{"id":7234,"date":"2020-11-19T15:35:17","date_gmt":"2020-11-19T06:35:17","guid":{"rendered":"https:\/\/www2.hiro-clinic.or.jp\/?p=7234"},"modified":"2026-02-26T11:07:29","modified_gmt":"2026-02-26T02:07:29","slug":"ger-13607dna","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/","title":{"rendered":"\u30c9\u30a4\u30c4\u306e\u5358\u4e00\u65bd\u8a2d\u306b\u304a\u3051\u308b\u80ce\u5150\u67d3\u8272\u4f53\u7570\u6570\u6027\u691c\u51fa\u306e\u305f\u3081\u306e13,607\u4f8b\u306e\u30eb\u30fc\u30c1\u30f3\u75c7\u4f8b\u306e\u9023\u7d9a\u30b7\u30ea\u30fc\u30ba\u306b\u304a\u3051\u308b\u7121\u7d30\u80deDNA\u306e\u5206\u6790"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p>Heike Borth<sup>1<\/sup> \u30fb Anna Teubert<sup>2<\/sup> \u30fb Ralf Glaubitz<sup>2<\/sup> \u30fb Sarah Knippenberg<sup>2<\/sup> \u30fb Nargul Kutur<sup>1<\/sup> \u30fb Thomas Winkler<sup>1<\/sup> \u30fb Bernd Eiben<sup>1<\/sup><\/p>\n\n\n\n<p>\u53d7\u7406:2020\u5e744\u670822\u65e5\/\u53d7\u7406:2020\u5e7410\u670820\u65e5<br>\u00a9\u8457\u8005(2020\u5e74\u4ee3)<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 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href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E7%B5%90%E6%9E%9C\" >\u7d50\u679c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E7%B5%90%E8%AB%96\" >\u7d50\u8ad6<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E3%82%AD%E3%83%BC%E3%83%AF%E3%83%BC%E3%83%89\" >\u30ad\u30fc\u30ef\u30fc\u30c9<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E3%81%AF%E3%81%98%E3%82%81%E3%81%AB\" >\u306f\u3058\u3081\u306b<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E9%9B%BB%E5%AD%90%E8%A3%9C%E8%B6%B3%E8%B3%87%E6%96%99\" >\u96fb\u5b50\u88dc\u8db3\u8cc7\u6599<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E7%B4%A0%E6%9D%90%E3%81%8A%E3%82%88%E3%81%B3%E6%96%B9%E6%B3%95\" >\u7d20\u6750\u304a\u3088\u3073\u65b9\u6cd5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E8%A2%AB%E9%A8%93%E8%80%85%E6%A4%9C%E4%BD%93%E3%81%AE%E8%A9%B3%E7%B4%B0\" >\u88ab\u9a13\u8005\/\u691c\u4f53\u306e\u8a73\u7d30<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#VeriSeq_NIPT_Solution_v2%E5%88%86%E6%9E%90%E6%B3%95\" >VeriSeq NIPT Solution v2\u5206\u6790\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E7%B5%B1%E8%A8%88\" >\u7d71\u8a08<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E7%B5%90%E6%9E%9C-2\" >\u7d50\u679c<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E5%B9%B4%E3%80%81%E9%80%B1%E3%80%81%E5%B9%B3%E5%9D%87%E5%80%A4%E3%81%AESEM%E6%A8%99%E6%BA%96%E8%AA%A4%E5%B7%AE%E3%80%81BMI%E3%83%9C%E3%83%87%E3%82%A3%E3%83%9E%E3%82%B9%E3%82%A4%E3%83%B3%E3%83%87%E3%83%83%E3%82%AF%E3%82%B9\" >\u5e74\u3001\u9031\u3001\u5e73\u5747\u5024\u306eSEM\u6a19\u6e96\u8aa4\u5dee\u3001BMI\u30dc\u30c7\u30a3\u30de\u30b9\u30a4\u30f3\u30c7\u30c3\u30af\u30b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E8%A1%A82_%E9%AB%98%E3%83%AA%E3%82%B9%E3%82%AFNIPT%E7%97%87%E4%BE%8B%E3%81%AE%E6%84%9F%E5%BA%A6%E3%80%81%E7%89%B9%E7%95%B0%E5%BA%A6%E3%80%81%E3%81%8A%E3%82%88%E3%81%B3%E9%99%BD%E6%80%A7%E7%9A%84%E4%B8%AD%E7%8E%87\" >\u88682 \u9ad8\u30ea\u30b9\u30afNIPT\u75c7\u4f8b\u306e\u611f\u5ea6\u3001\u7279\u7570\u5ea6\u3001\u304a\u3088\u3073\u967d\u6027\u7684\u4e2d\u7387<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E8%80%83%E5%AF%9F\" >\u8003\u5bdf<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E8%AC%9D%E8%BE%9E\" >\u8b1d\u8f9e<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E8%91%97%E8%80%85%E3%81%AE%E8%B2%A2%E7%8C%AE\" >\u8457\u8005\u306e\u8ca2\u732e<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E5%80%AB%E7%90%86%E5%9F%BA%E6%BA%96%E3%81%B8%E3%81%AE%E6%BA%96%E6%8B%A0\" >\u502b\u7406\u57fa\u6e96\u3078\u306e\u6e96\u62e0<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E5%88%A9%E7%9B%8A%E7%9B%B8%E5%8F%8D\" >\u5229\u76ca\u76f8\u53cd<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E5%80%AB%E7%90%86%E7%9A%84%E6%89%BF%E8%AA%8D\" >\u502b\u7406\u7684\u627f\u8a8d<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E5%8F%82%E5%8A%A0%E3%81%99%E3%82%8B%E3%81%93%E3%81%A8%E3%81%AB%E5%90%8C%E6%84%8F%E3%81%99%E3%82%8B\" >\u53c2\u52a0\u3059\u308b\u3053\u3068\u306b\u540c\u610f\u3059\u308b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E3%82%AA%E3%83%BC%E3%83%97%E3%83%B3%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9\" >\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\" >\u53c2\u8003\u6587\u732e<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/#%E5%87%BA%E7%89%88%E7%A4%BE%E3%81%AE%E3%83%8E%E3%83%BC%E3%83%88\" >\u51fa\u7248\u793e\u306e\u30ce\u30fc\u30c8<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%A6%81%E7%B4%84\"><\/span><strong>\u8981\u7d04<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%9B%AE%E7%9A%84\"><\/span><strong>\u76ee\u7684<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>(<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>)\u306f\u3001\u6bcd\u4f53\u8840\u6f3f\u304b\u3089\u80ce\u5150\u67d3\u8272\u4f53\u7570\u6570\u6027\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u9ad8\u611f\u5ea6\u3067\u7279\u7570\u7684\u306a\u65b9\u6cd5\u3067\u3042\u308b\u3002 \u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u30c9\u30a4\u30c4\u306e\u5358\u4e00\u65bd\u8a2d\u304b\u3089\u306e13,607\u4f8b\u306e\u598a\u5a20\u306b\u304a\u3051\u308b\u65b0\u3057\u3044\u30da\u30a2\u672b\u7aef\u914d\u5217\u6c7a\u5b9a\u306b\u57fa\u3065\u304fNIPT\u5206\u6790\u6cd5\u306e\u6027\u80fd\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%96%B9%E6%B3%95\"><\/span>\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u4ee5\u524d\u306bNIPT\u3092\u53d7\u3051\u305f\u598a\u5a6613,607\u4eba\u304b\u3089\u306e\u30b5\u30f3\u30d7\u30eb\u3092\u3001\u4e00\u822c\u7684\u306a\u80ce\u5150\u30c8\u30ea\u30bd\u30df\u30fc\u304a\u3088\u3073\u30e2\u30ce\u30bd\u30df\u30fcX\u306e\u5b58\u5728\u306b\u3064\u3044\u3066VeriSeq <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> Solution v2\u5206\u6790\u6cd5\u3092\u7528\u3044\u3066\u5206\u6790\u3057\u3001\u81e8\u5e8a\u7684\u771f\u7406\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306e\u8ffd\u8de1\u8abf\u67fb\u3092\u884c\u3063\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%90%E6%9E%9C\"><\/span><strong>\u7d50\u679c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>13,607\u4f8b\u306e\u3046\u3061\u300113,509\u4f8b\u304cNIPT\u96fb\u8a71\u3092\u53d7\u3051\u30010.72%\u3068\u3044\u3046\u4f4e\u3044\u7814\u7a76\u5931\u6557\u7387\u3092\u3082\u305f\u3089\u3057\u305f\u3002 \u9ad8\u30ea\u30b9\u30af\u306e\u547c\u3073\u51fa\u3057\u306f188\u4ef6(1.4%)\u3067\u3001117\u30c8\u30ea\u30bd\u30df\u30fc21\u300134\u30c8\u30ea\u30bd\u30df\u30fc18\u300123\u30c8\u30ea\u30bd\u30df\u30fc13\u30011\u30c8\u30ea\u30bd\u30df\u30fc21 + 13\u300113\u30e2\u30ce\u30bd\u30df\u30fcX\u3067\u3042\u308a\u30014\u3064\u306e\u7570\u6570\u6027\u6761\u4ef6\u3059\u3079\u3066\u306b\u5bfe\u3057\u3066\u226798.89%\u306e\u9ad8\u611f\u5ea6\u304a\u3088\u3073\u7279\u7570\u5ea6\u304c\u5831\u544a\u3055\u308c\u305f\u3002 \u9ad8\u30ea\u30b9\u30af\u75c7\u4f8b\u306e\u3046\u3061\u3001\u81e8\u5e8a\u8ffd\u8de1\u30c7\u30fc\u30bf\u306f77.1%(145\/188)\u3067\u5165\u624b\u3067\u304d\u305f\u3002 \u9ad8\u30ea\u30b9\u30af\u547c\u3073\u51fa\u3057\u306e\u81e8\u5e8a\u8ffd\u8de1\u3067\u306f\u3001\u5168\u4f53\u7684\u306a\u967d\u6027\u9069\u4e2d\u7387\u306f84.8%(\u6f5c\u5728\u7684\u53ef\u80fd\u6027\u7bc4\u56f265.4\uff5e88.3%)\u3067\u3042\u3063\u305f\u3002 NIPT\u306e\u7d50\u679c\u306f\u3001\u80ce\u5150\u5206\u753b\u306e2%\u307e\u3067\u306e\u7bc4\u56f2\u306e\u80ce\u5150\u5206\u753b\u306e\u8a66\u6599\u306b\u3064\u3044\u3066\u63d0\u4f9b\u3055\u308c\u305f\u3002&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%90%E8%AB%96\"><\/span><strong>\u7d50\u8ad6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>VeriSeq <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> Solution v2\u5206\u6790\u6cd5\u306f\u3001\u65e2\u77e5\u306e\u81e8\u5e8a\u8ee2\u5e30\u3001\u9ad8\u3044\u5168\u4f53\u7684PPV\u3001\u304a\u3088\u3073\u4f4e\u3044\u5931\u6557\u7387\u306b\u57fa\u3065\u3044\u3066\u89b3\u5bdf\u3055\u308c\u305f\u9ad8\u611f\u5ea6\u304a\u3088\u3073\u9ad8\u7279\u7570\u5ea6\u3067\u3001\u4e00\u9023\u306e\u80ce\u5150\u753b\u5206\u306b\u308f\u305f\u3063\u3066\u80ce\u5150\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027\u3092\u691c\u51fa\u3057\u305f\u3002&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%82%AD%E3%83%BC%E3%83%AF%E3%83%BC%E3%83%89\"><\/span><strong>\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a> \u30fb \u80ce\u5150\u67d3\u8272\u4f53\u7570\u6570\u6027 \u30fb \u80ce\u5150\u5206\u753b \u30fb \u967d\u6027\u7684\u4e2d\u7387 \u30fb VeriSeq NIPT\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3<\/p>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%81%AF%E3%81%98%E3%82%81%E3%81%AB\"><\/span><strong>\u306f\u3058\u3081\u306b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>1997\u5e74\u306e\u6bcd\u4f53\u5faa\u74b0\u306b\u304a\u3051\u308b\u80ce\u5150\u7121\u7d30\u80deDNA(cfDNA)\u306e\u767a\u898b[1]\u306f\u3001\u80ce\u5150<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u5b58\u5728\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u305f\u3081\u306e\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>(<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>)\u6cd5\u306e\u958b\u767a\u3068\u5546\u696d\u7684\u5229\u7528\u3092\u4fc3\u9032\u3057\u305f\u3002 \u3053\u308c\u3089\u306eNIPT\u5206\u6790\u6cd5\u306f\u5f93\u6765\u306e\u8840\u6e05\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6cd5\u3088\u308a\u512a\u308c\u305f\u6027\u80fd\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a[2]\u3001\u6700\u8fd1\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001NIPT\u306f\u5358\u80ce\u598a\u5a20\u306b\u304a\u3044\u3066\u4e00\u822c\u7684\u306a\u80ce\u5150\u6027\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u5c11\u306a\u304f\u3068\u308298%\u3092\u691c\u51fa\u3067\u304d\u3001\u507d\u967d\u6027\u7387\u306f0.13%\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u305f[3]\u3002 \u4e00\u822c\u598a\u5a20\u96c6\u56e3\u306b\u304a\u3051\u308bNIPT\u306e\u4f7f\u7528\u306f\u3001\u30c9\u30a4\u30c4\u4eba\u985e\u907a\u4f1d\u5b66\u4f1a[4-7]\u3092\u542b\u3080\u591a\u304f\u306e\u5c02\u9580\u5b66\u4f1a\u306b\u3088\u3063\u3066\u652f\u6301\u3055\u308c\u3066\u304a\u308a\u3001cfDNA\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u542b\u3080\u51fa\u751f\u524d\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u95a2\u3059\u308b\u30c9\u30a4\u30c4\u8d85\u97f3\u6ce2\u533b\u5b66\u4f1a(DEGUM)\u3001\u30aa\u30fc\u30b9\u30c8\u30ea\u30a2\u8d85\u97f3\u6ce2\u533b\u5b66\u4f1a(OGUM)\u3001\u30b9\u30a4\u30b9\u8d85\u97f3\u6ce2\u533b\u5b66\u4f1a(SGUM)\u3001\u30c9\u30a4\u30c4\u80ce\u5150\u533b\u5b66\u8ca1\u56e3(FMF)\u306e\u63a8\u5968\u304c\u6700\u8fd1\u767a\u8868\u3055\u308c\u305f[8]\u3002 NIPT\u306e\u305f\u3081\u306e2015\u5e74\u30aa\u30fc\u30b9\u30c8\u30ea\u30a2-\u30b9\u30a4\u30b9-\u30c9\u30a4\u30c4\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u598a\u5a66\u5168\u54e1\u3092\u5bfe\u8c61\u306b\u80ce\u515021\u578b\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306bNIPT\u3092\u7528\u3044\u308b\u3053\u3068\u3092\u652f\u6301\u3057\u3066\u3044\u308b\u304c\u3001\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027\u307e\u305f\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/lp-143\/\">\u5fae\u5c0f\u6b20\u5931<\/a>\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u63a8\u5968\u3057\u3066\u3044\u306a\u3044[9]\u3002 \u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u306b\u5bfe\u3059\u308bcfDNA\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u6027\u80fd\u306f21\u30c8\u30ea\u30bd\u30df\u30fc\u3067\u89b3\u5bdf\u3055\u308c\u308b\u3082\u306e\u3088\u308a\u3082\u4f4e\u3044\u3053\u3068\u306b\u7559\u610f\u3059\u308b\u3002 \u30c9\u30a4\u30c4\u306e\u516c\u7684\u8cc7\u91d1\u306b\u3088\u308b\u4fdd\u967a\u5236\u5ea6\u306f\u3001\u8fd1\u3044\u5c06\u6765\u3001\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u306e\u5fc5\u8981\u6027\u304c\u5897\u5927\u3057\u3001\u7279\u5225\u306a\u30ea\u30b9\u30af\u3092\u4f34\u3046\u598a\u5a20\u4e2d\u306e\u4e00\u822c\u7684\u306a\u80ce\u5150\u6027\u30c8\u30ea\u30bd\u30df\u30fc\u306b\u5bfe\u3057\u3066NIPT\u3092\u30ab\u30d0\u30fc\u3059\u308b\u3053\u3068\u3092\u8a08\u753b\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>NIPT\u5206\u6790\u6cd5\u304c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3067\u304d\u308b\u6761\u4ef6\u306e\u7bc4\u56f2\u306f\u30012011\u5e74\u306e\u5546\u696d\u7684\u5229\u7528\u53ef\u80fd\u6027\u304b\u3089\u62e1\u5927\u3057\u3066\u3044\u308b\u3002 \u6700\u521d\u306b\u3001\u4e00\u822c\u7684\u306a\u80ce\u5150\u30c8\u30ea\u30bd\u30df\u30fc\u3001\u3059\u306a\u308f\u306121\u30c8\u30ea\u30bd\u30df\u30fc\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u3001\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u306e\u307f\u306e\u5b58\u5728\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u305fNIPT\u5206\u6790\u6cd5[10,11]\u3002 \u305d\u306e\u5f8c\u3001\u3053\u308c\u306f\u80ce\u5150\u306e\u6027\u304a\u3088\u3073\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027[12, 13]\u306b\u5bfe\u3059\u308b\u4efb\u610f\u306e\u691c\u67fb\u3092\u542b\u3080\u3088\u3046\u306b\u62e1\u5927\u3055\u308c\u3001\u305d\u306e\u5f8c\u3001\u4e00\u822c\u7684\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/lp-143\/\">\u5fae\u5c0f\u6b20\u5931<\/a>[14, 15]\u3001\u307e\u308c\u306a\u5e38\u67d3\u8272\u4f53\u7570\u6570\u6027\u3001\u304a\u3088\u3073\u90e8\u5206\u7684\u306a\u6b20\u5931\u304a\u3088\u3073\u91cd\u8907[16-18]\u306b\u5bfe\u3059\u308b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u9078\u629e\u80a2\u304c\u542b\u307e\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002 \u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u691c\u67fb\u5f8c\u306b\u6355\u6349\u3055\u308c\u308b\u8ffd\u52a0\u306e\u80ce\u5150\u5947\u5f62\u306f\u3001\u91cd\u7be4\u306a\u598a\u5a20\u5408\u4f75\u75c7\u3092\u4f34\u3046\u3053\u3068\u304c\u591a\u3044\u305f\u3081\u3001\u60a3\u8005\u306e\u7ba1\u7406\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b[16, 19]\u3002 \u8ffd\u52a0\u306e\u80ce\u5150\u5947\u5f62\u3092\u691c\u51fa\u3059\u308b\u5e02\u8ca9\u306eNIPT\u5206\u6790\u6cd5\u306e\u80fd\u529b\u306f\u3001\u5206\u6790\u6cd5\u3067\u4f7f\u7528\u3055\u308c\u308b\u6280\u8853\u306b\u4f9d\u5b58\u3059\u308b\u3002 \u73fe\u5728\u306e\u4e3b\u8981\u306aNIPT\u6280\u8853\u306f\u3001\u5927\u898f\u6a21\u4e26\u5217\u5168\u30b2\u30ce\u30e0\u6b21\u4e16\u4ee3\u914d\u5217\u6c7a\u5b9a(NGS)[20-22]\u3001\u4e00\u5869\u57fa\u591a\u578b(SNP)\u306b\u57fa\u3065\u304f\u6a19\u7684\u914d\u5217\u6c7a\u5b9a[23\u300124]\u3001\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u914d\u5217\u6c7a\u5b9a[25]\u3092\u542b\u307f\u3001\u305d\u306e\u3046\u3061\u306e\u3044\u304f\u3064\u304b\u306eNGS\u306b\u57fa\u3065\u304f\u5206\u6790\u6cd5\u306e\u307f\u304c\u3001\u307e\u308c\u306a\u5e38\u67d3\u8272\u4f53\u7570\u6570\u6027\u304a\u3088\u3073\u90e8\u5206\u7684\u6b20\u5931\u304a\u3088\u3073\u91cd\u8907\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306b\u73fe\u5728\u691c\u8a3c\u3055\u308c\u3066\u3044\u308b\u3002 \u5927\u898f\u6a21\u4e26\u5217\u914d\u5217\u6c7a\u5b9a\u6280\u8853\u306f\u3001\u5358\u4e00\u672b\u7aef\u914d\u5217\u6c7a\u5b9a\u307e\u305f\u306f\u30da\u30a2\u30c7\u30f3\u30c9\u914d\u5217\u6c7a\u5b9a\u306e\u3044\u305a\u308c\u304b\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b;\u30da\u30a2\u672b\u7aef\u914d\u5217\u6c7a\u5b9a\u306e\u4f7f\u7528\u306f\u3001DNA\u65ad\u7247\u30b5\u30a4\u30ba\u304a\u3088\u3073\u4f4d\u7f6e\u306e\u4e21\u65b9\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u306e\u3067\u3001\u6709\u5229\u3067\u3042\u308b\u3002 \u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u3001\u80ce\u5150\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u975e\u4fb5\u8972\u7684\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u3053\u306e\u7a2e\u306e\u914d\u5217\u6c7a\u5b9a\u3092\u7528\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a[26, 27]\u3001\u30da\u30a2\u30a8\u30f3\u30c9\u914d\u5217\u6c7a\u5b9a\u306e\u81e8\u5e8a\u4f7f\u7528\u306b\u95a2\u3059\u308b\u6700\u521d\u306e\u8ad6\u6587\u304c2017\u5e74\u306b\u767a\u8868\u3055\u308c\u305f[28]\u3002<\/p>\n\n\n\n    <a href=\"\/nipt\/cfdna-in-the-investigation-of-miscarriage\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u6d41\u7523\u8abf\u67fb\u306b\u304a\u3051\u308b\u7121\u7d30\u80deDNA\u306e\u6d3b\u7528 <\/div>\n          <div class=\"blog-card-excerpt\">\u6d41\u7523\u3001\u7121\u7d30\u80deDNA\u306b\u95a2\u3059\u308b\u6295\u7a3f\u3067\u3059\u3002...<\/div>\n      <\/div>\n    <\/a>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u598a\u5a20\u8840\u6f3f\u30b5\u30f3\u30d7\u30eb\u306e\u80ce\u5150\u5206\u753b(FF)\u306fNIPT\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b[29]\u3002 \u60a3\u8005\u7279\u6027\u306fNIPT\u30b5\u30f3\u30d7\u30eb\u306e\u80ce\u5150\u5206\u753b\u30ec\u30d9\u30eb\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u5728\u80ce\u9f62\u3068\u80ce\u5150\u5206\u753b\u3068\u306e\u9593\u306e\u6b63\u306e\u76f8\u95a2\u304a\u3088\u3073\u6bcd\u4f53\u4f53\u91cd\u3068\u80ce\u5150\u5206\u753b\u3068\u306e\u9593\u306e\u8ca0\u306e\u76f8\u95a2\u304c\u793a\u3055\u308c\u3066\u3044\u308b[24\u300130\u300131]\u3002 \u4f4e\u80ce\u5150\u5206\u753b\u306f\u3001NIPT\u5206\u6790\u6cd5\u5931\u6557\u306e\u4e3b\u306a\u7406\u7531\u306e1\u3064\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u308b\u3002 \u307e\u305f\u3001\u975e\u5e38\u306b\u4f4e\u3044\u80ce\u5150\u5206\u753b\u3092\u6709\u3059\u308b\u8a66\u6599\u306f\u3001\u7570\u6570\u6027\u3001\u7279\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>[23\u300132-34]\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u3082\u7814\u7a76\u306b\u3088\u308a\u793a\u3055\u308c\u3066\u3044\u308b;\u3053\u308c\u306f\u3001\u3044\u304f\u3064\u304b\u306eNIPT\u5206\u6790\u6cd5\u304c\u80ce\u5150\u5206\u753b\u30ab\u30c3\u30c8\u30aa\u30d5\u3092\u9069\u7528\u3059\u308b\u306e\u3067\u3001\u591a\u304f\u306e\u7f79\u60a3\u598a\u5a20\u3092\u898b\u9003\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u91cd\u8981\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u8457\u8005\u3089\u306e\u7814\u7a76\u5ba4\u306f\u30013000\u75c7\u4f8b\u306b\u304a\u3051\u308bcfDNA\u306e\u5206\u6790\u306b\u304a\u3051\u308bSNP\u30d9\u30fc\u30b9\u306eNIPT\u5206\u6790\u6cd5\u306e\u6027\u80fd\u306b\u3064\u3044\u3066\u4ee5\u524d\u306b\u5831\u544a\u3057\u305f[35]\u3002 \u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u300113,607\u306e\u4e00\u822c\u598a\u5a20\u30b5\u30f3\u30d7\u30eb\u306b\u304a\u3051\u308b\u80ce\u5150\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u691c\u67fb\u306b\u304a\u3044\u3066\u3001\u30da\u30a2\u30a8\u30f3\u30c9\u914d\u5217\u6c7a\u5b9a\u306b\u57fa\u3065\u304fNGS\u5206\u6790\u6cd5\u3067\u3042\u308bVeriSeq\u2122<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> Solution v2\u5206\u6790\u6cd5\u306e\u6027\u80fd\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002 \u6211\u3005\u306f\u307e\u305f\u3001\u6211\u3005\u306e\u7814\u7a76\u306b\u304a\u3051\u308b\u80ce\u5150\u5206\u753b\u306e\u5f79\u5272\u3092\u8abf\u67fb\u3057\u3001\u60a3\u8005\u7279\u6027\u304c\u7814\u7a76\u7d50\u679c\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u304b\u3069\u3046\u304b\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u3092\u671b\u3093\u3060\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%9B%BB%E5%AD%90%E8%A3%9C%E8%B6%B3%E8%B3%87%E6%96%99\"><\/span><strong>\u96fb\u5b50\u88dc\u8db3\u8cc7\u6599<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u3053\u306e\u8a18\u4e8b\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\uff08<a href=\"https:\/\/doi.org\/10.1007\/s00404-020-05856-0\" target=\"_blank\" rel=\"noopener\">Analysis of cell-free DNA in a consecutive series of 13,607 routine cases for the detection of fetal chromosomal aneuploidies in a single center in Germany<\/a>\uff09\u306b\u306f\u3001\u627f\u8a8d\u3055\u308c\u305f\u30e6\u30fc\u30b6\u30fc\u304c\u5229\u7528\u3067\u304d\u308b\u88dc\u8db3\u8cc7\u6599\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Bernd Eiben<br>eiben@eurogen.de<\/li>\n<\/ul>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u5b9f\u9a13\u533b\u5b66\u304a\u3088\u3073\u81e8\u5e8a\u907a\u4f1d\u30ec\u30a4\u30f3\/ Ruhr\u306e1 Amedes\u7814\u7a76\u6240\u3001\u30a6\u30a3\u30ea\u30fc\u30fb\u30d6\u30e9\u30f3\u30c8\u30d7\u30e9\u30c3\u30c44\u3001\u30a8\u30c3\u30bb\u30f3\u3001\u30c9\u30a4\u30c4<\/li>\n\n\n\n<li>Amedes\u907a\u4f1d\u5b66\u3001Georgstr\u3002 50\u300130159\u30cf\u30ce\u30fc\u30d0\u30fc\u3001\u30c9\u30a4\u30c4<\/li>\n<\/ol>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B4%A0%E6%9D%90%E3%81%8A%E3%82%88%E3%81%B3%E6%96%B9%E6%B3%95\"><\/span>\u7d20\u6750\u304a\u3088\u3073\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%A2%AB%E9%A8%93%E8%80%85%E6%A4%9C%E4%BD%93%E3%81%AE%E8%A9%B3%E7%B4%B0\"><\/span>\u88ab\u9a13\u8005\/\u691c\u4f53\u306e\u8a73\u7d30<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u672c\u5f8c\u308d\u5411\u304d\u89e3\u6790\u7814\u7a76\u3067\u306f\u30012017\u5e7412\u6708\u304b\u30892019\u5e744\u6708\u307e\u3067\u306e17\u304b\u6708\u9593\u306b\u53ce\u96c6\u3057\u305f\u4e00\u822c\u598a\u5a20\u96c6\u56e3\u304b\u3089NIPT\u3092\u53d7\u3051\u305f\u9023\u7d9a\u60a3\u800513,607\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002 \u598a\u5a2010\u9031\u4ee5\u4e0a\u306e\u5358\u80ce\u304a\u3088\u3073\u53cc\u80ce\u306e\u4e21\u65b9\u306e\u598a\u5a20\u30b5\u30f3\u30d7\u30eb\u3092\u672c\u7814\u7a76\u306b\u542b\u3081\u305f;\u9664\u5916\u57fa\u6e96\u306b\u306f\u65e2\u77e5\u306e\u6d88\u5931\u53cc\u80ce\u307e\u305f\u306f\u9ad8\u30b0\u30ec\u30fc\u30c9\u591a\u80ce\u598a\u5a20\u304c\u542b\u307e\u308c\u305f\u3002 \u672c\u7814\u7a76\u3067\u306f\u3001\u5143\u306e\u30b5\u30f3\u30d7\u30eb\u5206\u6790\u304b\u3089\u306e\u65e2\u5b58\u306e\u914d\u5217\u6c7a\u5b9a\u30d5\u30a1\u30a4\u30eb\u3092\u3001\u5b9f\u9a13\u5ba4\u3067\u5b9f\u65bd\u3055\u308c\u3066\u3044\u308b\u65b0\u3057\u3044NIPT\u5206\u6790\u3001VeriSeq <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> Solution v2\u306e\u30d0\u30a4\u30aa \u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9 \u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u3092\u7528\u3044\u3066\u518d\u5206\u6790\u3057\u305f\u3002 \u518d\u5206\u6790\u306e\u7d50\u679c\u306f\u3001\u60a3\u8005\u307e\u305f\u306f\u533b\u5e2b\u306b\u4f1d\u3048\u3089\u308c\u306a\u304b\u3063\u305f\u3002 Amedes\u306f\u3001\u9023\u90a6\u30c7\u30fc\u30bf\u4fdd\u8b77\u6cd5\u306e\u898f\u5b9a\u3092\u9075\u5b88\u3059\u308b\u3002 \u60a3\u8005\u306e\u540c\u610f\u306f\u3001\u9069\u5207\u306a\u54c1\u8cea\u7ba1\u7406\u3068NIPT\u5206\u6790\u6cd5\u306e\u6539\u5584\u306e\u305f\u3081\u306b\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3059\u308b\u305f\u3081\u306b\u3001\u8a66\u9a13\u306b\u95a2\u4e0e\u3057\u305f\u5168\u60a3\u8005\u304b\u3089\u5f97\u3089\u308c\u305f\u3002 \u3055\u3089\u306b\u3001\u8a66\u9a13\u306b\u7d44\u307f\u5165\u308c\u308b\u524d\u306b\u3001\u3059\u3079\u3066\u306e\u30c7\u30fc\u30bf\u3092\u540c\u5b9a\u89e3\u9664\u3057\u305f\u3002<\/p>\n\n\n\n<p>NIPT\u306e\u9069\u5fdc\u306b\u306f\u3001\u6bcd\u89aa\u306e\u9ad8\u9f62\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u306e\u967d\u6027\u7d50\u679c(\u8d85\u97f3\u6ce2\u3001\u8840\u6e05\u30de\u30fc\u30ab\u30fc)\u3001\u305d\u306e\u4ed6\u306e\u533b\u5b66\u7684\u7406\u7531\u3001\u307e\u305f\u306f\u60a3\u8005\u306e\u4e0d\u5b89\u304c\u542b\u307e\u308c\u305f\u3002 \u305d\u306e\u4ed6\u306e\u533b\u5b66\u7684\u7406\u7531\u3068\u3057\u3066\u306f\u3001\u7cd6\u5c3f\u75c5\u3001\u3066\u3093\u304b\u3093\u3001\u764c\u306a\u3069\u306e\u65e2\u77e5\u306e\u75be\u60a3\u3001\u5316\u5b66\u7642\u6cd5\u306a\u3069\u306e\u85ac\u7269\u7642\u6cd5\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u307e\u305f\u306f\u4ee5\u524d\u306b\u7f79\u60a3\u3057\u305f\u598a\u5a20\u3092\u542b\u3080\u598a\u5a20\u5408\u4f75\u75c7\u306e\u65e2\u5f80(\u4f8b\u300121\u300118\u300113\u3001\u30e2\u30ce\u30bd\u30df\u30fcX)\u3001\u5bb6\u65cf\u306e\u907a\u4f1d\u7684\u7570\u5e38(\u4f8b\u300121\u30c8\u30ea\u30bd\u30df\u30fc)\u3001\u307e\u305f\u306f\u8840\u7e01\u95a2\u4fc2\u306a\u3069\u304c\u3042\u3063\u305f\u3002 \u9069\u5fdc\u75c7\u306b\u95a2\u3059\u308b\u60c5\u5831\u304c\u306a\u3044\u5834\u5408\u306f\u3001\u60a3\u8005\u306e\u4e0d\u5b89\u307e\u305f\u306f\u6bcd\u89aa\u306e\u9ad8\u9f62(\u7279\u8a31\u304c35\u6b73\u4ee5\u4e0a\u306e\u5834\u5408)\u3092\u9069\u5fdc\u3068\u3057\u305f\u3002 \u4e0a\u8a18\u306e\u9069\u5fdc\u75c7\u306e\u3046\u3061\u3001\u8907\u6570\u306e\u9069\u5fdc\u75c7\u304c\u3042\u308b\u5834\u5408\u306b\u306f\u30011. \u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u967d\u6027\u30012. \u6bcd\u89aa\u306e\u5e74\u9f62\u304c\u9ad8\u3044\u30013. \u305d\u306e\u4ed6\u306e\u533b\u5b66\u7684\u7406\u7531\u30014. \u60a3\u8005\u306e\u4e0d\u5b89\u306a\u3069\u30011\u3064\u306e\u9069\u5fdc\u75c7\u7fa4\u306e\u307f\u3092\u5404\u60a3\u8005\u306b\u5272\u308a\u4ed8\u3051\u308b\u3053\u3068\u3092\u512a\u5148\u3057\u3066\u3001\u9069\u5fdc\u75c7\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002 \u7570\u306a\u308b\u9069\u5fdc\u7fa4\u306b\u5bfe\u3059\u308b\u75c7\u4f8b\u306e\u5206\u985e\u306e\u6b63\u78ba\u6027\u3001\u306a\u3089\u3073\u306b\u60a3\u8005\u306e\u65e2\u5f80\u6b74\u306e\u4ed6\u306e\u3059\u3079\u3066\u306e\u60c5\u5831\u304a\u3088\u3073\u81e8\u5e8a\u8ee2\u5e30\u306b\u95a2\u3059\u308b\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u306f\u3001\u53d7\u3051\u53d6\u3063\u305f\u60c5\u5831\u306e\u6b63\u78ba\u6027\u306b\u4f9d\u5b58\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u8a66\u9a13\u75c7\u4f8b\u306e\u81e8\u5e8a\u8ee2\u5e30\u3001\u3059\u306a\u308f\u3061\u81e8\u5e8a\u7684\u771f\u5b9f\u306f\u3001\u4fb5\u8972\u7684\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u6280\u8853(\u7d68\u6bdb\u30b5\u30f3\u30d7\u30ea\u30f3\u30b0(CVS)\u304a\u3088\u3073\/\u307e\u305f\u306f\u7f8a\u6c34\u7a7f\u523a\u5f8c\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u5206\u6790)\u3001\u53d7\u80ce\u7523\u7269\u5206\u6790(<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u7d44\u7e54\u307e\u305f\u306f\u80ce\u76e4\u30b5\u30f3\u30d7\u30eb\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u5206\u6790\u3001\u5256\u691c\u307e\u305f\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u8089\u773c\u7684\u8a55\u4fa1\u306a\u3069\u306e\u5256\u691c)\u3001\u306a\u3089\u3073\u306b\u51fa\u751f\u5f8c\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u5206\u6790\u3001\u306a\u3089\u3073\u306b\u8d85\u97f3\u6ce2\u691c\u67fb\u304a\u3088\u3073\u65b0\u751f\u5150\u306e\u8eab\u4f53\u8a3a\u5bdf\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u305f\u3002 \u80ce\u5150\u7570\u6570\u6027\u967d\u6027\u306eNIPT\u7d50\u679c\u306f\u3001\u4fb5\u8972\u7684\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u307e\u305f\u306f\u9ad8\u30ea\u30b9\u30af\u306eNIPT\u547c\u3073\u51fa\u3057\u3068\u4e00\u81f4\u3059\u308b\u8d85\u97f3\u6ce2\u3067\u89b3\u5bdf\u3055\u308c\u305f\u7570\u5e38\u306e\u3044\u305a\u308c\u304b\u306b\u3088\u3063\u3066\u59a5\u5f53\u6027\u304c\u78ba\u8a8d\u3055\u308c\u308c\u3070\u3001\u78ba\u8a8d\u3055\u308c\u305f\u3068\u307f\u306a\u3055\u308c\u305f\u3002 \u30c8\u30ea\u30bd\u30df\u30fc21\u300118\u300113\u3001\u307e\u305f\u306f\u30e2\u30ce\u30bd\u30df\u30fcX\u306b\u660e\u3089\u304b\u306b\u9069\u5408\u3057\u306a\u3044(\u4f8b\u3048\u3070\u3001\u5185\u53cd\u8db3\u3001\u814e\u76c2\u62e1\u5f35\u3001\u5fc3\u5ba4\u4e2d\u9694\u6b20\u640d\u306a\u3069\u306e\u5fc3\u81d3\u6b20\u640d\u3001\u307e\u305f\u306f\u80ce\u76e4\u6a5f\u80fd\u4e0d\u5168\u306b\u3088\u308b\u5b50\u5bae\u5185\u767a\u80b2\u5236\u9650)\u5065\u5eb7\u306a\u51fa\u751f\u5150\u306b\u5bfe\u3057\u3066\u3001\u4e3b\u6cbb\u533b\u304c\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3092\u63d0\u4f9b\u3057\u305f\u5834\u5408\u3001\u4f4e\u30ea\u30b9\u30afNIPT\u306e\u7d50\u679c\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3068\u307f\u306a\u3055\u308c\u305f\u3002<\/p>\n<\/div><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"VeriSeq_NIPT_Solution_v2%E5%88%86%E6%9E%90%E6%B3%95\"><\/span>VeriSeq NIPT Solution v2\u5206\u6790\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>NIPT\u5206\u6790\u306f\u3001VeriSeq <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> Solution v2\u30d0\u30a4\u30aa \u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9 \u30d1\u30a4\u30d7\u30e9\u30a4\u30f3(Illumina Inc., San Diego, CA, USA)\u3092\u7528\u3044\u3066\u884c\u3063\u305f\u3002 \u3053\u306e\u5206\u6790\u6cd5\u3067\u306f\u3001\u30da\u30a2\u672b\u7aef\u5869\u57fa\u914d\u5217\u6c7a\u5b9a\u6cd5\u3092\u4f7f\u7528\u3057\u3001\u4ee5\u4e0b\u306e2\u3064\u306e\u5831\u544a\u69d8\u5f0f\u3092\u6709\u3059\u308b:\u5171\u901a\u306e\u30c8\u30ea\u30bd\u30df\u30fc\u304a\u3088\u3073\u6027\u67d3\u8272\u4f53(\u9078\u629e\u3055\u308c\u305f\u5834\u5408)\u306b\u3064\u3044\u3066\u5831\u544a\u3059\u308b\u300c\u57fa\u672c\u300d\u3001\u304a\u3088\u3073\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u306e\u80ce\u5150\u5947\u5f62(\u307e\u308c\u306a\u5e38\u67d3\u8272\u4f53\u7570\u6570\u6027\u304a\u3088\u30737 Mb\u4ee5\u4e0a\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosome-partial-deletion-guide\/\">\u90e8\u5206\u6b20\u5931<\/a>\u304a\u3088\u3073\u91cd\u8907\u3092\u542b\u3080)\u306e\u5b58\u5728\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u89e3\u6790\u3002 \u5f53\u521d\u3001\u60a3\u8005\u304c\u5171\u901a\u306e\u30c8\u30ea\u30bd\u30df\u30fc\u304a\u3088\u3073\u6027\u67d3\u8272\u4f53(\u9078\u629e\u3055\u308c\u305f\u5834\u5408)\u306e\u30b5\u30f3\u30d7\u30eb\u306e\u5206\u6790\u306b\u540c\u610f\u3057\u3066\u3044\u305f\u305f\u3081\u3001\u672c\u7814\u7a76\u3067\u306f\u3001\u57fa\u672c\u30e2\u30fc\u30c9\u3092\u7528\u3044\u3066\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u305f\u3082\u306e\u4ee5\u5916\u306e\u7570\u5e38\u306b\u95a2\u3059\u308b\u7d50\u679c\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u306a\u3044\u3002 VeriSeq <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> Assay Software v2\u306b\u3088\u308b\u65e2\u5b58\u306e\u914d\u5217\u6c7a\u5b9a\u30d5\u30a1\u30a4\u30eb\u306e\u5206\u6790\u5f8c\u3001\u30b5\u30f3\u30d7\u30eb\u306f\u3001\u4e00\u822c\u7684\u306a\u80ce\u5150\u30c8\u30ea\u30bd\u30df\u30fc(21\u30c8\u30ea\u30bd\u30df\u30fc\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u3001\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>)\u304a\u3088\u3073\u30e2\u30ce\u30bd\u30df\u30fcX(\u30b7\u30f3\u30b0\u30eb\u30c8\u30f3\u306e\u307f)\u306b\u3064\u3044\u3066\u3001\u7570\u5e38\u691c\u51fa\u307e\u305f\u306f\u7570\u5e38\u691c\u51fa\u306a\u3057\u3068\u547c\u3070\u308c\u305f\u3002 \u554f\u984c\u306e\u8a66\u6599\u306e\u80ce\u5150\u5206\u753b\u63a8\u5b9a\u5024\u3082\u63d0\u4f9b\u3057\u305f\u3002<br>\u80ce\u5150\u5206\u753b\u306f\u89b3\u5bdf\u3055\u308c\u305f\u88ab\u8986\u7387\u30c7\u30fc\u30bf\u3068\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u30b5\u30a4\u30ba\u5206\u5e03\u3092\u7528\u3044\u3066\u63a8\u5b9a\u3057\u305f\u3002 \u30ab\u30d0\u30ec\u30c3\u30b8\u306b\u57fa\u3065\u304f\u63a8\u5b9a\u5024\u306f\u3001\u4ee5\u524d\u306b\u8a18\u8f09\u3055\u308c\u305f\u65b9\u6cd5\u306b\u985e\u4f3c\u3057\u305f\u65b9\u6cd5\u3092\u7528\u3044\u3066\u5f97\u3089\u308c\u305f[36]\u3002 \u30b5\u30a4\u30ba\u306b\u57fa\u3065\u304fFF\u63a8\u5b9a\u5024\u306f\u3001\u80ce\u5150\u306ecfDNA\u65ad\u7247\u304c\u5e73\u5747\u3057\u3066\u6bcd\u4f53\u306e\u65ad\u7247\u3088\u308a\u3082\u77ed\u3044\u3068\u3044\u3046\u4e8b\u5b9f\u306b\u57fa\u3065\u3044\u3066\u3044\u305f[27\u300136\u300137]\u3002<br>\u30c7\u30fc\u30bf\u5206\u6790\u5f8c\u3001\u5404\u30b5\u30f3\u30d7\u30eb\u306b\u3064\u3044\u3066\u5bfe\u6570\u5c24\u5ea6\u6bd4(LLR)\u30b9\u30b3\u30a2\u3092\u63d0\u4f9b\u3057\u305f\u3002 \u3053\u308c\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u306e\u63a8\u5b9aFF\u304a\u3088\u3073\u89b3\u5bdf\u3055\u308c\u305f\u30ab\u30d0\u30ec\u30c3\u30b8\u3092\u4e0e\u3048\u3089\u308c\u305f\u5834\u5408\u306b\u3001\u30b5\u30f3\u30d7\u30eb\u304c\u5f71\u97ff\u3092\u53d7\u3051\u308b\u78ba\u7387\u3067\u3042\u308b\u3002 \u5206\u6790\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306f\u307e\u305f\u3001\u500b\u5225\u5316\u80ce\u5150\u7570\u6570\u6027\u4fe1\u983c\u5ea6\u8a66\u9a13(iFACT)\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u3057\u304d\u3044\u5024\u30e1\u30c8\u30ea\u30c3\u30af\u3092\u4f7f\u7528\u3057\u3001\u3053\u308c\u306f\u3001\u305d\u306e\u30b5\u30f3\u30d7\u30eb\u306b\u3064\u3044\u3066\u306eFF\u63a8\u5b9a\u5024\u3092\u4e0e\u3048\u3089\u308c\u305f\u5404\u500b\u3005\u306e\u30b5\u30f3\u30d7\u30eb\u306b\u3064\u3044\u3066\u5341\u5206\u306a\u914d\u5217\u6c7a\u5b9a\u30ab\u30d0\u30ec\u30c3\u30b8\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u6c7a\u5b9a\u3059\u308b;\u3053\u306e\u3057\u304d\u3044\u5024\u3092\u6e80\u305f\u3055\u306a\u304b\u3063\u305f\u30b5\u30f3\u30d7\u30eb\u306f\u3001QC\u5931\u6557\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u305f\u3002 \u30ab\u30d0\u30ec\u30c3\u30b8\u306e\u5747\u4e00\u6027\u306e\u3088\u3046\u306a\u4ed6\u306eQC\u6e2c\u5b9a\u57fa\u6e96\u3082\u8003\u616e\u306b\u5165\u308c\u305f\u3002 \u307e\u305f\u3001\u3053\u306e\u691c\u67fb\u6cd5\u306fT-Statistics\u306e\u5024\u3092\u63d0\u4f9b\u3057\u3001\u4f4e\u30ea\u30b9\u30af\u3068\u9ad8\u30ea\u30b9\u30af\u306e\u30b5\u30f3\u30d7\u30eb\u3092\u533a\u5225\u3059\u308b\u306e\u306b\u5f79\u7acb\u3063\u305f\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%B1%E8%A8%88\"><\/span>\u7d71\u8a08<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Microsoft Excel 2010\u3092\u7528\u3044\u3066\u7d71\u8a08\u30c7\u30fc\u30bf\u89e3\u6790\u3092\u884c\u3063\u305f\u3002 \u8a72\u5f53\u3059\u308b\u5834\u5408\u3001\u5dee\u306e\u7d71\u8a08\u7684\u6709\u610f\u6027\u3092Student\u306et\u691c\u5b9a\u3067\u8a55\u4fa1\u3057\u3001p\u5024&lt;0.05\u3092\u6709\u610f\u3068\u307f\u306a\u3057\u305f\u3002 \u611f\u5ea6\u304a\u3088\u3073\u7279\u7570\u5ea6\u306e\u63a8\u5b9a\u5024\u306b\u3064\u3044\u3066\u4e8c\u980595%\u4fe1\u983c\u533a\u9593(CI)\u3092\u7b97\u51fa\u3057\u305f\u3002<br>\u7b2c1\u306e\u8840\u6db2\u8a66\u6599\u306e\u78ba\u5b9a\u7684\u3067\u306a\u3044NIPT\u7d50\u679c\u306e\u5834\u5408\u3001\u518d\u5206\u6790\u306e\u305f\u3081\u306b\u7b2c2\u306e\u8840\u6db2\u8a66\u6599\u3092\u63a1\u53d6\u3057\u305f\u3002 \u3053\u306e\u3088\u3046\u306a\u5834\u5408\u3001\u7d71\u8a08\u89e3\u6790\u3067\u306f\u6700\u521d\u306e\u89e3\u6790\u7d50\u679c\u3092\u9664\u5916\u3057\u3001\u60a3\u80051\u4eba\u306b\u3064\u304d1\u4ef6\u306e\u7d50\u679c\u306e\u307f\u3092\u7d71\u8a08\u8a55\u4fa1\u306b\u542b\u3081\u305f\u3002 \u307e\u305f\u3001\u6700\u521d\u306e\u8840\u6db2\u691c\u4f53\u306e\u5206\u6790\u3067NIPT\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u304c\u30014%\u672a\u6e80\u306e\u4f4eFF(3% FF\u307e\u305f\u306f2% FF)\u304c\u8a8d\u3081\u3089\u308c\u305f\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u3001\u518d\u5206\u6790\u306e\u305f\u3081\u306b\u5225\u306e\u8840\u6db2\u691c\u4f53\u3092\u63a1\u53d6\u3057\u3001\u3053\u308c\u3092\u5584\u610f\u306e\u8eab\u632f\u308a\u3068\u3057\u3066\u51e6\u7406\u3057\u305f\u3002 \u3053\u306e\u5834\u5408\u3082\u3001\u518d\u5206\u6790\u3067NIPT\u7d50\u679c\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u5834\u5408\u3092\u9664\u304d\u3001\u6700\u521d\u306e\u5206\u6790\u7d50\u679c\u3092\u7d71\u8a08\u89e3\u6790\u304b\u3089\u9664\u5916\u3057\u3001\u5f8c\u8005\u306e\u5834\u5408\u306f\u3001\u6700\u521d\u306e\u5206\u6790\u7d50\u679c\u30922%\u53c8\u306f3%\u306eFF\u306e\u7d71\u8a08\u306b\u542b\u3081\u3001\u518d\u5206\u6790\u4e0d\u6210\u529f\u3092\u9664\u5916\u3057\u305f\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%90%E6%9E%9C-2\"><\/span>\u7d50\u679c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5408\u8a0813,607\u306e\u598a\u5a20\u75c7\u4f8b\u304c\u7814\u7a76\u306b\u542b\u307e\u308c\u300113,333\u306e\u30b7\u30f3\u30b0\u30eb\u30c8\u30f3\u3068274\u306e\u53cc\u5b50\u306e\u598a\u5a20\u30b5\u30f3\u30d7\u30eb\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u3046\u3061\u300113,281\uff0897.6\uff05\uff09\u306f\u3001\u6700\u521d\u306e\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u306e\u5206\u6790\u6642\u306bNIPT\u306e\u7d50\u679c\u3092\u5f97\u307e\u3057\u305f\u3002\u6700\u521d\u306e\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3092\u4f7f\u7528\u3057\u3066\u7d50\u679c\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f326\u306e\u30b5\u30f3\u30d7\u30eb\u306e\u3046\u3061\u3001273\u304c2\u756a\u76ee\u306e\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3067\u7e70\u308a\u8fd4\u3057\u5206\u6790\u3092\u53d7\u3051\u3001228\uff0883.5\uff05\uff09\u306e\u30b1\u30fc\u30b9\u304c\u7d50\u679c\u3092\u5f97\u307e\u3057\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u5408\u8a0813,509\u4eba\u306e\u60a3\u8005\u304cNIPT\u306e\u7d50\u679c\u3092\u5f97\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u7814\u7a76\u306e\u5931\u6557\u7387\u306f0.72\uff05\uff0898 \/ 13,607\uff09\u3067\u3057\u305f\u3002\u81e8\u5e8a\u8ee2\u5e30\u306f2623\u4f8b\u3067\u5229\u7528\u53ef\u80fd\u3067\u3057\u305f\u3002\u7d50\u679c\u306f\u3001\u4fb5\u8972\u7684\u8a3a\u65ad\u6280\u8853\u3001\u8d85\u97f3\u6ce2\u3001\u307e\u305f\u306f\u65b0\u751f\u5150\u306e\u8eab\u4f53\u691c\u67fb\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3057\u305f\uff08\u88dc\u8db3\u88681;\u30aa\u30f3\u30e9\u30a4\u30f3\u30ea\u30bd\u30fc\u30b91\uff09\u3002<\/p>\n\n\n\n<p>\u5168\u4f53\u7684\u306a\u7814\u7a76\u306b\u542b\u307e\u308c\u308b13,607\u4eba\u306e\u60a3\u8005\u306e\u60a3\u8005\u306e\u4eba\u53e3\u7d71\u8a08\u3092\u88681\u306b\u793a\u3057\u307e\u3059\u3002\u3059\u3079\u3066\u306e\u60a3\u8005\u306e\u307b\u307c\u534a\u6570\u304c\u3001\u89aa\u306e\u4e0d\u5b89\u306e\u305f\u3081\u306b\u6700\u521d\u306bNIPT\u3092\u53d7\u3051\u308b\u3053\u3068\u3092\u9078\u629e\u3057\u307e\u3057\u305f\u3002\u7814\u7a76\u30b5\u30f3\u30d7\u30eb\u306e\u5e73\u5747\u80ce\u5150\u5206\u753b\u306f9.62\uff05\u3067\u3001\u7bc4\u56f2\u306f1.20\u301c33.94\uff05\u3067\u3057\u305f\u3002\u80ce\u5150\u306e\u5272\u5408\u3068\u60a3\u8005\u306eBMI\u306e\u95a2\u4fc2\u3092\u56f32\u306b\u793a\u3057\u307e\u3059\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u60a3\u8005\u306e86.6\uff05\u304c\u598a\u5a20\u521d\u671f\u306b\u691c\u67fb\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u5728\u80ce\u9031\u6570\u3068\u4ed6\u306e\u60a3\u8005\u306e\u7279\u5fb4\uff08\u6bcd\u4f53\u5e74\u9f62\u3001BMI\u3001\u80ce\u5150\u306e\u5272\u5408\uff09\u3068\u306e\u95a2\u4fc2\u3092\u88dc\u8db3\u56f31\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u30ea\u30bd\u30fc\u30b92\uff09\u306b\u793a\u3057\u307e\u3059\u3002\u4e88\u60f3\u901a\u308a\u3001BMI\u306f\u3001\u80ce\u5150\u306e\u5272\u5408\u3068\u540c\u69d8\u306b\u3001\u5728\u80ce\u9031\u6570\u306e\u5897\u52a0\u3068\u3068\u3082\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u80ce\u5150\u5206\u753b\u306e\u9855\u8457\u306a\u5897\u52a0\u306f\u3001\u598a\u5a2020\u9031\u4ee5\u4e0a\u304b\u3089\u306e\u307f\u89b3\u5bdf\u3055\u308c\u305f\u304c\u3001\u598a\u5a20\u306e\u524d\u306e\u9031\u3067\u306f\u3001\u80ce\u5150\u5206\u753b\u306e\u6709\u610f\u3067\u3042\u308b\u304c\u308f\u305a\u304b\u306a\u5897\u52a0\u306e\u307f\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u9069\u5fdc\u3068\u6bcd\u4f53\u306e\u5e74\u9f62\u3001BMI\u3001\u304a\u3088\u3073\u80ce\u5150\u306e\u5272\u5408\u3068\u306e\u95a2\u4fc2\u3082\u8abf\u67fb\u3055\u308c\u307e\u3057\u305f\uff08\u88dc\u8db3\u56f32;\u30aa\u30f3\u30e9\u30a4\u30f3\u30ea\u30bd\u30fc\u30b92\uff09\u3002<\/p>\n\n\n\n<p>NIPT\u306e\u7d50\u679c\u3092\u53d7\u3051\u305f13,509\u4eba\u306e\u60a3\u8005\u306e\u3046\u3061\u300198.6\uff05\uff0813,321\uff09\u304c\u4f4e\u30ea\u30b9\u30af\u3068\u547c\u3070\u308c\u30011.4\uff05\uff08188\uff09\u304c\u80ce\u5150\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u5b58\u5728\u306e\u9ad8\u30ea\u30b9\u30af\u3068\u547c\u3070\u308c\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u81e8\u5e8a\u8ee2\u5e30\u306f2623\u4f8b\u3067\u5229\u7528\u53ef\u80fd\u3067\u3057\u305f\uff08\u88dc\u8db3\u88681;\u30aa\u30f3\u30e9\u30a4\u30f3\u30ea\u30bd\u30fc\u30b91\uff09\u3002\u80ce\u5150\u306e\u7570\u6570\u6027\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u3068\u5831\u544a\u3055\u308c\u305f13,321\u4f8b\u306e\u3046\u3061\u30012478\u4f8b\uff0818.6\uff05\uff09\u306e\u81e8\u5e8a\u8ee2\u5e30\u304c\u5229\u7528\u53ef\u80fd\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u3046\u3061\u300121\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u75c7\u4f8b\u3067\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u507d\u9670\u6027\u306e\u547c\u3073\u51fa\u3057\u304c1\u3064\u3042\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u507d\u9670\u6027\u306e\u75c7\u4f8b\u306e\u80ce\u5150\u306e\u5272\u5408\u306f3\uff05\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>188\u306e\u30cf\u30a4\u30ea\u30b9\u30af\u30b3\u30fc\u30eb\u306e\u3046\u3061\u3001117\u306f21\u30c8\u30ea\u30bd\u30df\u30fc\u300134\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u300123\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u30011\u3064\u306f21 + <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u300113\u306fX\u30c8\u30ea\u30bd\u200b\u200b\u30df\u30fc\u30b3\u30fc\u30eb\u3067\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306e\u60a3\u8005\u306e1.3\uff05\u306f\u3001\u53e4\u5178\u7684\u306a\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u5b58\u5728\u3092\u6c42\u3081\u308b\u80af\u5b9a\u7684\u306aNIPT\u306e\u547c\u3073\u304b\u3051\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u9ad8\u30ea\u30b9\u30af\u75c7\u4f8b\u306e77.1\uff05\uff08145\/188\uff09\u306b\u3064\u3044\u3066\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c\u5229\u7528\u53ef\u80fd\u3067\u3057\u305f\u3002\u88682\u306b\u793a\u3059\u3088\u3046\u306b\u3001123\u4ef6\u306e\u771f\u967d\u6027\u75c7\u4f8b\u306822\u4ef6\u306e\u507d\u967d\u6027\u75c7\u4f8b\u306b\u57fa\u3065\u3044\u3066\u3001\u9ad8\u30ea\u30b9\u30af\u75c7\u4f8b\u306798.89\uff05\u4ee5\u4e0a\u306e\u611f\u5ea6\u306899.73\uff05\u4ee5\u4e0a\u306e\u7279\u7570\u6027\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002 21 + <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u306e1\u3064\u306e\u75c7\u4f8b\u306e\u7d50\u679c\u306f\u793a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u3053\u306e\u75c7\u4f8b\u306f\u771f\u967d\u6027\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u9ad8\u30ea\u30b9\u30af\u75c7\u4f8b\u306e\u5168\u4f53\u7684\u306aPPV\u306f84.8\uff05\uff08123\/145\uff09\u3067\u3057\u305f\u3002 21\u30c8\u30ea\u30bd\u30df\u30fc\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304a\u3088\u3073X\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u75c7\u4f8b\u306ePPV\u7d50\u679c\u3092\u88682\u306b\u793a\u3057\u307e\u3059\u3002\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u306e\u306a\u3044\u9ad8\u30ea\u30b9\u30af\u75c7\u4f8b\u304c\u3059\u3079\u3066\u771f\u967d\u6027\u307e\u305f\u306f\u3059\u3079\u3066\u771f\u9670\u6027\u3067\u3042\u308b\u3068\u3044\u3046\u4eee\u5b9a\u306b\u57fa\u3065\u3044\u3066\u3001\u7406\u8ad6\u7684\u306aPPV\u7bc4\u56f2\u3092\u8a08\u7b97\u3057\u307e\u3057\u305f\u3002\u9ad8\u30ea\u30b9\u30af\u75c7\u4f8b\u306e\u7406\u8ad6\u7684PPV\u7bc4\u56f2\u306f\u300165.4\uff05\uff08123\/188\uff09\u301c88.3\uff05\uff08166\/188\uff09\u3067\u3057\u305f\u3002\u6bcd\u4f53\u5e74\u9f62\u3001BMI\u3001\u304a\u3088\u3073FF\u306b\u3088\u308bNIPT\u7d50\u679c\u306e\u5c64\u5225\u5316\u306f\u3001\u88dc\u8db3\u56f33\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u30ea\u30bd\u30fc\u30b92\uff09\u306b\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u3068<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u306f\u3001\u6709\u610f\u306b\u4f4e\u3044\u80ce\u5150\u5206\u753b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08\u4f4e\u30ea\u30b9\u30af\u306eNIPT\u306e\u7d50\u679c\u3068\u6bd4\u8f03\u3057\u3066\u3001\u305d\u308c\u305e\u308cp &lt;0.01\u3068p &lt;0.001\uff09\u3002\u60a3\u8005\u306eBMI\u306b\u3088\u3063\u3066\u5c64\u5225\u5316\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u4f4e\u30ea\u30b9\u30af\u304a\u3088\u3073\u9ad8\u30ea\u30b9\u30af\u306eNIPT\u75c7\u4f8b\u306e\u80ce\u5150\u306e\u5272\u5408\u306f\u3001\u88dc\u8db3\u56f34\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u30ea\u30bd\u30fc\u30b92\uff09\u306b\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u771f\u967d\u6027\u304a\u3088\u3073\u507d\u967d\u6027\u306e\u9ad8\u30ea\u30b9\u30af\u75c7\u4f8b\u306eLLR\u30b9\u30b3\u30a2\u3068T\u7d71\u8a08\u5024\u3092\u88dc\u8db3\u88682\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u30ea\u30bd\u30fc\u30b91\uff09\u306b\u793a\u3057\u307e\u3059\u3002\u898b\u3066\u308f\u304b\u308b\u3088\u3046\u306b\u3001LLR\u30b9\u30b3\u30a2\u3068T\u7d71\u8a08\u5024\u306e\u4e21\u65b9\u304c\u3001\u771f\u967d\u6027\u306e21\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u5834\u5408\u3088\u308a\u3082\u507d\u967d\u6027\u306e21\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u5834\u5408\u306e\u65b9\u304c\u306f\u308b\u304b\u306b\u4f4e\u304b\u3063\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u5168\u4f53\u3068\u3057\u3066\u3001\u30b5\u30f3\u30d7\u30eb\u306e2.0\uff05\uff08264 \/ 13,509\uff09\u306e\u80ce\u5150\u306e\u5272\u5408\u306f4\uff05\u672a\u6e80\u3001\u30b5\u30f3\u30d7\u30eb\u306e43.9\uff05\uff085933 \/ 13,509\uff09\u306e\u80ce\u5150\u306e\u5272\u5408\u306f4\u301c8\uff05\u3001\u30b5\u30f3\u30d7\u30eb\u306e54.1\uff05\uff087312 \/ 13,509\uff09\u306e\u80ce\u5150\u306e\u5272\u5408\u306f8\uff05\u3092\u8d85\u3048\u308b\u80ce\u5150\u306e\u5272\u5408\u3002\u80ce\u5150\u306e\u5272\u5408\u306b\u3088\u308b\u9ad8\u30ea\u30b9\u30afNIPT\u306e\u7d50\u679c\u306e\u5185\u8a33\u3092\u56f33\u306b\u793a\u3057\u307e\u3059\u3002\u898b\u3066\u308f\u304b\u308b\u3088\u3046\u306b\u3001\u9ad8\u30ea\u30b9\u30af\u306e\u75c7\u4f8b\u306e\u5927\u90e8\u5206\u306f4\u301c8\uff05\uff0849.5\uff05; 93\/188\uff09\u306e\u80ce\u5150\u306e\u5272\u5408\u3067\u3057\u305f\u3002\u80ce\u5150\u306e\u5272\u5408\u304c4\uff05\u672a\u6e80\u306e264\u306e\u30b5\u30f3\u30d7\u30eb\u306e\u3046\u3061\u300121\u306fNIPT\u306b\u3088\u3063\u3066\u30cf\u30a4\u30ea\u30b9\u30af\u3068\u3057\u3066\u5206\u985e\u3055\u308c\u307e\u3057\u305f\uff086\u30c8\u30ea\u30bd\u30df\u30fc21\u30016\u30c8\u30ea\u30bd\u30df\u30fc18\u3001\u304a\u3088\u30739\u30c8\u30ea\u30bd\u30df\u30fc13\uff09\u3002\u3053\u308c\u3089\u306e21\u75c7\u4f8b\u306e\u3046\u30619\u75c7\u4f8b\u3067\u7d50\u679c\u304c\u5f97\u3089\u308c\u3001PPV\u306f66.7\uff05\u3067\u3057\u305f\uff08 6\/9\uff09\u3002\u4f4e\u30ea\u30b9\u30af\u306e\u75c7\u4f8b\u3067\u306f\u3001\u80ce\u5150\u306e\u5272\u5408\u304c4\uff05\u672a\u6e80\u306e\u75c7\u4f8b\u306798.1\uff05\uff0852\/53\uff09\u306eNPV\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u80ce\u5150\u306e\u5272\u5408\u304c4\u301c8\uff05\u306e\u5834\u5408\uff081198\/1198\uff09\u3001\u304a\u3088\u3073\u80ce\u5150\u306e\u5272\u5408\u304c8\uff05\u4ee5\u4e0a\u306e\u5834\u5408\uff081227\/1227\uff09\u306b\u300199.9\uff05\u3092\u8d85\u3048\u308bNPV\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"600\" height=\"504\" src=\"https:\/\/hiro-clinic.or.jp\/nipt\/wp-content\/uploads\/2020\/11\/flowchart_of_study.png\" alt=\"flowchart_of_study.png\" class=\"wp-image-7237\"\/><figcaption class=\"wp-element-caption\">\u56f31 \u8a66\u9a13\u8a66\u6599\u306e\u30d5\u30ed\u30fc\u30c1\u30e3\u30fc\u30c8<\/figcaption><\/figure>\n\n\n\n<table>\n<caption>\u88681 \u8a66\u9a13\u30b3\u30db\u30fc\u30c8\u306e\u60a3\u8005\u306e\u4eba\u53e3\u7d71\u8a08\u5b66\u7684\u7279\u6027<\/caption>\n<colgroup><col style=\"width:50%\">\n    <col style=\"width:50%\">\n<\/colgroup>\n<thead>\n<tr>\n<td>&nbsp;<\/td><td>\u8a66\u9a13\u30b3\u30db\u30fc\u30c8(n = 13,607)<\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th colspan=\"2\">\u6bcd\u89aa\u306e\u5e74\u9f62(\u6b73)<\/th>\n<\/tr>\n<tr>\n<td>\u5e73\u5747\u5024\u00b1\u6a19\u6e96\u8aa4\u5dee<\/td><td>33.68 \u00b1 0.04<\/td>\n<\/tr>\n<tr>\n<td>\u7bc4\u56f2<\/td><td>17.45\u201355.83<\/td>\n<\/tr>\n<\/table>\n<table>\n<colgroup><col style=\"width:50%\">\n    <col style=\"width:50%\">\n<\/colgroup>\n<tr>\n<th colspan=\"2\">\u598a\u5a20\u9031\u9f62<\/th>\n<\/tr>\n<tr>\n<td>\u5e73\u5747\u5024\u00b1\u6a19\u6e96\u8aa4\u5dee<\/td><td>12.48 \u00b1 0.02<\/td>\n<\/tr>\n<tr>\n<td>\u7bc4\u56f2<\/td><td>10.00\u201336.57<\/td>\n<\/tr>\n<\/table>\n<table>\n<colgroup><col style=\"width:50%\">\n    <col style=\"width:50%\">\n<\/colgroup>\n<tr>\n<th colspan=\"2\">BMI<\/th>\n<\/tr>\n<tr>\n<td>\u5e73\u5747\u5024\u00b1\u6a19\u6e96\u8aa4\u5dee<\/td><td>24.87 \u00b1 0.05<\/td>\n<\/tr>\n<tr>\n<td>\u7bc4\u56f2<\/td><td>15.05\u201360.96<\/td>\n<\/tr>\n<\/table>\n<table>\n<colgroup><col style=\"width:50%\">\n    <col style=\"width:50%\">\n<\/colgroup>\n<tr>\n<th colspan=\"2\">\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u9069\u5fdc[n(%)]<\/th>\n<\/tr>\n<tr>\n<td>\u6bcd\u89aa\u306e\u9ad8\u9f62<\/td><td>5755 (42.3)<\/td>\n<\/tr>\n<tr>\n<td>\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u967d\u6027\u7d50\u679c<\/td><td>819 (6.0)<\/td>\n<\/tr>\n<tr>\n<td>\u305d\u306e\u4ed6\u306e\u533b\u5b66\u7684\u691c\u67fb<\/td><td>748 (5.5)<\/td>\n<\/tr>\n<tr>\n<td>\u60a3\u8005\u306e\u4e0d\u5b89<\/td><td>6285 (46.2)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B4%E3%80%81%E9%80%B1%E3%80%81%E5%B9%B3%E5%9D%87%E5%80%A4%E3%81%AESEM%E6%A8%99%E6%BA%96%E8%AA%A4%E5%B7%AE%E3%80%81BMI%E3%83%9C%E3%83%87%E3%82%A3%E3%83%9E%E3%82%B9%E3%82%A4%E3%83%B3%E3%83%87%E3%83%83%E3%82%AF%E3%82%B9\"><\/span>\u5e74\u3001\u9031\u3001\u5e73\u5747\u5024\u306eSEM\u6a19\u6e96\u8aa4\u5dee\u3001BMI\u30dc\u30c7\u30a3\u30de\u30b9\u30a4\u30f3\u30c7\u30c3\u30af\u30b9<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u306e\u967d\u6027\u7d50\u679c\u306b\u306f\u3001\u8d85\u97f3\u6ce2\u691c\u67fb\u307e\u305f\u306f\u8840\u6e05\u30de\u30fc\u30ab\u30fc\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u542b\u307e\u308c\u308b<br>\u305d\u306e\u4ed6\u306e\u533b\u5b66\u7684\u7406\u7531\u306b\u306f\u3001\u4f8b\u3048\u3070\u3001\u8d85\u97f3\u6ce2\u7570\u5e38\u3001\u60a3\u8005\u306e\u65e2\u77e5\u306e\u75be\u60a3(\u4f8b\u3048\u3070\u3001\u7cd6\u5c3f\u75c5\u3001\u3066\u3093\u304b\u3093\u3001\u304a\u3088\u3073\u764c\u816b)\u3001\u6295\u85ac(\u4f8b\u3048\u3070\u3001\u5316\u5b66\u7642\u6cd5)\u3001\u307e\u305f\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u65e2\u5f80\u306a\u3069\u306e\u9ad8\u30ea\u30b9\u30af\u5bb6\u65cf\u6b74\u3001\u4ee5\u524d\u306e\u598a\u5a20\u306b\u304a\u3051\u308b\u907a\u4f1d\u7684\u7570\u5e38(\u4f8b\u3048\u3070\u300121\u30c8\u30ea\u30bd\u30df\u30fc\u300118\u300113\u30e2\u30ce\u30bd\u30df\u30fcX)\u3001\u5bb6\u65cf\u306b\u304a\u3051\u308b\u907a\u4f1d\u7684\u7570\u5e38(\u4f8b\u3048\u3070\u300121\u30c8\u30ea\u30bd\u30df\u30fc)\u3001\u307e\u305f\u306f\u8840\u7e01\u95a2\u4fc2\u304c\u542b\u307e\u308c\u308b\u3002<br>\f<\/p>\n<\/div><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"600\" height=\"431\" src=\"https:\/\/hiro-clinic.or.jp\/nipt\/wp-content\/uploads\/2020\/11\/relationship_between_fetal_fraction_and_patient_BMI.png\" alt=\"\" class=\"wp-image-7239\"\/><figcaption class=\"wp-element-caption\">\u56f32 \u80ce\u5150\u5206\u753b\u3068\u60a3\u8005BMI\u3068\u306e\u95a2\u4fc2<\/figcaption><\/figure>\n\n\n\n<div class=\"wp-block-group table2\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%A1%A82_%E9%AB%98%E3%83%AA%E3%82%B9%E3%82%AFNIPT%E7%97%87%E4%BE%8B%E3%81%AE%E6%84%9F%E5%BA%A6%E3%80%81%E7%89%B9%E7%95%B0%E5%BA%A6%E3%80%81%E3%81%8A%E3%82%88%E3%81%B3%E9%99%BD%E6%80%A7%E7%9A%84%E4%B8%AD%E7%8E%87\"><\/span>\u88682 \u9ad8\u30ea\u30b9\u30afNIPT\u75c7\u4f8b\u306e\u611f\u5ea6\u3001\u7279\u7570\u5ea6\u3001\u304a\u3088\u3073\u967d\u6027\u7684\u4e2d\u7387<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<table>\n<colgroup>\n<col style=\"width:20%\">\n    <col style=\"width:20%\">\n    <col style=\"width:20%\">\n    <col style=\"width:20%\">\n    <col style=\"width:20%\">\n<\/colgroup>\n<thead>\n<tr>\n<th><\/th><th>21\u30c8\u30ea\u30bd\u30df\u30fc<\/th><th><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a><\/th><th><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a><\/th><th>\u30e2\u30ce\u30bd\u30df\u30fcX<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th>\u75c7\u4f8b\u6570 (n)<\/th>\n<td>117<\/td>\n<td>34<\/td>\n<td>23<\/td>\n<td>13<\/td>\n<\/tr>\n<tr>\n<th>\u8ffd\u8de1\u8abf\u67fb\u4f8b [n]<\/th>\n<td>96(82.1)<\/td>\n<td>23(67.6)<\/td>\n<td>15(65.2)<\/td>\n<td>10(76.9)<\/td>\n<\/tr>\n<tr>\n<th>\u611f\u5ea6<span class=\"nowrap\">[%(n\/N;95%)]<\/span><\/th>\n<td>98.89(89\/90; 93.96\u201399.97)<\/td>\n<td>&gt; 99.99(19\/19; 82.35\u2013100)<\/td>\n<td>&gt; 99.99(9\/9; 66.37\u2013100)<\/td>\n<td>&gt; 99.99(5\/5; 47.82\u2013100)<\/td>\n<\/tr>\n<tr>\n<th>\u7279\u7570\u5ea6<span class=\"nowrap\">[%(n\/N;95%)]<\/span><\/th>\n<td>99.73(2566\/2573; 99.44\u201399.89)<\/td>\n<td>99.84(2496\/2500; 99.59\u201399.96)<\/td>\n<td>99.76(2486\/2492; 99.48\u201399.91)<\/td>\n<td>99.80(2482\/2487; 99.53\u201399.93)<\/td>\n<\/tr>\n<tr>\n<th>PPV <span class=\"nowrap\">[%(n\/N)]<\/span><\/th>\n<td>92.7(89\/96)<\/td>\n<td>82.6(19\/23)<\/td>\n<td>60.0(9\/15)<\/td>\n<td>50.0(5\/10)<\/td>\n<\/tr>\n<tr>\n<th>\u7406\u8ad6\u4e0a\u306e\u4f4e\u3044PPV <span class=\"nowrap\">[%(n\/N)]<\/span><\/th>\n<td>76.1(89\/117)<\/td>\n<td>55.9(19\/34)<\/td>\n<td>39.1(9\/23)<\/td>\n<td>38.5(5\/13)<\/td>\n<\/tr>\n<tr>\n<th>\u7406\u8ad6\u4e0a\u306e\u4e0a\u4f4dPPV <span class=\"nowrap\">[%(n\/N)]<\/span><\/th>\n<td>94.0(110\/117)<\/td>\n<td>88.2(30\/34)<\/td>\n<td>73.9(17\/23)<\/td>\n<td>61.5(8\/13)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%80%83%E5%AF%9F\"><\/span>\u8003\u5bdf<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u3053\u3053\u3067\u306f\u3001VeriSeq <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> Solution v2\u5206\u6790\u6cd5\u304c\u3001\u65e2\u77e5\u306e\u81e8\u5e8a\u8ee2\u5e30\u306b\u57fa\u3065\u3044\u3066\u89b3\u5bdf\u3055\u308c\u305f\u9ad8\u3044\u611f\u5ea6\u3068\u7279\u7570\u6027\u3067\u80ce\u5150\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3067\u304d\u305f\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u305f\u611f\u5ea6\u3068\u7279\u7570\u6027\u306f\u3001Gil\u3089\u306b\u3088\u308b\u6700\u8fd1\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u898b\u3064\u304b\u3063\u305f\u3082\u306e\u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u3059\u3002 [3]\u79c1\u305f\u3061\u306e\u7814\u7a76\u3067\u3082\u3001\u5168\u4f53\u7684\u306a\u6545\u969c\u7387\u306f1\uff05\u672a\u6e80\u3068\u4f4e\u304b\u3063\u305f\u3002\u81e8\u5e8a\u7814\u7a76\u306e\u5834\u5408\u3001\u967d\u6027\u306e\u4e88\u6e2c\u5024\u306f\u3001\u81e8\u5e8a\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c\u53ef\u80fd\u3067\u3042\u308c\u3070\u3001\u5206\u6790\u6cd5\u306e\u611f\u5ea6\u3068\u7279\u7570\u6027\u3068\u3068\u3082\u306b\u5831\u544a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u91cd\u8981\u306a\u6307\u6a19\u3067\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u9ad8\u30ea\u30b9\u30af\u306e\u75c7\u4f8b\u306e\u5927\u90e8\u5206\u3067\u81e8\u5e8a\u7684\u771f\u5b9f\u304c\u5229\u7528\u53ef\u80fd\u3067\u3057\u305f\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u3067\u306f\u3001\u7279\u306b21\u30c8\u30ea\u30bd\u30df\u30fc\u3068<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u306e\u75c7\u4f8b\u3067\u3001\u4ee5\u524d\u306e\u7814\u7a76\u3067\u793a\u3055\u308c\u305f\u3082\u306e\u3068\u540c\u69d8\u306e\u30ec\u30d9\u30eb\u3067\u9ad8\u3044PPV\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f[22\u300124\u300138]\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u306b\u304a\u3051\u308b\u4f4e\u30ea\u30b9\u30af\u75c7\u4f8b\u306e\u9650\u5b9a\u7684\u306a\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u3067\u306f\u300121\u30c8\u30ea\u30bd\u30df\u30fc\u75c7\u4f8b\u3067\u3042\u308b\u3068\u6c7a\u5b9a\u3055\u308c\u305f1\u3064\u306e\u507d\u9670\u6027\u75c7\u4f8b\u304c\u898b\u3064\u304b\u308a\u307e\u3057\u305f\u3002<br>\u307e\u305f\u3001\u7814\u7a76\u7d50\u679c\u306b\u5bfe\u3059\u308b\u60a3\u8005\u306e\u7279\u5fb4\u306e\u5f71\u97ff\u3082\u8abf\u3079\u307e\u3057\u305f\u3002\u5728\u80ce\u9031\u6570\u3068\u80ce\u5150\u306e\u5272\u5408\u306e\u9593\u306b\u6b63\u306e\u76f8\u95a2\u95a2\u4fc2\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u4ee5\u524d\u306e\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059[24\u300130\u300131]\u3002\u4e88\u60f3\u901a\u308a\u3001\u5728\u80ce\u9031\u6570\u3068BMI\u306e\u9593\u306b\u6b63\u306e\u76f8\u95a2\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304c\u967d\u6027\u3068\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u305f\u75c7\u4f8b\u3067\u306f\u80ce\u5150\u306e\u5272\u5408\u304c\u6709\u610f\u306b\u4f4e\u3044\u3053\u3068\u306b\u3082\u6ce8\u76ee\u3057\u307e\u3057\u305f\u3002NIPT\u5206\u6790\u6cd5\u3067\u5206\u6790\u3055\u308c\u308bcfDNA\u306f\u80ce\u76e4\u306b\u7531\u6765\u3059\u308b\u305f\u3081\u3001\u598a\u5a20\u4e2d\u306b\u4ee5\u524d\u306b\u5831\u544a\u3055\u308c\u305f\u80ce\u76e4\u306e\u4f53\u7a4d\u304c\u5c0f\u3055\u3044\u3053\u3068\u304c\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3057\u305f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u307e\u305f\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>[39]\u306e\u3044\u305a\u308c\u304b\u3067\u3001\u3053\u308c\u3089\u306e\u30c8\u30ea\u30bd\u30df\u30fc\u72b6\u614b\u306e\u7814\u7a76\u3067\u89b3\u5bdf\u3055\u308c\u305fFF\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u306e\u539f\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u79c1\u305f\u3061\u306e\u7814\u7a76\u306e\u5f37\u307f\u306e1\u3064\u306f\u3001\u4e00\u822c\u7684\u306a\u598a\u5a20\u96c6\u56e3\u304b\u3089\u306e\u60a3\u8005\u306e\u5927\u898f\u6a21\u306a\u30b3\u30db\u30fc\u30c8\u304c\u95a2\u4e0e\u3057\u3001\u305d\u306e\u60a3\u8005\u96c6\u56e3\u306b\u304a\u3051\u308bNIPT\u306e\u6709\u7528\u6027\u306e\u3055\u3089\u306a\u308b\u8a3c\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u3053\u306eNIPT\u5206\u6790\u6cd5\u306e\u9ad8\u3044\u30c6\u30b9\u30c8\u6027\u80fd\u3092\u793a\u3057\u3001NIPT\u967d\u6027\u306e\u75c7\u4f8b\u306b\u3064\u3044\u3066\u9ad8\u3044\u611f\u5ea6\u3001\u7279\u7570\u6027\u3001PPV\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u6700\u521d\u306e\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3067\u7d50\u679c\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u30b5\u30f3\u30d7\u30eb\u306b\u3064\u3044\u3066\u30012\u756a\u76ee\u306e\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3092\u518d\u691c\u67fb\u3057\u305f\u5f8c\u306e\u5206\u6790\u5931\u6557\u7387\u304c1\uff05\u672a\u6e80\u3068\u4f4e\u3044\u3053\u3068\u3082\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u5931\u6557\u7387\u304c\u4f4e\u3044\u3053\u3068\u306f\u3001NIPT\u306e\u7d50\u679c\u304c\u306a\u304f\u3066\u3082\u60a3\u8005\u304c\u4fb5\u8972\u7684\u306a\u8a3a\u65ad\u30c6\u30b9\u30c8\u3092\u53d7\u3051\u308b\u304b\u3069\u3046\u304b\u3092\u6c7a\u5b9a\u3059\u308b\u5fc5\u8981\u304c\u306a\u3044\u305f\u3081\u3001NIPT\u5206\u6790\u6cd5\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u6a5f\u80fd\u3067\u3042\u308a\u3001\u89aa\u306e\u4e0d\u5b89\u3092\u5897\u5927\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5c02\u9580\u5bb6\u5354\u4f1a\u306f\u3001\u5931\u6557\u3057\u305fNIPT\u30b5\u30f3\u30d7\u30eb\u3092\u9ad8\u30ea\u30b9\u30af\u3068\u898b\u306a\u3059\u3079\u304d\u3067\u3042\u308b\u3068\u63a8\u5968\u3059\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059[4\u300140\u300141]\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u306e\u9650\u754c\u306f\u3001\u7814\u7a76\u306e\u9061\u53ca\u7684\u6027\u8cea\u306e\u305f\u3081\u306b\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u5206\u6790\u6cd5\u306e\u8ffd\u52a0\u306e\u767a\u898b\u306b\u3064\u3044\u3066\u5831\u544a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u3053\u3068\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u307e\u308c\u306a\u5e38\u67d3\u8272\u4f53\u7570\u6570\u6027\u304a\u3088\u3073\u90e8\u5206\u7684\u306a\u6b20\u5931\u3068\u91cd\u8907\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u95a2\u9023\u3059\u308b\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u30c7\u30fc\u30bf\u3092\u63d0\u4f9b\u3067\u304d\u306a\u304b\u3063\u305f\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3057\u305f\u3002\u80ce\u5150\u306e\u5272\u5408\u304c\u4f4e\u3044\u5834\u5408\u306f\u6709\u5bb3\u306a\u7d50\u679c\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u80ce\u5150\u306e\u5272\u5408\u304c\u975e\u5e38\u306b\u4f4e\u3044\u5834\u5408\u3067\u3082\u80ce\u5150\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u3053\u306eNIPT\u5206\u6790\u6cd5\u306e\u80fd\u529b\u306f\u91cd\u8981\u3067\u3059[42]\u3002\u3057\u304b\u3057\u3001\u80ce\u5150\u306e\u5272\u5408\u304c4\uff05\u672a\u6e80\u3067\u3042\u308b\u79c1\u305f\u3061\u306e\u7814\u7a76\u306e\u30b5\u30f3\u30d7\u30eb\u6570\u304c\u5c11\u306a\u3044\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u4f4e\u30ec\u30d9\u30eb\u3067\u306eFF\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306e\u6709\u610f\u7fa9\u306a\u5206\u6790\u306f\u4e0d\u53ef\u80fd\u3067\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306e\u3082\u30461\u3064\u306e\u5236\u9650\u306f\u3001NIPT\u306e\u7d50\u679c\u304c\u9670\u6027\u306e\u75c7\u4f8b\u306e\u7d50\u679c\u60c5\u5831\u304c\u9650\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u4ed6\u306e\u591a\u304f\u306e\u516c\u958b\u3055\u308c\u305fNIPT\u7814\u7a76\u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u3059[22\u300124]\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u73fe\u5728\u3001\u30c9\u30a4\u30c4\u3067\u306fNIPT\u306e\u4fdd\u967a\u304c\u9069\u7528\u3055\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u60a3\u8005\u306fNIPT\u306e\u81ea\u5df1\u8ca0\u62c5\u3092\u652f\u6255\u3046\u5fc5\u8981\u304c\u3042\u308a\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u6cd5\u5916\u306a\u91d1\u984d\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u30c9\u30a4\u30c4\u306e\u516c\u7684\u8cc7\u91d1\u306b\u3088\u308b\u533b\u7642\u4fdd\u967a\u30b7\u30b9\u30c6\u30e0\u306f\u3001\u76e3\u8996\u306e\u5fc5\u8981\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u7279\u5b9a\u306e\u598a\u5a20\u304a\u3088\u3073\u7279\u5225\u306a\u30ea\u30b9\u30af\u306e\u3042\u308b\u598a\u5a20\u306b\u3064\u3044\u3066\u3001\u30c8\u30ea\u30bd\u30df\u30fc21\u300113\u3001\u304a\u3088\u307318\u306eNIPT\u3092\u30ab\u30d0\u30fc\u3059\u308b\u3053\u3068\u3092\u8a08\u753b\u3057\u3066\u3044\u307e\u3059\u3002 NIPT\u306e\u5168\u56fd\u7684\u306a\u5065\u5eb7\u4fdd\u967a\u306e\u5c0e\u5165\u306b\u3088\u308a\u3001\u80ce\u5150\u306e\u7570\u6570\u6027\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u5973\u6027\u306b\u5bfe\u3059\u308b\u3053\u306e\u30bf\u30a4\u30d7\u306e\u51fa\u751f\u524d\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u66f4\u65b0\u304c\u5927\u5e45\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059[43\u300144]\u3002 NIPT\u306f\u8a3a\u65ad\u30c6\u30b9\u30c8\u3067\u306f\u306a\u3044\u3053\u3068\u3001\u304a\u3088\u3073\u9ad8\u30ea\u30b9\u30af\u306eNIPT\u547c\u3073\u51fa\u3057\u306f\u3001CVS\u3084\u7f8a\u6c34\u7a7f\u523a\u306a\u3069\u306e\u4fb5\u8972\u7684\u306a\u8a3a\u65ad\u624b\u9806\u306b\u3088\u3063\u3066\u78ba\u8a8d\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u3092\u60a3\u8005\u306b\u901a\u77e5\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u7570\u5e38\u306a\u8d85\u97f3\u6ce2\u691c\u67fb\u306e\u5f8c\u306b\u9ad8\u30ea\u30b9\u30af\u3067\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u60a3\u8005\u306f\u3001\u9650\u5b9a\u3055\u308c\u305f\u80ce\u76e4<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u73fe\u8c61\u306a\u3069\u306e\u7406\u7531\u3067\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u8aa4\u3063\u305fNIPT\u7d50\u679c\u3092\u56de\u907f\u3059\u308b\u305f\u3081\u306b\u3001\u4fb5\u8972\u7684\u306a\u8a3a\u65ad\u624b\u9806\u3092\u53d7\u3051\u308b\u3053\u3068\u3092\u63a8\u5968\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059[45]\u3002<br>\u7d50\u8ad6\u3068\u3057\u3066\u3001VeriSeq <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> Solution v2\u5206\u6790\u6cd5\u306f\u3001\u79c1\u305f\u3061\u306e\u5927\u898f\u6a21\u306a\u96c6\u56e3\u306b\u304a\u3051\u308b\u80ce\u5150\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u691c\u51fa\u306b\u5f37\u529b\u306a\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"600\" height=\"375\" src=\"https:\/\/hiro-clinic.or.jp\/nipt\/wp-content\/uploads\/2020\/11\/ppv_values_for_high-risk_cases_for_cases_with_fetal_fractions.png\" alt=\"\" class=\"wp-image-7241\"\/><figcaption class=\"wp-element-caption\">\u56f33 \u80ce\u5150\u306e\u5206\u753b&lt;4%\u30014-8%\u3001&gt;8%\u306e\u9ad8\u30ea\u30b9\u30af\u75c7\u4f8b\u306ePPV\u5024<\/figcaption><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%AC%9D%E8%BE%9E\"><\/span>\u8b1d\u8f9e<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u8457\u8005\u306f\u3001\u3053\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u5354\u529b\u3057\u3066\u304f\u308c\u305fCosminDeciu\u3068SarahKinnings\u3001\u304a\u3088\u3073\u539f\u7a3f\u306e\u4f5c\u6210\u306b\u5354\u529b\u3057\u3066\u304f\u308c\u305fKristineJinnett\u3068KirstenCurnow\u306b\u611f\u8b1d\u3057\u307e\u3059\u3002 WolfKupatt\u3068ChristophKeck\uff08amedes\uff09\u306f\u3001\u5e38\u306bNIPT\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u512a\u308c\u305f\u65b9\u6cd5\u3067\u30b5\u30dd\u30fc\u30c8\u3057\u3001\u524d\u9032\u3055\u305b\u3066\u304d\u307e\u3057\u305f\u3002 \u307e\u305f\u3001\u80ce\u5150\u306e\u8ee2\u5e30\u306b\u95a2\u3059\u308b\u8cb4\u91cd\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u3066\u304f\u308c\u305f\u591a\u304f\u306e\u5a66\u4eba\u79d1\u533b\u306b\u611f\u8b1d\u3057\u307e\u3059\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%91%97%E8%80%85%E3%81%AE%E8%B2%A2%E7%8C%AE\"><\/span>\u8457\u8005\u306e\u8ca2\u732e<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u30c7\u30fc\u30bf\u5206\u6790\u3068\u7d19\u306e\u6e96\u5099\u306fHB\u3068BE\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002 \u30c7\u30fc\u30bf\u5206\u6790\u306e\u652f\u63f4\u306f\u3001NK\u3001AT\u3001\u304a\u3088\u3073SK\u306b\u3088\u3063\u3066\u63d0\u4f9b\u3055\u308c\u307e\u3057\u305f\u3002 \u8ad6\u6587\u306e\u6e96\u5099\u3068\u8b70\u8ad6\u306fRG\u3068TW\u306b\u3088\u3063\u3066\u652f\u63f4\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%80%AB%E7%90%86%E5%9F%BA%E6%BA%96%E3%81%B8%E3%81%AE%E6%BA%96%E6%8B%A0\"><\/span>\u502b\u7406\u57fa\u6e96\u3078\u306e\u6e96\u62e0<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%88%A9%E7%9B%8A%E7%9B%B8%E5%8F%8D\"><\/span>\u5229\u76ca\u76f8\u53cd<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u8457\u8005\u306f\u3001\u5229\u76ca\u76f8\u53cd\u304c\u306a\u3044\u3053\u3068\u3092\u5ba3\u8a00\u3057\u307e\u3059\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%80%AB%E7%90%86%E7%9A%84%E6%89%BF%E8%AA%8D\"><\/span>\u502b\u7406\u7684\u627f\u8a8d<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Amedes\u306f\u3001\u9023\u90a6\u30c7\u30fc\u30bf\u4fdd\u8b77\u6cd5\u306e\u898f\u5b9a\u3092\u9075\u5b88\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%8F%82%E5%8A%A0%E3%81%99%E3%82%8B%E3%81%93%E3%81%A8%E3%81%AB%E5%90%8C%E6%84%8F%E3%81%99%E3%82%8B\"><\/span>\u53c2\u52a0\u3059\u308b\u3053\u3068\u306b\u540c\u610f\u3059\u308b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u60a3\u8005\u306e\u540c\u610f\u306f\u3001NIPT\u5206\u6790\u6cd5\u306e\u9069\u5207\u306a\u54c1\u8cea\u7ba1\u7406\u3068\u6539\u5584\u306e\u305f\u3081\u306b\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3059\u308b\u305f\u3081\u306b\u3001\u7814\u7a76\u306b\u95a2\u4e0e\u3057\u305f\u3059\u3079\u3066\u306e\u60a3\u8005\u304b\u3089\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3059\u3079\u3066\u306e\u30c7\u30fc\u30bf\u306f\u3001\u8abf\u67fb\u306b\u542b\u307e\u308c\u308b\u524d\u306b\u533f\u540d\u5316\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%82%AA%E3%83%BC%E3%83%97%E3%83%B3%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9\"><\/span>\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u3053\u306e\u8a18\u4e8b\u306f\u30af\u30ea\u30a8\u30a4\u30c6\u30a3\u30d6\u30fb\u30b3\u30e2\u30f3\u30ba\u8868\u793a4.0\u56fd\u969b\u30e9\u30a4\u30bb\u30f3\u30b9\u306e\u4e0b\u3067\u30e9\u30a4\u30bb\u30f3\u30b9\u3055\u308c\u3066\u304a\u308a\u3001\u5143\u306e\u4f5c\u8005\u3068\u30bd\u30fc\u30b9\u306b\u9069\u5207\u306a\u30af\u30ec\u30b8\u30c3\u30c8\u3092\u4e0e\u3048\u3001\u63d0\u4f9b\u3059\u308b\u9650\u308a\u3001\u3042\u3089\u3086\u308b\u5a92\u4f53\u307e\u305f\u306f\u5f62\u5f0f\u3067\u306e\u4f7f\u7528\u3001\u5171\u6709\u3001\u9069\u5408\u3001\u914d\u5e03\u3001\u304a\u3088\u3073\u8907\u88fd\u3092\u8a31\u53ef\u3057\u307e\u3059\u3002\u30af\u30ea\u30a8\u30a4\u30c6\u30a3\u30d6\u30b3\u30e2\u30f3\u30ba\u30e9\u30a4\u30bb\u30f3\u30b9\u3078\u306e\u30ea\u30f3\u30af\u3001\u304a\u3088\u3073\u5909\u66f4\u304c\u884c\u308f\u308c\u305f\u304b\u3069\u3046\u304b\u3092\u793a\u3057\u307e\u3059\u3002\u3053\u306e\u8a18\u4e8b\u306e\u753b\u50cf\u307e\u305f\u306f\u305d\u306e\u4ed6\u306e\u30b5\u30fc\u30c9\u30d1\u30fc\u30c6\u30a3\u306e\u8cc7\u6599\u306f\u3001\u8cc7\u6599\u306e\u30af\u30ec\u30b8\u30c3\u30c8\u30e9\u30a4\u30f3\u306b\u5225\u6bb5\u306e\u8a18\u8f09\u304c\u306a\u3044\u9650\u308a\u3001\u8a18\u4e8b\u306e\u30af\u30ea\u30a8\u30a4\u30c6\u30a3\u30d6\u30b3\u30e2\u30f3\u30ba\u30e9\u30a4\u30bb\u30f3\u30b9\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u7d20\u6750\u304c\u8a18\u4e8b\u306e\u30af\u30ea\u30a8\u30a4\u30c6\u30a3\u30d6\u30b3\u30e2\u30f3\u30ba\u30e9\u30a4\u30bb\u30f3\u30b9\u306b\u542b\u307e\u308c\u3066\u304a\u3089\u305a\u3001\u610f\u56f3\u3055\u308c\u305f\u4f7f\u7528\u304c\u6cd5\u898f\u5236\u306b\u3088\u3063\u3066\u8a31\u53ef\u3055\u308c\u3066\u3044\u306a\u3044\u304b\u3001\u8a31\u53ef\u3055\u308c\u305f\u4f7f\u7528\u3092\u8d85\u3048\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u8457\u4f5c\u6a29\u6240\u6709\u8005\u304b\u3089\u76f4\u63a5\u8a31\u53ef\u3092\u5f97\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30e9\u30a4\u30bb\u30f3\u30b9\u306e\u30b3\u30d4\u30fc\u3092\u8868\u793a\u3059\u308b\u306b\u306f\u3001http:\/\/creativecommons.org\/licenses\/by\/4.0\/ \u306b\u30a2\u30af\u30bb\u30b9\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group references\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\"><\/span>\u53c2\u8003\u6587\u732e<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ol><li>Lo YM, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, Wainscoat JS (1997) \u6bcd\u4f53\u8840\u6f3f\u304a\u3088\u3073\u8840\u6e05\u4e2d\u306e\u80ce\u5150DNA\u306e\u5b58\u5728\u3002 Lancet 350(9076):485-487. https:\/\/doi.org\/10.1016\/s0140-6736(97)02174-0<\/li>\n<li>Norton ME, Baer RJ, Wapner RJ, Kuppermann M, JellifPawlowski LL, Currier RJ (2016) \u7121\u7d30\u80deDNA vs \u80ce\u5150<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u691c\u51fa\u306e\u305f\u3081\u306e\u9023\u7d9a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3002 Am J Obstet Gynecol 214(6):727\u2013726. https:\/\/doi.org\/10.1016\/j.ajog.2015.12.018<\/li>\n<li>Gil MM, Accurti V, Santacruz B, Plana MN, Nicolaides KH (2017) \u7570\u6570\u6027\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u304a\u3051\u308b\u6bcd\u4f53\u8840\u6db2\u4e2d\u306e\u7121\u7d30\u80deDNA\u306e\u5206\u6790: \u6700\u65b0\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002 \u8d85\u97f3\u6ce2<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/obgyn\/\">\u7523\u5a66\u4eba\u79d1<\/a>50(3):302-314\u3002 https:\/\/doi.org\/10.1002\/uog.17484<\/li>\n<li>Benn P\u3001Borrell A\u3001Chiu RW\u3001Cuckle H\u3001Dugoff L\u3001Faas B\u3001Gross S\u3001Huang T\u3001Johnson J\u3001Maymon R\u3001Norton M\u3001Odibo A\u3001Schielen P\u3001Spencer K\u3001Wright D\u3001Yaron Y (2015) Chromosome Abnormality Screening Committee\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u59d4\u54e1\u4f1a\u306e\u7acb\u5834\u8868\u660e\u3002 \u598a\u5a20\u671f35(8):725-734\u3002 https:\/\/doi.org\/10.1002\/pd.4608<\/li>\n<li>Gregg AR, Skotko BG, Benkendorf JL, Monaghan KG, Bajaj K, Best RG, Klugman S, Watson MS (2016) \u80ce\u5150\u7570\u6570\u6027\u306e\u975e\u4fb5\u8972\u6027\u51fa\u751f\u524d\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30012016\u5e74\u6539\u8a02: American College of Medical Genetics and Genomics\u306e\u7acb\u5834\u8868\u660e\u3002 \u907a\u4f1d\u5b50\u306f18(10):1056-1065\u3092\u6e80\u305f\u3059\u3002 https:\/\/doi.org\/10.1038\/ gim.2016.97<\/li>\n<li>Dondorp W, de Wert G, Bornchi DW, Bianchi DW, Bergmann C, Borry P, Chitty LS, Fellmann F, Forzano F, Hall A, Howard HC, Lucassen A, Ormond K, Peterlin B, Radojkovic D, Rogowski W, Soller A, Tibben A, Tibben Jaerg L, Tranebjaerg L, van El CG, Cornel MC, European Society of Human G, American Society of Human G (2015) \u7570\u6570\u6027\u304a\u3088\u3073\u305d\u308c\u4ee5\u4e0a\u306e\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>: \u51fa\u751f\u524d\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u304a\u3051\u308b\u8cac\u4efb\u3042\u308b\u9769\u65b0\u306e\u8ab2\u984c\u3002 Eur J Hum Genet 23(11):1438\u20131450. https:\/\/doi.org\/10.1038\/ejhg.2015.57<\/li>\n<li>Deutscheme Deutscheft Humangenetik \u306f\u3001MUTterlichen Blut \u3092\u4f7f\u7528\u3057\u3066DNA \u3092\u89e3\u6790\u3057\u307e\u3059\u3002 https:\/\/www.\u2981 gfhev.de\/leitlinien. 2013.<\/li>\n<li>Kozlowski P, Burkhardt T, Gombruch U, Gonser M, Kahler C, Kagan KO, von Kaisenberg C, Klaritsch P, Merz E, Steiner H, Tercanli S, Vetter K, Schramm T (2019) DEGUM, OGUM, SGUM, FMF Germany\u306e\u63a8\u5968\u4e8b\u9805\u3001\u8a73\u7d30\u306a\u8d85\u97f3\u6ce2\u691c\u67fb\u3001\u7121\u7d30\u80deDNA\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3001\u8a3a\u65ad\u624b\u6280\u3002 Ultraschall Med 40(2):176\u2013193. https:\/\/doi.org\/10.1055\/a-0631-8898<\/li>\n<li>Schmid M\u3001Klaritsch P\u3001Arzsch W\u3001Burkhardt T\u3001Duba HC\u3001Hausler M\u3001Hafner E\u3001Lang U\u3001Pertl B\u3001Speicher M\u3001Steiner H\u3001Tercanli S\u3001Merz E\u3001Heling KS\u3001Eiben B(2015)\u81e8\u5e8a\u306b\u304a\u3051\u308b\u80ce\u5150<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306b\u5bfe\u3059\u308b\u7121\u7d30\u80deDNA\u691c\u67fb:\u30aa\u30fc\u30b9\u30c8\u30ea\u30a2-\u30c9\u30a4\u30c4-\u30b9\u30a4\u30b9\u306e\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>(<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>)\u306e\u52e7\u544a\u3002 Ultraschall Med 36(5):507\u2013510. https:\/\/doi.org\/10.1055\/s-0035-1553804<\/li>\n<li>Nicolaides KH, Syngelaki A, Ashoor G, Birdir C, Touzet G (2012) \u30eb\u30fc\u30c1\u30f3\u306b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u305f\u598a\u5a20\u7b2c\u4e00\u671f\u96c6\u56e3\u306b\u304a\u3051\u308b\u80ce\u5150\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u975e\u4fb5\u8972\u7684\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u3002 Am J Obstet Gynecol 207(5):374.e371-376. https:\/\/doi.org\/10.1016\/j.ajog.2012.08.033<\/li>\n<li>Palomaki GE\u3001Deciu C\u3001Kloza EM\u3001Lambert-Messerlian GM\u3001Haddow JE\u3001Neveux LM\u3001Ehrich M\u3001van den Boom D\u3001Bombard AT\u3001Grody WW\u3001Nelson SF\u3001Canick JA(2012)\u6bcd\u4f53\u8840\u6f3f\u306eDNA\u914d\u5217\u6c7a\u5b9a\u306b\u3088\u308a\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u304a\u3088\u3073<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a>\u3068<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/\">\u30c0\u30a6\u30f3\u75c7<\/a>\u5019\u7fa4\u304c\u78ba\u5b9f\u306b\u540c\u5b9a\u3055\u308c\u305f:\u56fd\u969b\u5171\u540c\u7814\u7a76\u3002 \u907a\u4f1d\u5b50\u306f14(3):296-305\u3092\u6e80\u305f\u3059\u3002 https:\/\/doi.org\/10.1038\/gim.2011.73<\/li>\n<li>Samango-Sprouse C, Banjevic M, Ryan A, Sigurjonsson S, Zimmermann B, Hill M, Hall MP, Westemeyer M, Saucier J, Demko Z, Rabinowitz M (2013) SNP\u30d9\u30fc\u30b9\u306e\u975e\u4fb5\u8972\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306f\u3001\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027\u3092\u9ad8\u7cbe\u5ea6\u3067\u691c\u51fa\u3059\u308b\u3002 \u598a\u5a20\u671f33(7):643-649\u3002 https:\/\/doi.org\/10.1002\/pd.4159<\/li>\n<li>\u30de\u30ba\u30eb\u30fc\u30e0AR\u3001Dzakula Z\u3001Oeth P\u3001Wang H\u3001Jensen T\u3001Tynan J\u3001McCullough R\u3001Saldivar JS\u3001Ehrigh M\u3001van den Boom D\u3001Bombard AT\u3001Maeder M\u3001McLennan G\u3001Meschino W\u3001Palomaki GE\u3001Canick JA\u3001Deciu C(2013)\u6bcd\u4f53\u8840\u6f3f\u304b\u3089\u306e\u5faa\u74b0\u8840\u4e2d\u306e\u7121\u6027\u7d30\u80deDNA\u306e\u914d\u5217\u6c7a\u5b9a\u306b\u3088\u308b\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u975e\u4fb5\u8972\u6027\u524d\u691c\u51fa\u3002 \u598a\u5a20\u671f33(6):591-597\u3002 https:\/\/doi.org\/10.1002\/pd.4127<\/li>\n<li>Wapner RJ, Babiarz JE, Levy B, Stosic M, Zimmermann B, Sigurjonson S, Wayham N, Ryan A, Banjevic M, Lacroute P, Hu J, Hall MP, Demko Z, Siddiqui A, Rabinowitz M, Gross SJ, Hill M, Benn P (2015) \u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306e\u7bc4\u56f2\u62e1\u5927: \u80ce\u5150<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/lp-143\/\">\u5fae\u5c0f\u6b20\u5931<\/a>\u75c7\u5019\u7fa4\u306e\u691c\u51fa\u3002 Am J Obstet Gynecol 212(3):332\u2013339. https:\/\/doi.org\/10.1016\/j.ajog.2014.11.041<\/li>\n<li>Gross SJ\u3001Stosic M\u3001McDonald-McGinn DM\u3001Bassett AS\u3001Norvez A\u3001Dhamankar R\u3001Kobara K\u3001Kirkizla E\u3001Zimmermann B\u3001Wayham rJE\u3001Babiarz JE\u3001Ryan A\u3001Jinnett KN\u3001Denko Z\u3001Benn P (2016) 22q11.2\u6b20\u5931\u75c7\u5019\u7fa4\u306b\u5bfe\u3059\u308b\u4e00\u5869\u57fa\u591a\u578b\u306b\u57fa\u3065\u304f\u975e\u4fb5\u8972\u7684\u51fa\u751f\u524d\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u81e8\u5e8a\u7d4c\u9a13\u3002 \u8d85\u97f3\u6ce2<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/obgyn\/\">\u7523\u5a66\u4eba\u79d1<\/a>47(2):177-183\u3002 https<\/li>\n<li>https:\/\/doi.org\/10.1002\/uog.15754<\/li>\n<li>Pertile MD\u3001Halks-Miller M\u3001Flowers N\u3001Barbacioru C\u3001Kinnings SL\u3001Vavrek D\u3001Seltzer WK\u3001Bianchi DW (2017) \u307e\u308c\u306a\u5e38\u67d3\u8272\u4f53\u30c8\u30ea\u30bd\u30df\u30fc\u306f\u3001\u6bcd\u4f53\u306e\u8840\u6f3fDNA\u914d\u5217\u6c7a\u5b9a\u306b\u3088\u308a\u660e\u3089\u304b\u306b\u3055\u308c\u3001\u80ce\u5150\u80ce\u76e4\u75be\u60a3\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3092\u793a\u5506\u3059\u308b\u3002 \u79d1\u5b66\u30c8\u30e9\u30f3\u30b9\u30eb\u30e1\u30c3\u30c9 https:\/\/doi.org\/10.1126\/scitranslmed.aan1240<\/li>\n<li>Fiorentino F, Bono S, Pizzuti F, Duca S, Polverari A, Faieta M, Baldi M, Diano L, Spinella F (2017) \u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u975e\u4fb5\u8972\u6027\u51fa\u751f\u524d\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u81e8\u5e8a\u7684\u6709\u7528\u6027 \u598a\u5a20\u671f37(6):593-601\u3002 https:\/\/doi.org\/10.1002\/pd.5053<\/li>\n<li>Liang D, Lin Y, Qiao F, Li H, Wang Y, Zhang J, Liu A, Ji X, Ma D, Jiang T, Hu P, Xu Z (2018) 32,000\u4eba\u3092\u8d85\u3048\u308b\u5973\u6027\u306b\u304a\u3051\u308b\u7121\u7d30\u80deDNA\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u5f8c\u306e\u5468\u7523\u671f\u8ee2\u5e30: \u5358\u4e00\u306e\u4e09\u6b21\u65bd\u8a2d\u304b\u3089\u306e\u81e8\u5e8a\u8ffd\u8de1\u30c7\u30fc\u30bf\u3002 \u598a\u5a20\u671f38(10):755-764\u3002 https:\/\/doi.org\/10.1002\/pd.5328<\/li>\n<li>Scott F\u3001Bonifacio M\u3001Sandow R\u3001Ellis K\u3001Smet ME\u3001McLennan A (2018) \u307e\u308c\u306a\u5e38\u67d3\u8272\u4f53\u30c8\u30ea\u30bd\u30df\u30fc:\u91cd\u8981\u3067\u3001\u305d\u308c\u307b\u3069\u307e\u308c\u3067\u306f\u306a\u3044\u3002 \u598a\u5a20\u671f38(10):765-771\u3002 https:\/\/doi.org\/10.1002\/pd.5325<\/li>\n<li>Sehnert AJ, Rhees B, Comstock D, de Feo E, Heilek G, Burke J, Rava RP (2011) \u6bcd\u4f53\u8840\u6db2\u304b\u3089\u306e\u7121\u7d30\u80de\u80ce\u5150DNA\u306e\u5927\u898f\u6a21\u4e26\u884c\u914d\u5217\u6c7a\u5b9a\u306b\u3088\u308b\u80ce\u5150<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u6700\u9069\u691c\u51fa \u30af\u30ea\u30f3\u30b1\u30e057(7):1042-1049 https<\/li>\n<li>https:\/\/doi.org\/10.1373\/clinchem.2011.165910<\/li>\n<li>Ehrich M\u3001Zwiefhofer T\u3001Tynan JA\u3001Tynan L\u3001Tim R\u3001Lu V\u3001McCullough R\u3001McCarthy E\u3001Nygren AO\u3001Dean J\u3001Tang L\u3001Hu T\u3001Wang H\u3001Angkachatchai V\u3001Oeth P\u3001Cantor CR\u3001Bombard A\u3001van den Boom D(2011)\u6bcd\u4f53\u8840\u6db2\u4e2d\u306eDNA\u306e\u914d\u5217\u6c7a\u5b9a\u306b\u3088\u308b\u80ce\u5150\u30c8\u30ea\u30bd\u30df\u30fc21\u306e\u975e\u4fb5\u8972\u7684\u691c\u51fa:\u81e8\u5e8a\u72b6\u6cc1\u306b\u304a\u3051\u308b\u7814\u7a76\u3002 Am J Obstet Gynecol 204(3):205\u2013211. https:\/\/doi.org\/10.1016\/j.ajog.2010.12.060<\/li>\n<li>Taneja PA, Snyder HL, de Feo E, Kruglyak KM, Halks-Miller M, Curnow KJ, Bhatt S (2016) \u4e00\u822c\u7523\u79d1\u96c6\u56e3\u306b\u304a\u3051\u308b\u975e\u4fb5\u8972\u7684\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>: \u81e8\u5e8a\u6210\u7e3e\u304a\u3088\u30738\u4e075,000\u4f8b\u3092\u8d85\u3048\u308b\u75c7\u4f8b\u306b\u304a\u3051\u308b\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u8003\u616e\u4e8b\u9805\u3002 \u598a\u5a20\u671f36(3):237-243\u3002 https:\/\/doi.org\/10.1002\/pd.4766<\/li>\n<li>Pergament E\u3001Cuckle H\u3001Zimmermann B\u3001Banjevic M\u3001Sigurjonson S\u3001Ryan A\u3001Hall MP\u3001Dodd M\u3001Lacroute P\u3001Stosic M\u3001Chopra N\u3001Hunkapiller N\u3001Prosen DE\u3001McAdoo S\u3001Demko Z\u3001Siddiqui A\u3001Hill M\u3001Rabinowitz M(2014)\u9ad8\u30ea\u30b9\u30af\u304a\u3088\u3073\u4f4e\u30ea\u30b9\u30af\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3051\u308b\u4e00\u5869\u57fa\u591a\u578b\u306b\u57fa\u3065\u304f\u51fa\u751f\u524d\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3002 \u7523\u79d1\u5a66\u4eba\u79d1124(2 Pt 1):210\uff5e218\u3002 https:\/\/doi.org\/10.1097\/aog.0000000000000363<\/li>\n<li>Dar P\u3001Curnow KJ\u3001Gross SJ\u3001Hall MP\u3001Stosic M\u3001Demmko Z\u3001Zimmermann B\u3001Hill M\u3001Sigurjonson S\u3001Ryan A\u3001Banjevic M\u3001Kolacki PL\u3001Koch SW\u3001Strom CM\u3001Rabinowitz M\u3001Benn P (2014) \u5927\u898f\u6a21\u4e00\u5869\u57fa\u591a\u578b\u306b\u57fa\u3065\u304f\u975e\u4fb5\u8972\u7684\u51fa\u751f\u524d\u7570\u6570\u6027\u691c\u67fb\u306b\u3088\u308b\u81e8\u5e8a\u7d4c\u9a13\u304a\u3088\u3073\u8ffd\u8de1\u8abf\u67fb\u3002 Am J Obstet Gynecol 211(5):527.e521\u2013517. https:\/\/doi.org\/10.1016\/j.ajog.2014.08.006<\/li>\n<li>Juneau K\u3001Bogard PE\u3001Huang S\u3001Mohseni M\u3001Wang ET\u3001Ryvkin P\u3001Kingsley C\u3001Struble CA\u3001Oliphant A\u3001Zahn JM(2014)<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u306b\u57fa\u3065\u304f\u7121\u7d30\u80deDNA\u5206\u6790\u306f\u3001\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u3092\u6539\u5584\u3059\u308b\u3002 \u80ce\u5150\u8a3a\u65ad36(4):282-286\u3002 https:\/\/doi.\u2981 org\/10.1159\/000367626<\/li>\n<li>Fan HC, Blumenfeld YJ, Chitkara U, Hudgins L, Quake SR (2010) \u30da\u30a2\u672b\u7aef\u914d\u5217\u6c7a\u5b9a\u306b\u3088\u308b\u80ce\u5150\u304a\u3088\u3073\u6bcd\u4f53\u7121\u7d30\u80deDNA\u306e\u30b5\u30a4\u30ba\u5206\u5e03\u306e\u5206\u6790 \u30af\u30ea\u30f3\u30b1\u30e056(8):1279-1286 https:\/\/doi.org\/10.1373\/clinchem.2010.144188<\/li>\n<li>Yu SC, Chan YW, Zheng YW, Jiang P, Liao GJ, Sun H, Akolekar R, Leung TY, Go AT, van Vugt JM, Minekawa R, Oudejans CB, Nicolaides KH, Chiu RW, Lo YM (2014) \u8840\u6f3fDNA\u3092\u7528\u3044\u305f\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306e\u5206\u5b50\u8a3a\u65ad\u3002 Proc Natl Acad Sci USA 111(23):8583\u20138588. https:\/\/doi.org\/10.1073\/pnas.14061031111<\/li>\n<li>\u30cd\u30aa\u30dc\u30ca\u8a66\u9a13\u306eCirigliano V, Ordonez E, Rueda L, Syngelaki A, Nicolaides KH (2017) Performance \u8d85\u97f3\u6ce2<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/obgyn\/\">\u7523\u5a66\u4eba\u79d1<\/a>49(4):460-464\u3002 https:\/\/doi.org\/10.1002\/uog.17386<\/li>\n<li>Hui L, Bianchi DW (2020) \u80ce\u5150\u5206\u753b\u304a\u3088\u3073\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>: \u81e8\u5e8a\u533b\u304c\u77e5\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u3002 \u598a\u5a20\u8a3a\u65ad40(2):155-163\u3002 https:\/\/doi.org\/10.1002\/pd.5620<\/li>\n<li>Wang E, Batey A, Struble C, Musci T, Song K, Oliphant A (2013) \u6bcd\u4f53\u8840\u6f3f\u4e2d\u306e\u80ce\u5150\u7121\u7d30\u80deDNA\u306b\u5bfe\u3059\u308b\u598a\u5a20\u5e74\u9f62\u304a\u3088\u3073\u6bcd\u4f53\u4f53\u91cd\u306e\u5f71\u97ff \u598a\u5a20\u671f33(7):662-666\u3002 https:\/\/doi.org\/10.1002\/pd.4119<\/li>\n<li>Scott FP\u3001Menezes M\u3001Palma-Dias R\u3001Nisbet D\u3001Schluter P\u3001da Silva CF\u3001McLennan AC (2017) \u7121\u7d30\u80deDNA\u80ce\u5150\u5206\u753b\u304a\u3088\u3073\u691c\u67fb\u7cbe\u5ea6\u306e\u7d50\u679c\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u56e0\u5b50 J Matern Fetal Neonatal Med. https:\/\/doi.org\/10.1080\/14767 058.2017.1330881<\/li>\n<li>Ryan A, Hunkapiller N, Banjevic M, Vankayalapati N, Fong N, Jinnett KN, Demko Z, Zimmermann B, Sigurjonson S, Gross SJ, Hill M (2016) \u80ce\u5150\u7570\u6570\u6027\u691c\u51fa\u306e\u305f\u3081\u306e\u4e00\u5869\u57fa\u591a\u578b\u306b\u57fa\u3065\u304f\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306e\u5f37\u5316\u7248\u306e\u691c\u8a3c \u80ce\u5150\u8a3a\u65ad40(3):219-223\u3002 https:\/\/doi.org\/10.1159\/000442931<\/li>\n<li>Norton ME\u3001Jacobsson B\u3001Swamy GK\u3001Laurent LC\u3001Ranzini AC\u3001Brar H\u3001Tomlinson MW\u3001Pereira L\u3001Spitz JL\u3001Hollemon D\u3001Cuckle H\u3001Musci TJ\u3001Wapner RJ(2015)\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u975e\u4fb5\u8972\u7684\u691c\u67fb\u306e\u305f\u3081\u306e\u7121\u7d30\u80deDNA\u5206\u6790\u3002 N Engl J Med 372(17):1589-1597\u3002 https:\/\/doi.org\/10.1056\/NEJMoa1407349<\/li>\n<li>Fiorentino F, Bono S, Pizzuti F, Mariano M, Polverari A, Duca S, Sessa M, Baldi M, Diano L, Spinella F (2016) \u306e\u91cd\u8981\u6027<\/li>\n<li>\u975e\u4fb5\u8972\u7684\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u6cd5\u306e\u691c\u51fa\u9650\u754c\u306e\u6c7a\u5b9a \u598a\u5a20\u671f36(4):304-311\u3002 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\u6bcd\u4f53\u8840\u6f3f\u4e2d\u306e\u6bcd\u4f53\u304a\u3088\u3073\u80ce\u5150DNA\u306e\u30b5\u30a4\u30ba\u5206\u5e03\u3002 \u30af\u30ea\u30f3\u30b1\u30e050(1):88-92 https<\/li>\n<li>https:\/\/doi.org\/10.1373\/clinchem.2003.024893<\/li>\n<li>Xu L\u3001Huang H\u3001Lin N\u3001Wang Y\u3001He D\u3001Zhang M\u3001Chen M\u3001Chen L\u3001Lin Y(2019)\u975e\u4fb5\u8972\u7684\u7121\u7d30\u80de\u80ce\u5150DNA\u691c\u67fb:\u4e2d\u56fd\u5357\u6771\u90e8\u306b\u304a\u3051\u308b\u5358\u80ce\u598a\u5a2031,515\u4f8b\u306e\u591a\u65bd\u8a2d\u8ffd\u8de1\u8abf\u67fb\u7814\u7a76\u3002 \u8d85\u97f3\u6ce2<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/obgyn\/\">\u7523\u5a66\u4eba\u79d1<\/a>\u3002 https:\/\/doi.\u2981 org\/10.1002\/uog.20416<\/li>\n<li>Wegrzyn P, Faro C, Falcon O, Peralta CF, Nicolaides KH (2005) \u598a\u5a2011-13 + 6\u9031\u306e3\u6b21\u5143\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u6e2c\u5b9a\u3057\u305f\u80ce\u76e4\u5bb9\u7a4d: <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3068\u306e\u95a2\u9023\u6027\u3002 \u8d85\u97f3\u6ce2<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/obgyn\/\">\u7523\u5a66\u4eba\u79d1<\/a>26(1):28-32\u3002 https:\/\/doi.org\/10.1002\/uog.1923<\/li>\n<li>\u7c73\u56fd\u7523\u79d1\u5a66\u4eba\u79d1\u5b66\u4f1a\u3001\u598a\u7523\u5a66\u533b\u5b66\u4f1a(2016)\u8a3a\u7642\u516c\u5831No. 163\u4ef6\u306e\u8981\u7d04:\u80ce\u5150\u7570\u6570\u6027\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3002 \u7523\u79d1\u5a66\u4eba\u79d1127(5):979-981\u3002 https:\/\/doi.org\/10.1097\/aog.0000000000001439<\/li>\n<li>Salomon LJ\u3001Alfirevic Z\u3001Audibert F\u3001Kagan KO\u3001Paladini D\u3001Yeo G\u3001Raine-Fenning N (2017) ISUOG\u306f\u3001cfDNA\u7570\u6570\u6027\u691c\u67fb\u304c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u65b9\u91dd\u304a\u3088\u3073\u51fa\u751f\u524d\u8d85\u97f3\u6ce2\u8a3a\u7642\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u95a2\u3059\u308b\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u58f0\u660e\u3092\u66f4\u65b0\u3057\u305f\u3002 \u8d85\u97f3\u6ce2<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-clinic\/obgyn\/\">\u7523\u5a66\u4eba\u79d1<\/a>49(6):815-816\u3002 https:\/\/doi.org\/10.1002\/uog.17483<\/li>\n<li>Krishna I, Badell M, Loucks TL, Lindsay M, Samuel A (2016) \u5468\u7523\u671f\u306e\u6709\u5bb3\u8ee2\u5e30\u306f\u3001\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u3067\u80ce\u5150\u5206\u753b\u304c\u4f4e\u3044\u598a\u5a20\u3067\u3088\u308a\u983b\u7e41\u306b\u307f\u3089\u308c\u308b\u3002 \u598a\u5a20\u671f36(3):210-215\u3002 https:\/\/doi.org\/10.1002\/pd.4779<\/li>\n<li>Vinante V, Keller B, Huhn EA, Huang D, Lapaire O, ManegoldBrauer G (2018) \u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u306e\u305f\u3081\u306e\u5168\u56fd\u7684\u306a\u5065\u5eb7\u4fdd\u967a\u9069\u7528\u7bc4\u56f2\u306e\u5f71\u97ff Int J Gynaecol Obstet 141(2):189\u2013193. https:\/\/doi.org\/10.1002\/ijgo.12422<\/li>\n<li>Huang T, Dougan S, Walker M, Armour CM, Okun N (2018) \u30aa\u30f3\u30bf\u30ea\u30aa\u5dde\u306b\u304a\u3051\u308b\u80ce\u5150\u7570\u6570\u6027\u306b\u5bfe\u3059\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u30b5\u30fc\u30d3\u30b9\u306e\u5229\u7528\u306e\u52d5\u5411: \u8a18\u8ff0\u7684\u7814\u7a76\u3002 CMAJ 6(4):E436-E444\u3092\u958b\u304d\u307e\u3059\u3002 https:\/\/doi.org\/10.9778\/cmajo.20180046<\/li>\n<li>Eiben B (2016) <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>-eine kritische Betrachtung \u306e\u4e0b\u843d \u30d5\u30e9\u30a6\u30a8\u30ca\u30fc\u30c4\u30c857:567<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%87%BA%E7%89%88%E7%A4%BE%E3%81%AE%E3%83%8E%E3%83%BC%E3%83%88\"><\/span>\u51fa\u7248\u793e\u306e\u30ce\u30fc\u30c8<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u30b9\u30d7\u30ea\u30f3\u30ac\u30fc\u30fb\u30cd\u30a4\u30c1\u30e3\u30fc\u306f\u3001\u516c\u958b\u3055\u308c\u3066\u3044\u308b\u5730\u56f3\u304a\u3088\u3073\u6a5f\u95a2\u6240\u5c5e\u306b\u304a\u3051\u308b\u7ba1\u8f44\u6a29\u306e\u4e3b\u5f35\u306b\u95a2\u3057\u3066\u4e2d\u7acb\u7684\u3067\u3042\u308b\u3002<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"Heike Borth1 \u30fb Anna &#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/ger-13607dna\/\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":1,"featured_media":523,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[71],"tags":[489,43],"class_list":["post-7234","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatise","tag-nipt-3","tag-gene"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/7234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=7234"}],"version-history":[{"count":8,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/7234\/revisions"}],"predecessor-version":[{"id":125074,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/7234\/revisions\/125074"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/523"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=7234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=7234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=7234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}