{"id":85444,"date":"2024-11-14T14:22:01","date_gmt":"2024-11-14T05:22:01","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/7q36-3-duplication-syndrome\/"},"modified":"2025-08-22T17:03:26","modified_gmt":"2025-08-22T08:03:26","slug":"7q36-3-duplication-syndrome","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/7q36-3-duplication-syndrome\/?lang=en","title":{"rendered":"7q36.3 Microduplication Syndrome"},"content":{"rendered":"\n<div style=\"border:solid #ffe6e6 0.8rem;background-color: #fff9f9;padding:3% 5%;margin:1rem 0 3rem;\"><h2 style=\"margin-top:1rem;\">\u3053\u306e\u8a18\u4e8b\u306e\u307e\u3068\u3081<\/h2><p>7q36.3\u306e\u5fae\u5c0f\u91cd\u8907\u306f\u3001\u907a\u4f1d\u5b50\u8abf\u7bc0\u56e0\u5b50\u3068\u3057\u3066\u91cd\u8981\u306aZRS\u9818\u57df\u3092\u542b\u307f\u3001Sonic hedgehog\uff08SHH\uff09\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u7570\u5e38\u3092\u901a\u3058\u3066\u56db\u80a2\u5f62\u6210\u3084\u81d3\u5668\u767a\u751f\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u3053\u306e\u7570\u5e38\u306fTPT-PS\u3084\u8907\u5408\u7684\u306a\u5148\u5929\u6027\u75be\u60a3\u306b\u95a2\u9023\u4ed8\u3051\u3089\u308c\u3066\u304a\u308a\u3001\u8ffd\u52a0\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306e\u53ef\u80fd\u6027\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u3053\u306e\u5fae\u5c0f\u91cd\u8907\u304c\u81d3\u5668\u3084\u5f62\u614b\u5f62\u6210\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p><\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/7q36-3-duplication-syndrome\/?lang=en\/#Microduplication_at_7q363_and_Related_Disorders\" >Microduplication at 7q36.3 and Related Disorders<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/7q36-3-duplication-syndrome\/?lang=en\/#7q363_and_Triphalangeal_Thumb-Polysyndactyly_Syndrome_TPT-PS\" >7q36.3 and Triphalangeal Thumb-Polysyndactyly Syndrome (TPT-PS)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/7q36-3-duplication-syndrome\/?lang=en\/#Exceptional_Cases_with_Cardiovascular_and_Ocular_Abnormalities\" >Exceptional Cases with Cardiovascular and Ocular Abnormalities<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/7q36-3-duplication-syndrome\/?lang=en\/#The_Role_and_Broad_Impact_of_SHH_Signaling\" >The Role and Broad Impact of SHH Signaling<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/7q36-3-duplication-syndrome\/?lang=en\/#Additional_Genetic_Factors\" >Additional Genetic Factors<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/7q36-3-duplication-syndrome\/?lang=en\/#Future_Research_Directions\" >Future Research Directions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/7q36-3-duplication-syndrome\/?lang=en\/#References\" >References<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Microduplication_at_7q363_and_Related_Disorders\"><\/span>Microduplication at 7q36.3 and Related Disorders<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"20\" src=\"\/nipt\/wp-content\/uploads\/2024\/11\/7q36.3-hgtIdeo_genome_127a03_df7320-1024x20.png\" alt=\"7q36.3 \" class=\"wp-image-90788\"\/><\/figure><\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The <strong>7q36.3 microduplication<\/strong> is an important subject of genetic and clinical research. This region contains the evolutionarily conserved <strong>zone of polarizing activity regulatory sequence (ZRS)<\/strong>, a key long-range enhancer for the <strong>SHH<\/strong> gene. SHH functions as a <strong>morphogen<\/strong> during embryogenesis, regulating the proper development of organs and limbs. Variants and microduplications in this region have been linked to rare developmental disorders and malformations.<\/p>\n\n\n\n<p>To understand the influence of <strong>7q36.3 microduplications<\/strong> on organ and limb formation, it is essential to understand <strong>SHH<\/strong> function and the role of <strong>ZRS<\/strong>. During early embryogenesis, SHH provides critical signaling cues to establish the anterior-posterior and left-right axes. In limb buds, its localized expression in the <strong>zone of polarizing activity (ZPA)<\/strong> determines the precise number and shape of fingers and toes. Disruption of this finely tuned regulatory system can lead not only to limb malformations but also to broader multi-organ developmental issues.<\/p>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"923\" height=\"500\" src=\"\/nipt\/wp-content\/uploads\/2024\/11\/4d36d18c92a9f38fb1d67cb8d4277533.png\" alt=\"chromo7\" class=\"wp-image-89968\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7q363_and_Triphalangeal_Thumb-Polysyndactyly_Syndrome_TPT-PS\"><\/span>7q36.3 and Triphalangeal Thumb-Polysyndactyly Syndrome (TPT-PS)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>TPT-PS (Triphalangeal Thumb-Polysyndactyly Syndrome)<\/strong> is a relatively rare <strong>autosomal dominant<\/strong> disorder. It is characterized by:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A <strong>triphalangeal thumb<\/strong>, where the thumb has three phalanges instead of the normal two, resulting in an elongated thumb.<\/li>\n\n\n\n<li><strong>Syndactyly<\/strong>, or fusion of fingers or toes.<\/li>\n\n\n\n<li><strong>Polydactyly<\/strong>, or extra fingers or toes.<\/li>\n<\/ul>\n\n\n\n<p>The causative locus for this syndrome is <strong>7q36.3<\/strong>, where variations and duplications within the <strong>ZRS enhancer<\/strong> are the main contributors. The ZRS sequence regulates long-range SHH expression patterns, ensuring proper anterior-posterior axis formation in limb buds. Point mutations and duplications within this regulatory region have been linked not only to TPT-PS but also to <strong>Laurin-Sandrow syndrome<\/strong> and isolated <strong>congenital polydactyly<\/strong>.<\/p>\n\n\n\n<p>However, while TPT-PS primarily manifests with limb anomalies, it typically does <strong>not<\/strong> affect other organs such as the heart or eyes.<\/p>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n    <a href=\"\/nipt\/xp11-22-p11-23-duplication-syndrome\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">Xp11.22-p11.23 \u91cd\u8907\u75c7\u5019\u7fa4 <\/div>\n          <div class=\"blog-card-excerpt\">Xp11.22-p11.23\u91cd\u8907\u75c7\u5019\u7fa4\u306f\u3001X\u67d3\u8272\u4f53\u306ep11.22-p11.23\u9818\u57df\u306e\u91cd\u8907\u306b\u3088\u308a\u767a\u75c7\u3057\u3001\u767a\u9054\u9045\u5ef6\u3001\u77e5\u7684\u969c\u5bb3\u3001\u884c\u52d5\u7570\u5e38\u3001\u8eab\u4f53\u7684\u7570...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Exceptional_Cases_with_Cardiovascular_and_Ocular_Abnormalities\"><\/span>Exceptional Cases with Cardiovascular and Ocular Abnormalities<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Recently, there have been reports of patients with <strong>TPT-PS combined with severe cardiovascular diseases (CHD)<\/strong> and <strong>ocular malformations<\/strong>. In one family, a <strong>299 kb microduplication at 7q36.3<\/strong> was identified in all members with TPT-PS. Interestingly, <strong>congenital heart disease (such as double outlet right ventricle)<\/strong> and <strong>ocular anomalies (such as microphthalmia and optic disc coloboma)<\/strong> were present only in some members, indicating <strong>variable expressivity<\/strong>.<\/p>\n\n\n\n<p>This suggests that <strong>7q36.3 microduplications<\/strong> may have effects that go beyond limb development, potentially influencing the formation of the cardiovascular system and ocular structures.<\/p>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/nipt\/wp-content\/uploads\/2024\/11\/28020321_s.jpg\" alt=\"\u5fc3\u81d3\" class=\"wp-image-88825\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_Role_and_Broad_Impact_of_SHH_Signaling\"><\/span>The Role and Broad Impact of SHH Signaling<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The <strong>SHH gene<\/strong> plays a critical role that extends beyond limb patterning. It is essential for the development of the <strong>heart<\/strong> and <strong>eyes<\/strong>. Animal studies have demonstrated that overexpression of SHH can result in <strong>muscle hypertrophy<\/strong> and <strong>abnormal cellular proliferation<\/strong>. Likewise, inappropriate timing or levels of SHH expression can disrupt <strong>cardiac morphogenesis<\/strong> and <strong>ocular development<\/strong>.<\/p>\n\n\n\n<p>Particularly, changes in SHH expression levels\u2014either increases or decreases\u2014can critically affect downstream genes, including <strong>PAX2<\/strong>, during eye development, resulting in structural malformations.<\/p>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Additional_Genetic_Factors\"><\/span>Additional Genetic Factors<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>In some families, only certain members with a 7q36.3 duplication presented with cardiovascular or ocular anomalies, while others exhibited only TPT-PS. This points to the involvement of <strong>additional genetic or epigenetic factors<\/strong>.<\/p>\n\n\n\n<p>For example, another study described a patient presenting with <strong>TPT-PS and Tetralogy of Fallot<\/strong>, where the condition was attributed to a combination of a <strong>7q36.3 duplication<\/strong> and a <strong>22q11.21 deletion<\/strong>. This highlights how multiple genetic events can interact to produce complex phenotypes.In some families, only certain members with a 7q36.3 duplication presented with cardiovascular or ocular anomalies, while others exhibited only TPT-PS. This points to the involvement of <strong>additional genetic or epigenetic factors<\/strong>.<\/p>\n\n\n\n<p>For example, another study described a patient presenting with <strong>TPT-PS and Tetralogy of Fallot<\/strong>, where the condition was attributed to a combination of a <strong>7q36.3 duplication<\/strong> and a <strong>22q11.21 deletion<\/strong>. This highlights how multiple genetic events can interact to produce complex phenotypes.<\/p>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/nipt\/wp-content\/uploads\/2024\/11\/26529659_s.jpg\" alt=\"SHH\" class=\"wp-image-90808\"\/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Future_Research_Directions\"><\/span>Future Research Directions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>These findings demonstrate that <strong>7q36.3 microduplications<\/strong> are not only a primary driver of TPT-PS but may also contribute to broader multi-system abnormalities, including cardiac and ocular malformations.<\/p>\n\n\n\n<p>Further studies are needed to elucidate:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>How this region modulates <strong>SHH signaling<\/strong> across different tissues.<\/li>\n\n\n\n<li>The role of additional <strong>regulatory or epigenetic factors<\/strong> that may influence gene expression.<\/li>\n<\/ul>\n\n\n\n<p>Advancing this research will enhance the understanding of the diverse mechanisms by which microduplications lead to such complex developmental disorders.<\/p>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n    <a href=\"\/nipt\/2q31_1_duplication\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">2q31.1\u91cd\u8907\u75c7\u5019\u7fa4\u306b\u3064\u3044\u3066 <\/div>\n          <div class=\"blog-card-excerpt\">2q31.1\u91cd\u8907\u75c7\u5019\u7fa4\u306f\u30012\u756a\u67d3\u8272\u4f53\u306e\u907a\u4f1d\u5b50\u91cd\u8907\u306b\u3088\u308b\u5e0c\u5c11\u75be\u60a3\u3067\u3059\u3002\u767a\u9054\u9045\u5ef6\u3084\u5185\u81d3\u7570\u5e38\u304c\u7279\u5fb4\u3067\u3001\u65e9\u671f\u7642\u80b2\u3068\u533b\u7642\u7ba1\u7406\u304c\u751f\u6d3b\u306e\u8cea\u5411\u4e0a\u306b\u91cd\u8981\u3067\u3059\u3002...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"References\"><\/span>References<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.3892\/mmr.2016.6092\">Liu, Z., Yin, N., Gong, L., Tan, Z., Yin, B., Yang, Y., &amp; Luo, C. (2017). Microduplication of 7q36.3 encompassing the SHH long\u2011range regulator (ZRS) in a patient with triphalangeal thumb\u2011polysyndactyly syndrome and congenital heart disease. <em>Molecular medicine reports<\/em>, <em>15<\/em>(2), 793\u2013797. https:\/\/doi.org\/10.3892\/mmr.2016.6092<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.ejmg.2012.04.009\">Kroeldrup, L., Kjaergaard, S., Kirchhoff, M., Kock, K., Brasch-Andersen, C., Kibaek, M., &amp; Ousager, L. B. (2012). Duplication of 7q36.3 encompassing the Sonic Hedgehog (Shh) gene is associated with congenital muscular hypertrophy. <em>European Journal of Medical Genetics<\/em>, <em>55<\/em>(10), 557\u2013560. https:\/\/doi.org\/10.1016\/j.ejmg.2012.04.009<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/srep02587\">Aleksic, B., Kushima, I., Ohye, T., Ikeda, M., Kunimoto, S., Nakamura, Y., Yoshimi, A., Koide, T., Iritani, S., Kurahashi, H., Iwata, N., &amp; Ozaki, N. (2013). Definition and refinement of the 7q36.3 duplication region associated with schizophrenia. <em>Scientific Reports<\/em>, <em>3<\/em>(1), 2587. https:\/\/doi.org\/10.1038\/srep02587<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1186\/s12920-020-00821-x\">Zlotina, A., Melnik, O., Fomicheva, Y., Skitchenko, R., Sergushichev, A., Shagimardanova, E., Gusev, O., Gazizova, G., Loevets, T., Vershinina, T., Kozyrev, I., Gordeev, M., Vasichkina, E., Pervunina, T., &amp; Kostareva, A. (2020). A 300-kb microduplication of 7q36.3 in a patient with triphalangeal thumb-polysyndactyly syndrome combined with congenital heart disease and optic disc coloboma: A case report. <em>BMC Medical Genomics<\/em>, <em>13<\/em>(1), 175. https:\/\/doi.org\/10.1186\/s12920-020-00821-x<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2024). The UCSC Genome Browser database: 2025 update. Nucleic Acids Research, gkae974. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco Lins, P. R., Brooks, L., Budhanuru Ramaraju, S., Campbell, L. I., Carbajo Martinez, M., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024. Nucleic Acids Research, 52(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41586-021-03819-2\" target=\"_blank\" rel=\"noreferrer noopener\">Jumper, J <em>et al<\/em>. Highly accurate protein structure prediction with AlphaFold. <em>Nature<\/em> (2021)<\/a>.<\/li>\n\n\n\n<li><a href=\"https:\/\/academic.oup.com\/nar\/advance-article\/doi\/10.1093\/nar\/gkab1061\/6430488\" target=\"_blank\" rel=\"noreferrer noopener\">Varadi, M <em>et al<\/em>. AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. <em>Nucleic Acids Research <\/em>(2021)<\/a>.<\/li>\n<\/ul>\n\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n","protected":false},"excerpt":{"rendered":"\u3053\u306e\u8a18\u4e8b\u306e\u307e\u3068\u30817q36.3\u306e\u5fae\u5c0f\u91cd\u8907\u306f&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/7q36-3-duplication-syndrome\/?lang=en\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":101,"featured_media":90807,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[97],"tags":[],"class_list":["post-85444","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/85444","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/101"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=85444"}],"version-history":[{"count":15,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/85444\/revisions"}],"predecessor-version":[{"id":112045,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/85444\/revisions\/112045"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/90807"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=85444"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=85444"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=85444"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}