AGA Therapy and Genetic Screening: Advances in Personalized Medicine
この記事の概要
This article describes the importance of genetic screening and its specific methods in the treatment of AGA (male pattern baldness). The article also introduces actual cases and scientific evidence of predicting the efficacy of DHT inhibitors and other therapies, early detection, and formulation of treatment plans, and touches on the actual use of genetic screening and points to note. The book also touches on the actual use and cautions of genetic screening.
Introduction
AGA (male pattern baldness) is a common form of alopecia in men and is mainly caused by genetics and hormonal imbalance. Recent advances in medical technology have made genetic screening a new approach to AGA treatment. Through genetic screening, it is possible to predict individual genetic risk and treatment efficacy, enabling more effective personalized medicine. This article details how genetic screening can help in the treatment of AGA, its specific methods and scientific rationale.
AGA is caused by DHT (dihydrotestosterone), which is produced by the enzyme testosterone. DHT acts on hair follicles and causes hair loss by shortening the hair growth cycle:
Early stage: thinning of the frontal hairline and the crown of the head.
Mid-term stage: Thinning of hair in the frontal and parietal areas progresses, and the surface of the skin becomes easily visible.
Progressive stage: The frontal and parietal areas become even thinner, leaving only the temporal and occipital areas.
What is genetic screening?
Genetic screening is a technology that analyzes individual genetic information to predict risk and treatment efficacy for specific diseases; in AGA, genetic screening can be used to identify genetic factors and provide optimal treatment for individual patients.
Gene Screening Procedure
Sample collection: Samples of saliva, blood, etc. are collected.
Genetic analysis: Samples collected are analyzed in a specialized laboratory to identify genetic mutations and polymorphisms (SNPs) associated with AGA.
Reporting of results: A report is prepared on the genetic risk and predicted treatment effects based on the results of the analysis.
Formulation of treatment plan: Based on the report, the physician proposes the best treatment plan for the patient.
Genetic screening can reveal an individual patient’s genetic risk, allowing for more effective personalized medicine. For example, a patient with a genetic mutation involved in DHT production may be determined to benefit from a DHT-suppressing drug such as finasteride.
Prediction of Treatment Effectiveness
By using genetic screening, it is possible to predict the effectiveness of treatment. This allows for the selection of potentially effective treatments and the avoidance of unnecessary treatments.
Early detection and prevention
Early identification of genetic risk for AGA allows for preventive care. Early initiation of appropriate hair care and lifestyle modifications can slow the progression of AGA.
The Roots of Science
Numerous studies have been conducted on genes associated with AGA. For example, polymorphisms in the AR (androgen receptor) gene and the 5α-reductase gene are known to affect the risk of AGA. Recent studies also suggest that other genes (such as WNT10A and EDA2R) may be involved in the development of AGA.
Examples of actual applications of genetic screening
Case Study 1: Predicting the Effectiveness of Finasteride
When one patient started AGA treatment, a genetic screening was performed and a gene mutation involved in DHT production was identified. Based on these results, finasteride treatment was recommended, and when treatment was actually started, a clear increase in hair growth was observed 6 months later.
Case Study 2: Avoiding Minoxidil Resistance
When another patient did not respond to minoxidil, genetic screening identified a genetic mutation that was resistant to minoxidil. Based on this information, other treatments (PRP therapy and low-power laser therapy) were suggested, with effective results.
Precautions for Genetic Screening
Cost: Genetic screening is highly technical and can be expensive. Insurance coverage should also be checked.
Privacy: Be very careful when handling genetic information. Conduct your analysis at a reputable medical institution or laboratory to protect your privacy.
Interpretation of results: Since the results of genetic screening require specialized knowledge, it is important that the results are properly interpreted under the guidance of a specialist and incorporated into the treatment plan.
Summary
For men suffering from AGA, genetic screening is a powerful tool for effective personalized medicine.Through the prediction of genetic risk and treatment efficacy, the best treatment option can be selected to slow the progression of AGA and maintain healthy hair. Consider AGA treatment based on the advancement of personalized medicine by utilizing genetic screening.
AGA (androgenetic alopecia) is a disease called androgenetic alopecia, which, if left untreated, will progress and require early treatment. HIRO CLINIC uses the most advanced regenerative medicine technology to treat AGA. Our expert physicians will propose the appropriate treatment for each individual and support your concerns to the best of their ability.
