B: over35 Plan
The over35 plan examines for Patau Syndrome, Edwards Syndrome, and Down Syndrome which are among the most frequent congenital diseases caused by changes in the number of autosomal chromosomes, which are 22 pairs of chromosomes (44 chromosomes). This plan will also examine for trisomy and monosomy of all chromosomes 1-22 and sex chromosomes.
※ Determination of gender is possible for single fetus.
● Tests abnormalities in Chromosomes 1-22.
● For single fetus, abnormalities of sex chromosomes and gender/sex will be reported.
● For twins, you will be informed whether or not a Y chromosome is present.
Those who are over 35 years of age. Since trisomy of all chromosomes tends to occur more frequently in this age group.
Diseases that can be detected by this test
|21||Down syndrome||1 in 700|
|18||Edwards syndrome||1 in 6,000|
|13||Patau syndrome||1 in 10,000|
|X||Klinefelter’s syndrome||1 in 1,000|
|X||Turner’s syndrome||1 in 2,500|
|X||XXX syndrome||1 in 1,000|
|Y||XYY syndrome||1 in 1,000|
X-linked Recessive Inheritance Disorder
The following is a list of the major X-linked recessive inherited disorders.
Boys may develop the disease when they have a close relative with X-linked recessive inheritance, while girls are often asymptomatic carriers.
Note that NIPT cannot determine the presence or absence of X-linked recessive inherited disease. However, it is possible to verify the possibility of developing X-linked recessive inherited disease in a relative by examining the sex of the child.
The following are typical X-linked recessive genetic disorders:
|X||X-linked agammaglobulinemia (XLA)||Boys 1 in 100,000|
|X||Glucose-6-phosphate dehydrogenase deficiency||1 in 1,000|
|X||X-linked hypophosphatemic rickets (XLH)||1 in 20,000|
|X||Red-green colorblindness||1 in 20 to 500|
|X||Hemophilia||1 in 4 boys with maternal retention|
|X||Duchenne muscular dystrophy (DMD)||60% for boys 1 in 3,500 maternal retention|
|X||X-linked ichthyosis||1 in 2,000 to 6,000|
|X||Kallmann syndrome||1 in 10,000|
|X, Y||Leri-Weill dyschondrosteosis (LWD)|
A quarter of those with positive results didn’t know they turned positive
2.45%( around 518 people) of the total number of patients in the Hiro Clinic NIPT had positive results. (*As of March 2020 – June 2021)
About 27.3% of them were not able to find out that they had tested positive for a disease other than the ones that are reported/tested by the plan they selected. This includes 7.31% of those who chose the over35 plan.
Source: Hiro Clinic Research
Assuming 100% of those who were positive, whether or not the results are reported.
The 17.4% of all the pregnant women who took the over35 plan were detected to have chromosomal abnormalities not included in to the test coverage: Chromosome 1~22 trisomy/monosomy and sex chromosome abnormality.
Below is a chart showing the range of diseases that can be reported under the over35 Plan based on the percentage of overall disease types for those who are found to have a disease/disorder.
Scope of report on results of Full Set & over35 Plan
Source: Hiro Clinic Research
Consider a Full set plan that includes a very detailed examination.
The over35 plan can examine one fetus (single fetus) or twins.
All clinic tests are performed domestically in Japan, and results are usually delivered within 2~5 days (usually within 3~6 days for some clinics and partner facilities) from the day of blood collection. Please note that express delivery option is available at all Hiro Clinic NIPT clinics (within 2~3 days after blood collection), except for partner facilities.