{"id":85755,"date":"2020-08-04T14:52:00","date_gmt":"2020-08-04T05:52:00","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/"},"modified":"2025-10-11T10:24:27","modified_gmt":"2025-10-11T01:24:27","slug":"nipt-risk","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en","title":{"rendered":"Are there any risks with NIPT (new prenatal testing)? [Doctor-supervised]"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<div class=\"toc\">\n\t<ul>\n\t\t<li><a href=\"#c1\">What kind of test is NIPT (New Prenatal Diagnosis)? <\/a>\n\t\t\t<ul>\n\t\t\t\t<li><a href=\"#c1-1\">What you can learn from NIPT (New Prenatal Testing)<\/a><\/li>\n\t\t\t\t<li><a href=\"#c1-2\">When can I receive NIPT (New Prenatal Testing)? <\/a><\/li>\n\t\t\t<\/ul>\n\t\t<\/li>\n\t\t<li><a href=\"#c2\">Risks of NIPT (New Prenatal Testing)<\/a><\/li>\n\t\t<li><a href=\"#c3\">Confirmatory tests carry risks<\/a>\n\t\t\t<ul>\n\t\t\t\t<li><a href=\"#c3-1\">Villus test<\/a><\/li>\n\t\t\t\t<li><a href=\"#c3-2\">Amniocentesis<\/a><\/li>\n\t\t\t<\/ul>\n\t\t<\/li>\n\t\t<li><a href=\"#c4\">Risks of other prenatal tests<\/a>\n\t\t\t<ul>\n\t\t\t\t<li><a href=\"#c4-1\">Ultrasound examination (echo examination)<\/a><\/li>\n\t\t\t\t<li><a href=\"#c4-2\">Maternal serum marker test<\/a>\n\t\t\t\t\t<ul>\n\t\t\t\t\t\t<li><a href=\"#c4-2-1\">Quatro test<\/a><\/li>\n\t\t\t\t\t\t<li><a href=\"#c4-2-2\">Triple marker test<\/a><\/li>\n\t\t\t\t\t<\/ul>\n\t\t\t\t<\/li>\n\t\t\t\t<li><a href=\"#c4-3\">Combined inspection<\/a><\/li>\n\t\t\t<\/ul>\n\t\t<\/li>\n\t\t<li><a href=\"#c5\">Are there any risks in receiving NIPT (New Prenatal Testing) at an uncertified facility? <\/a>\n\t\t\t<ul>\n\t\t\t\t<li><a href=\"#5-1c\">About genetic counseling<\/a><\/li>\n\t\t\t<\/ul>\n\t\t<\/li>\n\t\t<li><a href=\"#c6\">\u307e\u3068\u3081<\/a><\/li>\n\t<\/ul>\n  <button class=\"toc_more\">Open table of contents<\/button>\n<\/div>\n\n\n<p style=\"width:100%;max-width:300px;margin:0 auto;\"><a href=\"\/nipt\/\" class=\"content-bnr about\"><img decoding=\"async\" src=\"\/nipt\/wp-content\/themes\/hiro_nipt\/img\/banner\/nipt04pc.png\" alt=\"\u80ce\u5150\u306e\u6027\u5225\u306f10\u9031\u76ee\u3067\u308f\u304b\u308b\"><\/a> <\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#What_is_NIPT_New_Prenatal_Testing\" >What is NIPT (New Prenatal Testing)?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#What_can_be_learned_from_NIPT_new_type_prenatal_testing\" >What can be learned from NIPT (new type prenatal testing)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#When_can_I_receive_NIPT_new_prenatal_testing\" >When can I receive NIPT (new prenatal testing)?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Risks_of_new_prenatal_testing\" >Risks of new prenatal testing<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Definitive_testing_carries_risks\" >Definitive testing carries risks<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Chorionic_villus_sampling\" >Chorionic villus sampling<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Amniocentesis\" >Amniocentesis<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Risks_of_other_prenatal_tests\" >Risks of other prenatal tests<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Ultrasound_examination_echo_examination\" >Ultrasound examination (echo examination)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Maternal_serum_marker_testing\" >Maternal serum marker testing<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Quattro_Test\" >Quattro Test<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Triple_Marker_Test\" >Triple Marker Test<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Combined_Inspection\" >Combined Inspection<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#Are_there_any_risks_to_undergoing_NIPT_new_prenatal_testing_at_an_uncertified_facility\" >Are there any risks to undergoing NIPT (new prenatal testing) at an uncertified facility?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#About_Genetic_Counseling\" >About Genetic Counseling<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\/#summary\" >summary<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\" id=\"c1\"><span class=\"ez-toc-section\" id=\"What_is_NIPT_New_Prenatal_Testing\"><\/span><strong>What is NIPT (New Prenatal Testing)?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT (New Prenatal Testing)<\/a>&nbsp;is a test that takes a sample of a pregnant woman&#8217;s blood and examines the DNA fragments of the fetus contained in it. DNA is like a blueprint filled with genetic information and is contained in cells called chromosomes. Genes in chromosomes are inherited from both the father and the mother. If there is an abnormality in the chromosomes, the baby in the womb may be born with a congenital abnormality.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> can be performed by simply taking a blood sample from the mother and does not involve direct invasion (damage) of the fetus, so it is also called &#8220;non-invasive prenatal genetic testing.&#8221;<\/p>\n\n\n\n    <a href=\"\/nipt\/nipt\/nipt\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u77e5\u7684\u969c\u304c\u3044\u304c\u308f\u304b\u308bNIPT\u3068\u306f\uff08NIPT\u306e\u57fa\u672c\uff09 <\/div>\n          <div class=\"blog-card-excerpt\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u3067\u884c\u3063\u3066\u3044\u308bNIPT\u306e\u307e\u3068\u3081\u3067\u3059\u3002\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u306eNIPT\u3067\u306f\u77e5\u7684\u969c\u5bb3\u30fb\u767a\u9054\u969c\u5bb3\u3092\u4f34\u3046\u591a\u6570\u306e\u75be\u60a3\u3092\u51fa\u751f\u524d\u306b\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c1-1\"><span class=\"ez-toc-section\" id=\"What_can_be_learned_from_NIPT_new_type_prenatal_testing\"><\/span><strong>What can be learned from NIPT (new type prenatal testing)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Congenital anomalies can occur regardless of the age at which a baby is born, and are said to occur in 3-5% of all newborns. Of these, chromosomal disorders caused by chromosomal abnormalities account for approximately 25% of congenital anomalies.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT (non-inferior prenatal testing)<\/a>&nbsp;mainly tests for three chromosomal abnormalities:&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\">Down syndrome (trisomy 21<\/a>&nbsp;),&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/?lang=en\">Edwards syndrome (trisomy 18)<\/a>&nbsp;, and&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/?lang=en\">Patau syndrome (trisomy 13).<\/a>&nbsp;Depending on the facility, it is also possible to check for all possible chromosomal abnormalities.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"\/nipt\/wp-content\/uploads\/2022\/09\/nipt-risk02.jpg\" alt=\"\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad\u3067\u5206\u304b\u308b\u3053\u3068\" class=\"wp-image-42011\"\/><\/figure><\/div>\n\n\n<p>The three specific congenital anomalies are as follows:<\/p>\n\n\n\n<figure class=\"wp-block-table\">\n<table>\n    <colgroup><col style=\"width:20%;\">\n    <col style=\"width:80%\">\n<\/colgroup><tbody>\n<tr>\n<th colspan=\"3\">Down syndrome (trisomy 21)<\/th>\n<\/tr>\n<th>\n<span class=\"writing-mode\">Symptoms<\/span>\n<\/th><td>\nGrowth failure, decreased muscle tone, and distinctive facial features<br>\n\u226aComplications\u226b Heart diseases, digestive malformations, and other thyroid and otorhinolaryngological diseases, etc.\n<\/td><\/tr>\n<tr><th>\n<span class=\"writing-mode\">About prognosis<\/span>\n<\/th><td>\nThey often attend support classes or special needs schools. They may also have great talent, such as in the arts. <br>Lifespan is approximately 50 to 60 years.\n<\/td><\/tr>\n<\/tbody><\/table>\n<\/figure>\n\n\n\n<figure class=\"wp-block-table\">\n<table>\n    <colgroup><col style=\"width:20%;\">\n    <col style=\"width:80%\">\n<\/colgroup><tbody>\n<tr>\n<th colspan=\"3\">Edwards syndrome (trisomy 18)<\/th>\n<\/tr>\n<th>\n<span class=\"writing-mode\">Symptoms<\/span>\n<\/th><td>Growth failure from the fetal period, problems with breathing and feeding<br><<Complications>> Heart disease, malformations of the gastrointestinal tract, joint contractures, etc.<\/td><\/ tr>\n<tr><th><span class=\"writing-mode\">About prognosis<\/span><\/th><td>\nDelays in physical and intellectual development are observed. Breathing assistance may be required. <br>There are many cases where the fetus dies during pregnancy. 50% of cases die within one month after childbirth, and 90% die within a year.<\/td><\/tr>\n<\/tbody><\/table>\n<\/figure>\n\n\n\n<figure class=\"wp-block-table\">\n<table>\n    <colgroup><col style=\"width:20%;\">\n    <col style=\"width:80%\">\n<\/colgroup><tbody>\n<tr>\n<th colspan=\"3\">Patau syndrome (trisomy 13)<\/th>\n<\/tr>\n<th>\n<span class=\"writing-mode\">Symptoms<\/span>\n<\/th><td>\nGrowth failure, breathing and eating disorders<br><<Complications>> Cleft lip and palate, heart disease, eye disease, etc.\n<\/td><\/tr>\n<tr><th>\n<span class=\"writing-mode\">About prognosis<\/span>\n<\/th><td>\nDelays in physical and intellectual development are observed. Breathing assistance may be required. <br>90% of cases die within 1 year after childbirth\n<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n\n\n\n    <a href=\"\/nipt\/nipt\/testing\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">NIPT(\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad)\u304b\u3089\u308f\u304b\u308b\u75be\u60a3\u4e00\u89a7 <\/div>\n          <div class=\"blog-card-excerpt\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u306eNIPT\u306f\u3001\u80ce\u5150\u306e\u5e38\u67d3\u8272\u4f53\u304a\u3088\u3073\u6027\u67d3\u8272\u4f53\u306e\u6570\u306e\u7570\u5e38\u306e\u4ed6\u3001\u90e8\u5206\u7684\u306a\u6b20\u5931\u30fb\u91cd\u8907\u75be\u60a3\u3001\u5fae\u5c0f\u6b20\u5931\u30fb\u91cd\u8907\u75be\u60a3\u3068\u3044\u3063\u305f\u67d3\u8272\u4f53\u306e\u90e8\u5206\u7684\u306a\u69cb...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c1-2\"><span class=\"ez-toc-section\" id=\"When_can_I_receive_NIPT_new_prenatal_testing\"><\/span><strong>When can I receive NIPT (new prenatal testing)?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT (new type prenatal testing)<\/a>&nbsp;can generally be performed from 10 weeks and 0 days of pregnancy. There are several methods for prenatal testing, but Hiro Clinic <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> can be performed as early as about 6 weeks of pregnancy (when pregnancy is confirmed by ultrasound examination).<\/p>\n\n\n\n<p>At Hiro Clinic <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>, we usually deliver results within 2 to 6 days (excluding some plans) after blood is drawn, so you can complete the test early in your pregnancy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"c2\"><span class=\"ez-toc-section\" id=\"Risks_of_new_prenatal_testing\"><\/span>Risks of new prenatal testing<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\"><\/a>Many people are concerned about whether&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT (new type prenatal testing) will have a negative impact on the health of the mother and child. The test only requires a blood sample from the pregnant woman, so there is almost no risk.<\/a><\/p>\n\n\n\n<p>You may feel some pain when the needle is inserted into your arm, but it will not have a significant effect on your body. Both mother and child can receive <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> without worrying about risks.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"c3\"><span class=\"ez-toc-section\" id=\"Definitive_testing_carries_risks\"><\/span>Definitive testing carries risks<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT (New Prenatal Testing)<\/a>&nbsp;can be performed with a fairly low risk&nbsp;, but if the test is positive, a definitive test must be performed to make a definitive diagnosis. This is because there are rare cases of false positives.&nbsp;<sub>*<\/sub><br>* The sensitivity of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> is said to be 96.5% for testing chromosome 21.<\/p>\n\n\n\n<p>Definitive tests are a burden to the mother and child and carry the risk of miscarriage. Specific tests include the following:<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c3-1\"><span class=\"ez-toc-section\" id=\"Chorionic_villus_sampling\"><\/span>Chorionic villus sampling<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>There are two ways to take the test: by inserting a needle directly into the abdomen, or by using a catheter through the vagina to take a sample. There is about a 1% risk of miscarriage, and other symptoms such as bleeding and water breaking may occur.<\/p>\n\n\n\n<p>This is a test that examines cells called chorionic villi, which are part of the placenta during early pregnancy. Choriolic villi are cells that are part of the placenta during early pregnancy. The test is performed between the 11th and 14th weeks of pregnancy.<\/p>\n\n\n\n<p>Chorionic villus sampling is performed by checking the position of the fetus using an ultrasound, but it is technically difficult and only a few medical institutions perform it.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c3-2\"><span class=\"ez-toc-section\" id=\"Amniocentesis\"><\/span>Amniocentesis<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>This test involves inserting a needle into the pregnant woman&#8217;s abdomen to collect amniotic fluid. Because the fetus drinks and urinates in amniotic fluid, it contains cells derived from the fetus. The test involves culturing the cells contained in the amniotic fluid and then analyzing their genes, so it takes about three weeks for the results to become available.<\/p>\n\n\n\n<p>Amniocentesis is a lower risk test than chorionic villus sampling, but there is a 0.2-0.3% chance of miscarriage or rupture of membranes. It is performed between the 15th and 18th weeks of pregnancy.<\/p>\n\n\n\n<p>&nbsp;Please note that the confirmatory test for&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT (new type prenatal diagnosis) is<\/a>&nbsp;not something that must be taken even if the test is positive. Chorionic villus sampling and amniocentesis can be done at the parents&#8217; request.<\/p>\n\n\n\n<figure class=\"wp-block-table\">\n<table class=\"reforming_cells\">\n    <colgroup><col style=\"width:24%\">\n    <col style=\"width:26%\">\n    <col style=\"width:50%\">\n<\/colgroup>\n    <thead>\n<tr>\n<th colspan=\"3\">Definitive test<\/th>\n<\/tr>\n    <\/thead>\n<tbody><tr>\n<th>Villus examination<\/th>\n<td>Definitive diagnosis<\/td>\n<td>\nBecause the needle is inserted into the abdomen, there is a risk of miscarriage (1%). Performed between 10 and 13 weeks of pregnancy.\n<\/td>\n<\/tr>\n<tr>\n<th>Amniotic fluid examination<\/th>\n<td>Definitive diagnosis<\/td>\n<td>\nBecause the needle is inserted into the abdomen, there is a risk of miscarriage. (0.3%) Performed between 15 and 18 weeks of pregnancy.\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"c4\"><span class=\"ez-toc-section\" id=\"Risks_of_other_prenatal_tests\"><\/span>Risks of other prenatal tests<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Some people may be concerned about the cost of <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">(new prenatal testing)<\/a>&nbsp;and the risks of definitive testing, and would like to know about other testing methods. Here we will look at the risks of tests other than <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c4-1\"><span class=\"ez-toc-section\" id=\"Ultrasound_examination_echo_examination\"><\/span>Ultrasound examination (echo examination)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Ultrasound examinations are also performed during prenatal checkups, and are also called echo examinations. Specifically, an ultrasound device is placed on the pregnant woman&#8217;s stomach, and the echo is visualized. During the examination, the pregnant woman can check the monitor together with the doctor.<\/p>\n\n\n\n<p>Ultrasound examinations are primarily performed to check the growth and development of the baby in the womb. However, they can also detect abnormalities in the baby, so in a broader sense they can be considered a form of prenatal diagnosis.<\/p>\n\n\n\n<p>You can also have a fetal ultrasound screening test during the second trimester, which involves taking a longer ultrasound scan than normal prenatal screening to check for any problems with the fetus.<\/p>\n\n\n\n<p>The test itself is non-invasive using ultrasound, so there is no risk to the baby. A gel is applied to the abdomen of the pregnant woman during the test, so she may feel cold.<\/p>\n\n\n\n<p>If the test reveals an abnormality, a confirmatory test will be required to confirm the diagnosis.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c4-2\"><span class=\"ez-toc-section\" id=\"Maternal_serum_marker_testing\"><\/span>Maternal serum marker testing<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>A blood test is used to check for the possibility of congenital abnormalities in the fetus. As with&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT (non-invasive prenatal testing)<\/a>&nbsp;, the test only involves drawing blood from the pregnant woman, so it is a low-risk test for the mother and child.<\/p>\n\n\n\n<p>The test can tell you about the following possible diseases:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>&nbsp;Down Syndrome (Trisomy 21)<\/li>\n\n\n\n<li>Edwards syndrome (trisomy 18)<\/li>\n\n\n\n<li>Neural tube defects such as spina bifida and anencephaly (open neural tube malformations)<\/li>\n<\/ul>\n\n\n\n<p>Maternal serum marker tests examine the components contained in the blood of pregnant women, and there are different types depending on which components are examined. Specific maternal serum marker tests include the following:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"c4-2-1\"><span class=\"ez-toc-section\" id=\"Quattro_Test\"><\/span>Quattro Test<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>This test checks for four components (hCG, AFP, uE3, and inhibin A) in the blood of pregnant women.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"c4-2-2\"><span class=\"ez-toc-section\" id=\"Triple_Marker_Test\"><\/span>Triple Marker Test<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>This test checks for three components (hCG, AFP, and uE3) in a pregnant woman&#8217;s blood.&nbsp;<\/p>\n\n\n\n<p>Regarding the Quadruple Test and the Triple Test, there is no significant difference in the accuracy of the two tests. The accuracy of a test refers to the rate at which a positive result is detected.<\/p>\n\n\n\n<p>However, the results of serum marker tests are expressed as probability, making them difficult to interpret. In addition, the test is only intended for screening purposes, and a definitive test is required for a diagnosis.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"\/nipt\/wp-content\/uploads\/2022\/09\/nipt-risk01.jpg\" alt=\"NIPT(\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad)\u306e\u63a1\u8840\" class=\"wp-image-42015\"\/><\/figure><\/div>\n\n\n<h3 class=\"wp-block-heading\" id=\"c4-3\"><span class=\"ez-toc-section\" id=\"Combined_Inspection\"><\/span>Combined Inspection<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>This test involves two things: a maternal serum marker test and an ultrasound test. Since it is a combination of a blood test and an ultrasound test, there is almost no risk to the mother and child.<\/p>\n\n\n\n<p>In the blood test, two fetal components (hCG and PAPP-A) contained in the pregnant woman&#8217;s blood are examined. The combined test can tell you about the possibility of the following congenital abnormalities.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Down Syndrome (Trisomy 21)<\/li>\n\n\n\n<li>Edwards syndrome (trisomy 18)<\/li>\n<\/ul>\n\n\n\n<p>As mentioned above, non-definitive tests that do not lead to a diagnosis, such as&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT (non-invasive prenatal testing)<\/a>&nbsp;, can be taken with almost no risk. On the other hand, if a non-definitive test is positive, a diagnosis can be obtained through definitive testing, which involves risk.<\/p>\n\n\n\n<p>Let&#8217;s summarize non-definitive tests, including <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>, once again.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-table\">\n<table class=\"reforming_cells\">\n    <colgroup><col style=\"width:24%\">\n    <col style=\"width:36%\">\n    <col style=\"width:40%\">\n<\/colgroup>\n<thead>\n<tr>\n<th colspan=\"3\">\ninconclusive test\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> (New Prenatal Diagnosis)<\/th>\n<td>\nDown syndrome (trisomy 21)<br>\nPatau syndrome (trisomy 13)<br>\nEdwards syndrome (trisomy 18)\n<br>\n<\/td>\n<td>\nSince it only involves drawing blood, there is little risk. Performed after 9 weeks of pregnancy.\n<\/td>\n<\/tr>\n<tr>\n<th>Ultrasonic examination<\/th>\n<td>\nEvaluation of the presence or absence of serious congenital abnormalities including Down syndrome (trisomy 21)\n<\/td>\n<td>\nThis test is also performed during prenatal checkups, and there are almost no risks. <br>\nEvaluation of the possibility of congenital abnormalities in the fetus is performed around 11 to 13 weeks of pregnancy. During the 19th to 20th and 28th to 30th weeks of pregnancy, we will monitor growth, development, and whether there are any heart or bone diseases.\n<\/td>\n<\/tr>\n<tr>\n<th>Maternal serum marker test<\/th>\n<td>Down syndrome (trisomy 21)<br>Edwards syndrome (trisomy 18)\n<br>Neural tube defect (open neural tube malformation)\n<\/td>\n<td>\nSince it only involves drawing blood, there is little risk. Performed after 15 to 18 weeks of pregnancy.\n<\/td>\n<\/tr>\n<tr>\n<th>Combined inspection<\/th>\n<td>\nDown syndrome (trisomy 21)\n<br>Trisomy 18\n<\/td>\n<td>\nIt is a test that combines ultrasound and blood sampling, and there is almost no risk. Performed around 11 to 13 weeks of pregnancy.\n<\/td>\n<\/tr>\n    <\/tbody>\n<\/table>\n<\/figure>\n\n\n\n    <a href=\"\/nipt\/maternal-serum-screening-test\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">\u6bcd\u4f53\u8840\u6e05\u30de\u30fc\u30ab\u30fc\u306e\u7279\u5fb4\u3068NIPT(\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad)\u3068\u306e\u6bd4\u8f03 <\/div>\n          <div class=\"blog-card-excerpt\">\u598a\u5a20\u306e\u6bd4\u8f03\u7684\u65e9\u3044\u9031\u6570\u304b\u3089\u53d7\u3051\u3089\u308c\u308bNIPT(\u65b0\u578b\u51fa\u751f\u524d\u8a3a\u65ad)\u3068\u6bcd\u4f53\u8840\u6e05\u30de\u30fc\u30ab\u30fc\u306f\u80ce\u5150\u306b21\u30c8\u30ea\u30bd\u30df\u30fc(\u30c0\u30a6\u30f3\u75c7\u5019\u7fa4)\u308418\u30c8\u30ea\u30bd\u30df\u30fc(\u30a8\u30c9\u30ef...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"c5\"><span class=\"ez-toc-section\" id=\"Are_there_any_risks_to_undergoing_NIPT_new_prenatal_testing_at_an_uncertified_facility\"><\/span><strong>Are there any risks to undergoing NIPT (new prenatal testing) at an uncertified facility?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\"><\/a>In addition to certified facilities, there are also non-certified facilities where&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT (new prenatal testing) can be performed.<\/a><\/p>\n\n\n\n<p>Non-certified facilities are not illegal, and they have the advantage of being able to perform tests that certified facilities cannot. Certified facilities can only test for three diseases with <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>:&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/about-down-syndrome\/?lang=en\">Down syndrome (trisomy 21)<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/patau-syndrome\/?lang=en\">Patau syndrome (trisomy 13)<\/a>&nbsp;, and&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/edwards-syndrome\/?lang=en\">Edwards syndrome (trisomy 18)<\/a>&nbsp;, but non-certified facilities can test for more detailed items, such as structural abnormalities such as numerical abnormalities of autosomes (chromosomes 1-22) and sex chromosomes, and deletions and duplications, depending on the facility.<\/p>\n\n\n\n<p>In addition, you may be able to get the same test done at a cheaper price than at a certified facility.<\/p>\n\n\n\n<p>Choose a testing facility that best suits your needs.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"c5-1\"><span class=\"ez-toc-section\" id=\"About_Genetic_Counseling\"><\/span><strong>About Genetic Counseling<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Genetic counselling involves providing evidence-based medical information to help people understand and deal with genetic diseases, worries and questions, as well as providing psychological and social support to help people solve their problems using medical techniques and information on their own.<\/p>\n\n\n\n<p>The decision to undergo prenatal testing can often be difficult for you to make, and genetic counselling can often help you make that decision.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">If you are unsure whether to take NIPT (new prenatal testing)<\/a>&nbsp;, it may be a good idea to consult with a medical institution that provides genetic counseling.<\/p>\n\n\n\n    <a href=\"\/nipt\/genetic-counseling\/\" class=\"blog-card\">\n      <div class=\"blog-card-content\">\n          <div class=\"blog-card-title\">NIPT\u306b\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306f\u5fc5\u8981\uff1f\u5185\u5bb9\u3084\u91cd\u8981\u6027\u3092\u89e3\u8aac <\/div>\n          <div class=\"blog-card-excerpt\">\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001NIPT\u306b\u304a\u3051\u308b\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u5fc5\u8981\u6027\u3084\u5177\u4f53\u7684\u306a\u5185\u5bb9\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002\u691c\u67fb\u3092\u53d7\u3051\u308b\u524d\u306e\u6ce8\u610f\u70b9\u3084\u3001\u5f8c\u6094\u3057\u306a\u3044\u305f\u3081\u306e\u5224\u65ad\u57fa\u6e96...<\/div>\n      <\/div>\n    <\/a>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"c6\"><span class=\"ez-toc-section\" id=\"summary\"><\/span>summary<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">NIPT (New Prenatal Testing)<\/a>&nbsp;is a test that can be performed early in pregnancy without putting any burden on the mother and child. At&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">Hiro Clinic NIPT<\/a>&nbsp;, in addition to the specified chromosomal abnormalities, we can also find out about the possibility of a wide range of congenital abnormalities.<\/p>\n\n\n\n<p>Also, many people think about taking <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a> to feel reassured, but there is a possibility that they may receive a positive result instead of a negative one. At&nbsp;<a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt\/\">Hiro Clinic NIPT<\/a>&nbsp;, we provide counseling and examinations after the test as follow-up in case the result is positive.<\/p>\n\n\n\n<p>If you are considering <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/\">NIPT<\/a>, please feel free to contact us.<\/p>\n","protected":false},"excerpt":{"rendered":"What kind of test is&#8230;\n <a href=\"https:\/\/www.hiro-clinic.or.jp\/nipt\/nipt-risk\/?lang=en\">\u7d9a\u304d\u3092\u8aad\u3080<\/a>","protected":false},"author":1,"featured_media":24800,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[97],"tags":[],"class_list":["post-85755","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/85755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/comments?post=85755"}],"version-history":[{"count":3,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/85755\/revisions"}],"predecessor-version":[{"id":117984,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/posts\/85755\/revisions\/117984"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media\/24800"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/media?parent=85755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/categories?post=85755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/nipt\/wp-json\/wp\/v2\/tags?post=85755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}