Hiro Clinic NIPT Cost and Features

What we can do to help you
have a safe birth

While you are excited to see your baby, we know that some expecting mothers are worried about their baby.
In order to eliminate such worries, knowing the health of the fetus in advance through a prenatal diagnosis will make it easier for you to prepare to welcome your incoming baby.

Hiro Clinic NIPT provides NIPT (non-invasive prenatal testing) that is safe for both mother and fetus. By requesting the test to Second Tokyo Clinical Laboratory, a specialized institution for human genetic testing in Japan, we are able to obtain results more quickly and accurately than with conventional NIPT, which was performed by an overseas specialized institution. Results are usually delivered within 2 to 5 days (usually within 3 to 6 days for some hospitals and cooperating facilities) after the blood sample is taken. For all Hiro Clinic NIPT clinics, except for the partner facilities, an express delivery option is available (delivery within 2~3 days after the blood collection). The VeriSeqNIPT Solution V2 system used at Second Tokyo Clinical Laboratory has been widely used for diagnosis in Europe and the United States, but Hiro Clinic NIPT is the first to introduce this system in Japan. As of May 2022, the number of tests performed in Japan has exceeded 20,000 cases, and the number of tests performed in Japan and overseas has exceeded 23,000 cases. We have accumulated a large number of cases and share the analysis results with the Second Tokyo Clinical Laboratory to improve our testing.

The barcode system issued by Hiro Clinic NIPT is smoothly read by the testing equipment at Second Tokyo Clinical Laboratory, so there is virtually no risk of misreading. We are proud to say that Hiro Clinic NIPT is the only clinic in Japan that can test for chromosomes other than chromosome 21, 18, and 13 trisomies and has tested a large number of cases. Hiro Clinic NIPT offers NIPT testing at a total of 10 clinics from Sapporo to Fukuoka. Each clinic is staffed by specialists in obstetrics and gynecology, pediatrics, and psychiatry. Each clinic is connected to each other through a network, which allows each specialist to cooperate with each other and answer various questions from expecting mothers.

Another important feature is that if the test result is positive, you can receive up to 200,000 yen in subsidies for amniotic fluid testing if you are a member of the Mutual Aid Society. The Mutual Aid Society will cover the cost of the amniotic fluid test regardless of which medical institution you have your amniotic fluid tested at. One of Hiro Clinic NIPT’s advantages is that sex chromosome and all autosomal aneuploidy testing is available at an affordable price.

At Hiro Clinic NIPT, we offer a variety of test set plans so that we can provide information that expectant mothers and their families wish to know and deliver it in an easy-to-understand manner. If you are not sure which type of test you want, please ask your Hiro Clinic NIPT doctor directly and we will answer your questions in details. We will clearly tell you what our tests can and cannot do.

Over 20,000 NIPT tests performed on pregnant women across Japan

In NIPT studies around the world, it is known that genetic disorders have both ethnic and regional characteristics.

However, despite the availability of various research data, mainly from Europe and the U.S. but also from Asia, there have been no reports of genetic disease data specifically on pregnant women in Japan.

Hiro Clinic NIPT has analyzed data from over 20,000 patients* who have undergone NIPT in cooperation with Second Tokyo
Clinical Laboratory. (*As of May 2022)
Based on these data, we propose test items that are truly necessary for pregnant women in Japan. Hiro Clinic NIPT believes that analyzing and reporting as much data as possible with the current technology protects the “right to know” of pregnant women.

Express delivery delivers results as fast as 2 days

At Hiro Clinic NIPT, results are usually delivered within 2~5 days (usually within 3 to 6 days for some clinics and partner facilities) from the day of blood collection. For all Hiro Clinic NIPT clinics except partner facilities, an express delivery option is available (delivery within 2~3 days after the blood collection).

Testing is available throughout Japan

There are now 10 Hiro Clinic NIPT clinics operating from Hokkaido to Hakata, and testing is also available at 14 partner clinics throughout Japan.

Positivity Score Report, an analysis of data from 10,000 pregnant women in Japan

If you get a positive result, you will know how positive it really is. Based on the results of over 10,000 NIPT tests performed at Hiro Clinic NIPT and the numerical analysis of amniotic fluid test results, we offer a free Positivity Score Report that provides a combination of a “Positivity Score” and “Positivity Predictive Rate”.

Twins can also be tested

双子の場合でも検査可能

Medical facilities affiliated with the NIPT Consortium do not offer NIPT testing for twins, and medical facilities outside of the NIPT Consortium only offer NIPT testing for twins with chromosomes 13, 18, and 21. However, Hiro Clinic NIPT can to examine all chromosomes for chromosomal heteroscedasticity and all autosomal partial deletions and duplications, even in twins. However, only the presence or absence of the Y chromosome can be tested for sex chromosomes at this time.

Consult with a specialist of the Japanese Society of Obstetrics and Gynecology

日本産科婦人科学会専門医による相談が可能です

Hiro Clinic NIPT Nagoya and Hakata are staffed by physicians specializing in obstetrics and gynecology from the Japanese Society of Obstetrics and Gynecology.
Since the consultation is with a specialist who has extensive experience in the field, you are welcome to ask any questions you may have about childbirth, even the most trivial ones.
You can also ask questions online from any Hiro Clinic NIPT clinic other than Nagoya and Hakata.

At our Nagoya Clinic, fetal ultrasound examinations can be performed prior to the NIPT examination. Having a thorough knowledge of the condition of the fetus before undergoing the NIPT examination gives patients a peace of mind.
Details here

Difference between accredited and non-accredited facilities
for NIPT (new non-invasive prenatal testing)

There are two types of facilities that can perform NIPT testing: Accredited and Non-accredited

What is an Accredited Facility?

Accredited facilities are NIPT facilities accredited by the Japanese Federation of Medical Societies.
The accreditation of a facility also imposes requirements on patients who undergo NIPT testing.

  1. when the fetus has a positive result for chromosomal abnormality on fetal ultrasound examination
  2. when the fetus has a positive result for chromosomal abnormality on maternal serum marker test
  3. if the mother has previously given birth to a child with a chromosomal abnormality
  4. both parents have a balanced Robertson translocation and there is a possibility of inherited chromosome abnormality

In addition to these requirements, there are other hurdles, such as having to be at least 35 years old and needing a referral letter from an obstetrician/gynecologist.

What is a Non-accredited Facility?

Non-accredited facilities are those that are not accredited by the Japan Federation of Medical Societies. The fact that a facility is not accredited does not mean that it is illegal.
Because there is no need to worry about the conditions presented by the Japanese Federation of Medical Societies, any pregnant woman can take the NIPT test.
Some medical institutions have well-equipped testing facilities, while others offer testing at specialized institutions outside of Japan.

Advantages & Disadvantages of Non-accredited Facilities

The main advantage of non-accredited facilities is that there are no requirements to undergo testing.
Of course, another major advantage is that there are no age restrictions or need for a physician’s referral.
Another advantage of non-accredited facilities is that you can choose what can be tested and the cost is lower.

So what are the disadvantages?
Since amniocentesis is not available, you may have to make your own appointment with a clinic where amniocentesis is available.
In such cases, this can be time-consuming.

We report not only on trisomy, but also on monosomy

Hiro Clinic NIPT reports not only trisomies (three chromosomes) but also monosomies (one chromosome) and other abnormalities on chromosomes 21, 18, 13, and all chromosomes.

All chromosome testing

全染色体検査

While the conventional NIPT examines for 21, 18, and 13 trisomies, the all-chromosome test examines for abnormalities in chromosomes 1 through 22 and in the number of sex chromosomes.

All autosomal whole region partial deletion/duplication disease

Although some facilities other than those in the NIPT Consortium can test for five types of partial deletion diseases (1p36 deletion syndrome, Wolff-Hirschhorn syndrome, Cri-du-chat syndrome, Prader-Willi syndrome, Angelman syndrome, and Di George syndrome), Hiro Clinic NIPT is the only facility in Japan* that can test for more than 54 types of all autosomal partial deletions and duplications. However, the minimum size that can be detected is 7 million bases. Deletions and duplications smaller than this are undetectable, so it is not possible to detect all whole autosomal partial deletions. If there is a partial deletion in a location that is reported as an all-autosomal whole region partial deletion disease, the test report is generated as that all-autosomal whole region partial deletion disease.
* As of October 2021

Ultrasound examinations attended by a specialist
of the Japanese Society of Obstetrics and Gynecology

日本産科婦人科学会専門医立ち合いの超音波検査も行えます

Hiro Clinic NIPT Nagoyahas a gynecologist and specialized gynecological equipment such as ultrasound machines to check the condition of the fetus prior to NIPT. For more details, please click here.

Cost of NIPT

Testing fee for NIPT

The cost of the test is approximately 150,000-210,000 yen, depending on the medical institution.
Most facilities accredited by the Japan Medical Association include the cost of the definitive test in the price of the new non-invasive prenatal testing (NIPT) (varies from facility to facility).

Testing fees for tests other than NIPT

The cost of amniocentesis and amniotic fluid testing, which involves puncturing amniotic fluid with a needle, ranges from 100,000 to 200,000 yen. Some medical institutions require hospitalization for each test, which incurs additional costs.
Ultrasound examinations are also performed at prenatal checkups and cost 20,000 to 30,000 yen.
The maternal blood collection marker test costs 20,000 to 30,000 yen, but many people opt for the ultrasound examination because it can only be performed after the 15th week.

Hiro Clinic NIPT Testing Fees

The Minimum Plan is an affordable plan at 99,000 yen that includes testing for Down syndrome and other conditions such as 21, 18, and 13 trisomies.
The Light Plan offers the Minimum Plan with an additional test for sex chromosomes (abnormal numbers) and costs 132,000 yen.
The “Medium Plan” can be added to the Light Plan to test 18 diseases on 5 chromosomes, and costs 165,000 yen.
The “Standard Plan” can test 18 diseases on 5 chromosomes for all trisomy and monosomy tests 1 to 22, and it costs 198,000 yen.
The 𝗼𝘃𝗲𝗿𝟯𝟱 Plan is for 165,000 yen and includes testing for all trisomies and monosomies 1 through 22, which are more likely to occur in pregnant women over 35 years of age.
The Full Set Plan includes testing for all trisomies and monosomies on chromosomes 1 through 22, plus all partial deletions and duplications on chromosomes 1 through 22, for 264,000 yen.

Down syndrome (chromosome 21) Base price:¥45,000 (¥49,500 including tax)

For those who want to check for only Down Syndrome, Hiro Clinic NIPT offers a single chromosome test for chromosome 21.
For those who want to check for only Edwards Syndrome or Patou Syndrome, we can perform the chromosome 18 and 13 test.
Although the test does not provide information on other chromosomes, this is the least expensive NIPT because the chromosome test costs ¥45,000(¥49,500 including tax).

※ The Japanese Society of Obstetrics and Gynecology, however, recommends simultaneous examination of 21, 18, and 13 trisomies at the very least.
In Europe and the United States, many pregnant women undergo NIPT, which generally includes testing for partial deletion of all autosomal regions and all chromosomes.

NIPT (non-invasive prenatal testing) is not deductible as a medical expense.

NIPT (non-invasive prenatal testing) is not eligible for medical expense deductions.
This is because the medical expense deduction is limited to medical treatment involving medical care and treatment.
Prenatal checkups, which are only examinations similar to physical examinations or health checkups, are not recognized as eligible medical treatment.
Also, it is not covered by medical insurance system as well. Be aware of this as it is often mistaken.

Examples of pregnancy and childbirth-related expenses that are deductible as medical expenses are as follows:

(1) Expenses for periodic checkups and examinations after a pregnancy is diagnosed, as well as hospital visits, are deductible as medical expenses. ※1

(2) If a woman is hospitalized for childbirth and is unable to use ordinary means of transportation such as trains or buses, and takes a cab, the cab fare is deductible as a medical expense. ※2

(3) Expenses for personal supplies such as bedclothes and toiletries purchased during hospitalization are not deductible as medical expenses.

(4) Meals paid to hospitals during hospitalization are generally deductible as medical expenses since they are paid as part of the hospitalization costs. ※3

※1 Although many hospital expenses are not documented with receipts, please make sure that you can clearly explain the actual expenses incurred by recording them in a household account book or other means.
※2 Transportation expenses for traveling back to the family home to give birth are not deductible as medical expenses.
※3 Food deliveries or eaten out is not deductible.

Mutual Aid Society System

Hiro Clinic NIPT can provide you mutual aid society sponsored by our affiliated laboratories. The membership fee is 3,000 yen (tax free).
By becoming a member, patients with positive test results can receive up to 200,000 yen (including tax) in subsidies for the cost of amniotic fluid testing.
This is a one-time payment and cash only. In addition, Second Tokyo Clinical Laboratory offers amniotic fluid exome analysis. In the case of a positive result, this test will be free of charge. By comparing the results of the exome analysis with the raw NIPT data, we can provide you with detailed test results.

Amniotic fluid testing Cost Assistance Program

There is a standard for subsidizing the cost of amniotic fluid testing.
① For all autosomal and sex chromosome aneuploidy positive results, we will assist with G-band and qf-PCR testing.
② For positive results in all autosomal whole region partial deletion and duplication disease, we will assist with G-band, qf-PCR, microarray, and FISH testing.

Sensitivity, Specificity, and Risk of amniotic fluid and chorionic villus tests

Trimester
-Test
1st-
viability test
2nd-
Amniotic fluid test
Sensitivity99.25%※199.4%※2
Specificity98.65%※299.5%※2
Mortality due
to testing
1.1%※30.4%※3

Amniotic fluid and chorionic villus tests, which are considered definitive tests, do not give 100% certainty.

※1. Hahnemann JM, Vejerslev LO. Accuracy of cytogenetic findings on chorionic villus sampling (CVS)—diagnostic consequences of CVS mosaicism and non-mosaic discrepancy in centres contributing to EUCROMIC 1986-1992. Prenat Diagn. 1997;17(9):801-820.
※2. Mid-trimester amniocentesis for prenatal diagnosis. Safety and accuracy. JAMA. 1976; 236(13): 1471-1476.
※3. Enzensberger C, Pulvermacher C, Degenhardt J, et al. Fetal loss rate and associated risk factors after amniocentesis, chorionic villus sampling and fetal blood sampling. Ultraschall Med. 2012;33(7):E75-9.

Adapted from illumina, Inc.

Hiro Clinic NIPT Testing Policy

At Hiro Clinic NIPT, there are no age restrictions on testing.
The following is a summary of the American College of Obstetricians and Gynecologists’ guidelines for NIPT.

Summary of Society Guidelines on NIPT

  • All women should be offered the option of aneuploidy screening,
    including NIPT, or diagnostic testing regardless of age.1- 3
  • If NIPT fails to give a result, alternate testing should be discussed
    with the patient because of increased risk for aneuploidy. 1-2
  • False positives and false negatives do occur. Diagnostic testing
    should be offered to any patient with a positive NIPT result. 1-3
  1. American Colege of Obstetriciansa nd Gynecologists. Screening for fetal aneuploidy. Practice Bulletin No.1 63.O bslef Gynecot.2 016;1 27(5):e123-137.
  2. Benn P, Borrell A, Chiu RWK,et al. Position statement from the Chromosome Abnormality Screening Committee on behalf of theB oardo f the lnte rnational Society for Prenatal Diagnosis. Prenat Oiagn.2 015;35(8):725-734.do i:10.1002/pd.4608.
  3. Gregg AR,S kotkoB G, Benkendorf JL,e t al. Noninvasive prenatat screening for fetala neuploidy,2 016u pdate: ap osition statement of the American College of MedicalGe netics and Genomics.G enet Med.2 016: doi:10.1038/gim.2016.97.

Doctor-supervised columns and an SNS where you can learn about the clinic.

Useful information for pregnant women in their daily lives is provided in the column page.
What to do from conceiving to delivering a baby? From questions during pregnancy to amniotic fluid testing and NIPT (new prenatal diagnosis). Please read this easy-to-understand article under the supervision of a doctor.

In addition, each clinic has its own SNS to provide information. You can find out more the atmosphere of the clinic in your area.
Please follow and like us on social networking sites from the Clinic Information page.

Complete the test in just one visit!

You will only have to visit the clinic once on the day of the test for NIPT.
If you would like to hear about the results in detail, a doctor will explain the results to you.

No referral letter is required for diagnosis.

A referral letter from a family doctor is not required, as is the case in larger hospitals.
Reservations can be made even using your phone, so please feel free to make reservations using the Web reservation form, which is available 24 hours a day.
※ Please bring your Mother and Child Handbook.

When can NIPT be performed?

NIPT can be done as early as 10 weeks of pregnancy. Appointments can be made as soon as the due date is known.
Also, there is no time limit for testing for NIPT. However, if you have a positive result and wish to have a definitive test,
Hiro Clinic NIPT recommends testing by the 15th week, as amniotic fluid testing is done at 15 to 18 weeks.
Results are usually available within 2-5 days after blood collection at Hiro Clinic NIPT (usually within 3-6 days at some hospitals and partner clinics). Express delivery option is available at all Hiro Clinic NIPT clinics except partner clinics (delivery within 2~3 days after blood collection).

You can come alone or with your children during your visit

NIPT can be done as early as 10 weeks of pregnancy. Pregnant women are welcome to come alone.

It is not required that both parents come to the clinic together, and a chaperone may come with you to the clinic. You may also bring your child with you.
Each clinic has an elevator so that you can come with an infant in a stroller.

※ Although we have taken sufficient measures against COVID 19 in the clinic, we have made an appointment system in order to prevent congestion due to the large number of people coming to the clinic during business hours. We ask for your understanding and cooperation. Due to the current coronavirus outbreak, we encourage you to come in as few people as possible.


Hiro Clinic NIPT System

Overview of NIPT Test

Test nameNIPT (Non-Invasive Prenatal Testing)
Blood collection
Medical institution
Hiro Clinic NIPT
Specimen10 ml of blood
Test SubjectsPregnant women after 10 weeks, Single or twin pregnancies
Age limitNone

NIPT Results for Low Risk Groups

ArticlesNumber of
pregnant women
Detection rateFalse Positives
Nicolaides et al.[※1]2049100%0.1%
Dan et al.[※2]11,105100%0.03%
Bianchi et al.[※3]2052100%0.3%
Norton et al.[※4]15,841100%0.06%
Zhang et al.[※5]147,31499.17%0.05%

[※1]Nicolaides KH,Syngelaki A, Ashoor G, Birdir C,Touzet G. Noninvasive prenatal testing for fetal trisomies in a routinely screened first-trimester population. Am J Obstet Gynecol 2012;207:374.el-6.

[※2]Dan S, Wang W, Ren J, Li Y, Hu H,Zu Z, et al. Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11105 pregnancies with mixed risk factors. Prenat Diagn 2012;32:1225-32.

[※3]Bianchi DW, Lamar Parker R, Wentworth J, Madankumar R, Saffer C, Das AF, et al. DNA sequencing versus standard prenatal aneuploidy screening. N Engl J Med 2014;370:799-808.

[※4]Norton ME, Jacobsson B, Swamy GK, Laurent LC, Ranzini AC, Brar H,et al. Cell-free DNA analysis for noninvasive examination of trisomy. N Engl J Med 2015;372:1589-97.

[※5]Zhang H, Gao Y, Jiang F, Fu M, Yuan Y, Guo Y, et al.Non-invasive prenatal testing for trisomies 21,18 and 13:clinical experience from 146958 pregnancies. Ultrasound Obstet Gynecol 2015;45:530-8.

Sensitivity and specificity of NIPT

Sensitivity and specificity
in 21 trisomies, 18 and 13

N=2028 Including mosaic

Sensitivity
Two-sided 95% confidence interval
Specificity
Two-sided 95% confidence interval
Trisomy 21> 99.9% (130/130)
(97.1%, 100%)
99.90% (1982/1984)
(99.63%, 99.97%)
Trisomy 18> 99.9% (41/41)
(91.4%, 100%)
99.90% (1995/1997)
(99.64%, 99.97%)
Trisomy 13> 99.9% (26/26)
(87.1%, 100%)
99.90% (2000/2002)
(99.64%, 99.97%)

Estimated sensitivity and specificity for twins

21 trisomy, 18 trisomy, 13 trisomy, presence of Y

Sensitivity
Two-sided 95% confidence interval
Specificity
Two-sided 95% confidence interval
Trisomy 2196.40%
(86.4%, 98.9%)
99.90%
(99.8%, > 99.9%)
Trisomy 1895.70%
(68.3%, 99.4%)
> 99.9%
(99.9%, > 99.9%)
Trisomy 1393.60%
(64.1%, 98.9%)
> 99.9%
(99.9%, > 99.9%)
Presence of Y> 99.9%
(99.9%, > 99.9%)
> 99.9%
(99.7%, > 99.9%)

Chromosomal aneuploidy and fetal gender identity

Sex ClassificationPhysical findingsGenetic Testing
ResultGirlsBoysXXXYXOXXXXXYXYYOther
abnormalities
Unknown
NegativeXX9970210200000
NegativeXY0966015000001
PositiveXO00001900100
PositiveXXX00000170010
PositiveXXY00000023010
PositiveXYY00000001100
Total99796621152117231221

Sensitivity and Specificity of Veriseq NIPT Solution V2
for Detecting Any Abnormality (including Mosaic)

SensitivitySpecificity
Estimate %(n/N)95.5% (318/333)99.34% (1954/1967)
Two-sided
95% confidence interval
92.7%, 97.3%98.87%, 99.61%

Sensitivity and Specificity of All Autosomal Chromosomes (Including Mosaicism)

SensitivitySpecificity
Estimate %(n/N)96.4% (27/28)99.80% (2001/2005)
Two-sided
95% confidence interval
82.3%, 99.4%99.49%, 99.92%

All Autosomal Whole Region Partial Deletion/Duplication (Including Mosaicism)

SensitivitySpecificity
Estimate %(n/N)74.1% (20/27)99.80% (2001/2004)
Two-sided
95% confidence interval
55.3%, 86.8%99.49%, 99.92%

Differences in testing contents in different laboratories

This is a comparison table of inspection contents between Hiro Clinic NIPT and other inspection institutions.

Hiro Clinic NIPTNIPT ConsortiumMedical Institutions other
than NIPT Consortium
Testing InstituteAffiliated Second Tokyo Clinical
Laboratory (Bunkyo-ku, Tokyo)
Domestic Testing
(GeneTech etc.)
Overseas
(Verinata Healthcare etc)
Number of days
for inspection report
Delivery is usually within 2~5 days (usually within 3~6 days for some hospitals and partner facilities) from the time of blood collection. Please note that the express delivery option is available at all Hiro Clinic NIPT clinics, excluding partner facilities (delivery within 2~3 days from blood collection).1-2 weeks1-2 weeks
FeeLowest standard price in the industryExpensiveExpensive

Comparison by Testing Companies

While tests at NIPT Consortium and non-NIPT Consortium medical institutions can detect trisomies 21, 18, and 13 in sets of three, Hiro Clinic NIPT can test not only chromosomes 21, 18, and 13, but also other chromosomes 1 to 22 as individual chromosomes.

Chromosome 21, 18, and 13 trisomy

Only Second Tokyo Clinical Laboratory can provide a positivity score report, and GeneTech and Verinata Healthcare cannot provide a positivity score report.

Second Tokyo Clinical LaboratoryGene
Tech
Verinata
HealthCare
No. 21 Can be tested as a stand-alone test (※positivity score report)
Full set, Recommended, Junior, over35, Light, Minimum, Stand-alone test
Possible with a set
of 3 chromosomes
Possible with a set
of 3 chromosomes
No. 18 Can be tested alone (※positivity score report)
Full set, Recommended, Junior, over35, Light, Minimum
No. 13 Can be tested alone (※positivity score report)
Full set, Recommended, Junior, over35, Light, Minimum
常染色体(1~22番染色体)の染色体単体検査、 ミニマムプラン、 ライトプラン、 over35,プラン、 ミディアムプラン、 スタンダードプラン、 おすすめプラン、 フルセットプラン
Twins can also be tested Only single fetuses can be tested. Sex chromosomes cannot be tested.

Positivity Score Report

Positivity Score is an optional service of Hiro Clinic NIPT. If the NIPT is positive, the Positivity Score Report will help you decide if you should have an amniotic fluid test.

Second Tokyo Clinical LaboratoryGene
Tech
Verinata
Healthcare
Positivity Score Chromosomes 21, 18, and 13 trisomy only××
Twins can also be tested Only single fetuses can be tested. Sex chromosomes cannot be tested.

Chromosome 21, 18, and 13 Monosomy

Autosomal monosomy is a condition in which a pair of chromosomes, usually two, is deleted and only one is present.
The survival probability of monosomy is not high, and cases of miscarriage are reported to be common.
Only Tokyo Clinical Laboratory can test for each autosomal monosomy, and GeneTech and Verinata Healthcare cannot test for this condition.

Second Tokyo Clinical LaboratoryGene
Tech
Verinata
Healthcare
No. 21 Included in Testing for #21.
Full set, Recommended, Junior, over35, Light, Minimum, Stand-alone testing plans
××
No. 18 Included in Testing for #21.
Full set, Recommended, Junior, over35, Light Test Plans
××
No. 13 Included in Testing for #13.
Full set, Recommended, Junior, over35, Light Test Plans
××
常染色体(1~22番染色体)の染色体単体検査、 性染色体検査、 ミニマムプラン、 ライトプラン、 over35,プラン、 ミディアムプラン、 スタンダードプラン、 おすすめプラン、 フルセットプラン
Twins can also be tested Only single fetuses can be tested. Sex chromosomes cannot be tested.

Sex chromosome test

Testing for sex chromosomes is appropriate when there is a close relative with X-linked recessive inheritance; X-linked recessive inheritance occurs primarily in boys, but girls are often asymptomatic carriers. For more information on sex chromosome abnormalities, click here.

Second Tokyo Clinical LaboratoryGene
Tech
Verinata
Healthcare
Sex chromosome test Full set, Recommended, Junior, over35, Light Sex Chromosomes Test Plans×
性染色体検査、 ミニマムプラン、 ライトプラン、 over35,プラン、 ミディアムプラン、 スタンダードプラン、 おすすめプラン、 フルセットプラン
Twins can also be tested Only single fetuses can be tested. Sex chromosomes cannot be tested.

All Chromosome Trisomy

Second Tokyo Clinical LaboratoryGene
Tech
Verinata
Healthcare
1 Full set, Recommended, Junior, over35 test plans ×
2 Full set, Recommended, Junior, over35 test plans ×
3 Full set, Recommended, Junior, over35 test plans ×
4 Full set, Recommended, Junior, over35 test plans ×
5 Full set, Recommended, Junior, over35 test plans ×
6 Full set, Recommended, Junior, over35 test plans ×
7 Full set, Recommended, Junior, over35 test plans ×
8 Full set, Recommended, Junior, over35 test plans ×
9 Full set, Recommended, Junior, over35 test plans ×
10 Full set, Recommended, Junior, over35 test plans ×
11 Full set, Recommended, Junior, over35 test plans ×
12 Full set, Recommended, Junior, over35 test plans ×
13 Can be tested stand-alone (*positive score possible)
Full set, Recommended, Junior over35, Light, Minimum Test Plans
Possible with chromosome
sets 21, 18, and 13
Possible with chromosome
sets 21, 18, and 13
14 Full set, Recommended, Junior, over35 test plans ×
15 Full set, Recommended, Junior, over35 test plans ×
16 Full set, Recommended, Junior, over35 test plans ×
17 Full set, Recommended, Junior, over35 test plans ×
18 Can be tested stand-alone (*positive score possible)
Full set, Recommended, Junior over35, Light, Minimum Test Plans
Possible with chromosome
sets 21, 18, and 13
Possible with chromosome
sets 21, 18, and 13
19 Full set, Recommended, Junior, over35 test plans ×
20 Full set, Recommended, Junior, over35 test plans ×
21 Can be tested stand-alone (*positive score possible)
Full set, Recommended, Junior over35, Light, Minimum Test Plans
Possible with chromosome
sets 21, 18, and 13
Possible with chromosome
sets 21, 18, and 13
22 Full set, Recommended, Junior, over35 test plans ×
over35,プラン、 ミディアムプラン、 スタンダードプラン、 おすすめプラン、 フルセットプラン
Twins can also be tested Only single fetuses can be tested. Sex chromosomes cannot be tested.

All Chromosome Monosomy

Second Tokyo Clinical LaboratoryGene
Tech
Verinata
Healthcare
1 Full set, Recommended, Junior, over35 test plans ××
2 Full set, Recommended, Junior, over35 test plans ××
3 Full set, Recommended, Junior, over35 test plans ××
4 Full set, Recommended, Junior, over35 test plans ××
5 Full set, Recommended, Junior, over35 test plans ××
6 Full set, Recommended, Junior, over35 test plans ××
7 Full set, Recommended, Junior, over35 test plans ××
8 Full set, Recommended, Junior, over35 test plans ××
9 Full set, Recommended, Junior, over35 test plans ××
10 Full set, Recommended, Junior, over35 test plans ××
11 Full set, Recommended, Junior, over35 test plans ××
12 Full set, Recommended, Junior, over35 test plans ××
13 Can be tested stand-alone (*positive score possible)
Full set, Recommended, Junior over35, Light, Minimum Test Plans
××
14 Full set, Recommended, Junior, over35 test plans ××
15 Full set, Recommended, Junior, over35 test plans ××
16 Full set, Recommended, Junior, over35 test plans ××
17 Full set, Recommended, Junior, over35 test plans ××
18 Can be tested stand-alone (*positive score possible)
Full set, Recommended, Junior over35, Light, Minimum Test Plans
××
19 Full set, Recommended, Junior, over35 test plans ××
20 Full set, Recommended, Junior, over35 test plans ××
21 Can be tested stand-alone (*positive score possible)
Full set, Recommended, Junior over35, Light, Minimum Test Plans
××
22 Full set, Recommended, Junior, over35 test plans ××
over35,プラン、 ミディアムプラン、 スタンダードプラン、 おすすめプラン、 フルセットプラン
Twins can also be tested Only single fetuses can be tested. Sex chromosomes cannot be tested.

Partial Deletion of All Autosomal Regions

Hiro Clinic NIPT only reports on all autosomal whole region partial deletions of 7 million bases or more.

Second Tokyo Clinical LaboratoryGene
Tech
Verinata
Healthcare
1 All Areas
Full set, Recommended, Junior Test Plans
× 1p36 area only
2 All Areas
Full set, Recommended, Junior Test Plans
××
3 All Areas
Full set, Recommended, Junior Test Plans
××
4 All Areas
Full set, Recommended, Junior Test Plans
× 4p area only
5 All Areas
Full set, Recommended, Junior Test Plans
× 5p area only
6 All areas
Full Set Test Plans
××
7 All Areas
Full set, Recommended, Junior Test Plans
××
8 All Areas
Full set, Recommended, Junior Test Plans
××
9 All areas
Full Set Test Plans
××
10 All Areas
Full set, Recommended, Junior Test Plans
××
11 All areas
Full Set Test Plans
××
12 All areas
Full Set Test Plans
××
13 All areas
Full Set Test Plans
××
14 All areas
Full Set Test Plans
××
15 All Areas
Full set, Recommended, Junior Test Plans
× 15q11 area only
16 All areas
Full Set Test Plans
××
17 All areas
Full Set Test Plans
××
18 All Areas
Full set, Recommended, Junior Test Plans
××
19 All areas
Full Set Test Plans
××
20 All Areas
Full set, Recommended, Junior Test Plans
××
21 All Areas
Full set, Recommended, Junior Test Plans
××
22 All Areas
Full set, Recommended, Junior Test Plans
× 22q11.2 area only
over35プラン、 ミディアムプラン、 スタンダードプラン、 おすすめプラン、 フルセットプラン
Twins can also be tested Only single fetuses can be tested. Sex chromosomes cannot be tested.
※Only partial deletions of 7 million bases or more of the base will be covered.
Verinata Healthcare can report deletions up to about 2 million bases. However, the technique is not disclosed and there is no guarantee that 2 million bases are covered.
Hiro Clinic NIPT has previously submitted 1095 microdeletion tests on chromosomes 1, 4, 5, 15, and 22 to Verinata Healthcare, but none have been reported as positive. It is possible that this is less common in Japanese.
Hiro Clinic NIPT can also submit your specimens to Verinata Healthcare upon your request.

Partial Duplication

Hiro Clinic NIPT only reports on all autosomal whole region partial deletions of 7 million bases or more.

Second Tokyo Clinical LaboratoryGene
Tech
Verinata
Healthcare
1 All Areas
Full set, Recommended, Junior Test Plans
××
2 All Areas
Full set, Recommended, JuniorTest Plans
××
3 All Areas
Full set, Recommended, JuniorTest Plans
××
4 All Areas
Full set, Recommended, Junior Test Plans
××
5 All Areas
Full set, Recommended, Junior Test Plans
××
6 All areas
Full Set Test Plans
××
7 All Areas
Full set, Recommended, Junior Test Plans
××
8 All Areas
Full set, Recommended, Junior Test Plans
××
9 All areas
Full Set Test Plans
××
10 All Areas
Full set, Recommended, Junior Test Plans
××
11 All areas
Full Set Test Plans
××
12 All areas
Full Set Test Plans
××
13 All areas
Full Set Test Plans
××
14 All areas
Full Set Test Plans
××
15 All Areas
Full set, Recommended, Junior, Test Plans
××
16 All areas
Full Set Test Plans
××
17 All areas
Full Set Test Plans
××
18 All Areas
Full set, Recommended, Junior Test Plans
××
19 All areas
Full Set Test Plans
××
20 All Areas
Full set, Recommended, Junior,Test Plans
××
21 All Areas
Full set, Recommended, Junior Test Plans
××
22 All Areas
Full set, Recommended, Junior Test Plans
××
over35プラン、 ミディアムプラン、 スタンダードプラン、 おすすめプラン、 フルセットプラン
Twins can also be tested Only single fetuses can be tested. Sex chromosomes cannot be tested.
※Only partial deletions of 7 million bases or more of the base will be covered.
Only Second Tokyo Clinical Laboratory and Verinata Healthcare can check for partial duplication.
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