{"id":7686,"date":"2020-12-09T22:09:06","date_gmt":"2020-12-09T13:09:06","guid":{"rendered":"https:\/\/www2.hiro-clinic.or.jp\/?p=7686"},"modified":"2026-06-11T16:31:15","modified_gmt":"2026-06-11T07:31:15","slug":"cfdna-in-the-investigation-of-miscarriage","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/","title":{"rendered":"\u6d41\u7523\u8abf\u67fb\u306b\u304a\u3051\u308b\u7121\u7d30\u80deDNA\u306e\u6d3b\u7528"},"content":{"rendered":"\n<h2 class=\"wp-block-heading hidden-heading\"><\/h2>\n\n\n\n<h3 class=\"wp-block-heading hidden-heading\"><\/h3>\n\n\n\n<p>Emily Colley <sup>1,2,3,*<\/sup>, Adam J. Devall <sup>1,2<\/sup>, Helen Williams <sup>1,4<\/sup> , Susan Hamilton <sup>3<\/sup>, Paul Smith <sup>1,2<\/sup>, Neil V. Morgan <sup>5<\/sup> , Siobhan Quenby <sup>6,7<\/sup>, Arri Coomarasamy <sup>1,2<\/sup> and Stephanie Allen <sup>3<\/sup> <\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Tommy\u2019s National Centre for Miscarriage Research, Birmingham Women\u2019s and Children\u2019s Hospital, Birmingham B15 2TG, UK; A.J.Devall@bham.ac.uk (A.J.D.); H.M.Williams.1@bham.ac.uk (H.W.); paul.smith@doctors.org.uk (P.S.); A.Coomarasamy@bham.ac.uk (A.C.)<\/li>\n\n\n\n<li>Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK<\/li>\n\n\n\n<li>West Midlands Regional Genetics Laboratory, Birmingham Women\u2019s and Children\u2019s Hospital, Birmingham B15 2TG, UK; susan.hamilton15@nhs.net (S.H.); stephanie.allen13@nhs.net (S.A.)<\/li>\n\n\n\n<li>Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston B15 2TT, UK<\/li>\n\n\n\n<li>Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; N.V.Morgan@bham.ac.uk<\/li>\n\n\n\n<li>Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7HL, UK; S.Quenby@warwick.ac.uk<\/li>\n\n\n\n<li>Tommy\u2019s National Centre for Miscarriage Research, University Hospitals Coventry &amp; Warwickshire NHS Trust, Coventry CV2 2DX, UK<\/li>\n<\/ol>\n\n\n\n<p>* Correspondence: emily.colley1@nhs.net<\/p>\n\n\n\n<p>Received: 1 October 2020; Accepted: 22 October 2020; Published: 26 October 2020<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#%E6%A6%82%E8%A6%81\" >\u6982\u8981:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#%E3%82%AD%E3%83%BC%E3%83%AF%E3%83%BC%E3%83%89\" >\u30ad\u30fc\u30ef\u30fc\u30c9:<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#1_%E5%BA%8F%E7%AB%A0\" >1. \u5e8f\u7ae0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#2_Materials_and_Methods\" >2. Materials and Methods<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#21_%E5%80%AB%E7%90%86%E7%9A%84%E6%89%BF%E8%AA%8D\" >2.1. \u502b\u7406\u7684\u627f\u8a8d<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#22_%E6%82%A3%E8%80%85%E3%82%B5%E3%83%B3%E3%83%97%E3%83%AB\" >2.2. \u60a3\u8005\u30b5\u30f3\u30d7\u30eb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#23_%E6%A4%9C%E4%BD%93%E3%81%AE%E5%87%A6%E7%90%86\" >2.3. \u691c\u4f53\u306e\u51e6\u7406<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#24_%E7%B4%B0%E8%83%9E%E9%81%BA%E4%BC%9D%E5%AD%A6%E7%9A%84%E5%88%86%E6%9E%90\" >2.4. \u7d30\u80de\u907a\u4f1d\u5b66\u7684\u5206\u6790<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#25_%E7%84%A1%E7%B4%B0%E8%83%9EDNA%E6%A4%9C%E6%9F%BB\" >2.5. \u7121\u7d30\u80deDNA\u691c\u67fb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#3_%E7%B5%90%E6%9E%9C\" >3. \u7d50\u679c<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#4_%E8%AD%B0%E8%AB%96\" >4. \u8b70\u8ad6<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#5_%E7%B5%90%E8%AB%96\" >5. \u7d50\u8ad6<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#%E8%91%97%E8%80%85%E3%81%AE%E8%B2%A2%E7%8C%AE\" >\u8457\u8005\u306e\u8ca2\u732e<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#%E8%B3%87%E9%87%91%E6%8F%90%E4%BE%9B\" >\u8cc7\u91d1\u63d0\u4f9b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#%E8%AC%9D%E8%BE%9E\" >\u8b1d\u8f9e<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#%E5%88%A9%E7%9B%8A%E7%9B%B8%E5%8F%8D\" >\u5229\u76ca\u76f8\u53cd<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\" >\u53c2\u8003\u6587\u732e<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/#%E5%87%BA%E7%89%88%E8%80%85%E6%B3%A8\" >\u51fa\u7248\u8005\u6ce8<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%A6%82%E8%A6%81\"><\/span>\u6982\u8981:<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u7d044\u56de\u306e\u598a\u5a20\u306b1\u56de\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3057\u3001\u305d\u306e\u3046\u3061\u306e50\uff05\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304c\u539f\u56e0\u3067\u3059\u30023\u56de\u9023\u7d9a\u3057\u3066<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3057\u305f\u5f8c\u306f\u3001\u53d7\u80ce\u751f\u6210\u7269\uff08POC\uff09\u7d44\u7e54\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b66\u7684\u691c\u67fb\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7121\u7d30\u80deDNA\uff08cfDNA\uff09\u306f\u51fa\u751f\u524d\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u5229\u7528\u3055\u308c\u3066\u304d\u305f\u304c\u3001\u975e\u598a\u5a20\u3067\u306f\u307b\u3068\u3093\u3069\u884c\u308f\u308c\u3066\u3044\u306a\u3044\u3002\u6211\u3005\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306b\u304a\u3051\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3092\u8b58\u5225\u3059\u308b\u305f\u3081\u306b\u3001\u6bcd\u4f53\u306e\u8840\u6db2\u304b\u3089\u306e cfDNA \u306e\u4f7f\u7528\u3092\u8abf\u67fb\u3057\u305f\u3002\u7b2c 1 \u671f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3092\u7d4c\u9a13\u3057\u305f\u5973\u6027\u306e\u8840\u6db2\u30b5\u30f3\u30d7\u30eb 100,2 \u4f8b\u3092\u53ce\u96c6\u3057\uff0c\u4fdd\u5b58\u3057\u305f\uff0e\u5e73\u5747\u598a\u5a20\u5e74\u9f62\u306f 7.1 \u9031\uff08\u7bc4\u56f2\uff1a5\uff5e11 \u9031\uff09\u3067\u3042\u3063\u305f\uff0e\u672c\u7814\u7a76\u3067\u306f\u3001POC\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u306e\u306a\u3044\u30b5\u30f3\u30d7\u30eb\u306f\u5206\u6790\u3057\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<p>CfDNA\u3092\u62bd\u51fa\u3057\u3001\u4fee\u6b63\u3055\u308c\u305f\u5e02\u8ca9\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\u3092\u7528\u3044\u3066\u5206\u6790\u3057\u305f\u3002\u7d50\u679c\u306f\u60a3\u8005\u306b\u306f\u63d0\u4f9b\u3055\u308c\u306a\u304b\u3063\u305f\u300257 \u30b5\u30f3\u30d7\u30eb\u3067\u306f\u3001POC \u5206\u6790\u306b\u3088\u308b\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306fPOC\u89e3\u6790\u306e47\uff05\uff0827\/57\uff09\u3067\u540c\u5b9a\u3055\u308c\u3001cfDNA\u89e3\u6790\u3067\u306f59\uff05\uff0816\/27\uff09\u304c\u6b63\u3057\u304f\u540c\u5b9a\u3055\u308c\u305f\u3002\u5408\u8a08\u3067\u306f\u300175\uff05\uff0843\/57\uff09\u306e\u7d50\u679c\u304c\u6b63\u3057\u304f\u540c\u5b9a\u3055\u308c\u305f\u3002\u5e73\u5747\u7684\u306a cfDNA \u80ce\u5150\u753b\u5206\u306f 6%(2-19%)\u3067\u3042\u3063\u305f\u3002\u7d50\u8ad6\u3068\u3057\u3066\u3001\u300c\u80ce\u5150\u7387\u300d\u304c\u5341\u5206\u306b\u9ad8\u3044\u5834\u5408\u306b\u306f\u3001cfDNA\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306b\u304a\u3051\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u691c\u51fa\u306b\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u304c\u3001\u5168\u4f53\u7684\u306a\u7d50\u679c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u5909\u6570\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3088\u308a\u591a\u304f\u306e\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E3%82%AD%E3%83%BC%E3%83%AF%E3%83%BC%E3%83%89\"><\/span>\u30ad\u30fc\u30ef\u30fc\u30c9:<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\uff1b\u7121\u7d30\u80deDNA\uff1b\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u5206\u6790\uff1b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_%E5%BA%8F%E7%AB%A0\"><\/span>1. \u5e8f\u7ae0<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u598a\u5a20\u521d\u671f\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306f\u3001\u598a\u5a20\u4e2d\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u5408\u4f75\u75c7[1]\u3067\u3042\u308a\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3068\u5b9a\u7fa9\u3055\u308c\u3066\u3044\u307e\u3059\u30025\u4eba\u306b1\u4eba\u306e\u598a\u5a20\u304c\u81ea\u7136<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3067\u7d42\u308f\u308b[2]\u304c\u3001\u305d\u306e50\uff05\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b[3]\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304c\u598a\u5a20<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u6839\u672c\u7684\u306a\u75c5\u56e0\u3067\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u306f\u3001\u5c06\u6765\u306e\u598a\u5a20\u306e\u4e88\u5f8c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u91cd\u8981\u3067\u3059\u3002\u6563\u767a\u6027\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304c\u598a\u5a20\u55aa\u5931\u306e\u539f\u56e0\u3067\u3042\u308b\u5834\u5408\u3001\u67d3\u8272\u4f53\u88dc\u4f53\u304c\u6b63\u5e38\u3067\u3042\u308b\u5834\u5408\u3088\u308a\u3082\u3001\u5c06\u6765\u306e\u598a\u5a20\u306e\u4e88\u5f8c\u306f\u826f\u597d\u3067\u3059\u3002\u305d\u306e\u5834\u5408\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u539f\u56e0\u304c\u67d3\u8272\u4f53\u4ee5\u5916\u306b\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u67d3\u8272\u4f53\u518d\u914d\u5217\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u60aa\u3044\u5834\u5408\u306f\u3001\u4e21\u89aa\u306e\u3069\u3061\u3089\u304b\u304c\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u67d3\u8272\u4f53\u518d\u914d\u5217\u3092\u6301\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u5c06\u6765\u306e\u598a\u5a20\u304c\u540c\u3058\u307e\u305f\u306f\u4ed6\u306e\u4e0d\u5747\u8861\u306a\u67d3\u8272\u4f53\u518d\u914d\u5217\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u306b\u306f\u3001\u518d\u767a\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u89aa\u306e\u6838\u578b\u691c\u67fb\u306e\u305f\u3081\u306e\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3092\u63a1\u53d6\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>Royal College of Obstetricians and Gynaecologists (RCOG) Green-top Guideline No.17 [4]\u3067\u306f\u30013\u56de\u76ee\u4ee5\u964d\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u5f8c\u306e\u598a\u5a20\u7d44\u7e54\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u5206\u6790\u3001\u307e\u305f\u306f\u598a\u5a20\u7d44\u7e54\u304c\u5165\u624b\u3067\u304d\u306a\u3044\u5834\u5408\u306f\u89aa\u30b5\u30f3\u30d7\u30eb\u306e\u6838\u578b\u5206\u6790\u3092\u63a8\u5968\u3057\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u3001\u598a\u5a20\u7d44\u7e54\u306e\u7570\u5e38\u306e\u691c\u51fa\u306b\u306f\u3001\u7d30\u80de\u57f9\u990a\u3084G\u30d0\u30f3\u30c9\u67d3\u8272\u4f53\u5206\u6790\u304c\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u3002\u3057\u304b\u3057\u3001\u53d7\u3051\u53d6\u3063\u305f\u7d44\u7e54\u306e\u8cea\u304c\u60aa\u3044\u3053\u3068\u3001\u305d\u306e\u3088\u3046\u306a\u7d44\u7e54\u304b\u3089\u7d30\u80de\u3092\u57f9\u990a\u3059\u308b\u3053\u3068\u304c\u56f0\u96e3\u3067\u3042\u308b\u3053\u3068\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/lp-143\/\">\u5fae\u5c0f\u6b20\u5931<\/a>\u75c7\u5019\u7fa4\u3084\u91cd\u8907\u75c7\u5019\u7fa4\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u5206\u89e3\u80fd\u304c\u9650\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u306a\u3069\u304b\u3089\u3001\u3057\u3070\u3057\u3070\u9ad8\u3044\u5931\u6557\u7387\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u5b9a\u91cf\u7684\u86cd\u5149PCR\uff08QF-PCR\uff09\u3084<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u306a\u3069\u306e\u5206\u5b50\u30d9\u30fc\u30b9\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u7814\u7a76\u5ba4\u3092\u8d85\u3048\u3066\u5b9f\u65bd\u3055\u308c\u3066\u304d\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u73fe\u5728\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u305f\u3081\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u80ce\u76e4\u6210\u5206\u3068\u80ce\u5150\u6210\u5206\u304b\u3089\u306a\u308b\u598a\u5a20\u7d44\u7e54\uff08\u598a\u5a20\u751f\u7523\u7269\uff08POC\uff09\u3068\u547c\u3070\u308c\u308b\uff09\u3092\u7528\u3044\u3066\u884c\u308f\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u7d44\u7e54\u306f\u3001\u80ce\u5150\u7d44\u7e54\u3092\u8b58\u5225\u3057\u3001DNA\u62bd\u51fa\u3084\u7d30\u80de\u57f9\u990a\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u3001\u65b0\u9bae\u3067\u3001\u6c5a\u67d3\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u56fa\u5b9a\u3055\u308c\u3066\u3044\u306a\u3044\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u306e\u8aa4\u8a3a\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u6bcd\u4f53\u7d30\u80de\u6c5a\u67d3\uff08MCC\uff09\u306e\u30ea\u30b9\u30af\u304c\u4f34\u3046\u3002POC\u30b5\u30f3\u30d7\u30eb\u306f\u3001\u80ce\u5150\u7d44\u7e54\u3068\u7d61\u307f\u5408\u3063\u305f\u6bcd\u4f53\u7d44\u7e54\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u6bcd\u4f53\u7d30\u80de\u306f\u3001\uff24\uff2e\uff21\u62bd\u51fa\u4e2d\u306b\u6bcd\u4f53\uff24\uff2e\uff21\u3092\u3082\u305f\u3089\u3057\u305f\u80ce\u5150\u7d44\u7e54\u306e\u9078\u629e\u4e2d\u306b\u6301\u3061\u8d8a\u3055\u308c\u305f\u308a\u3001\u7d30\u80de\u57f9\u990a\u4e2d\u306b\u6bcd\u4f53\u7d30\u80de\u304c\u904e\u5270\u306b\u5897\u6b96\u3057\u305f\u308a\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3055\u3089\u306b\u3001\u591a\u304f\u306e\u5834\u5408\u3001\uff30\uff2f\uff23\u306f\u5229\u7528\u3067\u304d\u306a\u3044\u304b\u3001\u307e\u305f\u306f\u60a3\u8005\u306b\u3088\u3063\u3066\u8fd4\u5374\u3055\u308c\u306a\u3044\u3002<\/p>\n\n\n\n<p>\u7121\u7d30\u80de DNA (cfDNA) \u306f\u3001Dennis Lo [5] \u306b\u3088\u3063\u3066\u521d\u3081\u3066\u540c\u5b9a\u3055\u308c\u3001\u598a\u5a66\u306e\u8840\u6f3f\u4e2d\u306e cfDNA \u306e\u5c0f\u7247\u304c\u80ce\u5150\u306e\u5168\u30b2\u30ce\u30e0\u3092\u8868\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002cfDNA\u306f\u3059\u3067\u306b\u51fa\u751f\u524d\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u73fe\u5728\u307e\u3067\u306e\u3068\u3053\u308d\u3001\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u306f\u307b\u3068\u3093\u3069\u884c\u308f\u308c\u3066\u3044\u307e\u305b\u3093\u3002Clark-Ganheart et al.\u3068Yaron et al.\u306b\u3088\u308b2\u4ef6\u306e\u7814\u7a76 [6,7]\u306e\u307f\u304c\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u8a2d\u5b9a\u3067\u306ecfDNA\u306e\u4f7f\u7528\u3092\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d7\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u30b3\u30db\u30fc\u30c8\u7814\u7a76 Clark-Ganheart \u3089 [6] \u306f\u3001\u975e\u598a\u5a20\u306e 50 \u4f8b\u306e cfDNA \u30b5\u30f3\u30d7\u30eb\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u8d85\u97f3\u6ce2\u691c\u67fb\u306b\u3088\u308b\u598a\u5a20\u5e74\u9f62\u306f6.1\u9031\u304b\u308938.4\u9031\u307e\u3067\u306e\u7bc4\u56f2\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30b5\u30f3\u30d7\u30eb\u306e\u3046\u3061\u300150\u30b5\u30f3\u30d7\u30eb\u4e2d38\u30b5\u30f3\u30d7\u30eb\u3067\u5831\u544a\u53ef\u80fd\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u3001\u305d\u306e\u3046\u30618\u30b5\u30f3\u30d7\u30eb\u3067\u306f\u30c8\u30ea\u30bd\u30df\u30fc\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002Yaron\u3089\u306b\u3088\u308b\u7814\u7a76[7]\u3067\u306f\u300114\u9031\u672a\u6e80\u3067\u306e\u598a\u5a20\u55aa\u5931\u3092\u5206\u6790\u3059\u308b\u305f\u3081\u306bcfDNA\u3092\u691c\u67fb\u3057\u307e\u3057\u305f\u3002\u5408\u8a08\u306786\u4f8b\u306e\u598a\u5a20\u3067\u3001\uff08CVS\u30b5\u30f3\u30d7\u30ea\u30f3\u30b0\u304b\u3089\u306e\uff09\u540c\u7b49\u306ePOC\u3092\u6709\u3059\u308bcfDNA\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u80ce\u5150\u5206\u753b\u306e\u4e2d\u592e\u5024\u306f5%\u3067\u3057\u305f\u300286\u30b5\u30f3\u30d7\u30eb\u306e\u3046\u3061\u300155\u30b5\u30f3\u30d7\u30eb\uff0864\uff05\uff09\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304c\u3042\u308a\u3001\u305d\u306e\u3046\u306130\u30b5\u30f3\u30d7\u30eb\uff0855\uff05\uff09\u306f\u6a19\u6e96\u7684\u306a\u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>\uff09\u5bfe\u6570\u5c24\u5ea6\u6bd4\uff08LLR\uff09\u30ab\u30c3\u30c8\u30aa\u30d5\u3092\u7528\u3044\u3066\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u611f\u5ea6\u3092\u4e0a\u3052\u308b\u305f\u3081\u306b\u300150\u30b5\u30f3\u30d7\u30eb\u306e\u300c\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30bb\u30c3\u30c8\u300d\u3092\u4f7f\u7528\u3057\u3066\u598a\u5a20\u55aa\u5931\u7279\u7570\u7684\u306a\u95be\u5024\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u691c\u51fa\u7387\u306f82\uff05\u306b\u5411\u4e0a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>CfDNA\u306f\u3001\u7c21\u5358\u306a\u8840\u6db2\u691c\u67fb\u306b\u3088\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u8a3a\u65ad\u306e\u6642\u70b9\u3067\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u67d3\u8272\u4f53\u539f\u56e0\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u975e\u5e38\u306b\u6709\u7528\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306b\u304a\u3051\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u691c\u51fa\u306bcfDNA\u3092\u3069\u306e\u3088\u3046\u306b\u5229\u7528\u3067\u304d\u308b\u304b\u3092\u691c\u8a0e\u3057\u3001\u305d\u306e\u7d50\u679c\u3092POC\u691c\u67fb\u306e\u7d50\u679c\u3068\u6bd4\u8f03\u3059\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_Materials_and_Methods\"><\/span>2. Materials and Methods<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading hidden-heading\"><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"21_%E5%80%AB%E7%90%86%E7%9A%84%E6%89%BF%E8%AA%8D\"><\/span>2.1. \u502b\u7406\u7684\u627f\u8a8d<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306fTommy&#8217;s National Centre for Miscarriage Research\u3067\u884c\u308f\u308c\u3001IRAS\u30d7\u30ed\u30b8\u30a7\u30af\u30c8ID, 215646\u3067\u7814\u7a76\u502b\u7406\u627f\u8a8d\uff08REC reference. 16\/WM\/0423, 23\/11\/2016, West Midlands-South Birmingham Research Ethics Committee\uff09\u304a\u3088\u3073Health Research Authority\uff08HRA\uff09\u306e\u627f\u8a8d\u3092\u53d7\u3051\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"22_%E6%82%A3%E8%80%85%E3%82%B5%E3%83%B3%E3%83%97%E3%83%AB\"><\/span>2.2. \u60a3\u8005\u30b5\u30f3\u30d7\u30eb<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u65e9\u671f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3092\u7d4c\u9a13\u3057\u3001Birmingham Women&#8217;s and Children&#8217;s Hospital\u304c\u4e3b\u50ac\u3059\u308bTommy&#8217;s National Centre for Miscarriage Research\u3092\u53d7\u8a3a\u3057\u305f\u60a3\u8005\u304b\u3089\u30a4\u30f3\u30d5\u30a9\u30fc\u30e0\u30c9\u30fb\u30b3\u30f3\u30bb\u30f3\u30c8\u3092\u5f97\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p>NHS\u30c8\u30e9\u30b9\u30c8\u3068University Hospital Coventry &amp; Warwickshire NHS\u30c8\u30e9\u30b9\u30c8\u306f\u30012017\u5e742\u6708\u304b\u30892019\u5e747\u6708\u307e\u3067\u306e\u9593\u306b \u540c\u610f\u306b\u306f\u3001\u60a3\u8005\u306ePOC\u3068\u907a\u4f1d\u7269\u8cea\u3092\u7528\u3044\u3066\u4f5c\u696d\u3059\u308b\u3053\u3068\u3078\u306e\u540c\u610f\u304c\u660e\u793a\u7684\u306b\u542b\u307e\u308c\u3066\u3044\u305f\u3002\u30b5\u30f3\u30d7\u30eb\u306f\u533b\u5b66\u7814\u7a76\u3078\u306e\u5bc4\u4ed8\u3068\u3057\u3066\u53ce\u96c6\u3055\u308c\u3001\u7d44\u7e54\uff08\u8907\u6570\u53ef\uff09\u306f\u30d2\u30c8\u7d44\u7e54\u6cd5\uff08HTA\uff09\u306b\u5f93\u3063\u3066\u53d6\u308a\u6271\u308f\u308c\u305f\u3002\u63d0\u4f9b\u8005\u306f\u3001\u66f4\u306a\u308b\u4f7f\u7528\u306e\u305f\u3081\u306b\u540c\u610f\u3092\u64a4\u56de\u3059\u308b\u80fd\u529b\u3092\u7dad\u6301\u3057\u305f\u304c\u3001\u53d6\u5f97\u5f8c\u306e\u30b5\u30f3\u30d7\u30eb\u306b\u5bfe\u3059\u308b \u6a29\u5229\u306f\u4fdd\u6301\u3057\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<p>\u8cc7\u683c\u57fa\u6e96\u306b\u306f\u3001\uff11\uff16\u6b73\u4ee5\u4e0a\u306e\u6bcd\u89aa\u306e\u5e74\u9f62\u3068\u3001\u598a\u5a20\u7d44\u7e54\u304c\u539f\u4f4d\u7f6e\u306b\u6b8b\u3063\u3066\u3044\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u8a3a\u65ad\u6642\u306e\u8d85\u97f3\u6ce2\u691c\u67fb\u3067\u78ba\u8a8d\u3055\u308c\u305f\u598a\u5a20\u671f\u9593\u304c\uff11\uff12\u9031\u672a\u6e80\u3067\u3042\u308b\u3053\u3068\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u30b5\u30f3\u30d7\u30eb\u306f\u3001\u5bfe\u5fdc\u3059\u308b POC \u5206\u6790\u3067\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u5834\u5408\u306b\u89e3\u6790\u306b\u542b\u307e\u308c\u305f\u304c\u30017 \u4f8b\u306e\u65e2\u77e5\u306e 3 \u500d\u4f53\u75c7\u4f8b\u3092\u9664\u3044\u3066\u306f\u9664\u5916\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<p>\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u306f cfDNA \u5206\u6790\u3068 \u03b2hCG \u30ec\u30d9\u30eb\u306e\u8a55\u4fa1\u306e\u305f\u3081\u306b\u63a1\u53d6\u3057\u305f\u3002\u7121\u7d30\u80deDNA BCT (STRECK) \u30c1\u30e5\u30fc\u30d6\u3067 cfDNA \u306e\u305f\u3081\u306b 10 mL \u307e\u3067\u306e\u6bcd\u4f53\u8840\u6db2\u3092\u63a1\u53d6\u3057\u3001\u80ce\u5150\u306e\u598a\u5a20\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001\u53ef\u80fd\u3067\u3042\u308c\u3070\u8d85\u97f3\u6ce2\u3067\u51a0-\u81c0\u90e8\u9577 (CRL) \u3092\u6e2c\u5b9a\u3057\u305f\u3002POC\u691c\u67fb\u3067\u5f97\u3089\u308c\u305f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306f\u3001\u6a19\u6e96\u7684\u306a\u60a3\u8005\u30b1\u30a2\u3092\u4ecb\u3057\u3066\u60a3\u8005\u306b\u4f1d\u3048\u305f\u3002CfDNA\u306e\u7d50\u679c\u306f\u60a3\u8005\u3068\u5171\u6709\u3055\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"23_%E6%A4%9C%E4%BD%93%E3%81%AE%E5%87%A6%E7%90%86\"><\/span>2.3. \u691c\u4f53\u306e\u51e6\u7406<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u5168\u8840\u304b\u3089\u8840\u6f3f\u3092\u4e8c\u91cd\u9060\u5fc3\u6cd5\u3067\u5206\u96e2\u3057\u3001DNA LoBind\u30c1\u30e5\u30fc\u30d6\uff08\u30a8\u30c3\u30da\u30f3\u30c9\u30eb\u30d5\uff09\u306b1 mL\u306e\u30a2\u30ea\u30b3\u30fc\u30c8\u3067\u79fb\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30a2\u30ea\u30b3\u30fc\u30c8\u306f\u4f7f\u7528\u3059\u308b\u307e\u3067-80\u2103\u3067\u4fdd\u5b58\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"24_%E7%B4%B0%E8%83%9E%E9%81%BA%E4%BC%9D%E5%AD%A6%E7%9A%84%E5%88%86%E6%9E%90\"><\/span>2.4. \u7d30\u80de\u907a\u4f1d\u5b66\u7684\u5206\u6790<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>3 \u56de\u76ee\u4ee5\u964d\u306e\u9023\u7d9a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u5f8c\u306e POC \u306b\u3064\u3044\u3066\u306f\u3001RCOG Green-top \u30ac\u30a4\u30c9\u30e9\u30a4\u30f3 No.17 [4] \u306b\u5f93\u3063\u3066\u3001\u53d7\u80ce\u7523\u7269\uff08POC\uff09\u3092\u30eb\u30fc\u30c1\u30f3\u306e\u81e8\u5e8a\u691c\u4f53\u3068\u3057\u3066\u63a1\u53d6\u3057\u3001\u6a19\u7684\u5316 QF-PCR \u3068\u67d3\u8272\u4f53<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u89e3\u6790\uff08CMA\uff09\u3092\u884c\u3063\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305a\u3001POC \u306e DNA \u306b\u5bfe\u3057\u3066 QF-PCR \u306b\u3088\u308b\u30c8\u30ea\u30bd\u30df\u30fc\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u5b9f\u65bd\u3057\u3001\u30c8\u30ea\u30bd\u30df\u30fc 13\u300118 \u307e\u305f\u306f 21\u3001\u4e09\u500d\u4f53\u3001\u6027\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u691c\u67fb\u3092\u884c\u3063\u305f\u3002QF-PCR\u3067\u7570\u5e38\u3067\u3042\u308c\u3070\u5831\u544a\u3055\u308c\u305f\u3002\u6b63\u5e38\u3067\u3042\u308c\u3070\u3001OGT CytoSure 8 \u00d7 60 k Constitutional v3\u30c7\u30b6\u30a4\u30f3\u3001\u30a8\u30af\u30bd\u30f3\/\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u306e\u5206\u89e3\u80fd\u306f\uff5e500 DDD\/ClinGen\u3067\u30ad\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3055\u308c\u305f\u767a\u751f\u907a\u4f1d\u5b50\u3068\u75c7\u5019\u7fa4\u9818\u57df\u3001\u968e\u5c64\u5316\u3055\u308c\u305f\u30d0\u30c3\u30af\u30dc\u30fc\u30f3\u306e\u5206\u89e3\u80fd\u306f\uff5e120\uff5e500 kb\u3001CytoSure v4.9\u3068CBS\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u7528\u3044\u305f\u30d3\u30eb\u30c9GRCh37\u3067\u306e\u89e3\u6790\u3092\u7528\u3044\u3066\u3001CMA\u691c\u67fb\u3092\u5b9f\u65bd\u3057\u305f\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u89e3\u6790\u3067\u306f\u30011Mb\u3092\u8d85\u3048\u308b\u30b3\u30d4\u30fc\u6570\u306e\u4e0d\u5747\u8861\u304c\u691c\u51fa\u3055\u308c\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u3088\u308a\u9ad8\u3044\u5206\u89e3\u80fd\u304c\u5f97\u3089\u308c\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"25_%E7%84%A1%E7%B4%B0%E8%83%9EDNA%E6%A4%9C%E6%9F%BB\"><\/span>2.5. \u7121\u7d30\u80deDNA\u691c\u67fb<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u5916\u90e8\u306e\u691c\u67fb\u6a5f\u95a2\u306b\u3088\u308b\u691c\u67fb\u306b\u540c\u610f\u3057\u305f\u60a3\u8005\u304b\u3089\u306e\u8840\u6f3f\uff081 mL\uff09\u3092\u30b1\u30f3\u30d6\u30ea\u30c3\u30b8\u306e\u30a4\u30eb\u30df\u30ca\u7814\u7a76\u6240\u306b\u63d0\u51fa\u3057\u3001\u4ee5\u524d\u306b\u8aac\u660e\u3057\u305f\u3088\u3046\u306b\u4fee\u6b63\u3057\u305f\u30a4\u30eb\u30df\u30caVeriSeq\u2122  NIPT\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3v2\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3092\u7528\u3044\u306624\u30b5\u30f3\u30d7\u30eb\u30d0\u30c3\u30c1\u3067\u51e6\u7406\u3057\u305f[8,9]\u304c\u3001\u6700\u65b0\u306e\u5206\u6790\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0[10]\u3092\u4f7f\u7528\u3057\u3001\u3044\u304f\u3064\u304b\u306e\u5c0f\u3055\u306a\u4fee\u6b63\u3092\u52a0\u3048\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_%E7%B5%90%E6%9E%9C\"><\/span>3. \u7d50\u679c<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u304c\u78ba\u8a8d\u3055\u308c\u305f\u5f8c\u3001\u5408\u8a08102\u500b\u306ecfDNA\u30b5\u30f3\u30d7\u30eb\u304c\u53ce\u96c6\u3055\u308c\u307e\u3057\u305f\u3002102\u500b\u306e\u30b5\u30f3\u30d7\u30eb\u306f\u3059\u3079\u3066\u3001NextSeq500\u4e0a\u306eVeriSeq\u2122 <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> v2 Solution\u5206\u6790\u306b\u3088\u3063\u3066\u5206\u6790\u3055\u308c\u305f\u3002\u5bfe\u5fdc\u3059\u308b POC \u30b5\u30f3\u30d7\u30eb\u3092 85 \u500b\u53d7\u3051\u53d6\u3063\u305f\u3002\u5408\u8a08\u3067 64 \u4f8b\u306e\u598a\u5a20\u3067 POC \u5206\u6790\u306b\u3088\u308b\u5bfe\u5fdc\u3059\u308b\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7d50\u679c\u304c\u5f97\u3089\u308c\u300121 \u4f8b\u306e POC \u30b5\u30f3\u30d7\u30eb\u306f\u5206\u6790\u306b\u9069\u3055\u305a\u300117 \u4f8b\u306e cfDNA \u30b5\u30f3\u30d7\u30eb\u306f\u5bfe\u5fdc\u3059\u308b POC \u30b5\u30f3\u30d7\u30eb\u3092\u53d7\u4fe1\u3057\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u672a\u53d7\u9818\u306e POC \u30b5\u30f3\u30d7\u30eb 17 \u4f8b\u3068\u5206\u6790\u306b\u9069\u3055\u306a\u3044 21 \u4f8b\u306e POC \u30b5\u30f3\u30d7\u30eb\u306f cfDNA \u5206\u6790\u304b\u3089\u9664\u5916\u3055\u308c\u3001\u65e2\u77e5\u306e\u4e09\u500d\u4f53\u598a\u5a20\u306f\u9664\u5916\u3055\u308c\u307e\u3057\u305f\uff08\u56f3 1\uff09\u3002<\/p>\n\n\n\n    <a href=\"\/nipt\/ger-13607dna\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u30c9\u30a4\u30c4\u306e\u5358\u4e00\u65bd\u8a2d\u306b\u304a\u3051\u308b\u80ce\u5150\u67d3\u8272\u4f53\u7570\u6570\u6027\u691c\u51fa\u306e\u305f\u3081\u306e13,607\u4f8b\u306e\u30eb\u30fc\u30c1\u30f3\u75c7\u4f8b\u306e\u9023\u7d9a\u30b7\u30ea\u30fc\u30ba\u306b\u304a\u3051\u308b\u7121\u7d30\u80deDNA\u306e\u5206\u6790 <\/div>\n          <div class=\"blog-card-excerpt\">\u4ee5\u524d\u306bNIPT\u3092\u53d7\u3051\u305f\u598a\u5a6613,607\u4eba\u304b\u3089\u306e\u30b5\u30f3\u30d7\u30eb\u3092\u3001\u4e00\u822c\u7684\u306a\u80ce\u5150\u30c8\u30ea\u30bd\u30df\u30fc\u304a\u3088\u3073\u30e2\u30ce\u30bd\u30df\u30fcX\u306e\u5b58\u5728\u306b\u3064\u3044\u3066VeriSeq NIPT S...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306f 27\/57 \u4f8b\uff0847%\uff09\u3067 POC \u5206\u6790\u306b\u3088\u308a\u78ba\u8a8d\u3055\u308c\u305f\u3002\u60a3\u8005\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u7279\u5fb4\u3092\u88681\u306b\u307e\u3068\u3081\u305f\u3002\u5bfe\u5fdc\u3059\u308b\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u3092\u884c\u3063\u305f57\u4f8b\u304b\u3089\u3001\u5e73\u5747\u5e74\u9f62\u306f34\u6b73\uff0820\uff5e43\u6b73\uff09\u3067\u3001\u81e8\u5e8a\u598a\u5a207.1\u9031\uff085\uff5e11\u9031\uff09\u3001\u80ce\u5150\u7387\u306f6\uff05\uff082\uff5e19\uff05\uff09\u3067\u3042\u3063\u305f\u3002VeriSeq\u2122 \u3092\u7528\u3044\u3066\u3001\u907a\u4f1d\u7684\u7570\u5e3816\/27\uff0859\uff05\uff09\u3001\u907a\u4f1d\u7684\u306b\u6b63\u5e38\u306a\u30b5\u30f3\u30d7\u30eb27\/30\uff0890\uff05\uff09\u3092\u542b\u3080\u30b5\u30f3\u30d7\u30eb\u306e\u5408\u8a0870\uff05\uff0840\/57\uff09\u304c\u6b63\u3057\u304f\u540c\u5b9a\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u30b3\u30db\u30fc\u30c8\u304c\u6bd4\u8f03\u7684\u5c0f\u3055\u304b\u3063\u305f\u3082\u306e\u306e\u3001\u611f\u5ea659\uff05\uff0816\/27\uff09\u3001\u7279\u7570\u5ea690\uff05\uff0827\/30\uff09\u3001\u7cbe\u5ea675\uff05\uff0843\/57\uff09\u306b\u76f8\u5f53\u3059\u308b\u3002<\/p>\n\n\n\n<figure class=\"fig_svg1\">\n<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 363.04 759.06\">\n\t<defs>\n\t\t<style>\t\t\n.fig_svg1 svg .a{fill:#bfefc9;}\n.fig_svg1 svg .a,.fig_svg1 svg .b,.fig_svg1 svg .f{stroke:#231815;stroke-miterlimit:10;}\n.fig_svg1 svg .a,.fig_svg1 svg .f{stroke-width:0.5px;}\n.fig_svg1 svg .b{fill:none;stroke-width:1.5px;}\n.fig_svg1 svg .c{fill:#231815;}\n.fig_svg1 svg .d{font-size:12px;letter-spacing:0.02em;}\n.fig_svg1 svg .e{letter-spacing:0.27em;}\n.fig_svg1 svg .f{fill:#ffe79c;}\n.fig_svg1 svg .g{letter-spacing:0.27em;}\n.fig_svg1 svg .h{letter-spacing:0.02em;}\n.fig_svg1 svg .i{letter-spacing:-0.48em;}\n.fig_svg1 svg .j{letter-spacing:-0.23em;}\n.fig_svg1 svg .k{letter-spacing:-0.48em;}\n.fig_svg1 svg .l{letter-spacing:0.09em;}\n.fig_svg1 svg .m{letter-spacing:0.11em;}\n.fig_svg1 svg .n{letter-spacing:0.09em;}\n.fig_svg1 svg .o{letter-spacing:0.02em;}\n.fig_svg1 svg .p{letter-spacing:0.27em;}\n<\/style>\n\t<\/defs>\n\t<rect class=\"a\" x=\"173.84\" y=\"509.36\" width=\"188.95\" height=\"62.36\" rx=\"8.86\"><\/rect>\n\t<line class=\"b\" x1=\"85.29\" y1=\"141.62\" x2=\"85.29\" y2=\"231.87\"><\/line>\n\t<polygon class=\"c\" points=\"79.73 227.66 85.29 230.02 90.84 227.66 85.29 240.83 79.73 227.66\"><\/polygon>\n\t<line class=\"b\" x1=\"85.29\" y1=\"184.62\" x2=\"161.37\" y2=\"184.62\"><\/line>\n\t<polygon class=\"c\" points=\"157.16 190.17 159.52 184.62 157.16 179.06 170.33 184.62 157.16 190.17\"><\/polygon>\n\t<text class=\"d\" transform=\"translate(189.57 536.36)\">\u9664\u5916: \u4e09\u500d\u4f53\u7d30\u80de\n\t\t<tspan x=\"30\" y=\"16\" xml:space=\"preserve\">\u907a\u4f1d\u5b66\u7684\u7d50\u679c (7)<\/tspan>\n\t<\/text>\n\t<rect class=\"f\" x=\"0.25\" y=\"244.25\" width=\"170.08\" height=\"85.04\" rx=\"14.17\"><\/rect>\n\t<text class=\"d\" transform=\"translate(12.13 283.03)\">\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u306e\u305f\u3081\u306e\n\t\t<tspan x=\"19.57\" y=\"15\">POC\u30b5\u30f3\u30d7\u30eb85\u500b<\/tspan>\n\t<\/text>\n\t<line class=\"b\" x1=\"85.29\" y1=\"329.62\" x2=\"85.29\" y2=\"419.87\"><\/line>\n\t<polygon class=\"c\" points=\"79.73 415.66 85.29 418.02 90.84 415.66 85.29 428.83 79.73 415.66\"><\/polygon>\n\t<line class=\"b\" x1=\"85.29\" y1=\"372.62\" x2=\"161.37\" y2=\"372.62\"><\/line>\n\t<polygon class=\"c\" points=\"157.16 378.17 159.52 372.62 157.16 367.06 170.33 372.62 157.16 378.17\"><\/polygon>\n\t<line class=\"b\" x1=\"85.29\" y1=\"487.62\" x2=\"85.29\" y2=\"577.87\"><\/line>\n\t<polygon class=\"c\" points=\"79.73 573.66 85.29 576.02 90.84 573.66 85.29 586.83 79.73 573.66\"><\/polygon>\n\t<line class=\"b\" x1=\"85.29\" y1=\"530.62\" x2=\"161.37\" y2=\"530.62\"><\/line>\n\t<polygon class=\"c\" points=\"157.16 536.17 159.52 530.62 157.16 525.06 170.33 530.62 157.16 536.17\"><\/polygon>\n\t<rect class=\"f\" x=\"0.25\" y=\"431.42\" width=\"170.08\" height=\"56.69\" rx=\"14.17\"><\/rect>\n\t<text class=\"d\" transform=\"translate(16 464.03)\">64 \u5bfe\u5fdc\u3059\u308b\u907a\u4f1d\u5b50\u306e\u7d50\u679c<\/text>\n\t<rect class=\"f\" x=\"0.25\" y=\"588.73\" width=\"170.08\" height=\"170.08\" rx=\"14.17\"><\/rect>\n\t<text class=\"d\" transform=\"translate(12.88 634.03)\">57 \u5bfe\u5fdc\u3059\u308b\u907a\u4f1d\u5b66\u7684\u7d50\u679c\n\t\t<tspan x=\"-0.75\" y=\"15\">\u6709\u610f\u306a\u30b3\u30d4\u30fc\u6570\u306e\u4e0d\u5747\u8861\u304c<\/tspan>\n\t\t<tspan x=\"23.73\" y=\"30\">\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f<\/tspan>\n\t\t<tspan x=\"39.86\" y=\"45\">30\u30b5\u30f3\u30d7\u30eb<\/tspan>\n\t\t<tspan x=\"5.37\" y=\"65\">\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u691c\u51fa\u3055\u308c\u305f<\/tspan>\n\t\t<tspan x=\"39.86\" y=\"80\">27\u30b5\u30f3\u30d7\u30eb<\/tspan>\n\t\t<tspan x=\"17.41\" y=\"95\">\uff0845 X\u30923\u3064\u542b\u3080\uff09<\/tspan>\n\t<\/text>\n\t<rect class=\"f\" x=\"0.25\" y=\"0.25\" width=\"170.08\" height=\"141.73\" rx=\"14.17\"><\/rect>\n\t<text class=\"d\" transform=\"translate(54.97 39.03)\">\u4fee\u6b63\u3055\u308c\u305f\n\t\t<tspan x=\"-16.25\" y=\"15\">Illumina VeriSeq <\/tspan>\n\t\t<tspan x=\"-34.7\" y=\"30\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> \u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3 v2<\/tspan>\n\t\t<tspan x=\"-36.72\" y=\"45\">\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3092\u4f7f\u7528\u3057\u3066<\/tspan>\n\t\t<tspan x=\"-18.36\" y=\"60\">\u30b7\u30fc\u30b1\u30f3\u30b9\u3055\u308c\u305f<\/tspan>\n\t\t<tspan x=\"-5.66\" y=\"75\">102\u30b5\u30f3\u30d7\u30eb<\/tspan>\n\t<\/text>\n\t<rect class=\"a\" x=\"175.05\" y=\"163.02\" width=\"186.74\" height=\"56.69\" rx=\"7.6\"><\/rect>\n\t<text class=\"d\" transform=\"translate(187.55 188.04)\">\u9664\u5916: \u5bfe\u5fdc\u3059\u308bPOC\u30b5\u30f3\u30d7\u30eb\n\t\t<tspan x=\"30\" y=\"16\" xml:space=\"preserve\">\u3092\u53d7\u4fe1\u3057\u3066\u3044\u306a\u3044(17)<\/tspan>\n\t<\/text>\n\t<rect class=\"a\" x=\"174.12\" y=\"351.02\" width=\"188.67\" height=\"59.53\" rx=\"8.65\"><\/rect>\n\t<text class=\"d\" transform=\"translate(188.57 376.36)\">\u9664\u5916: \u80ce\u5150\u7269\u8cea\u306e\u306a\u3044\n\t\t<tspan x=\"30\" y=\"16\" xml:space=\"preserve\">\u30b5\u30f3\u30d7\u30eb \/ MCC (21)<\/tspan>\n\t<\/text>\n<\/svg>\n<figcaption><strong>\u56f31.<\/strong> cfDNA\u30b5\u30f3\u30d7\u30eb\u306e\u9664\u5916\/\u9664\u5916\u3092\u8aac\u660e\u3059\u308b\u30d5\u30ed\u30fc\u30c1\u30e3\u30fc\u30c8\u3002MCC\uff1a\u6bcd\u4f53\u7d30\u80de\u6c5a\u67d3\uff1b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>\uff1a\u30aa\u30f3\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\uff1bPOC\uff1a\u53d7\u80ce\u306e\u7523\u7269\u3002<\/figcaption>\n<\/figure>\n\n\n\n<table>\n<caption><strong>\u88681.<\/strong>\u5206\u6790\u306b\u9069\u3057\u305f\u5bfe\u5fdc\u3059\u308b\u53d7\u80ce\u7523\u7269\uff08POC\uff09\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u305fcfDNA\u30b5\u30f3\u30d7\u30eb\u306e\u7279\u5fb4\uff08\u4e09\u500d\u4f53\u598a\u5a20\u3092\u9664\u304f\uff09<\/caption>\n<colgroup>\n<col style=\"width:25%;\">\n<col style=\"width:25%;\">\n<col style=\"width:25%;\">\n<col style=\"width:25%;\">\n<\/colgroup>\n<thead>\n<tr>\n<th><\/th><th>\u5408\u8a08 (n = 57)<\/th><th>\u67d3\u8272\u4f53\u7684\u306b\u6b63\u5e38<br>(n = 30)<\/th><th><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a><br>(n = 27)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u6bcd\u4f53\u5e74\u9f62(\u5e74)<br>(\u5e73\u5747\u5024\u3068\u7bc4\u56f2)<\/td>\n<td>34<br>(20-43)<\/td>\n<td>31<br>(20-41)<\/td>\n<td>37<br>(24-43)<\/td>\n<\/tr>\n<tr>\n<td>\u904e\u53bb\u306e\u640d\u5931<br>(\u5e73\u5747\u5024\u3068\u7bc4\u56f2)<\/td>\n<td>3.8<br>(0-14)<\/td>\n<td>4.1<br>(0-14)<\/td>\n<td>3.3<br>(0-6)<\/td>\n<\/tr>\n<tr>\n<td>\u598a\u5a20\u5e74\u9f62(\u9031)<br>(\u5e73\u5747\u5024\u3068\u7bc4\u56f2)<\/td>\n<td>7.1<br>(5-11)<\/td>\n<td>7.4<br>(5-11)<\/td>\n<td>6.4<br>(5-9.3)<\/td>\n<\/tr>\n<tr>\n<td>\u03b2hCG (mIU\/mL)<br>(\u5e73\u5747\u5024\u3068\u7bc4\u56f2)<\/td>\n<td>38,356<br>(69-263,766)<\/td>\n<td>50,632<br>(69-263,766)<\/td>\n<td>21,538<br>(491-100,638)<\/td>\n<\/tr>\n<tr>\n<td>\u80ce\u5150\u306e\u5272\u5408(%)<br>(\u5e73\u5747\u5024\u3068\u7bc4\u56f2)<\/td>\n<td>6<br>(2-19)<\/td>\n<td>7<br>(2-19)<\/td>\n<td>5<br>(3-12)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p>CfDNA\u89e3\u6790\u3067\u306f\u3001\u7570\u5e3816\u4f8b\u3001\u6b63\u5e3827\u4f8b\u3092\u542b\u308043\/57\u4f8b\uff0875\uff05\uff09\u304c\u6b63\u3057\u304f\u540c\u5b9a\u3055\u308c\u305f\u3002\u88682\u306f\u3001POC\u3067\u7570\u5e38\u304c\u691c\u51fa\u3055\u308c\u305f\u75c7\u4f8b\u306ePOC\u7d50\u679c\u3068cfDNA\u691c\u67fb\u7d50\u679c\u3092\u6bd4\u8f03\u3057\u305f\u3082\u306e\u3067\u3042\u308b\u3002POC\u3067\u691c\u51fa\u3055\u308c\u305f\u7570\u5e38\u306f\u3001\u5171\u901a\u30c8\u30ea\u30bd\u30df\u30fc\uff083\uff09\u3001\u30e2\u30ce\u30bd\u30df\u30fcX\uff082\uff09\u300145\u3001X\u3068\u8907\u5408\u3057\u305f\u5171\u901a\u30c8\u30ea\u30bd\u30df\u30fc\uff081\uff09\u3001\u30e2\u30ce\u30bd\u30df\u30fc21\uff081\uff09\u3001\u5b8c\u5168\u30ec\u30a2\u30c8\u30ea\u30bd\u30df\u30fc\uff0814\uff09\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u30ec\u30a2\u30c8\u30ea\u30bd\u30df\u30fc\uff082\uff09\u3001\u30b3\u30d4\u30fc\u6570\u5909\u7570\uff084\uff09\u3067\u3042\u3063\u305f\u3002\u5e0c\u5c11\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u4e2d\u3067\u306f\u3001\u30c8\u30ea\u30bd\u30df\u30fc22\u3068\u30c8\u30ea\u30bd\u30df\u30fc15\u304c\u6700\u3082\u591a\u304b\u3063\u305f\u3002\u80ce\u5150\u5206\u753b\u306f3\uff5e12\uff05\uff08\u5e73\u57475\uff05\uff09\u3067\u3042\u3063\u305f\u3002CfDNA \u306e\u7d50\u679c\u306f 40\/57 \u30b5\u30f3\u30d7\u30eb\u3067 POC \u306e\u7d50\u679c\u3068\u5b8c\u5168\u306b\u4e00\u81f4\u3057\u3066\u3044\u305f\u3002CfDNA\u306e\u7d50\u679c\u306f27\/30\u4f8b\u3067\u6b63\u5e38\u306a\u7d50\u679c\u3092\u751f\u3058\u3001\u65e2\u77e5\u306e\u6b63\u5e38\u4f8b\u306e3\/30\u4f8b\u3067\u4e0d\u4e00\u81f4\u306a\u7d50\u679c\u3092\u751f\u3058\u305f\u30022\u3064\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u30b5\u30f3\u30d7\u30eb\uff08\u30b5\u30f3\u30d7\u30ebID 51\u3068586\uff09\u306fcfDNA\u691c\u67fb\u3067\u306f\u6b63\u3057\u304f\u540c\u5b9a\u3055\u308c\u306a\u304b\u3063\u305f\u304c\u3001\u3053\u308c\u3089\u306e\u30b5\u30f3\u30d7\u30eb\u3067\u306f\u4ed6\u306e\u4e0d\u5747\u8861\u304c\u691c\u51fa\u3055\u308c\u305f\u3002\u30b5\u30f3\u30d7\u30ebID 228\u3067\u306fPOC\u3067\u30e2\u30ce\u30bd\u30df\u30fc21\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u304c\u3001cfDNA\u691c\u67fb\u3067\u306f\u4ed6\u306e\u3044\u304f\u3064\u304b\u306e\u67d3\u8272\u4f53\u3067CNV\u304c\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>4\u3064\u306e\u30b5\u30f3\u30d7\u30eb\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3057\u305f\u3082\u306e\u3067\u3001POC\u5206\u6790\u3067\u67d3\u8272\u4f53\u4ee5\u4e0b\u306e\u6b20\u5931\u3068\u91cd\u8907\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08\u30b5\u30f3\u30d7\u30ebID 133\u3001202\u3001303\u3001319\uff09\u30027q22.1q36.3\u306b56Mb\u306e\u91cd\u8907\u306819q13.12q13.43\u306b21Mb\u306e\u672b\u7aef\u91cd\u8907\u304ccfDNA\u5206\u6790\u306b\u3088\u3063\u3066\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u300213q13.3q34\u306b70Mb\u306e\u6b20\u5931\u30017q36.2q36.3\u306b6Mb\u306e\u672b\u7aef\u6b20\u5931\u30014q34.3q35.2\u306b9Mb\u306e\u672b\u7aef\u91cd\u8907\u30015q33.1q35.3\u306b30Mb\u306e\u672b\u7aef\u6b20\u5931\u304ccfDNA\u89e3\u6790\u3067\u306f\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<p>cfDNA\u89e3\u6790\u3068POC\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u306e\u9593\u306e\u7d50\u679c\u547c\u3073\u51fa\u3057\u3092\u6539\u5584\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u898b\u308b\u305f\u3081\u306b\u3001\u7570\u306a\u308b\u598a\u5a20\u3001\u03b2hCG\u5024\u304a\u3088\u3073\u80ce\u5150\u5206\u753b\u30ab\u30c3\u30c8\u30aa\u30d5\u3092\u7528\u3044\u30663\u3064\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u30b0\u30eb\u30fc\u30d7\u5316\u3057\u305f(\u88683)\u3002\u598a\u5a20\u671f\u9593\u306f\u30017\u9031\u672a\u6e80\u30017\uff5e8\u9031\u30018\u9031\u4ee5\u4e0a\u3001\u598a\u5a20\u4e0d\u660e\u306e4\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u3051\u305f\u3002\u3053\u308c\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u598a\u5a20\u671f\u9593\u304c\u9577\u304f\u306a\u308b\u306b\u3064\u308c\u3066\u3001cfDNA\u691c\u67fb\u3067\u6b63\u3057\u304f\u540c\u5b9a\u3055\u308c\u305f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304c\u5897\u52a0\u3057\u305f\u3002\u03b2hCG\u5024\u306f\u30018000\u672a\u6e80\u30018000\uff5e35000\u300135000mIU\/mL\u4ee5\u4e0a\u306e3\u7fa4\u306b\u5206\u3051\u305f\u3002\u3053\u308c\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u03b2hCG\u5024\u304c\u5897\u52a0\u3059\u308b\u3068\u3001cfDNA\u691c\u67fb\u3067\u6b63\u3057\u304f\u540c\u5b9a\u3055\u308c\u305f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3082\u5897\u52a0\u3057\u305f\u3002\u80ce\u5150\u5206\u753b\u7fa4\u30923\u7fa4\u306b\u5206\u3051\u305f\u30025\u672a\u6e80\u30015\uff5e8\u30019\u4ee5\u4e0a\u306e3\u7fa4\u306b\u5206\u3051\u305f\u3002\u3053\u3053\u3067\u3082\u3001\u80ce\u5150\u5206\u753b\u7fa4\u306e\u5897\u52a0\u306b\u4f34\u3044\u3001cfDNA\u691c\u67fb\u306b\u3088\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e\u6b63\u7b54\u7387\u3082\u5897\u52a0\u3057\u305f\u3002<\/p>\n\n\n\n<div class=\"table-sp-scroll\">\n<table>\n<caption><strong>\u88682.<\/strong> \u4fee\u6b63\u3055\u308c\u305fIllumina VeriSeq\u2122 \u975e\u4fb5\u8972\u7684<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">\u51fa\u751f\u524d\u8a3a\u65ad<\/a>\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>\uff09\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3v2\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3092\u7528\u3044\u305fcfDNA\u306e\u89e3\u6790\u3068\u3001POC\u967d\u6027\u7d50\u679c\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/amniocentesis-microarray\/\">\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4<\/a>\u89e3\u6790\u306e\u907a\u4f1d\u7684\u8ee2\u5e30\u3068\u306e\u6bd4\u8f03<\/caption>\n<thead>\n<tr>\n<th>\u30b5\u30f3\u30d7\u30eb<br>ID<\/th><th>\u598a\u5a20(\u9031)<\/th><th>CRL(mm)<\/th><th>BhCG<br>(mIU\/mL)<\/th><th>\u6bcd\u4f53\u5e74\u9f62<br>(\u5e74)<\/th><th>\u524d\u56de<br>\u55aa\u5931\u8005\u6570<\/th><th>POC\u7d50\u679c<\/th><th>POC<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/#anchor_sex\">\u6027\u5225<\/a><\/th><th>CfDNA\u7d50\u679c<\/th><th>CfDNA<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/#anchor_sex\">\u6027\u5225<\/a><\/th><th>\u80ce\u5150\u7387<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th>4<\/th><td>7 + 2<\/td><td>2.8<\/td><td>19,247<\/td><td>40<\/td><td>2<\/td><td>22\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u5973\u6027<\/td><td>\u7570\u5e38\u306a\u3057<\/td><td>\u5973\u6027<\/td><td>4%<\/td>\n<\/tr>\n<tr>\n<th>51<\/th><td>5 + 4<\/td><td>2<\/td><td>12,725<\/td><td>34<\/td><td>6<\/td><td>4<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u7537\u6027<\/td><td>\u691c\u51fa\u6e08: \u6b20\u5931 (10) (p15.3q21.1)<\/td><td>\u7537\u6027<\/td><td>4%<\/td>\n<\/tr>\n<tr>\n<th>99<\/th><td>6 + 0<\/td><td>\u672a\u8a18\u9332<\/td><td>5111<\/td><td>27<\/td><td>4<\/td><td>5\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u7537\u6027<\/td><td>\u7570\u5e38\u306a\u3057<\/td><td>\u7537\u6027<\/td><td>6%<\/td>\n<\/tr>\n<tr>\n<th>133<\/th><td>\u672a\u8a18\u9332<\/td><td>\u672a\u8a18\u9332<\/td><td>57,348<\/td><td>34<\/td><td>4<\/td><td>7q36.2q36.3\u306e\u672b\u7aef\u6b20\u5931(6Mb)\u306819q13.12q13.43\u306e\u672b\u7aef\u91cd\u8907(21Mb)<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: \u91cd\u8907 (19) (q13.12q13.43)<\/td><td>\u5973\u6027<\/td><td>7%<\/td>\n<\/tr>\n<tr>\n<th>163<\/th><td>8 + 4<\/td><td>20.1<\/td><td>13,466<\/td><td>24<\/td><td>3<\/td><td>\u30bf\u30fc\u30ca\u30fc\u75c7\u5019\u7fa4<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: XO<\/td><td>\u5973\u6027<\/td><td>7%<\/td>\n<\/tr>\n<tr>\n<th>164<\/th><td>6 + 0<\/td><td>9<\/td><td>6774<\/td><td>42<\/td><td>2<\/td><td>15\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: +15<\/td><td>\u5973\u6027<\/td><td>5%<\/td>\n<\/tr>\n<tr>\n<th>175<\/th><td>8 + 0<\/td><td>No FP seen<\/td><td>5323<\/td><td>34<\/td><td>6<\/td><td>\u30bf\u30fc\u30ca\u30fc\u75c7\u5019\u7fa4<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: XO<\/td><td>\u5973\u6027<\/td><td>5%<\/td>\n<\/tr>\n<tr>\n<th>176<\/th><td>7 + 0<\/td><td>14<\/td><td>491<\/td><td>43<\/td><td>2<\/td><td>15\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: +15<\/td><td>\u5973\u6027<\/td><td>5%<\/td>\n<\/tr>\n<tr>\n<th>202<\/th><td>6 + 0<\/td><td>5<\/td><td>13,819<\/td><td>29<\/td><td>4<\/td><td>4q34.3q35.2\uff089Mb\uff09\u306e\u672b\u7aef\u91cd\u8907\u304a\u3088\u30735q33.1q35.3\uff0830Mb\uff09\u306e\u672b\u7aef\u6b20\u5931<\/td><td>\u5973\u6027<\/td><td>\u7570\u5e38\u306a\u3057<\/td><td>\u5973\u6027<\/td><td>4%<\/td>\n<\/tr>\n<tr>\n<th>228<\/th><td>7 + 0<\/td><td>12<\/td><td>6220<\/td><td>41<\/td><td>5<\/td><td>21\u30e2\u30ce\u30bd\u30df\u30fc<\/td><td>\u7537\u6027<\/td><td>\u691c\u51fa\u6e08: \u91cd\u8907 (15) (q21.3q23); \u91cd\u8907 (20) (q11.21q13.12)<\/td><td>\u7537\u6027<\/td><td>3%<\/td>\n<\/tr>\n<tr>\n<th>245<\/th><td>\u672a\u8a18\u9332<\/td><td>6.5<\/td><td>14,762<\/td><td>33<\/td><td>3<\/td><td>22\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u7537\u6027<\/td><td>\u7570\u5e38\u306a\u3057<\/td><td>\u7537\u6027<\/td><td>4%<\/td>\n<\/tr>\n<tr>\n<th>260<\/th><td>7 + 0<\/td><td>\u672a\u8a18\u9332<\/td><td>5194<\/td><td>43<\/td><td>2<\/td><td>22\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u7537\u6027<\/td><td>\u7570\u5e38\u306a\u3057<\/td><td>\u7537\u6027<\/td><td>4%<\/td>\n<\/tr>\n<tr>\n<th>\u30b5\u30f3\u30d7\u30eb<br>ID<\/th><th>\u598a\u5a20(\u9031)<\/th><th>CRL(mm)<\/th><th>BhCG<br>(mIU\/mL)<\/th><th>\u6bcd\u4f53\u5e74\u9f62<br>(\u5e74)<\/th><th>\u524d\u56de<br>\u55aa\u5931\u8005\u6570<\/th><th>POC\u7d50\u679c<\/th><th>POC<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/#anchor_sex\">\u6027\u5225<\/a><\/th><th>CfDNA\u7d50\u679c<\/th><th>CfDNA<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/testing\/#anchor_sex\">\u6027\u5225<\/a><\/th><th>\u80ce\u5150\u7387<\/th>\n<\/tr>\n<tr>\n<th>264<\/th><td>6 + 0<\/td><td>4<\/td><td>14,002<\/td><td>33<\/td><td>\u672a\u8a18\u9332<\/td><td><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/\">13\u30c8\u30ea\u30bd\u30df\u30fc<\/a><\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: +13; +16<\/td><td>\u5973\u6027<\/td><td>4%<\/td>\n<\/tr>\n<tr>\n<th>279<\/th><td>6 + 0<\/td><td>6<\/td><td>8429<\/td><td>40<\/td><td>4<\/td><td>7\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: +7<\/td><td>\u5973\u6027<\/td><td>12%<\/td>\n<\/tr>\n<tr>\n<th>287<\/th><td>\u672a\u8a18\u9332<\/td><td>4<\/td><td>\u672a\u8a18\u9332<\/td><td>42<\/td><td>0<\/td><td>12\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: +12<\/td><td>\u5973\u6027<\/td><td>4%<\/td>\n<\/tr>\n<tr>\n<th>290<\/th><td>5 + 0<\/td><td>5.2<\/td><td>44,313<\/td><td>39<\/td><td>0<\/td><td>16\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: +16<\/td><td>\u5973\u6027<\/td><td>7%<\/td>\n<\/tr>\n<tr>\n<th>303<\/th><td>6 + 0<\/td><td>1.9<\/td><td>34,087<\/td><td>35<\/td><td>3<\/td><td>13q13.3q34\u3067\u306e\u6b20\u5931 (70 Mb)<\/td><td>\u5973\u6027<\/td><td>\u7570\u5e38\u306a\u3057<\/td><td>\u5973\u6027<\/td><td>5%<\/td>\n<\/tr>\n<tr>\n<th>319<\/th><td>7 + 0<\/td><td>9.3<\/td><td>13,642<\/td><td>40<\/td><td>6<\/td><td>\u91cd\u8907 7q22.1q36.3 (56 Mb)<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: \u91cd\u8907 (7) (q22.1q31.1)<\/td><td>\u5973\u6027<\/td><td>7%<\/td>\n<\/tr>\n<tr>\n<th>328<\/th><td>\u672a\u8a18\u9332<\/td><td>4.4<\/td><td>2983<\/td><td>42<\/td><td>3<\/td><td>11\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u5973\u6027<\/td><td>\u7570\u5e38\u306a\u3057<\/td><td>\u5973\u6027<\/td><td>4%<\/td>\n<\/tr>\n<tr>\n<th>400<\/th><td>5 + 6<\/td><td>4.6<\/td><td>29,052<\/td><td>42<\/td><td>5<\/td><td>22\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u7537\u6027<\/td><td>\u691c\u51fa\u6e08: +22<\/td><td>\u7537\u6027<\/td><td>3%<\/td>\n<\/tr>\n<tr>\n<th>462<\/th><td>6 + 1<\/td><td>3<\/td><td>22,429<\/td><td>40<\/td><td>2<\/td><td>15\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u7537\u6027<\/td><td>\u691c\u51fa\u6e08: +15<\/td><td>\u7537\u6027<\/td><td>5%<\/td>\n<\/tr>\n<tr>\n<th>519<\/th><td>9 + 3<\/td><td>26.31<\/td><td>100,638<\/td><td>28<\/td><td>6<\/td><td>21\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u7537\u6027<\/td><td>\u691c\u51fa\u6e08: +21<\/td><td>\u7537\u6027<\/td><td>10%<\/td>\n<\/tr>\n<tr>\n<th>529<\/th><td>7 + 0<\/td><td>\u672a\u8a18\u9332<\/td><td>21,171<\/td><td>39<\/td><td>5<\/td><td>\u30c8\u30ea\u30bd\u30df\u30fc21\u3068\u30e2\u30ce\u30bd\u30df\u30fcX<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: +21<\/td><td>\u5973\u6027<\/td><td>5%<\/td>\n<\/tr>\n<tr>\n<th>541<\/th><td>7 + 3<\/td><td>12.02<\/td><td>42,333<\/td><td>33<\/td><td>2<\/td><td>15\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: +15<\/td><td>\u5973\u6027<\/td><td>8%<\/td>\n<\/tr>\n<tr>\n<th>586<\/th><td>6 + 0<\/td><td>5.28<\/td><td>22,435<\/td><td>41<\/td><td>2<\/td><td><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u30c8\u30ea\u30bd\u30df\u30fc17<\/td><td>\u5973\u6027<\/td><td>\u691c\u51fa\u6e08: \u6b20\u5931 (6) (p25.1p22.3); +18<\/td><td>\u5973\u6027<\/td><td>4%<\/td>\n<\/tr>\n<tr>\n<th>816<\/th><td>5 + 0<\/td><td>FP\u306f\u898b\u3089\u308c\u306a\u3044<\/td><td>5852<\/td><td>40<\/td><td>3<\/td><td><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/\">18\u30c8\u30ea\u30bd\u30df\u30fc<\/a><\/td><td>\u5973\u6027<\/td><td>\u7570\u5e38\u306a\u3057<\/td><td>\u5973\u6027<\/td><td>4%<\/td>\n<\/tr>\n<tr>\n<th>965<\/th><td>7 + 6<\/td><td>14.7<\/td><td>73,962<\/td><td>42<\/td><td>3<\/td><td>15\u30c8\u30ea\u30bd\u30df\u30fc<\/td><td>\u7537\u6027<\/td><td>\u691c\u51fa\u6e08: +15<\/td><td>\u7537\u6027<\/td><td>\u7121\u52b9<\/td>\n<\/tr>\n<\/tbody>\n<tfoot>\n<tr><td colspan=\"11\">\u7dd1\u3067\u793a\u3055\u308c\u305fCfDNA\u306e\u7d50\u679c\u306fPOC\u306e\u7d50\u679c\u3068\u4e00\u81f4\u3057\u3001\u8d64\u3067\u793a\u3055\u308c\u305f\u7d50\u679c\u306fPOC\u306e\u7d50\u679c\u3068\u4e00\u81f4\u3057\u306a\u3044\u3002<\/td>\n<\/tr><\/tfoot>\n<\/table>\n<\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<table>\n<caption><strong>Table 3.<\/strong> POC\u306eCfDNA\u5bfe\u6838\u578b<\/caption>\n<colgroup>\n<col style=\"width:25%;\">\n<col style=\"width:25%;\">\n<col style=\"width:25%;\">\n<col style=\"width:25%;\">\n<\/colgroup>\n<thead>\n<tr>\n<td colspan=\"2\"><\/td>\n<th colspan=\"2\">CfDNA\u306e\u7d50\u679c<\/th>\n<\/tr>\n<tr>\n<td colspan=\"2\"><\/td>\n<th>\u6b63\u5e38\u306b\u8a8d\u8b58 (%)<\/th>\n<th>\u8a8d\u8b58\u3055\u308c\u306a\u3044 (%)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n    <td><\/td>\n    <td>\u5408\u8a08<\/td>\n    <td>43 (75.4)<\/td>\n    <td>14 (324.6)<\/td>\n<\/tr>\n<tr>\n<th rowspan=\"4\">\u598a\u5a20\u671f\u9593\uff08\u9031\uff09<\/th>\n<td>7\u9031\u672a\u6e80<\/td>\n<td>14 (66.7)<\/td>\n<td>7 (33.3)<\/td>\n<\/tr>\n<tr>\n<td>7\uff5e8\u9031<\/td>\n<td>10 (76.9)<\/td>\n<td>3 (23.1)<\/td>\n<\/tr>\n<tr>\n<td>8\u4ee5\u4e0a<\/td>\n<td>11 (100.0)<\/td>\n<td>0 (0.0)<\/td>\n<\/tr>\n<tr>\n<td>\u4e0d\u660e<\/td>\n<td>8 (53.3)<\/td>\n<td>7 (46.7)<\/td>\n<\/tr>\n<tr>\n<th rowspan=\"3\">\u03b2hCG (mIU\/mL)<\/th>\n<td>8000\u672a\u6e80<\/td>\n<td>9 (60.0)<\/td>\n<td>6 (40.0)<\/td>\n<\/tr>\n<tr>\n<td>8000\uff5e35,000<\/td>\n<td>14 (66.7)<\/td>\n<td>7 (33.3)<\/td>\n<\/tr>\n<tr>\n<td>35,000\u4ee5\u4e0a<\/td>\n<td>19 (95.0)<\/td>\n<td>1 (5.0)<\/td>\n<\/tr>\n<tr>\n<th rowspan=\"3\">\u80ce\u5150\u306e\u5272\u5408(%)<\/th>\n<td>5\u672a\u6e80<\/td>\n<td>13 (59.1)<\/td>\n<td>9 (40.9)<\/td>\n<\/tr>\n<tr>\n<td>5\uff5e8<\/td>\n<td>19 (79.2)<\/td>\n<td>5 (20.8)<\/td>\n<\/tr>\n<tr>\n<td>9\u4ee5\u4e0a<\/td>\n<td>10 (100.0)<\/td>\n<td>0 (0.0)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_%E8%AD%B0%E8%AB%96\"><\/span>4. \u8b70\u8ad6<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u79c1\u305f\u3061\u306ecfDNA\u7814\u7a76\u30b3\u30db\u30fc\u30c8\u306f\u3001\u30d0\u30fc\u30df\u30f3\u30ac\u30e0\u5973\u6027\u75c5\u9662\u304a\u3088\u3073\u5927\u5b66\u75c5\u9662\u30b3\u30d9\u30f3\u30c8\u30ea\u30fc\u304a\u3088\u3073\u30a6\u30a9\u30ea\u30c3\u30af\u30b7\u30e3\u30fc\u306b\u3042\u308bTommy&#8217;s National Centre for Miscarriage Research\u3092\u901a\u3058\u3066\u52df\u96c6\u3055\u308c\u307e\u3057\u305f\u3002\u5408\u8a08102\u30b5\u30f3\u30d7\u30eb\u3092\u6539\u5909VeriSeq\u2122 <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> V2\uff08\u30a4\u30eb\u30df\u30ca\uff09\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3057\u300157\u30b5\u30f3\u30d7\u30eb\u3092\u5bfe\u5fdc\u3059\u308bPOC\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u3067\u5206\u6790\u3057\u305f\u3002<\/p>\n\n\n\n<p>cfDNA\u89e3\u6790\u306f\u30013\u3064\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u5206\u3051\u3066\u89e3\u6790\u3057\u305f\uff08\u88683\uff09\u3002\u80ce\u5150\u5206\u7387\u304c\u4f4e\u3044\u5834\u5408\u30015%\u672a\u6e80\u306e\u80ce\u5150\u5206\u7387\u3067\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304c\u78ba\u8a8d\u3055\u308c\u305f\u30b5\u30f3\u30d7\u30eb\u306f60%\u3057\u304b\u306a\u304f\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u304c\u4e8c\u5375\u6027\u598a\u5a20\u306e\u3082\u306e\u3067\u3042\u3063\u305f\u3002\u4e00\u65b9\u3001\u80ce\u5150\u7387\u304c9\uff05\u4ee5\u4e0a\u306e\u5834\u5408\u306f\u3001100\uff05\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7d50\u679c\u304c\u6b63\u3057\u304f\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u6211\u3005\u306e\u7814\u7a76\u3067\u306f\u3001\u80ce\u5150\u7387\u304c5\uff05\u4ee5\u4e0a\u3067\u3042\u308c\u3070\u3001\u7570\u5e38\u306e\u5927\u90e8\u5206\u304c\u691c\u51fa\u3067\u304d\u308b\u3053\u3068\u306b\u6ce8\u76ee\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30b5\u30f3\u30d7\u30eb\u6570\u304c\u5c11\u306a\u304f\u3001\u751f\u7269\u5b66\u7684\u306a\u3070\u3089\u3064\u304d\u304c\u3042\u308b\u305f\u3081\u3001\u6b63\u78ba\u306a\u30ab\u30c3\u30c8\u30aa\u30d5\u3092\u5b9a\u7fa9\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>POC\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u3068cfDNA\u691c\u67fb\u306e\u9593\u306b\u89b3\u5bdf\u3055\u308c\u305f\u4e0d\u4e00\u81f4\u306f\u3001\u9589\u3058\u8fbc\u3081\u3089\u308c\u305f\u80ce\u76e4<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u75c7\u304c\u539f\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002CfDNA\u5206\u6790\u3067\u306f\u80ce\u76e4\/\u7d30\u80de\u82bd\u7d30\u80de\u306e\u307f\u306b\u7531\u6765\u3059\u308bDNA\u3092\u691c\u67fb\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001POC\u691c\u67fb\u3067\u306f\u80ce\u5150\u7d44\u7e54\u3068\u5168\u80ce\u76e4\u7d44\u7e54\u304b\u3089\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u7d50\u679c\u306b\u4e0d\u4e00\u81f4\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u30022 \u3064\u306e\u30b1\u30fc\u30b9\u3067\u306f\u3001cfDNA \u691c\u67fb\u3067\u306f\u540c\u5b9a\u3067\u304d\u306a\u304b\u3063\u305f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u907a\u4f1d\u5b50\u7570\u5e38\u304c POC \u5206\u6790\u3067\u540c\u5b9a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30c8\u30ea\u30bd\u30fc\u30e0\u7d30\u80de\u306b\u9650\u5c40\u3057\u305f\u80ce\u76e4<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u5316\u306b\u3088\u308b\u3082\u306e\u304b\u3001\u307e\u305f\u306f\u73fe\u5728\u306e\u65b9\u6cd5\u306e\u9650\u754c\u306b\u3088\u308b\u3082\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u306f\u3069\u306e\u3088\u3046\u306a\u65b9\u6cd5\u3067\u3082\u8a3a\u65ad\u304c\u56f0\u96e3\u3067\u3042\u308a\u3001cfDNA\u89e3\u6790\u306f\u751f\u7269\u5b66\u7684\u306b\u95a2\u9023\u6027\u306e\u3042\u308b\u7570\u5e38\u306a\u7d30\u80de\u682a\u3092\u691c\u51fa\u3059\u308b\u4e0a\u3067\u3001\u73fe\u5728\u306ePOC\u691c\u67fb\u306e\u88dc\u52a9\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u30c8\u30df\u30fc\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u7814\u7a76\u306e\u305f\u3081\u306e\u56fd\u7acb\u30bb\u30f3\u30bf\u30fc\u306f\u3001\u518d\u767a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3092\u53d7\u3051\u3066\u3044\u308b\u5bb6\u65cf\u306e\u30b1\u30a2\u3092\u5c02\u9580\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5bb6\u65cf\u306f\u3001\u3044\u3064\u598a\u5a20\u3059\u308b\u304b\u3092\u975e\u5e38\u306b\u610f\u8b58\u3057\u3066\u304a\u308a\u3001\u6700\u521d\u306e\u598a\u5a20\u671f\u9593\u4e2d\u306b\u6ce8\u610f\u6df1\u304f\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3059\u308b\u3053\u3068\u3067\u5229\u76ca\u3092\u5f97\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u79c1\u305f\u3061\u306e\u7814\u7a76\u30b3\u30db\u30fc\u30c8\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306f\u3001\u4ed6\u306e\u7814\u7a76\u3088\u308a\u3082\u65e9\u304f\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f\u3002Clark-Ganheart\u3089[6]\u306f16.9\u9031\uff086.1-37.2\uff09\u3001Yaron\u3089[7]\u306f9.6\u9031\uff085.1-13.6\uff09\u3092\u8a18\u9332\u3057\u3066\u3044\u308b\uff08\u56f32\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u3084\u4ed6\u306e\u7814\u7a76\u3067\u306f\u3001\u598a\u5a20\u7d44\u7e54\u304c\u307e\u3060\u539f\u4f4d\u7f6e\u306b\u3042\u308b\u598a\u5a20\u55aa\u5931\u4f8b\u306e\u5927\u90e8\u5206\u3067\u306f\u3001cfDNA\u3092\u7528\u3044\u3066<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306e59\uff05\u3092\u6b63\u3057\u304f\u540c\u5b9a\u3057\u3001POC\u306e\u7d50\u679c\u3068\u306e\u4e00\u81f4\u7387\u306f75\uff05\u3067\u3057\u305f\u3002\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001Clark-Ganheart\u3089[6]\u306f\u3001\u5229\u7528\u53ef\u80fd\u306a\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7d50\u679c\u304c\u3042\u308b\u5834\u5408\u306b\u306f87.5\uff05\u306e\u4e00\u81f4\u7387\u3092\u793a\u3057\u3001Yaron\u3089[7]\u306f\u3001\u598a\u5a20\u640d\u5931\u7279\u7570\u7684LLR\u95be\u5024\u3092\u7528\u3044\u305f\u5834\u5408\u306b\u306f82\uff05\u306e\u4e00\u81f4\u7387\u3092\u793a\u3057\u305f\u3002Yaron\u3089[7]\u306f\u300150\u4f8b\u3092\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30bb\u30c3\u30c8\u3068\u3057\u3066\u4f7f\u7528\u3057\u3001\u598a\u5a20\u640d\u5931\u7279\u7570\u7684LLR\u95be\u5024\u3092\u8a2d\u5b9a\u3057\u305f\u3002\u5168\u4f53\u7684\u306a\u691c\u51fa\u7387\u306f\u3001\u975e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u75c7\u4f8b86\u4f8b\u306782\uff05\u3067\u3042\u3063\u305f\u3002\u3053\u308c\u306f\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30bb\u30c3\u30c8\u306b\u57fa\u3065\u3044\u3066\u598a\u5a20\u640d\u5931\u7279\u7570\u7684\u306aLLR\u3092\u540c\u5b9a\u3057\u305f\u5f8c\u306b\u9054\u6210\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u3053\u306e\u30b3\u30db\u30fc\u30c8\u306b\u5fc5\u8981\u306aLLR\u304c\u5358\u80ce\u598a\u5a20\u3068\u306f\u7570\u306a\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u6bd4\u8f03\u306e\u305f\u3081\u306b\u3001\u6211\u3005\u306e\u7814\u7a76\u3067\u306f\u6a19\u6e96\u7684\u306aNIPT LLR\u30ab\u30c3\u30c8\u30aa\u30d5\u3092\u7528\u3044\u3066cfDNA\u3092\u5206\u6790\u3057\u3066\u304a\u308a\u3001\u598a\u5a20\u55aa\u5931\u7279\u7570\u7684\u306aLLR\u3092\u6301\u3064\u3053\u3068\u3067\u691c\u51fa\u7387\u304c\u5411\u4e0a\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u306e\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u306f\u3001Yaron\u3089[7]\u304c\u63d0\u6848\u3057\u305f\u3082\u306e\u3068\u540c\u69d8\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u7528\u3044\u3066\u3001\u3053\u306e\u30b3\u30db\u30fc\u30c8\u306e\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3059\u3079\u3066\u306e\u5e38\u67d3\u8272\u4f53\u30c8\u30ea\u30bd\u30df\u30fc\u306e\u691c\u51fa\u7387\u3092\u6700\u9069\u5316\u3059\u308b\u305f\u3081\u306b\u4fee\u6b63\u3055\u308c\u305fLLR\u3092\u7528\u3044\u305f\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u3092\u7528\u3044\u305f\u8a66\u9a13\u3092\u5b9f\u65bd\u3059\u308b\u3053\u3068\u3067\u3042\u308d\u3046\u3002<\/p>\n\n\n\n<figure class=\"fig_svg2\">\n<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 424.02 395.52\">\n\t<defs>\n\t\t<style>.fig_svg2 svg .a,.fig_svg2 svg .b,.fig_svg2 svg .r,.fig_svg2 svg .fig_svg2 svg .s{fill:none;stroke-miterlimit:10;}\n.fig_svg2 svg .a{stroke:#61adff;}\n.fig_svg2 svg .b,\n.fig_svg2 svg .r,\n.fig_svg2 svg .s{stroke:#000;}\n.fig_svg2 svg .b{stroke-width:0.5px;}\n.fig_svg2 svg .c{font-size:12px;}\n.fig_svg2 svg .c,\n.fig_svg2 svg .k{}\n.fig_svg2 svg .d{font-size:18.24px;}\n.fig_svg2 svg .e{letter-spacing:0.06em;}\n.fig_svg2 svg .f{letter-spacing:0.15em;}\n.fig_svg2 svg .g{letter-spacing:0.06em;}\n.fig_svg2 svg .h{letter-spacing:0.04em;}\n.fig_svg2 svg .i{letter-spacing:-0.02em;}\n.fig_svg2 svg .j{letter-spacing:0.04em;}\n.fig_svg2 svg .k{writing-mode:tb;text-orientation:upright;glyph-orientation-vertical:0deg;font-size:13.68px;}\n.fig_svg2 svg .l{letter-spacing:0.12em;}\n.fig_svg2 svg .m{letter-spacing:0.23em;}\n.fig_svg2 svg .n{letter-spacing:0.25em;}\n.fig_svg2 svg .o{fill:red;}\n.fig_svg2 svg .p{fill:#29ce3d;}\n.fig_svg2 svg .q{fill:#2511ed;}\n.fig_svg2 svg .r{stroke-width:0.75px;}\n.fig_svg2 svg .s{stroke-width:2px;}\ntext[writing-mode=\"tb\"] {\n  letter-spacing: -4px;\n}\n<\/style>\n\t<\/defs>\n\t<line class=\"a\" x1=\"55.51\" y1=\"41.59\" x2=\"424.02\" y2=\"41.59\"><\/line>\n\t<line class=\"a\" x1=\"55.51\" y1=\"81.22\" x2=\"424.02\" y2=\"81.22\"><\/line>\n\t<line class=\"a\" x1=\"55.51\" y1=\"120.84\" x2=\"424.02\" y2=\"120.84\"><\/line>\n\t<line class=\"a\" x1=\"55.51\" y1=\"160.47\" x2=\"424.02\" y2=\"160.47\"><\/line>\n\t<line class=\"a\" x1=\"55.51\" y1=\"200.09\" x2=\"424.02\" y2=\"200.09\"><\/line>\n\t<line class=\"a\" x1=\"55.51\" y1=\"239.72\" x2=\"424.02\" y2=\"239.72\"><\/line>\n\t<line class=\"a\" x1=\"55.51\" y1=\"279.34\" x2=\"424.02\" y2=\"279.34\"><\/line>\n\t<line class=\"a\" x1=\"55.51\" y1=\"318.97\" x2=\"424.02\" y2=\"318.97\"><\/line>\n\t<line class=\"a\" x1=\"55.51\" y1=\"358.59\" x2=\"424.02\" y2=\"358.59\"><\/line>\n\t<line class=\"b\" x1=\"62.51\" y1=\"41.59\" x2=\"62.51\" y2=\"358.59\"><\/line>\n\t<text class=\"c\" transform=\"translate(35.27 45.39)\">40<\/text>\n\t<text class=\"c\" transform=\"translate(35.27 85.39)\">35<\/text>\n\t<text class=\"c\" transform=\"translate(35.27 124.39)\">30<\/text>\n\t<text class=\"c\" transform=\"translate(35.27 164.39)\">25<\/text>\n\t<text class=\"c\" transform=\"translate(35.27 203.39)\">20<\/text>\n\t<text class=\"c\" transform=\"translate(35.27 243.39)\">15<\/text>\n\t<text class=\"c\" transform=\"translate(35.27 282.39)\">10<\/text>\n\t<text class=\"c\" transform=\"translate(39.27 322.39)\">5<\/text>\n\t<text class=\"c\" transform=\"translate(39.27 362.39)\">0<\/text>\n\t<text class=\"d\" transform=\"translate(70.01 16.05)\">\n\t\t<tspan class=\"e\">cffDNA\u89e3\u6790\u306b\u3088\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u598a\u5a20\u5e74\u9f62\u4e2d\u592e\u5024<\/tspan>\n\t<\/text>\n\t<text class=\"k\" transform=\"translate(6.84 160.09)\" glyph-orientation-vertical=\"0\" writing-mode=\"tb\">\n\t\t<tspan class=\"l\">\u598a\u5a20\uff08\u9031\uff09<\/tspan>\n\t<\/text>\n\t<circle class=\"o\" cx=\"169.01\" cy=\"283.09\" r=\"3.5\"><\/circle>\n\t<rect class=\"p\" x=\"240.01\" y=\"220.09\" width=\"7\" height=\"7\"><\/rect>\n\t<polygon class=\"q\" points=\"326.75 299.09 322.71 306.09 330.79 306.09 326.75 299.09\"><\/polygon>\n\t<line class=\"r\" x1=\"169.01\" y1=\"298.59\" x2=\"169.01\" y2=\"267.09\"><\/line>\n\t<line class=\"s\" x1=\"165.51\" y1=\"266.59\" x2=\"172.6\" y2=\"266.59\"><\/line>\n\t<line class=\"s\" x1=\"165.51\" y1=\"297.59\" x2=\"172.6\" y2=\"297.59\"><\/line>\n\t<line class=\"r\" x1=\"243.97\" y1=\"316.59\" x2=\"243.97\" y2=\"57.26\"><\/line>\n\t<line class=\"s\" x1=\"240.47\" y1=\"56.76\" x2=\"247.56\" y2=\"56.76\"><\/line>\n\t<line class=\"s\" x1=\"240.47\" y1=\"315.76\" x2=\"247.56\" y2=\"315.76\"><\/line>\n\t<line class=\"r\" x1=\"326.97\" y1=\"318.59\" x2=\"326.97\" y2=\"268.59\"><\/line>\n\t<line class=\"s\" x1=\"323.47\" y1=\"317.76\" x2=\"330.56\" y2=\"317.76\"><\/line>\n\t<line class=\"s\" x1=\"323.47\" y1=\"268.76\" x2=\"330.56\" y2=\"268.76\"><\/line>\n\t<text class=\"c\" transform=\"translate(254.01 227.5)\">16.9<\/text>\n\t<text class=\"c\" transform=\"translate(179.39 291.5)\">9.6<\/text>\n\t<text class=\"c\" transform=\"translate(336.7 308.5)\">7.1<\/text>\n\t<circle class=\"o\" cx=\"97.35\" cy=\"387.76\" r=\"3.5\"><\/circle>\n\t<rect class=\"p\" x=\"193.01\" y=\"384.09\" width=\"7\" height=\"7\"><\/rect>\n\t<polygon class=\"q\" points=\"339.75 384.09 335.71 391.09 343.79 391.09 339.75 384.09\"><\/polygon>\n\t<text class=\"c\" transform=\"translate(108.48 391.45)\">Yaron et al.<\/text>\n\t<text class=\"c\" transform=\"translate(207.48 391.45)\">Clark-Ganheart et al.<\/text>\n\t<text class=\"c\" transform=\"translate(348.48 391.45)\">This study<\/text>\n<\/svg>\n<figcaption>\n<strong>\u56f32.<\/strong> \u8d85\u97f3\u6ce2\u30b9\u30ad\u30e3\u30f3\u306b\u3088\u308b\u598a\u5a20\u55aa\u5931\u306e\u598a\u5a20\u6570 [6,7]\n<\/figcaption>\n<\/figure>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u3084\u4ed6\u306e\u7814\u7a76[6,7]\u3067\u306f\u3001cfDNA\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u3078\u306e\u907a\u4f1d\u7684\u5bc4\u4e0e\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u5229\u7528\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u4f7f\u7528\u3059\u308b\u30a2\u30c3\u30bb\u30a4\u306b\u4f9d\u5b58\u3057\u3066\u898b\u9003\u3055\u308c\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u907a\u4f1d\u7684\u7570\u5e38\u304c\u307e\u3060\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\uff08\u4f8b\uff1a\u30c8\u30ea\u30d7 \u30ed\u30a4\u30c9\u3084<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u30b5\u30f3\u30d7\u30eb\u3001\u4f4e\u80ce\u5150\u7387\/\u4f4e\u598a\u5a20\u6642\u306e\u5e38\u67d3\u8272\u4f53\u30c8\u30ea\u30bd\u30df\u30fc\uff09\u3002\u4e09\u500d\u4f53\u306e\u75c7\u4f8b\u306f\u3001\u4fee\u6b63\u3055\u308c\u305fIllumina VeriSeq\u2122 <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> solution v2\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3067\u306f\u691c\u51fa\u3067\u304d\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u672c\u7814\u7a76\u3068Yaron\u3089[7]\u306e\u4e21\u65b9\u3067\u9664\u5916\u3055\u308c\u305f\u3002\u3057\u304b\u3057\u3001cfDNA\u306e\u89e3\u6790\u306e\u305f\u3081\u306e\u4e00\u5869\u57fa\u591a\u578b\u30d9\u30fc\u30b9\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u4e09\u500d\u4f53\u75c7\u4f8b\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306f\u305a\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>cfDNA\u306f\u3001\u73fe\u5728\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u691c\u67fb\u3092\u5b8c\u5168\u306b\u7f6e\u304d\u63db\u3048\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002Yaron\u3089[7]\u306f\u3001\u518d\u767a\u6027\u598a\u5a20\u55aa\u5931\u306b\u304a\u3051\u308bcfDNA\u691c\u67fb\u3092\u5229\u7528\u3059\u308b\u518d\u767a\u6027\u598a\u5a20\u55aa\u5931\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u63d0\u6848\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<p>3\u56de\u76ee\u4ee5\u964d\u306e\u598a\u5a20\u55aa\u5931\u304c\u8a3a\u65ad\u3055\u308c\u305f\u5834\u5408\u3001Royal College of Obstetricians and Gynaecologists (RCOG) Green-top Guidelines No.17 [4]\u306b\u3088\u308b\u73fe\u5728\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u598a\u5a20\u7d44\u7e54\u306b\u80ce\u5150\u7570\u6570\u6027\u304c\u306a\u3044\u304b\u3069\u3046\u304b\u3092\u691c\u67fb\u3059\u308b\u3053\u3068\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30eb\u30fc\u30c1\u30f3\u691c\u67fb\u3068\u4e26\u884c\u3057\u3066\u3001\u6bcd\u4f53\u306e\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3092\u63a1\u53d6\u3057\u3066cfDNA\u691c\u67fb\u3092\u5b8c\u4e86\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002cfDNA\u691c\u67fb\u3067\u7570\u6570\u6027\u304c\u691c\u51fa\u3055\u308c\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u7406\u7531\u304c\u8aac\u660e\u3055\u308c\u305f\u5834\u5408\u3001\u6570\u5024\u8aa4\u5dee\u306f\u901a\u5e38\u6563\u767a\u7684\u306b\u767a\u751f\u3057\u3001\u305d\u306e\u5f8c\u306e\u598a\u5a20\u304c\u6210\u529f\u3059\u308b\u53ef\u80fd\u6027\u306f\u30de\u30a4\u30ca\u30b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u306a\u3044\u305f\u3081\u3001\u305d\u308c\u4ee5\u4e0a\u306e\u4f5c\u696d\u306f\u5fc5\u8981\u3042\u308a\u307e\u305b\u3093\u3002cfDNA\u306f\u30a2\u30f3\u30d0\u30e9\u30f3\u30b9\u306a<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u3057\u304b\u691c\u51fa\u3057\u306a\u3044\u306e\u3067\u3001\u3082\u3057cfDNA\u691c\u67fb\u3067<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u304c\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u5834\u5408\u306f\u3001cfDNA\u691c\u67fb\u3067\u691c\u51fa\u3067\u304d\u306a\u3044<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\uff08CNV\u3001\u4e09\u500d\u4f53\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/mosaicism\/\">\u30e2\u30b6\u30a4\u30af<\/a>\u30b5\u30f3\u30d7\u30eb\u306a\u3069\uff09\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001POC\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u5206\u6790\u3092\u63a8\u5968\u3059\u3079\u304d\u3067\u3042\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u5fc5\u8981\u306aPOC\u691c\u67fb\u306e\u6570\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u3001POC\u304c\u5229\u7528\u3067\u304d\u306a\u3044\u591a\u304f\u306e\u60a3\u8005\u306b\u5bfe\u3057\u3066\u7d50\u679c\u304c\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002POC\u304c\u5229\u7528\u3067\u304d\u306a\u3044\u5834\u5408\u3067\u3082\u3001\u3044\u304f\u3064\u304b\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306f\u898b\u9003\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u306b\u6ce8\u610f\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u4e0d\u5747\u8861\u306a\u8ee2\u5ea7\u304c\u78ba\u8a8d\u3055\u308c\u305f\u5834\u5408\u306b\u306f\u3001\u4e21\u89aa\u306e\u3069\u3061\u3089\u304b\uff08\u307e\u305f\u306f\u4e21\u65b9\uff09\u304c\u3053\u306e\u8ee2\u5ea7\u306e\u30ad\u30e3\u30ea\u30a2\u3067\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001\u89aa\u306e\u6838\u578b\u691c\u67fb\u3092\u63a8\u5968\u3059\u3079\u304d\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_%E7%B5%90%E8%AB%96\"><\/span>5. \u7d50\u8ad6<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading hidden-heading\"><\/h3>\n\n\n\n<p>\u598a\u5a20\u55aa\u5931\u306e\u907a\u4f1d\u7684\u7d50\u679c\u3092\u77e5\u308b\u3053\u3068\u306f\u3001\u5c06\u6765\u306e\u598a\u5a20\u306e\u4e88\u5f8c\u3092\u77e5\u308b\u305f\u3081\u306b\u3001\u60a3\u8005\u306e\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u969b\u306b\u5fdc\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u598a\u5a20\u55aa\u5931\u306b\u4f34\u3046\u7f6a\u60aa\u611f\u304b\u3089\u89e3\u653e\u3055\u308c\u3001\u5fc3\u7406\u7684\u306a\u30b5\u30dd\u30fc\u30c8\u3092\u63d0\u4f9b\u3059\u308b\u306e\u306b\u3082\u5f79\u7acb\u3064\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u539f\u56e0\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/chromosomal-abnormality\/\">\u67d3\u8272\u4f53\u7570\u5e38<\/a>\u306b\u3088\u308b\u3082\u306e\u304b\u3069\u3046\u304b\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306bcfDNA\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u3001\u691c\u67fb\u7528\u306e\u598a\u5a20\u7d44\u7e54\u304c\u5229\u7528\u3067\u304d\u306a\u3044\u3001\u3042\u308b\u3044\u306f\u60a3\u8005\u306e\u5e0c\u671b\u306b\u3088\u308a\u3001\u5f93\u6765\u306e\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u691c\u67fb\u304c\u5229\u7528\u3067\u304d\u306a\u3044\u60a3\u8005\u306b\u5927\u304d\u306a\u81e8\u5e8a\u7684\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u3057\u304b\u3057\u3001cfDNA\u691c\u67fb\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u8a3a\u65ad\u6642\u306b\u598a\u5a20\u3057\u305f\u307e\u307e\u306e\u5834\u5408\u306b\u306e\u307f\u5b9f\u65bd\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u79c1\u305f\u3061\u306f\u3001\u598a\u5a20\u7d44\u7e54\u304c\u307e\u3060\u539f\u4f4d\u7f6e\u306b\u3042\u308b\u3068\u304d\u306b\u6bcd\u4f53\u8840\u6f3f\u30b5\u30f3\u30d7\u30eb\u3092\u63a1\u53d6\u3057\u3001\u5341\u5206\u306a\u80ce\u5150\u5206\u753b\u304c\u3042\u308b\u5834\u5408\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u30b1\u30fc\u30b9\u3067cfDNA\u3092\u4f7f\u7528\u3057\u3066<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u306e\u907a\u4f1d\u7684\u7570\u5e38\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306a\u308b\u4f5c\u696d\u306f\u3001\u3053\u306e\u691c\u67fb\u3092\u6539\u5584\u3057\u3001\u305d\u308c\u304c\u81e8\u5e8a\u7684\u306b\u9069\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u3001\u5168\u4f53\u306e\u7d50\u679c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5909\u6570\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n<a href=\"https:\/\/www.hiro-clinic.or.jp\/app\/registration\/\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u78ba\u304b\u306a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u305f\u9078\u629e<br \/>\u5b89\u5fc3\u306e<span>NIPT\u691c\u67fb<\/span><\/p>\n<p class=\"btn\">\u3054\u4e88\u7d04\u306f\u3053\u3061\u3089<\/p>\n<\/div>\n<p><\/a>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%91%97%E8%80%85%E3%81%AE%E8%B2%A2%E7%8C%AE\"><\/span>\u8457\u8005\u306e\u8ca2\u732e<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>E.C.&#8211;\u30c7\u30fc\u30bf\u89e3\u6790\u3068\u57f7\u7b46; A.J.D.&#8211;\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3068\u502b\u7406\u7684\u627f\u8a8d; H.W.&#8211;\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3001\u502b\u7406\u7684\u627f\u8a8d\u3001\u52a9\u6210\u91d1\u7ba1\u7406\u3068\u7de8\u96c6; S.H.&#8211;\u30c7\u30fc\u30bf\u89e3\u6790\u3068\u6279\u5224\u7684\u8a55\u4fa1; P.S.&#8211;\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3068\u6279\u5224\u7684\u8a55\u4fa1; N.V.M.&#8211;\u76e3\u4fee\u3068\u6279\u5224\u7684\u8a55\u4fa1; S.Q.&#8211;\u6279\u5224\u7684\u8a55\u4fa1; A.C.&#8211;\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3001\u76e3\u4fee\u3068\u6279\u5224\u7684\u8a55\u4fa1; S.A.&#8211;\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3001\u76e3\u4fee\u3001\u6279\u5224\u7684\u8a55\u4fa1\u3001\u30c7\u30fc\u30bf\u89e3\u6790\u3001\u57f7\u7b46\u3068\u7de8\u96c6. \u3059\u3079\u3066\u306e\u8457\u8005\u306f\u539f\u7a3f\u3092\u8aad\u307f\u3001\u516c\u8868\u3055\u308c\u305f\u30d0\u30fc\u30b8\u30e7\u30f3\u306e\u539f\u7a3f\u306b\u540c\u610f\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%B3%87%E9%87%91%E6%8F%90%E4%BE%9B\"><\/span>\u8cc7\u91d1\u63d0\u4f9b<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306f\u3001\u30c8\u30df\u30fc\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u7814\u7a76\u306e\u305f\u3081\u306e\u30c8\u30df\u30fc\u306e\u56fd\u7acb\u30bb\u30f3\u30bf\u30fc\u306b\u8cc7\u91d1\u3092\u63d0\u4f9b\u3057\u3066\u3044\u308b\u30c8\u30df\u30fc\u306e\u6148\u5584\u56e3\u4f53\u304b\u3089\u8cc7\u91d1\u63d0\u4f9b\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%AC%9D%E8%BE%9E\"><\/span>\u8b1d\u8f9e<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u8457\u8005\u306f\u3001Lieve Page-Christians\u3001Philippa Burns\u3001Patrizia Di Pietro\u3001Cosmin Deciu\u3001Sarah Kinnings\u3001Eoin Brown\u3001Victoria Corey\u3001Kathryn Robinson\u3001Sven Schaffer\u3001Sucheta Bhatt\u3001Barbara Baggiani\u3001Matt Smith\u3001Marion Burdin\u3001Jasmin Dehnhardt\u306b\u611f\u8b1d\u3057\u307e\u3059\u3002\u8457\u8005\u3089\u306f\u3001\u60a3\u8005\u306e\u52df\u96c6\u3068\u30b5\u30f3\u30d7\u30eb\u53ce\u96c6\u3092\u884c\u3063\u305f\u30d0\u30fc\u30df\u30f3\u30ac\u30e0\u5973\u6027\u30fb\u5b50\u4f9b\u75c5\u9662\u306e\u30c8\u30df\u30fc\u56fd\u7acb<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/abortion\/\">\u6d41\u7523<\/a>\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3068\u5927\u5b66\u75c5\u9662\u30b3\u30f4\u30a7\u30f3\u30c8\u30ea\u30fc\uff06\u30a6\u30a9\u30ea\u30c3\u30af\u30b7\u30e3\u30fc\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306b\u611f\u8b1d\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%88%A9%E7%9B%8A%E7%9B%B8%E5%8F%8D\"><\/span>\u5229\u76ca\u76f8\u53cd<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u8457\u8005\u306f\u5229\u76ca\u76f8\u53cd\u3092\u5ba3\u8a00\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\"><\/span>\u53c2\u8003\u6587\u732e<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading hidden-heading\"><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Roberts, C.; Lowe, C. Where have all the conceptions gone? Lancet 1975, 305, 498-499. [CrossRef] <\/li>\n\n\n\n<li>Macklon, N.S.; Geraedts, J.P.M.; Fauser, B.C.J.M. Conception to ongoing pregnancy: The \u2018black box\u2019 of early pregnancy loss. Hum. Reprod. Updat. 2002, 8, 333-343. [CrossRef] [PubMed] <\/li>\n\n\n\n<li>Choi, T.Y.; Lee, H.M.; Park, W.K.; Jeong, S.Y.; Moon, H.S. Spontaneous abortion and recurrent miscarriage: A comparison of cytogenetic diagnosis in 250 cases. Obstet. Gynecol. Sci. 2014, 57, 518-525. [CrossRef] [PubMed] <\/li>\n\n\n\n<li>Regan, L.; Backos, M.; Rai, R. The Investigation and Treatment of Couples with Recurrent First-Trimester and Second-Trimester Miscarriage; RCOG Green-top Guideline No.17; Royal College of Obstetricians and Gynaecologists: London, UK, 2011. <\/li>\n\n\n\n<li>Lo, Y.M.D.; Corbetta, N.; Chamberlain, P.F.; Rai, V.; Sargent, I.L.; Redman, C.W.; Wainscoat, J.S. Presence of fetal DNA in maternal plasma and serum. Lancet 1997, 350, 485-487. 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[CrossRef] [PubMed] <\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%87%BA%E7%89%88%E8%80%85%E6%B3%A8\"><\/span>\u51fa\u7248\u8005\u6ce8<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>MDPI\u306f\u3001\u516c\u958b\u3055\u308c\u3066\u3044\u308b\u5730\u56f3\u3084\u6a5f\u95a2\u306e\u6240\u5c5e\u6a5f\u95a2\u306e\u7ba1\u8f44\u6a29\u306b\u95a2\u3059\u308b\u4e3b\u5f35\u306b\u3064\u3044\u3066\u306f\u4e2d\u7acb\u7684\u306a\u7acb\u5834\u3092\u7dad\u6301\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"cc\">\n    <figure><img decoding=\"async\" src=\"\/nipt\/wp-content\/themes\/hiro_nipt\/img\/cc_by.png\" alt=\"CC By\"><\/figure>\n    <p>\u00a9 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http:\/\/creativecommons.org\/licenses\/by\/4.0\/). <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"Emily Colley 1,2,3,*&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/cfdna-in-the-investigation-of-miscarriage\/\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":1,"featured_media":523,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[71],"tags":[489,84],"class_list":["post-7686","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatise","tag-nipt-3","tag-veriseq"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/7686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=7686"}],"version-history":[{"count":10,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/7686\/revisions"}],"predecessor-version":[{"id":109642,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/7686\/revisions\/109642"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/523"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=7686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=7686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=7686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}