u51fa\u751f\u65f6\u4f53\u91cd1,720g (&lt;3 centile) \uff0c\u8eab\u9ad839cm (&lt;3 centile) \uff0c\u6795\u524d\u989d\u5468\u957f (OFC) 31cm (&lt;3 centile) \u3002<br>\u60a3\u8005\u5728\u5a74\u513f\u521d\u671f\u4f4f\u96624\u6b21 (\u7531\u4e8e\u80ba\u90e8\u611f\u67d32\u6b21,\u624b\u672f\u5207\u9664\u5de6\u811a\u591a\u4f59\u811a\u8dbe\u548c\u9690\u777e6\u4e2a\u67081\u6b21,\u56e0\u8111\u79ef\u6c348\u4e2a\u6708\u8111\u5ba4\u8179\u819c\u5206\u6d41\u624b\u672f\u6700\u540e\u4e00\u6b21) \u3002<br>\u65e9\u671f\u7684\u53d1\u80b2\u91cc\u7a0b\u7891\u51fa\u73b0\u5168\u9762\u7684\u5ef6\u8fdf\u3002\u5728\u4ed6\u51fa\u751f\u540e12\u4e2a\u6708\u53ef\u4ee5\u505a\u9888\u56fa\u5b9a,16\u4e2a\u6708\u53ef\u4ee5\u5750\u7acb\u3002<br>\u81f3\u4eca24\u4e2a\u6708,\u60a3\u8005\u53d1\u80b2\u4e0d\u5168,\u4f53\u91cd10.6kg (5\u767e\u5206\u6bd4\u6570) ,\u8eab\u9ad878cm (\u5c0f\u4e8e5\u767e\u5206\u6bd4\u6570) ,\u6795\u524d\u5468\u957f48cm (50\u767e\u5206\u6bd4\u6570) \u3002\u8eab\u4f53\u7279\u5f81\u4e3b\u8981\u8868\u73b0\u4e3a\u524d\u56df\u95e8\u8f83\u5927\uff0c\u9762\u90e8\u5916\u89c2\u7565\u663e\u7c97\u7cd9\u3002\u9f3b\u5b50\u8f83\u77ed,\u9f3b\u5b54\u524d\u503e,\u4eba\u4e2d\u5149\u6ed1(<strong>\u56fe1-A<\/strong>)\u3002 \u8033\u6735\u5904\u4e8e\u6b63\u5e38\u4f4d\u7f6e,\u5927\u5c0f\u548c\u5f62\u72b6\u5747\u6b63\u5e38\u3002\u4e0a\u989a\u7684\u7259\u9f88\u5f88\u539a\uff0c\u5f88\u7a84\u3002\u60a3\u8005\u4ea6\u6709\u5de6\u8db3\u7b2c5\u6307\u659c\u6307\u548c\u591a\u6307\u7578\u5f62(<strong>\u56fe1-B\u3001C<\/strong>)\u3002<\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p><strong>\u56fe1<\/strong>. \u591a\u53d1\u5148\u5929\u6027\u5f02\u5e38\u3002 <\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"225\" height=\"252\" src=\"\/nipt\/wp-content\/uploads\/2021\/10\/12q24.31-q24-a-a.jpg\" alt=\"\" class=\"wp-image-18273\">(A)\u9762\u90e8\u7565\u5fae\u53d8\u5927,\u9f3b\u5b54\u524d\u503e,\u4eba\u4e2d\u5149\u6ed1\u3002 \u8033\u6735\u56fa\u5b9a\u6b63\u5e38,\u5927\u5c0f\u548c\u5f62\u72b6\u6b63\u5e38<\/figure><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/uploads\/2021\/10\/12q24.31-q24-a-b.jpg\" alt=\"\" class=\"wp-image-18275\" width=\"194\" height=\"280\"\/><figcaption>(B)\u624b\u7684\u7b2c5\u6307\u659c\u6307<\/figcaption><\/figure><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"400\" height=\"242\" src=\"\/nipt\/wp-content\/uploads\/2021\/10\/12q24.31-q24-a-c.jpg\" alt=\"\" class=\"wp-image-18277\"\/><figcaption>(C)\u5de6\u811a\u591a\u8dbe\u75c7<\/figcaption><\/figure><\/div>\n<\/div><\/div>\n\n\n\n<p>\u5728\u795e\u7ecf\u5b66\u7684\u8bc4\u4f30\u4e2d,\u503c\u5f97\u6ce8\u610f\u7684\u662f\u4ee5\u5f15\u8d77\u4e25\u91cd\u81ea\u6b8b\u7684\u5934\u90e8\u78b0\u649e\u4e3a\u7279\u5f81\u7684\u81ea\u6211\u653b\u51fb\u884c\u4e3a\u3002\u60a3\u8005\u5448\u75c9\u631b\u6027\u9ad8\u5ea6\u7d27\u5f20\uff0c\u808c\u8171\u53cd\u5c04\u5267\u70c8,\u4e0d\u80fd\u72ec\u7acb\u884c\u8d70\u6216\u8bf4\u8bdd\u3002<br>MRI\u663e\u793a\u5e55\u4e0a\u8111\u79ef\u6c34\uff0c\u89c6\u89c9\u4ea4\u53c9\u51f9\u9677,\u8584\u8111\u6881,\u4fa7\u8111\u5ba4\u548c\u7b2c\u4e09\u8111\u5ba4\u6269\u5927,\u900f\u660e\u9694\u819c\u7f3a\u635f\u548c\u8111\u4f4e\u9ad3\u9798\u5f62\u6210<strong>(\u56fe2)<\/strong>\u3002<\/p>\n\n\n\n<div class=\"wp-block-group alignwide\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p><strong>\u56fe2<\/strong>. \u00a0MRI\u00a0 T2\u7a81\u51fa\u7bad\u5934\u56fe\u50cf\u3002\u8111\u810a\u6881\u5f88\u8584\u5f31\u3002 MRI\u00a0 T2\u52a0\u6743\u51a0\u72b6\u52a8\u8109\u56fe\u50cf\u3002<\/p>\n\n\n\n<div class=\"wp-block-group alignwide\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"300\" height=\"295\" src=\"\/nipt\/wp-content\/uploads\/2021\/10\/12q24.31-q24-b-a.jpg\" alt=\"\" class=\"wp-image-18279\"\/><figcaption>(A)\u4f34\u6709\u5c0f\u8111\u5e55\u4e0a\u79ef\u6c34\u548c\u89c6\u89c9\u4ea4\u53c9\u51f9\u9677\u6c14\u6ce1\u7684\u6c34\u7f51 (\u7bad\u5934) \u3002<\/figcaption><\/figure><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"299\" height=\"353\" src=\"\/nipt\/wp-content\/uploads\/2021\/10\/12q24.31-q24-b-b.jpg\" alt=\"\" class=\"wp-image-18281\"\/><figcaption>(B)\u8f74\u56fe\u50cf\u3002<\/figcaption><\/figure><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"297\" height=\"353\" src=\"\/nipt\/wp-content\/uploads\/2021\/10\/12q24.31-q24-b-c.jpg\" alt=\"\" class=\"wp-image-18283\"\/><figcaption>(C)\u4fa7\u8111\u5ba4\u548c\u7b2c\u4e09\u8111\u5ba4\u6269\u5f20\u3001\u900f\u660e\u95f4\u9694\u7f3a\u635f (\u7bad\u5934C) \u548c\u8111\u9ad3\u9798\u51cf\u5c11<\/figcaption><\/figure><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<p>\u4eba\u7c7b\u57fa\u56e0\u7ec4CGH\u5fae\u9635\u521760K (Agilent Technologies\u2122) \u63ed\u793a\u4e86\u4ece\u57fa\u56e0\u7ec4\u4f4d\u7f6e (123.309.075bp) \u5230q\u81c2\u8fd1\u7aef (132.283.607bp) \uff0c arr [NCBI 36\/Hg 18] 12q24\u768412q24.31\u7684\u4e2d\u5fc3\u5f00\u59cb\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u672b\u7aef\u7f3a\u5931<\/a>\u300231-q 24.33 (123.309.075-132.283.607) X1\u8bca\u65ad\u4e3a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">12q\u7f3a\u5931\u7efc\u5408\u75c7<\/a>\u3002\u8be5\u68c0\u67e5\u7531\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7814\u7a76\u4e2d\u5fc3 (\u751f\u7269\u79d1\u5b66\u7814\u7a76\u6240-\u5723\u4fdd\u7f57\u5927\u5b66) \u4e8e2011\u5e74\u8fdb\u884c\u3002<\/p>\n\n\n\n<p>\u901a\u8fc7\u4f7f\u7528\u9635\u5217\u6bd4\u8f83\u57fa\u56e0\u7ec4\u6df7\u5408 (aCGH) ,\u4e0eASD\u76f8\u5173\u7684\u516c\u77e5<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u9057\u4f20\u75be\u75c5<\/a>\u7684\u6570\u91cf\u6b63\u5728\u589e\u52a0\u3002\u4e0e\u7c7b\u4f3c\u7684\u81ea\u95ed\u75c7\u8ba4\u77e5\u884c\u4e3a\u8868\u578b\u76f8\u5173\u7684\u8fd9\u79cd\u9057\u4f20\u591a\u6837\u6027\u4ea7\u751f\u4e86\u300c\u75c7\u72b6\u6027\u81ea\u95ed\u75c7\u300d \u6216 \u300c\u590d\u5408\u6027\u81ea\u95ed\u75c7\u300d(\u4e0e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u9057\u4f20\u6027\u75be\u75c5\/\u9057\u4f20\u6027\u7efc\u5408\u75c7<\/a>\u76f8\u5173\u7684\u81ea\u95ed\u75c7) \u7684\u6982\u5ff5,\u8be5\u6982\u5ff5\u9002\u7528\u4e8e\u5177\u6709\u81f3\u5c11\u4e00\u79cd\u5f62\u6001\u5f02\u5e38\/\u7578\u5f62\u6216\u4e25\u91cd\u667a\u529b\u969c\u788d\u7684\u4e2a\u4f53\u3002\u8fd9\u8fdd\u53cd\u4e86\u300c\u65e0\u75c7\u72b6\u81ea\u95ed\u75c7\u300d \u7684\u6982\u5ff5,\u6b64\u5916<br>\u300c\u5355\u7eaf\u6027\u300d \/ \u300c\u7eaf\u7cb9\u6027\u300d \/ \u300c\u7279\u53d1\u6027\u81ea\u95ed\u75c7 (\u5b64\u7acb\u6027\u81ea\u95ed\u75c7) \u300d \u662f\u6307\u4e2d\u5ea6\u667a\u529b\u969c\u788d\u8005\u6709\u6b63\u5e38\u7684\u8ba4\u77e5\u529f\u80fd,\u6ca1\u6709\u5176\u4ed6\u76f8\u5173\u7684\u8ff9\u8c61\u6216\u75c7\u72b6\u3002<sup><a href=\"#reference02\">(2)<\/a><\/sup><br>\u8fd9\u79cd\u75c7\u72b6\u6027\u5b64\u72ec\u75c7\u75c5\u4f8b\u7684\u9057\u4f20\u5b66\u68c0\u67e5\u53ef\u4ee5\u5bfc\u81f4\u5bf9\u7f55\u89c1\u75be\u75c5\/\u6216\u62a5\u544a\u4e0d\u8db3\u7684\u75be\u75c5\u7684\u8bc6\u522b\u3002\u5728\u8fd9\u4e9b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u67d3\u8272\u4f53\u5f02\u5e38<\/a>\u4e2d\uff0c 12q24.31-q24.33<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7aef\u7c92\/\u4e9a\u7aef\u7c92\u7684\u7f3a\u5931<\/a>\u5f88\u5c11\u89c1\uff0c\u73b0\u5c06\u4ee5\u5f80\u62a5\u9053\u75c5\u4f8b\u7684\u4e3b\u8981\u4e34\u5e8a\u8868\u73b0\u603b\u7ed3\u4e8e\u88681\u3002<br>\u4f5c\u8005\u7684\u60a3\u8005\u5177\u6709\u4e0e\u5176\u4ed6\u60a3\u6709<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">12q\u7f3a\u5931<\/a>\u7684\u60a3\u8005\u6240\u5448\u73b0\u7684\u76f8\u4f3c\u7684\u51e0\u79cd\u8868\u578b\u8868\u73b0,\u4f8b\u5982\u53d1\u80b2\u5ef6\u8fdf\u3001\u9762\u90e8\u7c97\u7cd9\u3001\u53d1\u80b2\u4e0d\u826f\u3001\u524d\u989d\u5927\u7684\u56df\u95e8,\u8bed\u8a00\u53d1\u80b2\u8fdf\u7f13\u548c\u659c\u6307\u75c7\u3002\u53ea\u6709\u4e00\u9879\u7814\u7a76\u8868\u660e\u7236\u6bcd\u662f\u8868\u4eb2\uff0c\u6211\u4eec\u5728\u60a3\u8005\u7684\u75c5\u53f2\u4e2d\u4e5f\u89c2\u5bdf\u5230\u4e86\u8fd9\u4e00\u70b9\u3002\u8fd9\u4e9b\u53d1\u73b0\u5c06\u8be6\u7ec6\u5730\u6709\u52a9\u4e8e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">12q\u7f3a\u5931<\/a>\u7684\u57fa\u56e0\u578b\/\u8868\u578b\u76f8\u5173\u6027\u7684\u8868\u8fbe,\u5e76\u4e14\u4e0e\u53e6\u5916\u7684\u60a3\u8005\u7684\u6bd4\u8f83\u5c06\u7ee7\u7eed\u6dfb\u52a0\u5230\u8be5\u4e34\u5e8a\u8bf4\u660e\u4e2d\u3002<br><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u7f3a\u5931<\/a>\u533a\u57df\u5305\u542b52\u4e2a\u6ce8\u91ca\u57fa\u56e0\u3002\u5728\u8fd9\u4e9bP2RX2\u548cACADS\u4e2d\uff0c\u6211\u4eec\u5e94\u8be5\u6ce8\u610f\u5448\u73b0\u7ed9\u60a3\u8005\u7684\u53d1\u80b2\u5ef6\u8fdf\u3001\u884c\u4e3a\u548c\u793e\u4f1a\u95ee\u9898\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA\"><\/span><strong>\u7ed3\u8bba<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u7f55\u89c1\u7efc\u5408\u75c7\u7684\u8be6\u7ec6\u53d1\u73b0\u6709\u52a9\u4e8e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\"><strong>12q\u7f3a\u5931<\/strong><\/a>\u7684\u57fa\u56e0\u578b\/\u8868\u578b\u76f8\u5173\u6027\u7684\u8868\u8fbe,\u5e76\u4e14\u4e0e\u5176\u4ed6\u60a3\u8005\u7684\u6bd4\u8f83\u5c06\u7ee7\u7eed\u6dfb\u52a0\u5230\u8be5\u4e34\u5e8a\u8bf4\u660e\u4e2d\u3002\u5bf9\u6709\u75c7\u72b6\u81ea\u95ed\u75c7\u75c5\u4f8b\u7684\u9057\u4f20\u5b66\u7814\u7a76\u6709\u52a9\u4e8e\u8bc6\u522b\u7f55\u89c1\/\u6216\u672a\u77e5\u7684\u75be\u75c5\u3002<br>\u4f5c\u8005\u5f3a\u8c03\u9057\u4f20\u5206\u6790\u5bf9\u7814\u7a76\u667a\u969c,\u7578\u5f62,\u53d1\u80b2\u8fdf\u7f13\u548c\u591a\u53d1\u6027\u5148\u5929\u6027\u5f02\u5e38\u60a3\u8005<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u67d3\u8272\u4f53\u5f02\u5e38<\/a>\u7684\u91cd\u8981\u6027\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%80%83%E5%AF%9F\"><\/span><strong>\u8003\u5bdf<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u6700\u8fd1,\u6d41\u884c\u75c5\u5b66\u548c\u5206\u5b50\u9057\u4f20\u5b66\u7684\u6280\u672f\u8fdb\u6b65\u5728\u795e\u7ecf\u6027\u7cbe\u795e\u75c5\u7684\u9057\u4f20\u5b66\u9886\u57df\u5e26\u6765\u4e86\u65b0\u7684\u53d1\u73b0\u3002\u8fd9\u4e9b\u65b0\u53d1\u73b0\u4e5f\u4e0e\u81ea\u95ed\u75c7\u7684\u9057\u4f20\u5b66\u9886\u57df\u6709\u5173\uff0c\u5e76\u6269\u5c55\u4e86\u4e0eASD\u76f8\u5173\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/partialdeletions\/?lang=zh-hans\">\u9057\u4f20\u6027\u75be\u75c5<\/a>\u7684\u73b0\u6709\u77e5\u8bc6<sup><a href=\"#reference01\">(1)<\/a><\/sup>\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%BD%9C%E8%80%85%E4%BF%A1%E6%81%AF\"><\/span><strong>\u4f5c\u8005\u4fe1\u606f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Lin J: http:\/\/orcid.org\/0000-0002-7433-6231<br>\u82cf\u838e\u00b7\u6797GR:http:\/\/orcid.org\/0000-0001-9930-7288<br>Antunes FC: http:\/\/orcid.org\/0000-0001-5571-3321<br>\u97e6\u65af\u52d2LB:http:\/\/orcid.org\/0000-0001-6700-0396<br>\u65af\u7279\u96f7\u5c14:http:\/\/orcid.org\/0000-0002-2859-4678<br>\u5188\u963f\u5c14\u7ef4\u65afCL:http:\/\/orcid.org\/0000-0003-2468-8885<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\"><\/span><strong>\u53c2\u8003\u6587\u732e<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol class=\"wp-block-list\"><li><a name=\"reference01\"><\/a>Park HR, Lee JM, Moon HE, Lee DS, Kim BN, Kim J, et al\u3002\u76ee\u524d\u5bf9\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u7406\u89e3\u7684\u7b80\u77ed\u7efc\u8ff0\u3002\u795e\u7ecf\u5143\u91872016\u53f7;25 (1) :1 -13.\u8ba8\u8bba\u3002<\/li><li><a name=\"reference02\"><\/a>Marshall CR, Noor A, Vincent JB, Lionel AC, Feuk L, Skaug J, et al\u3002\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u67d3\u8272\u4f53\u7ed3\u6784\u7a81\u53d8\u3002Am J Hum Genet.2008;82 (2) :477-88.<\/li><li><a name=\"reference03\"><\/a>Al-ZahraniJ,Al-DosariN, AbuDheim N, Alshidi TA, Colak D,Al-HabitO, et al.\u67d3\u8272\u4f5312q24.31-q 24.33\u7684\u7f3a\u5931\u5bfc\u81f4\u591a\u4e2a\u53d8\u4f53\u7279\u5f81\u548c\u53d1\u80b2\u8fdf\u7f13:\u4e0e\u7b2c\u4e00\u4e2a\u5d4c\u5408\u4f53\u60a3\u8005\u548c12q24qter\u7f3a\u9677\u76f8\u5173\u7684\u8868\u578b\u6982\u8ff0\u3002Mol Cytogenet.2011;4:9.<\/li><li><a name=\"reference04\"><\/a>\u5c3c\u4e9a\u4f50\u592b\uff0c\u7eb3\u74e6\u5179Z,\u6cd5\u5b98AN,\u6258\u91cc\u8036\u7f57\uff0c\u9a6c\u4e01CL,\u4e9a\u5f53MP\u30022\u4f8b12q\u4e9a\u7aef\u7c92\u7f3a\u5931\u60a3\u8005\u7684\u57fa\u56e0\u578b\/\u8868\u578b\u76f8\u5173\u6027\u3002Am J Med Genet A.2007;143 A (22) :2700 -5.<\/li><li><a name=\"reference05\"><\/a>Plotner PL, Smith JL, Northrup H.Deletion 12q:12q24.31q24.32\u7b2c2\u4f8b\u7f3a\u5931\u60a3\u8005\u3002Am J Med Genet A.2003;118 A (4) :350 -2.<\/li><li><a name=\"reference06\"><\/a>Sathya P, Tomkins DJ, Freeman V, Paes B, Nowaczyk MJ.de novo\u7f3a\u593112q:12q24.31q24.33\u62a5\u544a\u7f3a\u5931\u7684\u60a3\u8005\u3002Am J Med Genet.1999;84 (2) :116 -9.<\/li><li><a name=\"reference07\"><\/a>Baple E, Palmer R, Hennekam RC.12q24.31\u7684\u5fae\u7f3a\u5931\u53ef\u80fd\u4e0e\u65b0\u751f\u513f\u97e6\u5fb7\u66fc\u7efc\u5408\u75c7\u76f8\u4f3c\u3002\u6469\u5c14\u7efc\u5408\u75c7\u30022010;1 (1) :42 -5.<\/li><li><a name=\"reference08\"><\/a>Choury E, Choucair N, Abou Ghoch J, El Sabbagh S, Corbani S, Megarbane A.\u5173\u4e8e\u4ece\u80f0\u5c9b\u7d20\u4f9d\u8d56\u6027\u7cd6\u5c3f\u75c5\u7236\u4eb2\u9057\u4f20\u768412q24.31\u5fae\u7f3a\u5931\u60a3\u8005\u7684\u62a5\u544a\u3002\u6469\u5c14\u7efc\u5408\u75c7\u30022013;4 (3) :136 -42.<\/li><li><a name=\"reference09\"><\/a>Qiao Y, Tyson C, Hrynchak M,Lopez-RangelE, Hildebrand J, Martell S, et al\u30022.7M\u7ec6\u80de\u9057\u4f20\u5b66\u9635\u5217\u5728\u7279\u53d1\u6027\u81ea\u95ed\u75c7\/\u6216\u667a\u529b\u969c\u788d\u53d7\u8bd5\u8005\u4e2d\u7528\u4e8eCNV\u68c0\u6d4b\u7684\u4e34\u5e8a\u5e94\u7528Krine Jenet 2013;83 (2) :145 -54.<\/li><li><a name=\"reference10\"><\/a>Palumbo O, Palumbo P, Delvecchio M, Palladino T, Stallone R, Crisetti M, et al.12q24.31\u7684\u7ec6\u5316:\u5173\u4e8e\u667a\u529b\u969c\u788d\uff0c\u5b9a\u578b\uff0c\u766b\u75eb\u53d1\u4f5c\u548c\u9762\u90e8\u7578\u5f62\u7684\u5973\u5b69\u7684\u62a5\u9053\u3002Am J Med Genet A.2015;167 A (2) :438 -44.\u8ba8\u8bba\u3002<\/li><\/ol>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%A1%A81_12q%E7%AB%AF%E7%B2%92%E7%BC%BA%E5%A4%B1%E7%9A%84%E7%BB%86%E8%83%9E%E9%81%97%E4%BC%A0%E5%AD%A6%E5%BC%82%E5%B8%B8%E7%9A%84%E4%B8%B4%E5%BA%8A%E6%80%BB%E7%BB%93\"><\/span>\u88681. <strong>12q\u7aef\u7c92\u7f3a\u5931\u7684\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\u7684\u4e34\u5e8a\u603b\u7ed3<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<section class=\"note_table\">\n<p><strong>\u88681<\/strong> \u5305\u542b2p16p21\u533a\u57df\u7684\u7f3a\u5931\u62a5\u544a\u793a\u4f8b<\/p>\n<div class=\"table-sp-scroll\">\n<figure>\n<table>\n<colgroup>\n    <col style=\"width:20%\">\n    <col style=\"width:40%\">\n    <col style=\"width:40%\">\n<\/colgroup>\n<thead>\n<tr>\n<th>\u9057\u4f20\u63cf\u8ff0<\/th><th>\u53c2\u8003<\/th><th>\u8868\u578b<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>46, XY, del (12) (q 24.31-q24.33), \u5d4c\u5408\u4f53<\/td><td>Al-Zahrani\u7b49\u4eba(3) <\/td><td>8\u5c81\uff0c IGF-1\u7b49\u7ea7\u975e\u5e38\u4f4e\u7684\u4e25\u91cd\u751f\u957f\u5ef6\u8fdf,\u53d1\u80b2\u5ef6\u8fdf,\u9762\u90e8\u5f62\u6001\u5f02\u5e38,\u8f83\u4f4e\u7684\u8033\u6735,\u9690\u777e\u4e0e\u9634\u830e\u77ed\u5c0f,\u8098\u90e8\u7578\u5f62<\/td>\n<\/tr>\n<tr>\n<td>46, XY, 12q subelomeric deletion; 1.<\/td><td rowspan=\"2\">Niyazov\u7b49\u4eba(4) <\/td><td>8\u5c81\uff0c\u8bed\u8a00\u53d1\u80b2\u8fdf\u7f13,\u89c5\u98df\u884c\u4e3a,\u6ce8\u610f\u529b\u7f3a\u9677\u591a\u52a8\u969c\u788d,\u75bc\u75db\u9608\u503c\u9ad8,\u9762\u90e8\u5f62\u6001\u65e0\u5f02\u5e38,\u524d\u53d1\u7b2c2\u6bdb\u53d1\u589e\u591a,\u624b\u81c2\u5341\u5b57\u7578\u5f62\u3002\u659c\u89c6\u548c\u80a5\u80d6<\/td>\n<\/tr>\n<tr>\n<td>46, XY, 12q subelomeric deletion; 4.5Mb; 22 \u57fa\u56e0<\/td><td>12\u5c81\uff0c\u5de6\u505c\u7ad9\uff0c\u80be\u810f\u5f02\u5e38(\u591a\u56ca\u5de6\u80be\uff0c\u53f3\u80be\u5f02\u4f4d) \u3002\u8868\u76ae\u6c9f\uff0c\u5c0f\u8033\uff0c\u8282\u5f8b\u5ef6\u8fdf,\u4e2d\u5ea6ID,\u98df\u7269\u641c\u7d22\u884c\u4e3a\u548c\u81ea\u6b8b \u884c\u4e3a<\/td>\n<\/tr>\n<tr>\n<td>46, XY, del (12) (q24.31q24.32) <\/td><td>Plotner \u7b49\u4eba(5)<\/td><td>9\u4e2a\u6708\u5927\uff0c\u6c14\u7ba1\u8f6f\u5316\uff0c\u751f\u6b96\u5668\u6a21\u7cca\u4e0d\u6e05, Dandy Warca\u7efc\u5408\u75c7,\u9762\u90e8\u7c97\u7cd9,\u524d\u80f8\u90e8\u80a5\u5927,\u816d\u4e0b\u5782\u3002\u5de6\u773c\u7751\u4e0b\u5782\u3001\u539a\u7259\u9f88\u3001\u820c\u5934\u5927\u3001\u8f7b\u5ea6\u5168\u8eab\u4f4e\u5f20\u529b\u3001\u9634\u56ca\u5206\u88c2\u3001\u53cc\u4fa7\u53ef\u89e6\u53ca\u7684\u777e\u4e38\u3001\u9634\u830e\u5c0f\u3001\u624b\u6307\u957f\u3001\u6307\u5c16\u8fdf\u6ede (9\u4e2a\u6708\u540e\u65e0\u6cd5\u4fdd\u6301\u5750\u59ff\u3001\u4e0d\u80fd\u884c\u8d70\u3001\u4e0d\u80fd\u5480\u56bc\u6216\u541e\u54bd) \u3002<\/td>\n<\/tr>\n<tr>\n<td>46, XY, del (12) (q24.31q24.33)<\/td><td>Sathya \u7b49\u4eba(6)<\/td><td>\u51fa\u751f12\u4e2a\u6708\uff0c\u53d1\u80b2\u8fdf\u7f13 (\u51fa\u751f20\u4e2a\u6708\uff0c\u53d1\u80b2\u7a0b\u5ea6\u4e3a10-12\u4e2a\u6708) ,\u65e0\u751f\u6b96\u5668\u5f02\u5e38\u3002\u751f\u6b96\u5668\u5f02\u5e38\u3001\u5c0f\u5934\u7578\u5f62\u3001\u5927\u803b\u9aa8\u8102\u80aa\u57ab\u3001\u9ab6\u9aa8\u5b54\u3001\u624b\u6307\u5c16\u7ec6\u3001\u5341\u4e8c\u6307\u80a0\u3001\u6241\u5e73\u8db3\u3001\u5fc3\u810f\u5f02\u5e38 (\u5468\u819c\u6027VSD\u3001\u8f7b\u5ea6\u4e09\u5c16\u74e3\u53cd\u6d41\u3001secundum ASD\u3001\u8f7b\u5ea6\u53cc\u5fc3\u5ba4\u548c\u5de6\u5fc3\u623f\u6269\u5f20\u3001\u8f7b\u5ea6\u4e09\u5c16\u74e3\u5173\u95ed\u4e0d\u5168) \u3001\u9762\u90e8\u7578\u5f62,\u6bd4\u5982\u5927\u9cde\u72b6\u9f3b\u5b50\u548c\u5149\u6ed1\u7684\u7ebf\u72b6\u4f53\u3002\u9762\u90e8\u7578\u5f62 (\u5927\u9cde\u72b6\u9f3b\u5b50,\u5149\u6ed1\u7684\u7ebf\u72b6\u4f53,\u5927\u8033\u6735<\/td>\n<\/tr>\n<tr>\n<td>46, XX, del (12) (q24.31)<\/td><td>Baple et al. (7) <\/td><td>13\u5c81\uff0c\u54ac\u5408\u4e0d\u6b63\uff0c\u8fc7\u5ea6\u6210\u957f,\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7,\u53d1\u80b2\u8fdf\u7f13 (1\u5c81\u534a\u884c\u8d70,2\u5c81\u53ef\u8bb2\u51e0\u4e2a\u5b57) ,\u4e25\u91cd\u7126\u8651\u75c7,\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d,\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u667a\u529b\u969c\u788d,\u5507\u816d\u88c2,\u5bbd\u9f3b\u5e95,\u9f13\u8d77\u7684\u9762\u988a,\u9ad8\u5ea6\u62f1\u5f62\u7684\u816d\u90e8\u3002\u56db\u80a2\u8f83\u5927,\u624b\u6307\u8f7b\u5fae\u5c16\u7ec6,\u8db3\u8dbe\u8f83\u77ed,\u5de6\u4fa7\u7b2c4\u6307\u57cb\u4e8e\u8fd1\u7aef,\u7b2c4\u638c\u9aa8\u77ed\u7f29\u3002<\/td>\n<\/tr>\n<tr>\n<td>46, XX, del (12) (q24.31)<\/td><td>Chouery et al. (8)<\/td><td>2\u5c81\uff0c\u53d1\u80b2\u5ef6\u8fdf(\u57281\u5c81\u534a\u7684\u65f6\u5019\uff0c\u4e0d\u80fd\u5728\u6ca1\u6709\u652f\u6491\u7684\u60c5\u51b5\u4e0b\u5750\u7acb,\u65e0\u6cd5\u722c\u884c\/\u6216\u8bf4\u8bdd,\u7f3a\u4e4f\u793e\u4ea4\u4e92\u52a8\u6280\u5de7,\u5f88\u5c11\u505a\u51fa\u53cd\u5e94\u548c\u5fae\u7b11,\u5728\u652f\u6491\u4e0b\u80fd\u8d70\u51e0\u6b65) ,\u5a74\u5e7c\u513f\u75c9\u631b,\u4f4e\u5f20\u529b,\u5c0f\u5934\u7578\u5f62,\u6241\u5e73\u7684\u8138,\u9f13\u80c0\u7684\u8138\u988a,\u5de8\u5927\u7684\u820c\u5934,\u9ad8\u5ea6\u5f13\u5f62\u7684\u4e0a\u989a,\u540e\u7a81\u75c7,\u72ed\u7a84\u7684\u8033\u5b54,\u5496\u5561\u6591,\u4f4e\u5fc3\u5f8b\u5931\u5e38 <\/td>\n<\/tr>\n<tr>\n<td>46, XX, del (12) (q24.31) <\/td><td>Qiao et al.(9)<\/td><td>8\u5c81\uff0c\u5355\u53d1\u4e3b\u52a8\u8109\u74e3\u72ed\u7a84\uff0c\u5168\u7403\u6027\u53d1\u80b2\u8fdf\u7f13,\u4e2d\u5ea6ID,\u5507\u816d\u88c2\u4e0a\u7fd8\u3002\u53e3\u9f7f\u4e0d\u6e05,\u8033\u6735\u5c0f\u800c\u4f4e,\u540e\u7ffb,\u9f3b\u6839\u8f83\u9ad8,\u9f3b\u6839\u90e8\u8f83\u7c97,\u9876\u7aef\u5448\u65b9\u5f62\u3002\u7a81\u51fa\u7684\u524d\u9f7f\u548c\u72ed\u7a84\u7684\u4e0a\u989a\uff0c\u975e\u5e38\u7ea4\u7ec6\u7684\u624b\u6307\u548c\u7a81\u51fa\u7684\u6307\u5c16\u57ab\u3002\u6307\u7532\u4e24\u4e2a\u90e8\u4f4d\u53d1\u80b2\u4e0d\u826f,\u6709\u6591\u70b9\u6e7f\u75b9\u548c\u8f83\u539a\u7684\u9c7c\u9cde\u72b6\u76ae\u80a4,\u5176\u8bca\u65ad\u5982\u4e0b\u3002T\u7ec6\u80de\u76ae\u80a4\u6dcb\u5df4\u7624 (\u8170\u90e8\u8272\u7d20\u6c89\u6dc0) \u3002<\/td>\n<\/tr>\n<tr>\n<td>46, XX, del (12) (q24.31)<\/td><td>Palumbo\u7b49\u4eba(10)<\/td><td>12\u5c81\uff0c\u672a\u77e5\u8eab\u4efd,\u766b\u75eb,\u9648\u89c4\u5b9a\u578b,\u53e3\u5507\u7f3a\u635f,\u9762\u988a\u81a8\u9686,\u6301\u7eed\u6027\u5375\u5706\u5b54\u672a\u95ed\u3002\u4f4e\u8840\u7cd6\u53d1\u4f5c\uff0c\u4ece\u51fa\u751f\u540e\u51e0\u4e2a\u6708\u5f00\u59cb\u75c9\u631b\u6027\u56db\u80a2\u762b\u75ea,\u603b\u4f53\u53d1\u80b2\u8fdf\u7f13 (2.5\u5c81\u5f00\u59cb\u8d70\u8def\u548c\u8bf4\u8bdd) 2.5\u5c81\u5f00\u59cb\u8d70\u8def,4\u5c81\u5f00\u59cb\u8bf4\u8bdd) ,\u53d1\u80b2\u4e0d\u826f\u7684\u8dbe\u9aa8,\u7b2c4\u638c\u9aa8\u8fd1\u7aef\u88ab\u57cb\u6ca1\u3002\u9762\u90e8\u7578\u5f62\u7684\u7279\u5f81\u662f\u957f\u692d\u5706\u5f62\u7684\u8138,\u5507\u816d\u88c2\u5411\u4e0b,\u9f3b\u5e95\u5bbd,\u9f3b\u5b50\u9ad8\u3002\u9f3b\u6839\u90e8\u8f83\u9ad8,\u816d\u90e8\u8f83\u9ad8,\u7259\u9f7f\u5bc6\u96c6,\u4e0b\u5507\u6731\u7ea2\u8272\u5b8c\u6574,\u4e3a\u5e38\u67d3\u8272\u4f53\u3002\u8033\u6735\u53c8\u5927\u53c8\u7a84\uff0c\u6709\u7c97\u87ba\u65cb\u3002\u8111\u78c1\u5171\u632f\u6210\u50cf\u663e\u793a\u8111\u5ba4\u53d1\u80b2\u4e0d\u5168<\/td>\n<\/tr>\n<tr>\n<td>46, XY, del (12) (q24.31-q24.33) 9Mb<\/td><td>\u73b0\u9636\u6bb5\u7684\u60a3\u8005<\/td><td>12\u5c81\uff0c\u53d1\u80b2\u8fdf\u7f13\uff0c\u4e0d\u80fd\u81ea\u4e3b\u884c\u8d70\u548c\u8bf4\u8bdd\uff0c\u53d1\u80b2\u4e0d\u826f,\u524d\u989d\u8f83\u5927,\u9762\u90e8\u7c97\u7cd9,\u9f3b\u5b50\u77ed\u5c0f,\u9f3b\u5b54\u7fd8\u8d77,\u820c\u5934\u5149\u6ed1\u3002\u4e0a\u816d\u72ed\u7a84,\u7259\u9f88\u8f83\u539a,\u5de6\u624b\u7b2c5\u6307\u5448\u659c\u9888,\u6709\u653b\u51fb\u6027\u884c\u4e3a,\u75c9\u631b\u53cd\u5c04\u6d3b\u8dc3\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<\/div>\n<\/section>\n\n\n\n<p>IGF-1:\u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b50-I;\u8eab\u4efd:\u667a\u80fd\u969c\u788d;VSD:\u5ba4\u95f4\u9694\u7f3a\u635f;\u623f\u95f4\u9694\u7f3a\u635f:\u623f\u95f4\u9694\u7f3a\u635f\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%A6%82%E4%BD%95%E5%BC%95%E7%94%A8%E8%BF%99%E7%AF%87%E6%96%87%E7%AB%A0\"><\/span><strong>\u5982\u4f55\u5f15\u7528\u8fd9\u7bc7\u6587\u7ae0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Lin J, Souza-Lin GR, Antunes FC, Wessler LB,<br>Streck EL, Gon\u00e7alves CL. \u4e0e\u81ea\u95ed\u75c7\u76f8\u5173<br>12q(12q24.31-q24.33)\u7684\u7f3a\u5931:\u8fdb\u4e00\u6b65<br>\u975e\u5e38\u7f55\u89c1\u7684\u75be\u75c5\u62a5\u544a \u5b9e\u4f8b<br>(\u5723\u4fdd\u7f57) 2020;18:eRC5335\u3002 http:\/\/dx.doi.org\/<br>10.31744\/einstein_journal\/2020RC5335<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%BB%E8%A6%81%E4%BD%9C%E8%80%85\"><\/span><strong>\u4e3b\u8981\u4f5c\u8005:<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u8d39\u5c14\u5357\u8fbe\u00b7\u5eb7\u00b7\u5b89\u5ef7\u65af<br>\u533b\u5b66\u751f\u7269\u5b66\u7cfb<br>\u5927\u5b66\u793e\u4f1a\u79d1\u5b66<br>\u5723\u5361\u5854\u5229\u7eb3\u65af<br>\u963f\u8d1d\u5c3c\u8fbe\u00b7\u4f69\u5fb7\u7f57\u00b7\u624e\u4f69\u91cc\u5c3c1,798\u7f8e\u5206<br>Zip\u4ee3\u7801: 88701-480 &#8211; Tubaro, SC, Brazil<br>\u7535\u8bdd:(55 48) 99906-9929<br>\u7535\u5b50\u90ae\u4ef6:fernandacoan@hotmail.com<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%8E%A5%E6%94%B6%E6%97%A5%E6%9C%9F\"><\/span><strong>\u63a5\u6536\u65e5\u671f:<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>2019\u5e748\u670818\u65e5<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%8F%97%E7%90%86\"><\/span>\u53d7\u7406:<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u5e73\u621029\u5e7411\u670829\u65e5<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%89%88%E6%9D%832020\"><\/span><strong>\u7248\u67432020<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u6b64\u5185\u5bb9\u5df2\u83b7\u5f97\u8bb8\u53ef\u3002<br>\u5728\u77e5\u8bc6\u5171\u4eab\u4e0b<br>\u5c5e\u60274.0\u56fd\u9645\u8bb8\u53ef\u8bc1<\/p>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"\u5982\u679c\u4f7f\u752812q24.31-q24.33&#8230;.\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/12q24-31-q24-33deletion\/?lang=zh-hans\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":1,"featured_media":898,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-49294","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/49294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=49294"}],"version-history":[{"count":8,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/49294\/revisions"}],"predecessor-version":[{"id":84224,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/49294\/revisions\/84224"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/898"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=49294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=49294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=49294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}