There are several options for drugs and treatments that can be used in combination with finasteride to maximize the effectiveness of treating AGA (androgenetic alopecia). Below are medications and treatments that are commonly recommended for use with finasteride.
1. Minoxidil
Effect
- Mechanism of action: Minoxidil is a vasodilator that increases blood circulation, increases the supply of nutrients to the hair follicles, and promotes hair growth.
- Effect: When used in combination with finasteride, it can be expected to increase hair density and increase hair growth.
How to use
- Topical medicine: Apply minoxidil solution or foam directly to the scalp twice a day.
- Oral medicine: In some cases it may be used as an oral medication, but this is usually done under the supervision of a doctor.
Spironolactone is often used as a diuretic, but it also has anti-androgenic properties and is sometimes used to treat hair loss in women.
2. Spironolactone
Mechanism of action
- Anti-androgenic effect:
- Spironolactone binds to androgen receptors and prevents androgens (testosterone and DHT) from binding to the receptors.
- This has the effect of suppressing the effect of androgens on the hair follicles and slowing down the progression of hair loss.
- Aldosterone antagonism:
- Spironolactone also acts as an aldosterone receptor antagonist and has diuretic effects that promote sodium and water excretion.
- Although the diuretic effect itself is not directly related to AGA treatment, the anti-androgenic effect helps suppress hair loss.
How to use
- Oral medicine: Spironolactone is prescribed as a tablet and is usually recommended to be taken once or twice a day. Your doctor will determine the dosage depending on your individual symptoms.
Effect
- Female pattern hair loss: Spironolactone is particularly effective against female pattern hair loss, and can be expected to suppress the progression of hair loss by regulating hormone balance.
- Men’s use: It should be used with caution in men as it has a strong anti-androgenic effect. It may be considered as an adjunctive option, especially in men, when finasteride or dutasteride treatment is ineffective, but it must be used under the supervision of a doctor due to the high risk of side effects.
Side effect
- woman: Side effects such as irregular menstruation, breast tenderness, and increased blood potassium concentration have been reported.
- male: Side effects such as decreased libido, erectile dysfunction, and breast enlargement have been reported, and it has a strong suppressive effect on male hormones, so it must be used with caution.
3. Corticosteroids
Effect
- Mechanism of action: It has anti-inflammatory properties and is effective in suppressing damage to hair follicles caused by autoimmune reactions.
- Effect: Used especially when a combination of alopecia areata is suspected.
How to use
- Topical medicine: Steroid lotions and creams that are applied directly to the scalp.
- Oral medicine: In severe cases, oral steroids may be prescribed.
4. Low-Level Laser Therapy (LLLT)
Effect
- Mechanism of action: It is believed that the low-power laser stimulates the cells in the hair follicle, increasing blood circulation and promoting hair growth.
- Effect: When used in combination with finasteride, it can be expected to improve hair growth and density.
How to use
- Device: Treatment is performed regularly using a helmet-type or comb-type device.
5. Lifestyle improvements and supplements
Effect
- Nutritional support: Adequate nutrient intake is important for healthy hair growth.
- Effect: Supports hair health by supplying nutrients such as vitamins, minerals, zinc, and iron as supplements.
How to use
- Balanced diet: Eat healthy and get the nutrients you need.
- Supplement: Use nutritional supplements as needed.
Summary
Medications and treatments that can be used in conjunction with finasteride to enhance the effectiveness of AGA treatment include minoxidil, dutasteride, corticosteroids, low-power laser therapy, and lifestyle changes and supplements. By combining these treatments, we can expect more effective AGA treatment. It is important to determine the most appropriate treatment plan under the guidance of a specialist, depending on your individual symptoms and circumstances.
