There is a strong link between AGA (male pattern baldness) and genes. Genetic factors are believed to significantly influence the onset and progression of AGA. Below is a detailed explanation of the relationship between AGA and genes.
Influence of heredity
- Family History:
- AGA is strongly related to family history; if a parent or sibling has AGA, you are at a higher risk of developing AGA yourself.
- The likelihood of being affected by AGA increases, especially if there is a history of AGA in the paternal or maternal family.
- Genetic Patterns:
- The inheritance of AGA is due to multifactorial inheritance (multiple genes are involved), which means that not only a single gene but also multiple genes interact to contribute to the development of the disease.
Related genes
- Androgen receptor (AR) gene:
- The androgen receptor gene, located on the X chromosome, is strongly associated with AGA.
- When this gene is mutated, hair follicles become sensitive to DHT (dihydrotestosterone), resulting in progressive hair loss.
- Because it is inherited from the mother, maternal family history has a significant impact on AGA.
- 5-alpha-reductase gene:
- Genes encoding 5-alpha-reductase, the enzyme that converts testosterone to DHT, are also involved in AGA.
- High activity of this enzyme increases DHT production and promotes hair loss.
- Other related genes:
- Many other genes are also implicated in the risk of AGA, but the specific mechanisms and degree of influence are still under study.
Genetic testing
- Use of genetic testing:
- Some medical and research institutions now offer genetic testing to assess the risk of AGA.
- Genetic testing can provide advance knowledge of one’s AGA risk, but it is difficult to make definitive predictions because environmental factors as well as genes affect the risk.
Interaction with environmental factors
- Lifestyle:
- In addition to genetic factors, lifestyle habits such as diet, stress, smoking, and alcohol consumption can also influence the progression of AGA.
- Even in cases of high genetic risk, progression can be slowed by maintaining appropriate lifestyle habits.
Summary
AGA is a disease strongly related to genetic factors, with family history and mutations in certain genes increasing the risk of developing the disease. However, in addition to genetic factors, lifestyle and environmental factors also play an important role; even in cases of high risk for AGA, it is possible to slow the progression of the disease by taking early measures and maintaining appropriate lifestyle habits. Optimal prevention and treatment in consultation with a medical specialist is recommended.
