Dutasteride is a drug used to treat AGA (male pattern baldness) and, like finasteride, is a 5-alpha-reductase inhibitor. The mechanism by which Dutasteride exerts its effect on AGA is as follows
Mechanism of action of Dutasteride
- Inhibition of 5-alpha-reductase:
- Dutasteride is a potent inhibitor of the enzyme 5-alpha-reductase.
- 5-alpha-reductase is an enzyme that converts testosterone into the more potent androgen dihydrotestosterone (DHT).
- Type 1 and type 2 5-alpha-reductase inhibition:
- Dutasteride inhibits both type 1 and type 2 5-alpha-reductase.
- Finasteride primarily inhibits type 2, while Dutasteride effectively inhibits both types and thus has a broader DHT suppression effect.
- DHT reduction:
- The action of Dutasteride significantly reduces the conversion of testosterone to DHT by inhibiting 5-alpha-reductase.
- This significantly reduces DHT levels in the blood and scalp.
- Reduced impact on hair follicles:
- DHT has a strong inhibitory effect on hair follicles (hair roots), causing follicle miniaturization.
- Miniaturized hair follicles will prevent hair growth and produce thin, short hair.
- When DHT is reduced by Dutasteride, the inhibitory effect on hair follicles is reduced and follicular miniaturization is reduced.
- Normalization of the hair cycle:
- The normalization of the hair cycle (hair growth cycle) occurs as the effects of DHT are reduced.
- The growth phase is prolonged and the return of dormant hair follicles back to the growth phase is facilitated.
- This increases hair density and decreases hair loss.
Effects of Dutasteride
- Increased hair growth: Clinical trials have shown that Dutasteride increases hair density and decreases hair loss.
- Delay of progression: It has been shown to slow the progression of AGA, and with long-term use, the progression of hair loss can be reduced.
- Comparison with finasteride: Dutasteride is a more potent DHT inhibitor than finasteride, and some studies have shown it to be more effective than finasteride.
Precautions for use
- SIDE EFFECTS: Side effects such as decreased libido, erectile dysfunction, and decreased semen volume have been reported in some men with the use of Dutasteride. These side effects are generally mild and often recover after discontinuation of the drug.
- Prohibited use during pregnancy: Dutasteride should not be touched or taken by women, especially if they are pregnant, as its use can affect the fetus.
- Safety of long-term use: Although the safety of long-term use has been confirmed, periodic physician visits and follow-up are recommended.
Summary
Dutasteride reduces DHT production by potently inhibiting type 1 and type 2 5-alpha-reductase, thereby reducing its inhibitory effect on hair follicles. This slows the progression of AGA and promotes hair growth. When using this product, it is important to use it appropriately under the guidance of a medical specialist, paying attention to side effects and contraindications.
