{"id":70728,"date":"2021-06-18T16:24:00","date_gmt":"2021-06-18T07:24:00","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/"},"modified":"2025-12-24T14:48:38","modified_gmt":"2025-12-24T05:48:38","slug":"false-negative-positive","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en","title":{"rendered":"&#8216;I had a negative NIPT.&#8217; Why does this happen &#8211; false negatives and false positives \u3010supervised by doctor\u3011?"},"content":{"rendered":"\n<style>\nh1, p, p.break-normal{\nword-break: normal;\n}\n#article .post_content p {\nword-break: normal;\n}\n<\/style>\n\n\n\n<div class=\"toc\">\n<ul>\n  <li><a href=\"#c1\">NIPT is a nonconclusive test to determine the likelihood of disease<\/a><\/li>\n  <li><a href=\"#c2\">Accuracy of NIPT and its implications<\/a>\n    <ul>\n      <li><a href=\"#c2-1\">What is sensitivity?<\/a><\/li>\n      <li><a href=\"#c2-2\">What is specificity?<\/a><\/li>\n      <li><a href=\"#c2-3\">What is the target rate?<\/a><\/li>\n      <li><a href=\"#c2-4\">False positives and false negatives<\/a><\/li>\n    <\/ul>\n  <\/li>\n  <li><a href=\"#c3\">Three NIPT test results: &#8216;negative&#8217;, &#8216;positive&#8217; and &#8216;withholding judgment&#8217;<\/a><ul>\n    <li><a href=\"#c3-1\">Being &#8216;negative&#8217; for NIPT<\/a><\/li>\n    <li><a href=\"#c3-2\">Being &#8216;positive&#8217; for NIPT<\/a><\/li>\n    <li><a href=\"#c3-3\">What is withholding judgment?<\/a><\/li><\/ul><\/li>\n    <li><a href=\"#c3-4\">What is a positive score?<\/a><\/li>\n<\/ul>\n  <button class=\"toc_more\">Open table of contents<\/button>\n<\/div>\n\n\n<p style=\"width:100%;max-width:300px;margin:0 auto;\"><a href=\"\/nipt\/\" class=\"content-bnr about\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/themes\/hiro_nipt\/img\/banner\/nipt03pc.png\" alt=\"\u598a\u5a2018\u9031\u76ee\u307e\u3067\u306e\u65b9\u306f\u307e\u3060\u9593\u306b\u5408\u3044\u307e\u3059\"><\/a> <\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#NIPT_is_a_nonconclusive_test_to_determine_the_likelihood_of_disease\" >NIPT is a nonconclusive test to determine the likelihood of disease<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#Accuracy_of_NIPT_and_its_implications\" >Accuracy of NIPT and its implications<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#What_is_sensitivity\" >What is sensitivity?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#What_is_specificity\" >What is specificity?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#What_is_the_target_rate\" >What is the target rate?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#False_positives_and_false_negatives\" >False positives and false negatives<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#Three_NIPT_test_results_%E2%80%98negative_%E2%80%98positive_and_%E2%80%98withholding_judgment\" >Three NIPT test results: &#8216;negative&#8217;, &#8216;positive&#8217; and &#8216;withholding judgment&#8217;<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#Being_%E2%80%98negative_for_NIP\" >Being &#8216;negative&#8217; for NIP<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#Being_%E2%80%98positive_for_NIPT\" >Being &#8216;positive&#8217; for NIPT<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#What_is_withholding_judgment\" >What is withholding judgment?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\/#What_is_a_positive_score\" >What is a positive score?<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\" id=\"c1\"><span class=\"ez-toc-section\" id=\"NIPT_is_a_nonconclusive_test_to_determine_the_likelihood_of_disease\"><\/span>NIPT is a nonconclusive test to determine the likelihood of disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Prenatal diagnosis is a test to find out whether the baby in your womb has a birth defect caused by a specific chromosomal abnormality (chromosomal disease).<\/p>\n\n\n\n<p>There are two types of prenatal diagnosis: non-confirmatory tests, which tell whether a chromosomal abnormality is possible, and confirmatory tests, which tell for certain whether a disease is present.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT<\/a> is one of the &#8216;non-confirmatory tests&#8217;. It uses a PCR (polymerase chain reaction) test to check for abnormalities in the baby&#8217;s DNA in the mother&#8217;s blood. The three chromosomal abnormalities that can be detected by <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT<\/a> are <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/?lang=en\">13-trisomy (Patau syndrome)<\/a>, <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/?lang=en\">18-trisomy (Edwards syndrome)<\/a>, <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\">21-trisomy (Down syndrome)<\/a>.<\/p>\n\n\n\n    <a href=\"\/nipt\/nipt\/nipt\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u77e5\u7684\u969c\u304c\u3044\u304c\u308f\u304b\u308bNIPT\u3068\u306f\uff08NIPT\u306e\u57fa\u672c\uff09 <\/div>\n          <div class=\"blog-card-excerpt\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u884c\u3063\u3066\u3044\u308bNIPT\u306e\u307e\u3068\u3081\u3067\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u306eNIPT\u3067\u306f\u77e5\u7684\u969c\u5bb3\u30fb\u767a\u9054\u969c\u5bb3\u3092\u4f34\u3046\u591a\u6570\u306e\u75be\u60a3\u3092\u51fa\u751f\u524d\u306b\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"c2\"><span class=\"ez-toc-section\" id=\"Accuracy_of_NIPT_and_its_implications\"><\/span>Accuracy of NIPT and its implications<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The terms &#8216;sensitivity&#8217;, &#8216;specificity&#8217;, &#8216;positive predictive value&#8217; and &#8216;negative predictive value&#8217; are often used to describe test accuracy.<\/p>\n\n\n\n<p>The meanings of these terms are explained below.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c2-1\"><span class=\"ez-toc-section\" id=\"What_is_sensitivity\"><\/span>What is sensitivity?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The probability that a person with a disease will test &#8216;positive&#8217; is called &#8216;sensitivity&#8217;. Tests with high sensitivity are less likely to miss a disease.<\/p>\n\n\n\n<p>A negative result is therefore more likely to rule out the absence of disease.<\/p>\n\n\n\n<p>On the other hand, less sensitive tests can miss a negative result, so other tests should be used in conjunction.<\/p>\n\n\n\n<p>is 99%, which is close to 100%, and the probability of missing a disease is extremely low.<\/p>\n\n\n\n<p>The test is more accurate than other non-confirmatory tests (80% for combined tests and 83% for maternal serum marker tests).<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"\/nipt\/wp-content\/uploads\/2022\/10\/false-negative-positive01.jpg\" alt=\"\u611f\u5ea6\u3001\u7279\u7570\u5ea6\u3068\u306f\uff1f\" class=\"wp-image-44215\"\/><\/figure><\/div>\n\n\n<h3 class=\"wp-block-heading\" id=\"c2-2\"><span class=\"ez-toc-section\" id=\"What_is_specificity\"><\/span>What is specificity?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>It is the probability that a person who does not have the disease will be &#8216;negative&#8217; in the test.<\/p>\n\n\n\n<p>A &#8216;positive&#8217; result is material for diagnosing a person as having the disease, as false positives rarely occur in highly specific tests.<\/p>\n\n\n\n<p>The specificity of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT<\/a> is 99.90%, which is almost 100%.<\/p>\n\n\n\n<p>This means that the probability of false negative results is very low, and if the test is &#8216;negative&#8217;, it is unlikely that a disease is present.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c2-3\"><span class=\"ez-toc-section\" id=\"What_is_the_target_rate\"><\/span>What is the target rate?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>In all tests, including prenatal diagnosis, it is very important to know how correct the results are. The probability that the test result is correct is called the &#8216;positive predictive value&#8217;.<\/p>\n\n\n\n<p>The probability that a person with a positive test result actually has the disease is called the &#8216;positive predictive value&#8217;, while the probability that a person with a negative test result actually does not have the disease is called the &#8216;negative predictive value&#8217;.<\/p>\n\n\n\n<p>The &#8216;positive predictive value&#8217; is most important for those undergoing <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT<\/a>.<\/p>\n\n\n\n<p>A high &#8216;positive predictive value&#8217; means that the probability that the test result is wrong and there is no real disease (false positive rate) is low, and a &#8216;positive&#8217; test result means that there is a high probability of disease.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c2-4\"><span class=\"ez-toc-section\" id=\"False_positives_and_false_negatives\"><\/span>False positives and false negatives<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>A &#8216;negative&#8217; test result in the presence of a disease is called a false negative, while a &#8216;positive&#8217; test result in the absence of a disease is called a false positive.<\/p>\n\n\n\n<p>The most common cause of false negative results is that the pregnancy is too early in the gestation week and there is not enough DNA in the baby to be detected.<\/p>\n\n\n\n<p>False positives can be caused by a number of factors, including the fact that the pregnancy was actually twins and one baby was lost early due to a chromosomal abnormality (Vanishing Twin), or a hidden disease on the mother&#8217;s side, such as a tumour or autoimmune disease.<\/p>\n\n\n\n<p>False positives and false negatives can also occur if the test is not carried out correctly, although this should not be the case.<\/p>\n\n\n\n    <a href=\"\/nipt\/nipt-inspection-results\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u72ec\u81ea\u306e\u9ad8\u7cbe\u5ea6\u30aa\u30ea\u30b8\u30ca\u30eb\u691c\u67fb\u5831\u544a\u66f8 <\/div>\n          <div class=\"blog-card-excerpt\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u72ec\u81ea\u958b\u767a\u306eNIPT\uff08\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad\uff09\u3092\u63d0\u4f9b\u3002\u967d\u6027\u30b9\u30b3\u30a2\u3084\u5fae\u5c0f\u6b20\u5931\u30fb\u91cd\u8907\u691c\u67fb\u306a\u3069\u3001\u7cbe\u5ea6\u3068\u60c5\u5831\u91cf\u306b\u3053\u3060\u308f\u3063\u305f\u691c\u67fb\u3067\u3001\u598a\u5a66\u3055\u3093...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"c3\"><span class=\"ez-toc-section\" id=\"Three_NIPT_test_results_%E2%80%98negative_%E2%80%98positive_and_%E2%80%98withholding_judgment\"><\/span>Three NIPT test results: &#8216;negative&#8217;, &#8216;positive&#8217; and &#8216;withholding judgment&#8217;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT<\/a> test results are divided into three categories: &#8216;negative&#8217;, &#8216;positive&#8217; and &#8216;withholding judgment&#8217;.<\/p>\n\n\n\n<p>To understand the test results correctly, it is necessary to know the correct meaning of each.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c3-1\"><span class=\"ez-toc-section\" id=\"Being_%E2%80%98negative_for_NIP\"><\/span>Being &#8216;negative&#8217; for NIP<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>A &#8216;negative&#8217; <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT<\/a> test result indicates that the probability of the baby having a chromosomal abnormality is extremely low.<\/p>\n\n\n\n<p>For example, in the case of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\">21 trisomy (Down syndrome)<\/a>, it is understood that there is a 99.99% probability (negative predictive value) that you are not carrying a baby with <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\">21 trisomy (Down syndrome)<\/a>.<\/p>\n\n\n\n<p>The negative predictive rate of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT<\/a> is known to be extremely high.<\/p>\n\n\n\n<p>In a survey of pregnant women in the general population, the rate was also very high at 99.98%, and the probability of false negatives occurring was very low, less than 0.1%.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c3-2\"><span class=\"ez-toc-section\" id=\"Being_%E2%80%98positive_for_NIPT\"><\/span>Being &#8216;positive&#8217; for NIPT<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>A &#8216;positive&#8217; <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT<\/a> test result indicates that the baby is likely to have a chromosomal abnormality.<\/p>\n\n\n\n<p>It is therefore necessary to undergo a &#8216;definitive test&#8217;, either a trophoblastic test or an amniotic fluid test, to confirm the diagnosis.<br>However, as both trophoblastic and amniocentesis tests carry a small risk of miscarriage, it is important that couples discuss whether to have a definitive test or not.<\/p>\n\n\n\n<p>Of the 72,526 cases performed in the <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> consortium between September 2013 and March 2019, 1,281 (1.77%) tested &#8216;positive&#8217;.<br>The most common positive cases were <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\"><\/a><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\">21 trisomy (Down syndrome)<\/a> with 776 (1.07%), followed by <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/?lang=en\">18-trisomy (Edwards syndrome)<\/a> with 388 (0.54%) and <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/?lang=en\"><\/a><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/?lang=en\">13-trisomy (Patau syndrome)<\/a> with 117 (0.16%).<br>As the <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> consortium targeted pregnant women at high risk of chromosomal abnormalities, the positive rate for pregnant women in the general population is considered to be even lower.<\/p>\n\n\n\n<p>If a baby tests &#8216;positive&#8217; for <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\"><\/a><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\">21 trisomy (Down syndrome)<\/a>, the probability that the baby really has <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\">21 trisomy (Down syndrome)<\/a><\/a> (positive predictive value) depends on the mother&#8217;s age.<br>The higher the age, the higher the positive predictive value, as the probability of actually carrying a baby with the disease (disease frequency) increases.<br>For example, the positive predictive value for a 25-year-old is as low as 49.8%, while it jumps to 76.7% for a 35-year-old and 90.9% for a 40-year-old.<\/p>\n\n\n\n<p>The positive predictive values for <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/?lang=en\"><\/a><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/?lang=en\">13-trisomy (Patau syndrome)<\/a> and <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/?lang=en\"><\/a><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/?lang=en\">18-trisomy (Edwards syndrome)<\/a> are also lower than for <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\">21 trisomy (Down syndrome)<\/a><\/a>, as the disease frequency is lower.<\/p>\n\n\n\n<p>The positive predictive values for pregnant women aged 40 and 40 years are reported to be 52.5% and 30.4% respectively.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c3-3\"><span class=\"ez-toc-section\" id=\"What_is_withholding_judgment\"><\/span>What is withholding judgment?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>is performed, less than 1% of the time, a &#8216;decision withheld&#8217; result may be given.<\/p>\n\n\n\n<p>This is due to a low level of baby-derived DNA in the mother&#8217;s blood, haemolysis, which is the breakdown of red blood cells in the mother&#8217;s blood, or a test error due to non-compliance with the measurement requirements of the testing equipment.<\/p>\n\n\n\n<p>The baby-derived DNA is thought to increase over the course of the pregnancy, so blood can be drawn again and tested.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"\/nipt\/wp-content\/uploads\/2022\/10\/false-negative-positive02.jpg\" alt=\"\u967d\u6027\uff1f\u9670\u6027\uff1f\" class=\"wp-image-44218\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\" id=\"c3-4\"><span class=\"ez-toc-section\" id=\"What_is_a_positive_score\"><\/span>What is a positive score?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A useful tool in deciding whether to undergo a definitive test is the &#8216;positive score&#8217;, which is provided only at <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">Hiro Clinic NIPT<\/a>. The Positive Score is a value that indicates how far away the actual test result is from the cut-off value (reference value), which is the borderline between positive and negative results.<br>If the &#8216;cut-off value&#8217; (reference value) and the actual test result are close, the likelihood of a false positive The higher the &#8216;positive score&#8217;, the further away from the &#8216;cut-off value&#8217; (reference value) the actual test result value is.<br>The results of more than 68,000 <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT<\/a>s performed at <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">Hiro Clinic NIPT<\/a> to date show that pregnant women with a higher &#8216;positive score&#8217; are more likely to have a &#8216;positive&#8217; amniotic fluid test.<\/p>\n\n\n\n<p>Also, a low &#8216;positive score&#8217; does not mean that false positives are more likely.<\/p>\n\n\n\n<p>Even if the actual test result value is relatively close to the &#8216;cut-off value&#8217; (reference value), if the positive predictive value is high, there is a high probability that the amniotic fluid test will be &#8216;positive&#8217;. A positive score report is attached to those who have undergone <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT<\/a> at <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">Hiro Clinic NIPT<\/a> and have tested positive for <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\">21 trisomy (Down syndrome)<\/a> and <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/?lang=en\">18 trisomy (Edwards syndrome)<\/a>.<\/p>\n\n\n\n<p>The Positive Score Report shows the positive target rate calculated for each age, week and chromosome, along with the &#8216;positive score&#8217;.<br>Use this information to help you decide whether to actually have an amniotic fluid test by knowing where you stand with your test results.<\/p>\n\n\n\n    <a href=\"\/nipt\/about-clinic\/positive-score\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">NIPT\uff08\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad\uff09\uff5c\u56fd\u518575,000\u4ef6\u306e\u30c7\u30fc\u30bf\u304b\u3089\u89e3\u6790\u3057\u305f\u300c\u967d\u6027\u30b9\u30b3\u30a2\u300d <\/div>\n          <div class=\"blog-card-excerpt\">\u967d\u6027\u30b9\u30b3\u30a2\u306f\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u306e\u307f\u304c\u63d0\u4f9b\u3059\u308b\u30b9\u30b3\u30a2\u3067\u3059\u3002\u7f8a\u6c34\u691c\u67fb\u306e\u7d50\u679c\u3068\u967d\u6027\u30b9\u30b3\u30a2\u306e\u95a2\u9023\u56f3\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u967d\u6027\u306e\u5ea6\u5408\u3044\u3092\u60a3\u8005\u306b\u308f\u304b\u308a\u3084\u3059...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<div class=\"wp-block-group references\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p id=\"block-a244249c-2043-4de0-ab86-8216e9b8f6f2\">\u3010References\u3011<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ministry of Health, Labour and Welfare &#8211; <a rel=\"noopener\" href=\"https:\/\/www.mhlw.go.jp\/content\/11908000\/000559098.pdf\" target=\"_blank\">NIPT: noninvasive prenatal testing<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"NIPT is a nonconclus&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/false-negative-positive\/?lang=en\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":1,"featured_media":25096,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[202],"tags":[],"class_list":["post-70728","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-prenatal-testing"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/70728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=70728"}],"version-history":[{"count":13,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/70728\/revisions"}],"predecessor-version":[{"id":120997,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/70728\/revisions\/120997"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/25096"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=70728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=70728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=70728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}