Comparison of the difference between the Quattro Test (Quattro Test) and NIPT (New Prenatal Diagnosis) [supervised by a physician].

Summary of this article

The Quattro test is a screening test that measures the components of a pregnant woman’s blood to test for probability. NIPT mainly tests for 13-trisomy, 18-trisomy, and 21-trisomy. While the Quattro test reports the results numerically, NIPT reports the results as negative or positive.

The gender of the fetus is known at 10 weeks.

What is Quattro Test (Quatro Test)?

Quattro test is a composition in the blood of a pregnant woman and examining the probability (how to sort out highly possible people and give a probability) The older the pregnant woman, the more likely it is to create a baby with a genetic disease.However, in Quattro Test, calculate the value based on the age of the pregnant woman as a basic value, and the number when the baby is a disease is calculated.In other words, Quattrotest can trust the test results in that can calculate the numerical value of each pregnant woman instead of only age. Comparing this number with a guide value, if a pregnant woman is lower than the guideline value, it will be “negative” and “positive” if it is high.


Types of diseases that can be detected by the Quattro test (Quatro test)

You can calculate the likelihood that your baby will have Down syndrome (trisomy 21) , Edwards syndrome (trisomy 18) , or open neurocanal malformation.

Quattro test accuracy

Quattrotest is a screening test as described above. According to a survey of a certain research institutionThe hit rate of down syndrome was 87 %. Similarly, the hit rate of open neurons is 83%,The rate of Edwards Syndrome is 77%, which is not a test of definitive diagnosis, but it shows a high value and is highly credible.

Period to see a test

The recommended period is the period when you can see the examination.From 15 weeks to 17 weeks of pregnancy.Even if it is around 15 weeks to 21 weeks of pregnancy, it can be consulted, but it is said that it is desirable to receive it by 17 weeks to determine whether to take an amniotic fluid test after looking at the test number.Please note that you will not be able to consult if you are less than 15 weeks of pregnancy.

Inspection method

The test method collects blood from a pregnant woman, measuring the blood component (AFP, HCG, UE3, INHIBIN A) and inspected.These configurations are pregnant babies or placenta -made ingredients.The numerical value of these compositions fluctuates as the baby grows, but also fluctuates as the baby is a target disease.Add the status of pregnant women to the value of this configuration to calculate the probability of whether the baby is a disease.The test is calculated because the probability of each is calculated in light of its own probability to the age of the pregnant woman.An old -fashioned pregnant woman tends to increase the probability of diagnostic tests.

What is revealed from the results of the Quattro test (Quatro test)

For each disease, a numerical value is determined as a guideline, and you can find out the probability that your baby has the disease. For example, if the probability of a disease is 1 in 100, out of 100 pregnant women with the same probability of 1 in 100, there is a chance that one of them is pregnant with a baby with the disease. Interprets high. In other words, if the result is negative, it is interpreted as “It is unlikely that the baby will have the target disease, but it cannot be determined that a baby with the target disease will never be born.” If the result is positive, it is interpreted as “The baby has the target disease.” “There is a high possibility that a baby with the target disease will be born, but we cannot be certain that a baby with the target disease will definitely be born.”

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Diagnosis after Quattro test (Quatro test) explained case by case

After confirming the results reported by the Quattro test, we will explain below the diagnosis to determine whether your baby has the target disease or not in order to obtain more accurate results.

(1) Cases of trisomy 18 or trisomy 21

To determine whether these diseases areYou have to have an amniotic fluid test .The amniotic fluid contains baby cells, and this cell is collected to find out if there is a chromosomal change.Chromosome abnormalities include changes in the number of chromosomes decreasing or increasing, and changes in the structure in which the shape of the chromosome changes.A amniotic fluid test is not a risk, because there is no risk because the amniotic fluid is collected by applying a thin needle to the abdomen of the pregnant woman.In the worst case, it is said that there is a slight possibility that a baby may miscarriage after the test.

What is trisomy 18 (Edwards syndrome)?

Trisomy 18 is a disease in which the normally two chromosomes become three due to an abnormality in the 18th chromosome. It has been confirmed that it causes various physical abnormalities and severe intellectual developmental disorders. Recently, with proper treatment, some babies seem to be able to live up to around 10 years of age, but no clear cure has yet been found.

What is trisomy 21 (Down syndrome)?

21 Trisomy is BasicallyIs a disease caused by three 21st chromosomes. Mainly the development of athletic ability and the growth of intellectual development will be delayed.It is also known to be more likely to cause other illnesses, and increase the probability of developing in conjunction with internal organs and heart illness.These diseases can be cured, so it is important to discover the disease early after giving birth and provide accurate medical care.In addition, it is becoming possible to operate socially even after adults by nursing care that has been carefully considered early.

(2) Cases of open neural tube malformation

There are tests to check the levels in amniotic fluid to determine the disease, and diagnostic imaging such as ultrasound. The amniotic fluid collection method is the same as described above.

What is open neural tube malformation?

Open neural tube malformation is a condition in which abnormalities occur in the baby’s spinal cord and brain because the baby’s neural tube, which is formed during early pregnancy, does not form properly. The main symptoms include anencephaly (a case in which the brain does not develop because the skull is not properly configured) and spina bifida (a case in which the spine does not develop properly). In the case of open spina bifida, alpha-fetoprotein flows out of the baby’s spine, so it can be tested before birth by measuring alpha-fetoprotein in the amniotic fluid. After giving birth, surgery will be required while the baby is still a newborn. Spina bifida obliterans is often unaware of it, and it is not uncommon for it to unexpectedly show up on X-rays taken during other checkups as an adult.

Comparison of the difference between the Quattro Test (Quattro Test) and NIPT (New Prenatal Diagnosis) [supervised by a physician].

What is NIPT (New Prenatal Testing)?

Up to this point, I have explained the Quattro Test in detail, but from now on, I will explain about NIPT (New Prenatal Test) by comparing and considering the differences between it and the Quattro Test.

NIPT (Non-Invasive Prenative Genetic Testing) was launched in the United States in October 2011, and in 2013 it was informed in 2013 as the name of “New Birth Diagnosis”.Unlike the previous test,It is a screening test that collects blood from pregnant women, analyzes the baby’s DNA fragments in the blood, and examines chromosome diseases and abnormalities.At present, inspections are possible from 6 weeks of pregnancy, and the risk of miscarriage and infectious diseases is small as in pre -prenatal diagnosis, and the reliability and credibility of the test results are compared to other tests.The feature is that it is expensive.The body burden on pregnant women is minimal, so all pregnant women can be tested with confidence.However, as in the case of Quattro Test, it is not a fixed inspection, so if the test result is positive,It is necessary to undergo a definitive diagnostic test that mainly determines test results such as amniotic fluid tests.

Points to note when undergoing NIPT

For pregnant women without specialized knowledge, it may be difficult to interpret the results of genetic tests such as NIPT (New Prenatal Testing) . For this reason, especially if the test result is positive, it is important to meet with a specialist such as a genetic counselor to confirm the detailed condition and to ensure that you can accurately understand the contents of the NIPT (New Prenatal Testing) test results. Sho. Up to this point, I have explained the Quattro test in detail, but from now on, I will explain about NIPT (New Prenatal Test) , comparing and considering the differences between it and the Quattro test. It is important to remember that the test results, like the Quattro test results, do not give a definitive answer as to whether a pregnant woman has a chromosomal disease. NIPT (New Prenatal Test) is a screening test that can tell whether a pregnant woman is negative or positive based on the test results. Please note that tests that give an absolute answer of “no disease” or “presence of disease” are definitive tests. There are many laboratories that carry out NIPT (New Prenatal Diagnostic Testing) tests, and each laboratory may report slightly different test results. For example, most testing organizations notify pregnant women of the results for each disease they are screening for, such as negative (decreased risk, negative) or positive (increased risk, positive).

Points to note regarding NIPT (New Prenatal Testing) test results

Please be careful of the following points regarding the test results of NIPT (New Prenatal Testing).

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Comparison of Quattro Test (Quatro Test) and NIPT (New Prenatal Diagnosis)

As explained above, the Quattro test and NIPT (New Prenatal Diagnosis) are test methods that examine whether there is a possibility that the baby has some kind of chromosomal abnormality by drawing blood from a pregnant woman and analyzing the components in the blood in detail. (pre-diagnosis) are the same, but there are some differences, so we will compare and explain the differences below.


Compare the differences in what each test reveals

Compare inspection items

The Quattro test can test for three types of congenital diseases: open neural tube malformations, trisomy 18 , and trisomy 21 , as well as the probability of chromosomal abnormalities.

On the other hand, NIPT (New Prenatal Testing) can mainly test for trisomy 13 (Patau syndrome) , trisomy 18 (Edwards syndrome) , and trisomy 21 (Down syndrome). At Hiro Clinic NIPT , in addition to testing chromosomes 13, 18, and 21, all chromosomes including sex chromosomes, we also test for all autosomal partial deletion diseases and all autosomal partial duplications.Diseases can also be tested.

Compare test results

For example, the results of the Quattro test are reported as a value of 1/100 , whereas in the case of NIPT (New Prenatal Testing) , the results are reported as negative or positive. This is a typical difference. Please note that the results of neither the Quattro test nor NIPT (New Prenatal Testing) are definitive. Therefore, if the test results indicate that there is a suspicion of some kind of congenital disease or that there is a risk of chromosomal abnormality, it is necessary to undergo a definitive diagnosis.

Compare differences in inspection conditions

Some hospitals , mainly those certified by the Japan Medical Association , have strict conditions such as age for receiving NIPT (New Prenatal Testing) . All hospitals have the same condition: “10 to 18 weeks after pregnancy,” but other conditions vary depending on the hospital, so you need to check with the hospital where you want to undergo the test.

On the other hand, any pregnant woman can undergo the Quattro test without any special conditions as long as she is between 15 and 21 weeks pregnant.

Compare which test most pregnant women request

In conclusion, not the former Quattro Test, but the latterNIPT (new prenatal diagnosis)At present, the number of pregnant women who want is increasing.As a reasonNIPT (new prenatal diagnosis)The accuracy of the test results is very high compared to the Quattro test.but,NIPT (new prenatal diagnosis)Then, if the result is positive, the probability is extremely low, but there is a risk of false positive.Therefore, if a report of positive and test results comes, the pregnant woman needs to be tested to determine the results of the test.However, if it is a negative diagnosis result,The negative rate is 99.9%, which is extremely probable for screening tests, and is trusted by the test results, so there is a merit that there is little possibility but there is a risk of miscarriage.。in this wayNIPT (new prenatal diagnosis)Is a very high test result than the Quattro test.NIPT (new prenatal diagnosis)This is why the number of pregnant women who want to inspect.

Comparison of the difference between the Quattro Test (Quattro Test) and NIPT (New Prenatal Diagnosis) [supervised by a physician].

NIPT (New Prenatal Diagnosis) at Hiro Clinic NIPT

As explained aboveNIPT (new prenatal diagnosis)The number of pregnant women who want to test has increased because the test results are very reliable compared to Quattro Test.but,NIPT (new prenatal diagnosis)In order to receive, some hospitals have some strict conditions, and the problem is that some pregnant women who want to see a doctor can not have a medical examination.Hiro Clinic NIPTIt is implementing inNIPT (new prenatal diagnosis)Then, there is no age limit and no letter of introduction is required.moreover,Part of the entire field of all -ingrained chromosomes in the whole field of duplicate diseaseorPartially partially pervasive chromosomesWe also carry out unique inspections that are not found in other facilities.In addition, it can be inspected even in twins.If you have a pregnant woman who is worried, please contact us.

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Article Editorial Supervisor

Dr. Kunihiko Shiraogawa

Dr. Kunihiko Shiraogawa

Head Doctor of Hiro Clinic NIPT Nagoya
Certified Obstetrician and Gynecologist, Japan Society of Obstetrics and Gynecology

As an obstetrician/gynecologist with nearly 40 years of extensive experience, he has worked with many pregnant women.
Currently, as the head doctor of Hiro Clinic NIPT Nagoya , he is in charge of NIPT testing, and also provides consultations to pregnant women online at all Hiro Clinic NIPT clinics in Japan.

Brief History

1982 – Aichi Medical University Hospital
1987 – OB/GYN, Kagoshima University Hospital
1993 – Head Doctor, Shiranogawa Clinic
2011 – Kaba Memorial Hospital
2019 – Okamoto Ishii Hospital
2020 – Head Director, Hiro Clinic NIPT Nagoya

Check his Profile here


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