R:Recommended Plan

¥200,000  ( ¥220,000 incl. tax )  
¥247,500for twins, including tax
If you are visiting a related clinic
¥220,000
(¥242,000 including tax)
¥269,500 for twins, incl. tax.

Hiro Clinic NIPT’s recommended plan is to examine all chromosomes plus chromosomes 1, 2, 3, 4, 5, 7, 8, 10, 15, 18, 20, 21, and 22 for partial deletions or duplications of all regions. Syndromes will be identified for the 12 known types. Deletion and duplication sites in other regions will also be included in the report.
This plan is recommended by Hiro Clinic NIPT, which has had over 17,000 people* tested. (*As of March 11, 2022)
Gender can also be identified.

  • ● Tests abnormalities in Chromosomes 1-22.

    1
    2
    3
    4
    5
    6
    7
    8
    9
    10
    11
    12
    13
    14
    15
    16
    17
    18
    19
    20
    21
    22
  • ● Tests Chromosomes 1,2,3,4,5,7,8,10,15,18,20,21,22 whole region for Partial deletion and Duplication disease abnormalities

    Deletion
    Duplication
    1
    2
    3
    4
    5
    7
    8
    10
    15
    18
    20
    21
    22
    X

    (Excluding Y)

  • ● For single baby, you will be informed of the sex chromosome abnormalities and gender/sex of the baby.

    XY
    XX
    XO
    XXY
    Others…
  • ● For twins, we will be informed whether or
    not a Y chromosome is present.

    Y

This plan is recommended to:

Those who are wondering about NIPT but would like to have a thorough test.
Those who have experienced repeated miscarriages.
Those who have experienced stillbirths.
This NIPT test is recommended for those who have some kind of disability in their immediate family.
It is also recommended for those who want to take the opportunity to examine themselves in detail.
This plan is designed based on a study involving over 17,000 pregnant women in Japan to determine the most appropriate test content based on age limitations, target chromosomes, and focus on pregnant women in Japan.

Diseases that can be detected by this test

ChromosomeDisease/DisorderOccurrence rate
21Down syndrome1 in 700
18Edwards syndrome1 in 6,000
13Patau syndrome1 in 10,000
1Trisomy/monosomy 1
2Trisomy/monosomy 2
3Trisomy/monosomy 3
4Trisomy/monosomy 4
5Trisomy/monosomy 5
6Trisomy/monosomy 6
7Trisomy/monosomy 7
8Trisomy/monosomy 8
9Trisomy/monosomy 9
10Trisomy/monosomy 10
11Trisomy/monosomy 11
12Trisomy/monosomy 12
14Trisomy/monosomy 14
15Trisomy/monosomy 15
16Trisomy/monosomy 16
17Trisomy/monosomy 17
19Trisomy/monosomy 19
20Trisomy/monosomy 20
22Trisomy/monosomy 22
ChromosomeDisease/DisorderOccurrence rate
XKlinefelter’s syndrome1 in 1,000
XTurner’s syndrome1 in 2,500
XXXX syndrome1 in 1,000
YXYY syndrome1 in 1,000
ChromosomeDisease/DisorderOccurrence rate
11q21.1 microdeletion syndrome 
11p36 deletion syndrome1 in 4,000 to 10,000
11q21.1 microduplication syndrome
2Nephronophthisis
2Holoprosencephaly
2Albright syndrome-like metacarpal/brachymetatarsia
ChromosomeDisease/DisorderOccurrence rate
33q29 microdeletion syndrome
4Wolf-Hirschhorn syndrome1 in 50,000
5Cornelia de Lange syndrome1 in 30,000 to 50,000
5Cri-du-chat syndrome1 in 20,000 to 50,000
5Sotos syndrome1 in 10,000 to 20,000
7Pallister-Hall syndrome
7Greig’s cerebral polydactyly
ChromosomeDisease/DisorderOccurrence rate
7Saethre-Chotzen syndrome
7Total anterior
encephalocele type 3
7Charge syndrome
7Williams syndrome
88p23.1 microdeletion syndrome
8Tricho-rhino-phalangeal syndrome type I
(TRPS type I)
8Langer-Giedion syndrome
88p23.1 microduplication syndrome
10Chromosome 10q24 duplication syndrome
ChromosomeDisease/DisorderOccurrence rate
15Prader-Willi syndrome1 in 16,000
15Angelman syndrome1 in 15,000
15Hypergrowth and intellectual disability
20Alagille syndrome
22Phelan-McDiarmid Syndrome
22Di George Syndrome
2222q11.2 deletion syndrome1 in 4,000
2222q11.2 duplication syndrome
22cat eye syndrome1 in 50,000

X-linked Recessive Inherited Diseases

The following is a list of the major X-linked recessive inherited diseases/disorders.

Boys may develop the disease/disorder when they have a close relative with X-linked recessive inherited disease/disorder, while girls are often asymptomatic carriers.

Note that NIPT cannot determine the presence or absence of X-linked recessive inherited disease/disorder. However, it is possible to verify the possibility of developing X-linked recessive inherited disease/disorder in a relative by examining the sex of the child.

The following are typical X-linked recessive genetic disorders:


ChromosomeDisease/DisorderOccurrence rate
XX-linked Agammaglobulinemia (XLA)Boys 1
in 100,000
XGlucose-6-phosphate dehydrogenase deficiency1 in 1000
XX-linked hypophosphatemic rickets (XLH)1 in 20,000
XRed-green color blindness1 in 20-500
XHemophilia1 in 4 boys with maternal carrier
ChromosomeDisease/DisorderOccurrence rate
XDuchenne muscular dystrophy60% for boys – 1 in 3,500 maternal carriers
XX-linked ichthyosis1 in 2,000 to 6,000
XKallmann’s syndrome1 in 10,000
X, YLeri-Weill syndrome 

New Prenatal Testing (NIPT)
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A quarter of those with positive results didn’t know they turned positive

2.45%( around 518 people) of the total number of patients in the Hiro Clinic NIPT had positive results. (*As of March 2020 – June 2021)
About 27.3% of them were not able to find out that they had tested positive for a disease other than the ones that are reported/tested by the plan they selected.

Positivity Report

Hiro Clinic Hiro Clinic Positivity Report Positivity Report

Source: Hiro Clinic Research

Assuming 100% of those who were positive, whether or not the results are reported.

A total of 8.7% of all respondents who took the Recommended plan were found to have chromosomal abnormalities that were outside the coverage of Recommended Plan: ‘trisomy/monosomy of chromosomes 1-22’, ‘sex chromosome abnormality’ and ‘partial deletion or duplication of the whole region of chromosomes 1, 2, 3, 4, 5, 7, 8, 10, 15, 18, 20, 21, 22’.

Below is a graph showing the range of diseases that can be reported under the recommended plan, based on the percentage of all disease/disorder types in the population of those who were found to have a disease/disorder.

Difference in the Scope of Reporting Results between the Full Set Plan & the Recommended Plan

Hiro Clinic Hiro Clinic NIPT NIPT Recommended Plan Recommended Plan

Source: Hiro Clinic Research

Consider a full-set plan that includes a detailed examination .

The recommended plan can examine one fetus (single fetus) or twins.
All clinic tests are performed domestically in Japan, and results are usually delivered within 2~5 days (usually within 3~6 days for some clinics and partner facilities) from the day of blood collection. Please note that express delivery option is available at all Hiro Clinic NIPT clinics (within 2~3 days after blood collection), except for partner facilities.

New Prenatal Testing (NIPT)
Over 28,000 completed cases
You can take the test
with an easy mind.

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View Plans
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